Iron metabolism inPseudomonas aeruginosabiofilm and the involved iron-targeted anti-biofilm strategies

Pseudomonas aeruginosais a gram-negative bacterium that exists in various ecosystems, causing severe infections in patients with AIDS or cystic fibrosis.P. aeruginosacan form biofilm on a variety of surfaces, whereby the bacteria produce defensive substances and enhance antibiotic-resistance, making themselves more adaptable to hostile environments.P. aeruginosaresistance represents one of the main causes of infection-related morbidity and mortality at a global level. Iron is required for the growth ofP. aeruginosabiofilm. This review summarises how the iron metabolism contributes to develop biofilm, and more importantly, it may provide some references for the clinic to achieve novel anti-biofilm therapeutics by targeting iron activities.

Automated summary

Pseudomonas aeruginosa, a gram-negative bacterium, is able to form biofilm on various surfaces, enhancing its antibiotic resistance and adaptability. Iron metabolism plays a crucial role in biofilm development of P. aeruginosa, offering potential targets for novel anti-biofilm therapeutics.