Article
Immunology
Haggai Bar-Yoseph, Shaqed Carasso, Shlomit Shklar, Alexander Korytny, Razi Even Dar, Haneen Daoud, Roni Nassar, Nitsan Maharshak, Khetam Hussein, Yuval Geffen, Yehuda Chowers, Naama Geva-Zatorsky, Mical Paul
Summary: The study provides a biological explanation for the effectiveness of FMT against CPE carriage, suggesting that the decolonization of CPE is likely mediated by changes in the composition and function of the microbiome.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
JongHoon Hyun, Sang Kil Lee, Jae Hee Cheon, Dong Eun Yong, Hong Koh, Yun Koo Kang, Moo Hyun Kim, Yujin Sohn, Yunsuk Cho, Yae Jee Baek, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Joon Sup Yeom, Jun Yong Choi
Summary: This study aimed to evaluate the genetic response of MDROs to FMT in patients infected with VRE, CPE, or VRE/CPE. The results showed that FMT decreased the expression of resistance genes and facilitated MDRO decolonisation.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Biochemistry & Molecular Biology
Jongbeom Shin, Jung-Hwan Lee, Soo-Hyun Park, Boram Cha, Kye Sook Kwon, Hyungkil Kim, Yong Woon Shin
Summary: This study found that fecal microbiota transplantation may be an effective method for clearing multidrug-resistant organisms from the intestinal tract, especially for carbapenem-resistant Enterobacteriaceae. Although the eradication effect on vancomycin-resistant enterococci was not significant, the overall negative-conversion rate was significantly higher in the FMT group.
Review
Gastroenterology & Hepatology
Kanchan Jaswal, Olivia A. Todd, Judith Behnsen
Summary: A diverse array of microorganisms, including bacteria as the most abundant and studied members, inhabit the human intestinal tract. However, the gut microbiome also consists of viruses, archaea, fungi, protists, and parasitic worms, which have been less studied but play important roles in health and disease. This review focuses on these understudied members, detailing their composition, development, and functional interactions with enteric pathogens. It presents both general concepts and specific examples of how non-bacterial gut communities modulate bacterial pathogenesis, highlighting the need for including these communities in future gut microbiome research.
Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Immunology
Pan Fu, Xinpeng Luo, Jun Shen, Leiyan He, Hua Rong, Chunling Li, Saige Chen, Lei Zhang, Aimin Wang, Chuanqing Wang
Summary: This study investigated carbapenemase-producing Enterobacteriaceae (CPE) strains isolated from children in Shanghai, China from 2016 to 2021. The results showed that NDM was the primary carbapenemase in children (67.6%), followed by KPC (26.4%), IMP (5.3%), and OXA-48 (0.6%). NDM-Kpn posed the most serious threat to infants, especially neonates, and the high-risk clone ST11 KPC-Kpn should be continuously monitored in children.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Microbiology
Jin-Jae Lee, Dongeun Yong, Ki Tae Suk, Dong Joon Kim, Heung-Jeong Woo, Seung Soon Lee, Bong-Soo Kim
Summary: The study evaluated changes in gut microbiota of CRE carriers during FMT and found it to be a potential option for CRE decolonization. The analysis of gut microbiota could help predict decolonization timing after FMT and determine the necessity of repeated FMT.
Article
Biochemistry & Molecular Biology
Kristopher D. Parker, Akhilendra K. Maurya, Hend Ibrahim, Sangeeta Rao, Petronella R. Hove, Dileep Kumar, Rama Kant, Bupinder Raina, Rajesh Agarwal, Kristine A. Kuhn, Komal Raina, Elizabeth P. Ryan
Summary: The study demonstrates that modified gut microbiota from humans consuming rice bran can protect mice from colon carcinogenesis, with specific microbial communities associated with colon health. The findings suggest that integrated dietary-FMT intervention strategies could be effective for colorectal cancer control, treatment, and prevention.
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Ye Peng, Suisha Liang, Kanchana Poonsuk, Hilda On, Sze Wang Li, Morgan Maxime Pascal Maurin, Ching Him Chan, Chak Lun Chan, Zhen Ye Sin, Hein Min Tun
Summary: This study identified both travel-related risk factors and microbial predictors for the risk of ESBL-E acquisition during international travels, including gut microbiota composition and dietary habits.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Infectious Diseases
Sarah Jolivet, Jeanne Couturier, Xavier Vuillemin, Cyril Gouot, Didier Nesa, Marine Adam, Eolia Brissot, Mohamad Mohty, Remy A. Bonnin, Laurent Dortet, Frederic Barbut
Summary: This study investigated a persistent outbreak of OXA-48 carbapenemase-producing Enterobacterales (CPE) in a haematological ward of a French teaching hospital, primarily Citrobacter freundii. Whole genome comparisons identified clonal dissemination from hospital environment to patients. Strict routine infection control measures and an intensive cleaning program helped to contain the outbreak.
