Review
Multidisciplinary Sciences
Wenping Wu, Jimin Zheng, Zongchao Jia
Summary: The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane composed of MCU, MCUb, EMRE, MICU1, and MICU2. Recent structural studies have provided insights into the component structures and their spatial relationship, contributing to a better understanding of mitochondrial Ca2+ uptake and regulation. Further research in this area could lead to advancements in studying mitochondrial Ca2+ permeation and related diseases.
Article
Biochemistry & Molecular Biology
Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Vikas Arige, Trayambak Pathak, J. Cory Benson, Martin T. Johnson, Ahmed Emam Abdelnaby, Natalia Lakomski, Nadine Hempel, Jung Min Han, Genevieve Dupont, David Yule, James Sneyd, Mohamed Trebak
Summary: The study demonstrates that MCU is a universal regulator of intracellular Ca2+ signaling across mammalian cell types, affecting Ca2+ signal transduction and nuclear translocation through multiple mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Md Imam Faizan, Tanveer Ahmad
Summary: Classical necroptosis signaling is mediated by death receptors and traditional caspase inhibitory signals, while a non-classical model of necroptosis with relatively unexplored molecular mechanism has emerged, showing close association with mitochondrial dysfunction. Contradictory reports complicate the definitiveness of this emerging model.
Article
Cell Biology
Beatrice D'Orsi, Natalia Niewidok, Heiko Dussmann, Jochen H. M. Prehn
Summary: The study revealed that BID and MTCH2 functionally interact to promote Ca2+-induced neuronal cell death, with BID translocating to mitochondria during this process and MTCH2 facilitating mitochondrial swelling and decreased energetics, ultimately leading to cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yulia Baburuna, Linda Sotnikova, Olga Krestinina
Summary: The protein phosphorylation of membrane-bound mitochondrial proteins is important in regulating the respiratory chain function, mPTP opening, and apoptosis. Calpain-3 was identified as a phosphorylated protein involved in mPTP regulation, with the calpain inhibitor calpeptin shown to suppress mPTP opening. Phosphorylated truncated CALP3 with a molecular weight of 60-62 contains p-Tyr, suggesting the involvement of protein tyrosine phosphatase in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Olga Krestinina, Yulia Baburina, Roman Krestinin
Summary: Mitochondria play a key role in heart function and diseases, with AST showing potential as a protective agent against oxidative damage and dysfunction in mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Macarena Rodriguez-Prados, Elena Berezhnaya, Maria Teresa Castromonte, Sergio L. Menezes-Filho, Melanie Paillard, Gyorgy Hajnoczky
Summary: Mitochondrial Ca2+ uptake is regulated by the mtCU complex, which consists of MCU, EMRE, and MICU1/2/3 subunits. MICU1 has been proposed to physically block the mtCU pore and regulate Ca2+ flux at different cytoplasmic [Ca2+]. We studied the mtCU in divalent-free conditions and found that MICU1 restricts Na+ influx, but some mtCU channels appear to lack MICU1-dependent gating in cells with high endogenous MICU1 expression. The rearrangement of mtCU and loss of MICU1 during mitoplast preparation might have affected previous studies in divalent-free conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Agnese De Mario, Anna Tosatto, Julia Marie Hill, Janos Kriston-Vizi, Robin Ketteler, Denis Vecellio Reane, Gino Cortopassi, Gyorgy Szabadkai, Rosario Rizzuto, Cristina Mammucari
Summary: In this study, amorolfine and benzethonium were identified as positive and negative modulators of the mitochondrial calcium uniporter (MCU), demonstrating their potential roles in muscle development and cancer progression.
