Review
Microbiology
Luana Langlois, Nadeem Akhtar, Kam C. Tam, Brian Dixon, Gregor Reid
Summary: The effective management strategies in aquaculture are essential for global food security. Probiotic microorganisms have the potential to restore and sustain health in fish, particularly in terms of immunity, growth rate, and protection against infection.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Biotechnology & Applied Microbiology
Ophelie Gervais, Carolina Penaloza, Remi Gratacap, Athina Papadopoulou, Mariana Beltran, Neil C. Henderson, Ross D. Houston, Musa A. Hassan, Diego Robledo
Summary: In this study, single-cell RNA sequencing was used to provide a high-dimensional insight into the transcriptional landscape of Atlantic salmon cells during early Infectious Salmon Anaemia Virus (ISAV) infection. The results showed a clear anti-viral response in infected cells, characterized by the upregulation of IFNA2 or IRF2. Additionally, uninfected bystander cells exhibited transcriptional differences, suggesting paracrine signaling from infected cells. This study identified potential key genes involved in the host-virus interaction, which can be targeted in future functional studies to enhance the resistance of Atlantic salmon to ISAV.
Article
Fisheries
Joao F. Romero, Ian A. Gardner, Larry Hammell, David Groman, Daryl Whelan, Nicole O'Brien, Leighanne J. Hawkins, Holly Burnley, Krishna Thakur
Summary: This study describes the epidemiology and genetic variants of an ISAV outbreak in southern Newfoundland, Canada in 2020 and 2021. Multiple ISAV variants were identified, including concurrent detection of different variants in one fish. Understanding the disease dynamics and changes is crucial for disease management plans.
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Na Rong, Jiangning Liu
Summary: Outbreaks of emerging infectious diseases pose a serious threat to public health security, human health, and economic development. An urgent need for an animal model that is susceptible to human pathogens arises after an outbreak. This article summarizes technologies and methods to induce animal susceptibility to human pathogens, analyzes the advantages and deficiencies of animal models developed using each method, and guides the selection of susceptible animals, potentially reducing the time needed to develop animal models during epidemics.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Sonali Tayal, Venugopal Bhatia, Tanya Mehrotra, Sonika Bhatnagar
Summary: This study curated experimental host-pathogen and host-host protein-protein interactions, annotated the domains and motifs of these proteins, and proposed the concept of mimicry pairs. The results were organized in a web-based resource called ImitateDB, which allows for easy querying of a large number of identified mimicry pairs in interacting host and pathogen proteins.
Article
Biochemistry & Molecular Biology
Amy K. Teffer, Scott G. Hinch, Kristina M. Miller, David. A. Patterson, Arthur L. Bass, Steven J. Cooke, Anthony P. Farrell, Terry D. Beacham, Jacqueline M. Chapman, Francis Juanes
Summary: The experiment found that sockeye salmon collected closer to the river entrance had less severe infections compared to those collected further upstream, likely due to differences in migration distance. Higher temperatures had a significant negative impact on the longevity of river-collected fish, while the effect on marine-collected fish was less significant. Cumulative stressors were detrimental to all fish, possibly due to extreme physiological disturbance.
Review
Immunology
Amanda Brosius Lutz, Salwan Al-Nasity, Boris W. Kramer, Martin Mueller
Summary: Chorioamnionitis, inflammation of the chorion and/or amnion during pregnancy, has significant implications for mother, fetus, and newborn; animal models play a crucial role in deepening understanding of the disease mechanisms; various animal models provide unique opportunities to study the inflammatory response and its consequences in chorioamnionitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
O. Gervais, A. Barria, A. Papadopoulou, R. L. Gratacap, B. Hillestad, A. E. Tinch, S. A. M. Martin, D. Robledo, R. D. Houston
Summary: The study found that the heritability of ISAV resistance is moderate with a polygenic architecture, but a significant quantitative trait locus was detected on chromosome 13. A mild up-regulation of the interferon pathway characterizes the response to the virus in heart samples from this population of Atlantic salmon, and candidate genes showing differential expression between samples with high and low breeding values for resistance were identified.