Article
Biochemistry & Molecular Biology
Zan Song, Lin Liu, Yanyi Xu, Ruofan Cao, Xianyong Lan, Chuanying Pan, Shengxiang Zhang, Haiyu Zhao
Summary: Chronic caffeine-induced sleep restriction affects the diversity and composition of the gut microbiota in mice and substantially alters the metabolic profiles of the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yong Kyun Kim, In Bok Chang, Han Sung Kim, Wonkeun Song, Seung Soon Lee
Summary: The study found that OXA-48-like and Klebsiella pneumoniae are associated with prolonged carriage of CPE. Additionally, patients with CP-K. pneumoniae, positive clinical specimen of CPE, and concurrent Clostridioides difficile infection are more likely to have prolonged carriage of CPE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eleni Xenofontos, Georgios Renieris, Maria Kalogridi, Dionyssia-Eirini Droggiti, Kalliopi Synodinou, Georgia Damoraki, Panagiotis Koufargyris, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis
Summary: Current research shows that gut colonization often precedes infection by carbapenem-resistant enterobacteria. Rifaximin has been found to effectively inhibit CRKP isolates and reduce KPC-KP gut colonization.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Caijun Zhao, Xiaoyu Hu, Min Qiu, Lijuan Bao, Keyi Wu, Xiangyue Meng, Yihong Zhao, Lianjun Feng, Shiyu Duan, Yuhong He, Naisheng Zhang, Yunhe Fu
Summary: This study demonstrates that gut microbiota disturbance caused by metabolic abnormalities of gut microbiota is associated with the occurrence and development of mastitis. The underlying mechanism of how gut dysbiosis leads to mastitis pathogenesis remains unclear. Additionally, the regulation of commensal bacteria and gut metabolism may provide a potential strategy for mastitis intervention.
Article
Gastroenterology & Hepatology
Jihye Park, Jae Hee Cheon, Kang-Moon Lee, Young-Ho Kim, Byong Duk Ye, Chang Soo Eun, Sung Hyun Kim, Sun Hee Lee, Joon Ho Lee, Stefan Schreiber
Summary: This study aimed to compare the clinical efficacy and safety of CT-P13 and originator infliximab in Crohn's disease treatment. The study found a significant correlation between early serum infliximab trough levels and treatment outcomes, and there were no statistical differences in serum trough levels and anti-drug antibody levels between CT-P13 and originator infliximab.
Article
Public, Environmental & Occupational Health
E. H. Lee, S. K. Lee, J. H. Cheon, H. Koh, J. A. Lee, C. H. Kim, J. N. Kim, K. H. Lee, S. J. Lee, J. H. Kim, J. Y. Ahn, S. J. Jeong, N. S. Ku, D. E. Yong, S. S. Yoon, J. S. Yeom, J. Y. Choi
Summary: This study aimed to compare the efficacy of different FMT methods for decolonizing MDRO and found that the oral capsule is an effective method. Discontinuation of antibiotics after FMT is a key factor in the success of decolonization.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Infectious Diseases
Jinnam Kim, Jung Ho Kim, Hi Jae Lee, Se Ju Lee, Changhyup Kim, Jung Ah Lee, Ki Hyun Lee, Won Kyung Pyo, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Seung Hyun Lee, Jun Yong Choi, Joon-Sup Yeom
Summary: Appropriate postoperative antibiotic treatment does not have a significant effect on the recurrence, mortality, or postoperative complications in patients with infective endocarditis (IE).
Article
Infectious Diseases
Se Ju Lee, Jinnam Kim, Ki Hyun Lee, Jung Ah Lee, Chang Hyup Kim, Su Hwan Lee, Byung Jo Park, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon-Sup Yeom, Jun Yong Choi
Summary: During the COVID-19 pandemic, the incidence of pneumothorax/pneumomediastinum associated with COVID-19 is higher, especially in critically ill patients. This study aims to identify the risk factors and clinical characteristics of pneumothorax/pneumomediastinum in COVID-19 patients.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Ki Hyun Lee, Dongju Won, Jinnam Kim, Jung Ah Lee, Chang Hyup Kim, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Hyunsoo Cho, Haerim Chung, June-Won Cheong, Seung-Tae Lee, Ji Eun Jang, Saeam Shin, Jin Young Ahn
Summary: Whole-genome sequencing of plasma microbial Aspergillus cell-free DNA is a useful noninvasive diagnostic approach for patients with hematologic malignancies and a high risk of invasive aspergillosis. It can accurately diagnose invasive aspergillosis in patients with hematologic malignancy or COVID-19.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
S. H. Park, S. R. Yoon, J. Y. Nam, J. Y. Ahn, S. J. Jeong, N. S. Ku, J. Y. Choi, J. -S. Yeom, J. H. Kim
Summary: This nationwide cohort study demonstrated an association between tuberculosis and osteoporosis as well as osteoporotic fractures. Tuberculosis was found to independently increase the incidence of osteoporosis and osteoporotic fractures, particularly hip fractures.
