期刊
JOURNAL OF MEDICAL ENTOMOLOGY
卷 58, 期 2, 页码 880-890出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jme/tjaa193
关键词
horse fly; tabanid; Flavivirus; insect-specific flavivirus; coevolution
资金
- Ministry of Health, Labor and Welfare
- Research Program on Emerging and Re-emerging Infectious Diseases from Japan Agency for Medical Research and Development (AMED)
- JSPS KAKENHI [JP18K19220, JP18H02856]
A novel flavivirus, named Tabanus rufidens flavivirus (TrFV), was discovered in Japanese horse fly during this study. TrFV was only detected in T. rufidens and showed a closer relationship to classical insect-specific flaviviruses (cISFs) rather than vertebrate-infecting flaviviruses (VIFs), indicating it is a novel member of the cISFs. This discovery provides new insights into the evolutionary history and dynamics of flaviviruses.
Tabanid flies (Tabanidae: Diptera) are common hematophagous insects known to transmit some pathogens mechanically or biologically to animals; they are widely distributed throughout the world. However, no tabanid-borne viruses, except mechanically transmitted viruses, have been reported to date. In this study, we conducted RNA virome analysis of several human-biting tabanid species in Japan, to discover and characterize viruses associated with tabanids. A novel flavivirus was encountered during the study in the Japanese horse fly, Tabanus rufidens (Bigot, 1887). The virus was detected only in T. rufidens, but not in other tabanid species, and as such was designated Tabanus rufidens flavivirus (TrFV). TrFV could not be isolated using a mammalian cell line and showed a closer phylogenetic relationship to the classical insect-specific flaviviruses (cISFs) rather than the vertebrate-infecting flaviviruses (VIFs), suggesting that it is a novel member of the cISFs. The first discovery of a cISF from Brachycera provides new insight into the evolutionary history and dynamics of flaviviruses.
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