Review
Immunology
Joao Fevereiro, Alexandra G. Fraga, Jorge Pedrosa
Summary: Buruli ulcer, caused by Mycobacterium ulcerans, is an emerging infectious disease with an uncommon infection pattern where the host relies on a highly orchestrated genetic landscape to control the infection.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Luis A. Arteaga-Blanco, Dumith Chequer Bou-Habib
Summary: The nanosized EVs released by cells play a crucial role in intercellular communication, regulating cellular homeostasis and potentially spreading pathogen-derived molecules. Studying EVs shed by human macrophages can provide insights into modulating host immune responses and developing innovative therapeutic strategies against infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Agriculture, Dairy & Animal Science
Simona Sciuto, Licia Colli, Andrea Fabris, Paolo Pastorino, Nadia Stoppani, Giovanna Esposito, Marino Prearo, Giuseppe Esposito, Paolo Ajmone-Marsan, Pier Luigi Acutis, Silvia Colussi
Summary: This review describes the application of genetics and genomics in controlling infectious diseases in aquaculture. Breeding for disease resistance can mitigate the impact of infectious diseases on aquaculture. However, the interaction between host and pathogen during breeding may lead to pathogenic changes. Therefore, the parallel characterization of pathogens and their genes is crucial in understanding pathogen evolution and applying appropriate mitigation strategies.
Review
Biotechnology & Applied Microbiology
Priyanka Mehta, Aparna Swaminathan, Aanchal Yadav, Partha Chattopadhyay, Uzma Shamim, Rajesh Pandey
Summary: Infectious diseases are the leading cause of morbidity and mortality worldwide. Understanding the complex interaction between infecting pathogens, host response, and microbial presence is crucial for determining disease severity and outcomes. High-throughput tools like multi-omics profiling and next-generation sequencing can help identify genetic factors associated with different disease presentations. However, integrating host-pathogen interactions remains a challenge. An integrative genomics method, such as RNA sequencing, can provide insights into the complexity of these interactions. Additionally, a holo-transcriptome-based technique can be used to explore functional microbiomes. This holistic approach allows for a comprehensive understanding of the interconnected domains that influence disease severity and clinical outcomes.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Ecology
Nicholas C. C. Wu
Summary: Understanding the impact of pathogen infection on different functional traits in amphibians infected with Batrachochytrium dendrobatidis (Bd) can provide insights into the pathogenesis of infectious diseases. This study found consistent effects of Bd infection on energy metabolism and decreased traits related to body condition, osmoregulation, and behavior. However, there were biases in the research focus, highlighting the need for studies on immune response, locomotor capacity, energy metabolism, and cardiovascular traits in relation to infectious diseases.
FUNCTIONAL ECOLOGY
(2023)
Article
Biophysics
Maria Elena Tarnok, Fanny Guzman, Luis F. Aguilar
Summary: This study investigated the influence of cholesterol content on membrane fusion facilitated by ISAV fusion peptides. Results showed that cholesterol affected membrane fusion, but the peptides did not require cholesterol in their membranes for fusion in the smallest lipid vesicles (0.2 μm LUV).
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Fisheries
Nicholas A. Robinson, Diego Robledo, Lene Sveen, Rose Ruiz Daniels, Aleksei Krasnov, Andrew Coates, Ye Hwa Jin, Luke T. Barrett, Marie Lillehammer, Anne H. Kettunen, Ben L. Phillips, Tim Dempster, Andrea Doeschl-Wilson, Francisca Samsing, Gareth Difford, Sarah Salisbury, Bjarne Gjerde, John-Erik Haugen, Erik Burgerhout, Binyam S. Dagnachew, Dominic Kurian, Mark D. Fast, Morten Rye, Marcela Salazar, James E. Bron, Sean J. Monaghan, Celeste Jacq, Mike Birkett, Howard I. Browman, Anne Berit Skiftesvik, David M. Fields, Erik Selander, Samantha Bui, Anna Sonesson, Stanko Skugor, Tone-Kari Knutsdatter Ostbye, Ross D. Houston
Summary: Disease and parasitism pose significant challenges to global aquaculture, and genetic technologies offer potential solutions. Understanding genetic mechanisms, developing tools for boosting host resistance, and applying genetic technologies can improve disease resistance and transform aquaculture.
