4.6 Article

Role of presymptomatic transmission of COVID-19: evidence from Beijing, China

期刊

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/jech-2020-214635

关键词

Communicable diseases; control of diseases; public health policy

资金

  1. Capital's Funds for Health Improvement and Research [2018-1-1012]
  2. Beijing Science and Technology Planning Project [Z201100005420010]

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The study found that at least 15% of 100 secondary COVID-19 cases were due to presymptomatic transmission of the virus, with the earliest presymptomatic contact event occurring 5 days prior to the index case's onset of symptoms. This highlights the importance of earlier contact tracing and preventing transmission opportunities before the onset of symptoms.
Background The presymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented in limited clusters, and it is predicted through modelling. However, there is a lack of evidence from observations with a large sample size. Methods We used data from meticulous contact tracing of people exposed to cases of SARS-CoV-2 to estimate the proportion of cases that result from the presymptomatic transmission of the virus in Beijing during January 2020 and February 2020. Results The results showed that presymptomatic transmission occurred in at least 15% of 100 secondary COVID-19 cases. The earliest presymptomatic contact event occurred 5 days prior to the index case's onset of symptoms, and this occurred in two clusters. Conclusions The finding suggested that the contact tracing period should be earlier and highlighted the importance of preventing transmission opportunities well before the onset of symptoms.

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