Article
Pharmacology & Pharmacy
Rakesh Kumar, Rajan Kumar, Neha Sharma, Navneet Khurana
Summary: Myrcene demonstrates neuroprotective effects in Alzheimer's disease mice by improving neurobehavioral and neuropathological changes, reducing oxidative damage, neuroinflammation, Aβ1-42 aggregations, etc. These activities indicate the potential of myrcene as a candidate for Alzheimer's disease treatment, either alone or in combination with donepezil.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Xuan Chen, Jinwen Yu, Liufeng Zheng, Zeyuan Deng, Hongyan Li
Summary: The combination of quercetin and lycopene has shown cardioprotective and neuroprotective effects in a mouse model of D-galactose-induced oxidative stress. The combination treatment alleviated histopathological injuries in the heart and hippocampus, reduced oxidative stress, inhibited inflammation, and activated antioxidant pathways.
Review
Biotechnology & Applied Microbiology
Harsh Kumar, Kanchan Bhardwaj, Marian Valko, Suliman Y. Alomar, Saleh H. Alwasel, Natalia Cruz-Martins, Daljeet Singh Dhanjal, Reena Singh, Kamil Kuca, Rachna Verma, Dinesh Kumar
Summary: Aging is an irreversible physiological degradation process of living organisms, primarily caused by oxidative stress and dysbiosis. D-galactose-induced aging has become a popular research topic and serves as an accelerated aging model. This review highlights the effects of D-galactose on various organs, the role of Lactobacillus in the aging process, and its antioxidative potential, while also critically considering the literature on animal models using Lactobacillus to mitigate D-galactose-induced aging.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Cui-Cui Sun, Zhong-Ping Yin, Ji-Guang Chen, Wen-Jun Wang, Guo-Dong Zheng, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang
Summary: The study found that dihydromyricetin can improve cognitive impairment in d-galactose-induced aging mice by regulating oxidative stress and inhibiting acetylcholinesterase.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ying Gao, Yongquan Xu, Junfeng Yin
Summary: This study found that selenomethionine (SeMet) has significant effects in improving age-related cognitive impairment. The results showed that SeMet improved the performance of mice with D-galactose-treated in various cognitive tests and reversed the biochemical abnormalities induced by D-galactose. Additionally, SeMet modulated the gut microbiota structure to alleviate dysbiosis caused by D-galactose. These findings provide evidence for the potential use of SeMet in preventing or adjuvant treatment of age-related cognitive impairment.
Article
Biochemistry & Molecular Biology
Ali H. El-Far, Yaser H. A. Elewa, Elsayeda-Zeinab A. Abdelfattah, Abdel-Wahab A. Alsenosy, Mustafa S. Atta, Khalid M. Abou-Zeid, Soad K. Al Jaouni, Shaker A. Mousa, Ahmed E. Noreldin
Summary: Administering D-galactose in aging animal models can cause oxidative damage, but a combination of thymoquinone and curcumin has shown promising results in preventing these alterations in brain and heart tissues. The combination significantly reduced necrosis and modulated the expression of various genes related to oxidative stress, suggesting its potential in aging prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Qian Yang, Yanhui Jiang, Shan Fu, Zhaopeng Shen, Wenwen Zong, Zhongning Xia, Zhaoya Zhan, Xiaolu Jiang
Summary: Polysaccharides from seaweed, especially Ulva lactuca polysaccharide extract (UPE), have been shown to have a significant ameliorative effect on renal injury induced by oxidative stress, demonstrating potential therapeutic benefits for oxidative damage diseases in the future.
Article
Biochemistry & Molecular Biology
Ammar Ali, Shahid Ali Shah, Nasib Zaman, Muhammad Nazir Uddin, Wajid Khan, Abid Ali, Muhammad Riaz, Atif Kamil
Summary: The study demonstrates the antioxidant potential of Vitamin D against D-Galactose induced oxidative stress mediated Alzheimer disease pathology in male adult albino mice, improving memory and neuronal synapse, and reducing AD pathophysiology. Vitamin D could potentially serve as a drug candidate in neurodegenerative diseases.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Review
Biochemistry & Molecular Biology
Laura Gomez-Virgilio, Alejandro Luarte, Daniela P. Ponce, Barbara A. Bruna, Maria Behrens
Summary: Among the proposed pathogenic mechanisms for Alzheimer's disease, increased oxidative stress appears to be a robust and early feature. Utilizing patient-derived peripheral cells may provide a more biologically relevant model for studying the disease. Analyzing olfactory neuronal precursors isolated non-invasively through NADH FLIM has the potential to reveal AD-related oxidative stress and accelerate the discovery of effective antioxidant therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Research has shown that hyperbaric oxygen therapy (HBOT) has a therapeutic effect on osteoporosis in both obese and lean aged rats. HBOT can partially improve bone microarchitecture and protect bone health in obese aged rats, while completely restoring bone microarchitecture in lean aged rats.
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that hyperbaric oxygen therapy can counteract obesity-induced aging-induced osteoporosis, restore the expression levels of certain genes in bone tissue, partially improve bone microarchitecture, and protect against obesity-induced demineralization in obese-aged rats.
Article
Biochemistry & Molecular Biology
Onesimus Mahdi, Samaila Musa Chiroma, Mohamad Taufik Hidayat Baharuldin, Nurul Huda Mohd Nor, Che Norma Mat Taib, Saravanan Jagadeesan, Shamala Devi, Mohamad Aris Mohd Moklas
Summary: The study found that WIN can reverse cognitive impairments and associated biochemical abnormalities caused by AlCl3 and D-gal, including increased levels of superoxide dismutase, glutathione, Nestin, and glial fibrillary acidic protein, decreased levels of malondialdehyde, and attenuation of aberrant cytoarchitecture in the rat's hippocampus. These findings suggest that WIN may be an effective candidate for the treatment of AD-related cognitive deficits.
Article
Neurosciences
Rakesh Kumar, Rajan Kumar, Neha Sharma, Navneet Khurana, Sachin Kumar Singh, Saurabh Satija, Meenu Mehta, Manish Vyas
Summary: The current study evaluates the pharmacological effects of bromelain obtained from pineapple stems on AD mice induced by AlCl3 and D-galactose. The study shows that bromelain can reverse cognitive impairment and provide neuroprotection in AD mice.
Review
Neurosciences
Sophie I. Hamstra, Brian D. Roy, Peter Tiidus, Adam J. MacNeil, Panagiota Klentrou, Rebecca E. K. MacPherson, Val A. Fajardo
Summary: Lithium is well-known for its mood-stabilizing effects in bipolar disorder treatment. Studies suggest that low doses of lithium may have beneficial effects on cardiovascular, musculoskeletal, metabolic, and cognitive function, as well as inflammatory and antioxidant processes. This review focuses on the potential benefits of low-dose lithium on the aging process and age-related diseases. Furthermore, it aims to provide mechanistic insights for future research in this field.
CURRENT NEUROPHARMACOLOGY
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)