Article
Pharmacology & Pharmacy
Yenju Chu, Abigail Wong, Haojie Chen, Liuhang Ji, Chaolong Qin, Wanshan Feng, Michael J. Stocks, Pavel Gershkovich
Summary: A military helicopter crash in Vietnam resulted in 13 deaths and 3 injuries. The cause of the accident is under investigation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Wanshan Feng, Chaolong Qin, Salah Abdelrazig, Ziyu Bai, Mekha Raji, Randa Darwish, YenJu Chu, Liuhang Ji, David A. Gray, Michael J. Stocks, Cris S. Constantinescu, David A. Barrett, Peter M. Fischer, Pavel Gershkovich
Summary: This study investigated the composition differences of different vegetable oils and their effects on promoting CBD lymphatic targeting and bioavailability. The results showed that olive oil led to the highest concentration of CBD in the lymphatic system and in the systemic circulation following oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Surgery
Babak Banan, Yan Wei, Ornella Simo, Patrick Tso, Naji N. Abumrad, Charles Robb Flynn, Sinju Sundaresan, Vance L. Albaugh
Summary: The optimized technique for cannulation of mesenteric lymph duct in mice has high success rates in collecting intestinal lymph, with PYY levels significantly increased post bile diversion.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Dan Zheng, Nathania J. Leong, Garima Sharma, Daniel Bonner, Jamie S. Simpson, Natalie L. Trevaskis, Christopher J. H. Porter
Summary: Targeted delivery of immunomodulators to the lymphatic system has the potential to enhance therapeutic efficacy. In this study, a series of structurally related triglyceride prodrugs of mycophenolic acid (MPA) were examined to optimize structure-lymphatic transport relationships. Prodrugs with medium-to long-chain spacers between MPA and the glyceride backbone were most effective in promoting lymphatic transport, while short-chain and very long-chain linkers were less preferred due to instability in the intestine or reduced solubility.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yenju Chu, Chaolong Qin, Wanshan Feng, Charles Sheriston, Yu Jane Khor, Concepcion Medrano-Padial, Birgit E. Watson, Teddy Chan, Binhua Ling, Michael J. Stocks, Peter M. Fischer, Pavel Gershkovich
Summary: The study indicates that the use of LCT-based formulation approach alone is not sufficient for effective delivery of TPV to MLNs. Future efforts should be directed towards a combined highly lipophilic prodrugs/lipid-based formulation approach to target TPV, other PIs, and potentially other classes of antiretroviral agents to viral reservoirs within the mesenteric lymphatic system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Teerapong Monmaturapoj, Jenny Scott, Paula Smith, Margaret C. Watson
Summary: The study explored antibiotic pharmacists' perceptions of factors influencing the implementation and sustainability of hospital-based ASPs, identifying organizational culture, national influences, continuous monitoring with feedback ASP data, and resources as key themes. It highlighted the importance of interventions and strategies at different levels to help implement and sustain ASPs in hospitals, emphasizing the role of national initiatives in contributing to their success.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Wanshan Feng, Chaolong Qin, Salah Abdelrazig, Ziyu Bai, Mekha Raji, Randa Darwish, YenJu Chu, Liuhang Ji, David A. Gray, Michael J. Stocks, Cris S. Constantinescu, David A. Barrett, Peter M. Fischer, Pavel Gershkovich
Summary: This study investigated the composition differences of different vegetable oils and their effects on promoting CBD lymphatic targeting and bioavailability. The results showed that olive oil led to the highest concentration of CBD in the lymphatic system and in the systemic circulation following oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Editorial Material
Pharmacology & Pharmacy
Sifei Han, Natalie Trevaskis, Pavel Gershkovich, Leonid Kagan
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oscar Cebadero-Dominguez, Concepcion Medrano-Padial, Maria Puerto, Soraya Sanchez-Ballester, Ana Maria Camean, Angeles Jos