Article
Oncology
Yae Jee Baek, Youn-Jung Lee, So Ra Park, Kyoo Hyun Kim, Seung-Hoon Beom, Choong-kun Lee, Sang Joon Shin, Sun Young Rha, Sinyoung Kim, Kyoung Hwa Lee, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Minkyu Jung, Jin Young Ahn
Summary: This study aimed to assess the humoral response to COVID-19 vaccination in solid cancer patients and analyze factors associated with immunogenicity. The results showed that cancer patients had lower antibody levels after the first vaccination compared to healthcare workers, but after the third vaccination, their antibody levels were comparable. However, the neutralizing antibody response to the Omicron variant was not robust in cancer patients who received the adenovirus vector-based vaccine as the primary series, suggesting the need for additional interventions to protect them from COVID-19.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Public, Environmental & Occupational Health
E. H. Lee, J. A. Lee, J. Y. Ahn, S. J. Jeong, N. S. Ku, J. Y. Choi, J-s. Yeom, Y. G. Song, S. H. Park, J. H. Kim
Summary: Obesity is associated with poor clinical outcomes in critically ill patients, but can have protective effects in certain clinical conditions. This study found that body mass index (BMI) was not associated with bloodstream infections (BSI) during extracorporeal membrane oxygenation (ECMO), but patients with higher BMI had lower in-hospital mortality during ECMO support.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Infectious Diseases
Jungmi Chae, Jun Yong Choi, Bongyoung Kim, Dong-Sook Kim
Summary: This study aimed to demonstrate antimicrobial utilization in pregnant women and identify related factors. The study found that the prescribing rate of antibiotics to pregnant women in South Korea has remained stably high, with an increase in the use of broad-spectrum beta-lactam penicillin. It is necessary to monitor antibiotics in pregnant women generally in accordance with recommendations.
Article
Oncology
Yoonyoung Jang, Taehwa Kim, Brian H. S. Kim, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Boyoung Park
Summary: This study aimed to estimate the medical cost of cancer in people who developed cancer after HIV infection in Korea. The study utilized the Korea National Health Insurance Service-National Health Information Database (NHIS-NHID). Among 16,671 patients diagnosed with HIV infection from 2004 to 2020 in Korea, we identified 757 patients newly diagnosed with cancer after HIV diagnosis. The study found higher medical costs for AIDS-defining cancers compared to non-AIDS-defining cancers, particularly non-Hodgkin's lymphoma in the first year of diagnosis.
JOURNAL OF CANCER PREVENTION
(2023)
Article
Pediatrics
Yoo Min Lee, Yoon Lee, So Yoon Choi, Hyun Jin Kim, Suk Jin Hong, Yunkoo Kang, Eun Hye Lee, Kyung Jae Lee, Youjin Choi, Dae Yong Yi, Seung Kim, Ben Kang
Summary: This study analyzed the current practice patterns of GI endoscopy among pediatric endoscopists in South Korea. The majority of pediatric endoscopists performed common GI endoscopic procedures, while rare procedures were mainly performed by adult endoscopists. Close communication and cooperation between pediatric and adult endoscopists are required for such rare procedures.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Rheumatology
Jihye Park, Hongyul An, Jiwoo Lim, I. Seul Park, Mi Hyun Kim, Ji Hyung Kim, Seung Won Kim, Young Il Koh, Eun Young Lee, Jae Hee Cheon
Summary: This study investigated the emergence rate of clonal haematopoiesis of indeterminate potential (CHIP) and its association with inflammatory markers in patients with Behcet's disease (BD). The results showed that the detection rate of CHIP in BD patients was 11.1%, which was not significantly different from the control group. Among the BD patients, DNMT3A mutations were the most common. CHIP carriers with BD had higher levels of inflammatory markers and older age compared to non-CHIP carriers with BD.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Joo Kyung Kim, Jae Hee Cheon
Summary: This study explored the use of probiotics and factors associated with their prescription in patients with inflammatory bowel disease (IBD). The results showed that increased disease activity may be associated with fewer prescriptions of probiotics. However, physicians prescribed probiotics to control symptoms in both UC and CD patients. The use of MTX and iron, as well as a history of IBD-related surgeries, were associated with more frequent probiotic prescriptions in CD patients.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2023)
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