REVIEWS IN AQUACULTURE
(2023)
Article
Fisheries
Richard S. Taylor, Roberto Carvalheiro, Amanda L. Patchett, Klara L. Verbyla, Jeremy Carson, James W. Wynne, Brad S. Evans, Curtis E. Lind, Harry King
Summary: This study found that resistance to yersiniosis is a heritable trait and that two consecutive year classes of salmon were highly correlated in terms of disease resistance. Genomic prediction was more accurate than traditional pedigree-based selective breeding, with an improvement of 9-14%. GWAS analysis confirmed that resistance to yersiniosis is a polygenic trait with no major QTL. Candidate genes identified suggest altered host interactions, inflammatory responses, and clearance of Y. ruckeri infection.
Article
Agriculture, Dairy & Animal Science
T. H. Noble, F. Samsing, N. Wade, S. Osborne, R. Addepalli, J. W. Wynne
Summary: Immune stimulation through feed additives, such as the LPS component in NovacqTM, can effectively combat diseases in shrimp farming and reduce antibiotic usage. In this study, lipopolysaccharide-like molecules from NovacqTM were found to stimulate a rapid and significant induction of the phenoloxidase response in shrimp hemocytes. Transcriptome analysis revealed an up-regulation of immune-related genes and the activation of transcription factors in the hemocytes, indicating the strong immunostimulatory ability of NovacqTM.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Fisheries
Chloe J. English, Angus Li, Andrew C. Barnes
Summary: This study attempted to optimize a single-step enzyme-linked immunosorbent assay (ELISA) using an Octet HTX instrument to quantify IgM specific to the hapten 2,4-dinitrophenol (DNP) in serum from Atlantic salmon. The assay proved to be a robust, repeatable, and high-throughput alternative to ELISA.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Stefania M. Vannetti, James W. Wynne, Chloe English, Christine Huynh, Ralph Knusel, Carolina de Sales-Ribeiro, Maro Widmer, Gary Delalay, Heike Schmidt-Posthaus
Summary: Nodular gill disease (NGD) is an infectious condition that primarily affects freshwater salmonids, causing respiratory problems and mortality. This study describes the first reported cases of NGD with amoeba infection in farmed rainbow trout in Switzerland.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Mark B. Adams, Ben T. Maynard, Megan Rigby, James W. Wynne, Richard S. Taylor
Summary: Amoebic gill disease (AGD) is a disease that negatively affects Atlantic salmon aquaculture by reducing fish performance and welfare. Despite progress in genetic selection, there has been limited focus on the response of interspecific hybrids to AGD challenge. This study found that the hybrids of Atlantic salmon and brown trout had a lower infection rate and improved gill signs of AGD, indicating their potential in fish disease management research.
Article
Biotechnology & Applied Microbiology
Petra R. Quezada-Rodriguez, Richard S. Taylor, Khattapan Jantawongsri, Barbara F. Nowak, James W. Wynne
Summary: This study aimed to investigate the relationship between microbial community profiles and gill pathology during a production cycle of Atlantic salmon in two commercial hatcheries. The relationships between gill histology, environmental conditions, and microbiome were determined using high-throughput data, and it was found that the commensal community of gill bacteria was related to melanin prevalence under commercial conditions.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Fisheries
James W. Wynne, Megan L. Rigby, Ben T. Maynard, Richard S. Taylor
JOURNAL OF FISH DISEASES
(2023)
Article
Environmental Sciences
Eve L. Draper, J. Duncan Whyatt, Richard S. Taylor, Sarah E. Metcalfe
Summary: Atmospheric dispersion models play a vital role in simulating pollutant concentrations, such as PM2.5, and accurately representing the background component is crucial for providing an accurate representation of the pollution load. With limited monitoring data available for PM2.5, it is important to evaluate different approaches for representing the background. In the case of Nottingham, UK, a directional approach based on multiple urban background monitoring sites provides the most reliable estimates.
ATMOSPHERIC ENVIRONMENT
(2023)
Meeting Abstract
Fisheries
Hanover Matz, Richard S. Taylor, Anthony K. Redmond, Thomas Hill, Rose Ruiz Daniels, Mariana Beltran, Neil C. Henderson, Daniel J. Macqueen, Helen Dooley
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)