Review
Biochemistry & Molecular Biology
Linlin Zhang, Jingyi Qi, Xu Zhang, Xiya Zhao, Peng An, Yongting Luo, Junjie Luo
Summary: Mitochondria are essential for cellular energy metabolism and the generation of oxygen free radicals, and also play a crucial role in cell death. Ca2+ acts as a messenger for cell proliferation and death, and is involved in the energy metabolism, physiology, and pathology of mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Astrid L. Basse, Marianne Agerholm, Jean Farup, Emilie Dalbram, Joachim Nielsen, Niels Ortenblad, Ali Altintas, Amy M. Ehrlich, Thomas Krag, Santina Bruzzone, Morten Dall, Roldan M. de Guia, Jonas B. Jensen, Andreas B. Moller, Anders Karlsen, Michael Kjaer, Romain Barres, John Vissing, Steen Larsen, Niels Jessen, Jonas T. Treebak
Summary: The study showed that NAMPT is crucial for maintaining cellular Ca2+ homeostasis and skeletal muscle development, which is vital for juvenile survival. Through analysis of skeletal muscle-specific Nampt KO mice, it was found that NAMPT plays a critical role in these processes.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Paulina Sander, Thomas Gudermann, Johann Schredelseker
Summary: Research on mitochondrial Ca2+ uptake mainly focuses on the function, regulation, and localization of the mitochondrial calcium uniporter complex (MCUC), while also investigating the role of the outer mitochondrial membrane channels in regulating this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rene Endlicher, Zdenek Drahota, Katerina Stefkova, Zuzana Cervinkova, Otto Kucera
Summary: The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-selective membrane pore with various functions. Its reversible opening protects cells from oxidative damage and allows Ca2+ ions efflux, while its irreversible opening leads to cell death. The sensitivity of the pore to Ca2+ ions changes with aging and plays a key role in disease pathogenesis.
Article
Biology
Giampaolo Morciano, Natalia Naumova, Piotr Koprowski, Sara Valente, Vilma A. Sardao, Yaiza Potes, Alessandro Rimessi, Mariusz R. Wieckowski, Paulo J. Oliveira
Summary: This review summarizes the intriguing phenomenon of the mitochondrial permeability transition pore (mPTP) in cell biology. Despite almost 50 years of research, the mechanisms of mPTP are still not definitively understood. From initially being considered an in vitro artifact to now being recognized for its physiological and pathological implications, the journey of mPTP research has been long and complex.
BIOLOGICAL REVIEWS
(2021)
Review
Physiology
Joanne F. Garbincius, John W. Elrod
Summary: The uptake and extrusion of calcium into and from the mitochondrial matrix have significant effects on cellular metabolism, signaling, and survival. Disruption of mitochondrial calcium cycling is associated with various diseases and inherited neuromuscular disorders. This review provides an overview of the molecular machinery involved in calcium flux across the inner mitochondrial membrane and discusses the physiological implications and potential therapeutic interventions for diseases characterized by aberrant calcium handling. Critical unanswered questions regarding the biology of calcium flux are also highlighted.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Higashitani, Mika Teranishi, Yui Nakagawa, Yukou Itoh, Surabhi Sudevan, Nathaniel J. Szewczyk, Yukihiko Kubota, Takaaki Abe, Takeshi Kobayashi
Summary: Sarcopenia, a syndrome characterized by age-related decline in skeletal muscle mass and strength, can be improved by suppressing mitochondrial calcium uniporter (MCU)-mediated Ca2+ influx into mitochondria. In this study, researchers found that aged muscle cells showed elevated resting mitochondrial Ca2+ levels and increased mitophagy, and suppressing MCU function improved movement in muscular dystrophy. These results suggest that elevated resting mitochondrial Ca2+ levels contribute to muscle decline with age and modulation of MCU activity could be an effective pharmacological target for muscle loss.
Article
Medical Laboratory Technology
Laurence Bessueille, Lynn Kawtharany, Thibaut Quillard, Claudia Goettsch, Anne Briolay, Nirina Taraconat, Stephane Balayssac, Veronique Gilard, Saida Mebarek, Olivier Peyruchaud, Francois Duboeuf, Caroline Bouillot, Anthony Pinkerton, Laura Mechtouff, Rene Buchet, Eva Hamade, Kazem Zibara, Caroline Fonta, Emmanuelle Canet-soulas, Jose luis Millan, David Magne
Summary: This study found that the activation of tissue-nonspecific alkaline phosphatase (TNAP) precedes and predicts calcification in atherosclerotic plaques, and TNAP inhibition prevents plaque calcification and protects arteries from atherosclerosis. The study also discovered that TNAP inhibition reduces blood levels of cholesterol and triglycerides, and ameliorates plaque calcification, thereby protecting arteries.
TRANSLATIONAL RESEARCH
(2023)
Article
Critical Care Medicine
Antoine Duclos, Cecile Payet, Loredana Baboi, Bernard Allaouchiche, Laurent Argaud, Frederic Aubrun, Julien Bohe, Frederic Dailler, Jean-Luc Fellahi, Jean-Jacques Lehot, Vincent Piriou, Thomas Rimmele, Delphine Terragrossa, Stephanie Polazzi, Claude Guerin
Summary: This study found that the familiarity level between nurses in the ICU has a significant impact on patient outcomes, with higher familiarity associated with lower risk of patient deaths.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jean-Pierre Chouraqui, Christophe Dupont, Andre Briend, Dominique Darmaun, Noel Peretti, Alain Bocquet, Martin Chalumeau, Arnaud De Luca, Francois Feillet, Marie-Laure Frelut, Dominique Guimber, Alexandre Lapillonne, Agnes Linglart, Jean-Christophe Roze, Umberto Simeoni, Dominique Turck
Summary: Reducing the burden of noncommunicable diseases (NCDs) is a global public health priority, and improving diet quality is recognized as an effective approach. The Nutri-Score (N-S) front-of-pack labeling logo helps consumers identify healthier prepackaged foods. Studies have shown that the N-S is an efficient tool for raising consumer awareness, understanding, and purchasing of healthier options, potentially reducing NCD prevalence. The N-S is currently voluntary in 7 European countries, but discussions are ongoing to establish a harmonized mandatory label. However, the impact of the N-S on children's dietary patterns and health needs further investigation, especially considering their specific nutritional requirements.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benoit Cosset, Monica Sigovan, Sara Boccalini, Fadi Farhat, Philippe Douek, Loic Boussel, Salim Aymeric Si-Mohamed
Summary: This study aimed to investigate the feasibility of identifying and characterizing the three most common types of endoleaks in a thoracic aorta aneurysm model using bicolor K-edge imaging and a biphasic contrast agent injection. The results showed that bicolor K-edge imaging allows for the bicolor characterization of thoracic aorta endoleaks in a single acquisition.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Review
Genetics & Heredity
Charles R. Lefevre, Francois Labarthe, Diane Dufour, Caroline Moreau, Marie Faoucher, Paul Rollier, Jean-Baptiste Arnoux, Marine Tardieu, Lena Damaj, Claude Bendavid, Anne-Frederique Dessein, Cecile Acquaviva-Bourdain, David Cheillan
Summary: Primary Carnitine Deficiency (PCD) will be included in the expansion of the French newborn screening program in 2023. Screening for PCD is complex and has a wide clinical spectrum. Some countries struggle with high false positive rates and have even removed PCD from their screening programs. To understand the risks and benefits, we reviewed the literature and identified hurdles and current practices in PCD newborn screening worldwide. In addition, we address the optimized screening algorithm for the implementation of PCD screening in France.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2023)
Article
Cardiac & Cardiovascular Systems
Camelia Acatrinei, Caroline Martin-Bonnet, Gilles Rioufol, Francis Bessiere
Summary: This case report describes a patient with Fontan circulation who developed IART and initial poor haemodynamic tolerance. Both IART ablation and transcatheter aortic valve replacement were performed during the same procedure, resulting in improved haemodynamics and control of the arrhythmia.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Review
Peripheral Vascular Disease
Narasimha Anaganti, Atrayee Chattopadhyay, Mathilde Di Filippo, M. Mahmood Hussain
Summary: This review provides an overview of new developments in gene editing technology, particularly in using CRISPR/Cas9-mediated gene editing to study lipoprotein assembly and secretion.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Critical Care Medicine
Martin Ruste, Matthias Jacquet-Lagreze, Jean-Luc Fellahi
Summary: Individualized hemodynamic optimization often requires cardiac output monitoring, which can be achieved through noninvasive technologies. Care providers need to be aware of the advantages and limitations of these technologies to ensure appropriate use for patient care.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Laurent Jacquin, Marion Battault, Nathan Mewton, Adrien Mantout, Cyrille Bergerot, Karim Tazarourte, Marion Douplat
Summary: The aim of this study was to describe the outcomes and associated factors in patients admitted to emergency departments with oxygen supply/demand imbalance, without considering troponin results or restrictive criteria for type 2 myocardial infarction. A retrospective cohort of 824 patients was analyzed, and in-hospital mortality, 3-year mortality, and major adverse cardiovascular events were reported as outcomes. The results showed that acute myocardial injury and type 2 myocardial infarction were significantly associated with in-hospital mortality, but did not have higher long-term mortality or major cardiovascular events after discharge.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amine Fikani, Martin Beaufigeau, Justine Vignon, Benoit Cosset, Ahmad Hayek, Fadi Farhat
Summary: This retrospective study analyzed consecutive patients who underwent surgery for VSR and found that post-operative use of ECLS was associated with more bleeding complications and the need for reintervention. Although mortality was similar, bleeding complications remain a major limitation for the use of ECLS.
JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Article
Critical Care Medicine
Thomas Metayer, Chloe Dumot, Florian Bernard, Pierre-Jean Le Reste, Anne-Laure Bernat, Helene Cebula, Charles-Henry Mallereau, Charles Peltier, Caroline le Guerinel, Denis Vivien, Michel Piotin, Evelyne Emery, Vianney Gillard, Arthur Leclerc, Elsa Magro, Francois Proust, Isabelle Pelissou-Guyotat, Stephane Derrey, Sorin Aldea, Charlotte Barbier, Alin Borha, Lawrence Nadin, Anais R. Briant, Thomas Gaberel
Summary: This study aimed to compare the functional outcomes of surgical evacuation in patients with ruptured middle cerebral artery aneurysm (MCAa) and intracerebral hematoma. The study found that clipping the aneurysm and concomitant hematoma evacuation can achieve better functional outcomes compared to endovascular therapy (EVT) followed by surgical evacuation.
NEUROCRITICAL CARE
(2023)
Article
Multidisciplinary Sciences
Martin Schwarzer, Umesh Kumar Gautam, Kassem Makki, Anne Lambert, Tomas Brabec, Amelie Joly, Dagmar Srutkova, Pierre Poinsot, Tereza Novotna, Stephanie Geoffroy, Pascal Courtin, Petra Petr Hermanova, Renata C. Matos, Jonathan J. M. Landry, Celine Gerard, Anne-Laure Bulteau, Tomas Hudcovic, Hana Kozakova, Dominik Filipp, Marie -Pierre Chapot-Chartier, Marek Sinkora, Noel Peretti, Ivo Gomperts Boneca, Mathias Chamaillard, Hubert Vidal, Filipe De Vadder, Francois Leulier
Summary: The intestinal microbiota plays a role in postnatal growth, and Lactiplantibacillus plantarum strain LpWJL has been found to support growth in undernourished animals. This strain stimulates insulin-like growth factor-1 (IGF-1) and insulin production and activity. Cell walls from LpWJL, as well as specific molecules, can promote growth despite undernutrition. NOD2 in intestinal epithelial cells is necessary for LpWJL-mediated IGF-1 production and growth promotion in malnourished animals.
Review
Medicine, General & Internal
Franck Zekre, Anita Duncan, Audrey Laurent, Maud Tusseau, Remi Pescarmona, Sophie Collardeau-Frachon, Camille Ohlmann, Sebastien Viel, Philippe Reix, Sarah Benezech, Alexandre Belot
Summary: Biological disease-modifying anti-rheumatic drugs (bDMARDs) targeting IL-6 and IL-1 beta are commonly used as a first-line therapy for systemic-onset juvenile idiopathic arthritis (sJIA), but they may increase the risk of pulmonary alveolar proteinosis (PAP). We report a new case of PAP-MAS successfully treated with Janus Kinase inhibitors (JAKi) and review previous clinical descriptions of this condition. Among the analyzed articles, the incidence of PAP-MAS among sJIA patients ranged from 1.28% to 12.9%. JAKi shows promise in treating lung disease associated with sJIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Damien Contou, Gaetan Beduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Remi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sebastien Preau, Nicolas de Prost
Summary: This study aimed to assess the sensitivity of skin biopsy in adult patients with meningococcal purpura fulminans. The results showed that skin biopsy combined with conventional culture and meningococcal PCR had a global sensitivity of 88%, and should be considered even after the initiation of antimicrobial treatment.
Article
Critical Care Medicine
Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maite Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stephane Ruckly, Jean-Marie Forel, Jean-Francois Timsit
Summary: Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV-associated-non-AIDS (HANA) conditions] may now be observed.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)