Summary: The interest in graphene materials has grown due to their potential applications in various fields, including food packaging. However, concerns regarding their safety have arisen as their intake may increase. This study aimed to evaluate the mutagenicity and genotoxicity of graphene oxide (GO) and reduced-graphene oxide (rGO) according to the recommendations of the European Food Safety Authority (EFSA). The results showed that GO was not mutagenic, but rGO exhibited mutagenic activity at certain concentrations and exposure times. Further investigation is needed to fully understand the toxic profile of rGO.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Sijia He, Yaqian Zhang, Changli Zhao, Xueqian Wang, Sravan Baddi, Beibei Wu, Xiaoqiu Dou, Chuanliang Feng
Summary: This study designed two simple derivatives and explored the influence of solvents on their morphological evolution. The results showed that different morphologies of assemblies have different effects on cell adhesion and proliferation behaviors.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Immunology
Sara Bettonte, Mattia Berton, Felix Stader, Manuel Battegay, Catia Marzolini
Summary: Strong inducers cannot be managed with long-acting cabotegravir and rilpivirine, while moderate inducers can be managed by adding daily oral rilpivirine to the monthly injection. Virtual clinical DDI studies using PBPK modeling provided recommendations for managing DDIs with rifampicin or rifabutin.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Mattia Berton, Sara Bettonte, Felix Stader, Manuel Battegay, Catia Marzolini
Summary: This study used a physiologically based pharmacokinetic framework to investigate the factors influencing drug disposition changes in obese individuals. The results showed that drug clearance increased due to enhanced hepatic and renal blood flows. Volume of distribution also increased, with variations depending on the drug's pKa and logP values.
CLINICAL PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Paula Muresan, Phoebe McCrorie, Fiona Smith, Catherine Vasey, Vincenzo Taresco, David J. Scurr, Stefanie Kern, Stuart Smith, Pavel Gershkovich, Ruman Rahman, Maria Marlow
Summary: This study developed polymeric microneedle (MN) patches for the treatment of CNS tumors. The results demonstrated successful drug release and penetration, providing a potential solution for local brain drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Alice Brookes, Adelaide Jewell, Wanshan Feng, Tracey D. Bradshaw, James Butler, Pavel Gershkovich
Summary: This study investigated the delivery of cannabidiol (CBD) to the brain following oral administration in lipid-based and lipid-free vehicles. It was observed that different formulations resulted in different CBD delivery to the whole brain and various brain regions, indicating the importance of oral formulation selection for optimal delivery to specific brain regions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Xiang Feng, Sijia He, Taiki Sato, Takumi Kondo, Koyo Uema, Kozo Sato, Hajime Kobayashi
Summary: This study aimed to enrich new biocatalysts for CO2 conversion by using a hybrid biological-inorganic (HBI) system. Environmental samples were inoculated into HBI systems with cobalt phosphorus (Co-P) alloy and cobalt phosphate (CoPi) as inorganic catalysts. The enrichment of hydrogen-oxidizing bacteria (HOB) was observed, and HOB-related sequences were identified through sequencing analysis. Four different HOB belonging to Mycobacterium, Hydrogenophaga, Xanthobacter, and Acidovorax genera were isolated, showing potential as HBI system biocatalysts.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yucui Zhao, Tingting Lu, Yanwei Song, Yanqin Wen, Zheng Deng, Jiahui Fan, Minghui Zhao, Ruyi Zhao, Yuntao Luo, Jianzhu Xie, Binjie Hu, Haoran Sun, Yiwei Wang, Sijia He, Yanping Gong, Jin Cheng, Xinjian Liu, Liang Yu, Jikun Li, Chuanyuan Li, Yongyong Shi, Qian Huang
Summary: Cancer cells enter a radiation-tolerant persister state by poly- and de-polyploidization to survive radiotherapy and repopulate the tumor, suggesting a new therapeutic concept to improve outcome of patients receiving radiotherapy.
Article
Chemistry, Organic
Jacob R. Immel, Bayan M. Alghafli, Allen Alonso Rodriguez Ugalde, Steven Bloom
Summary: One way to introduce chemical diversity into indoles is by oxidizing them to indolyl radical cations. These intermediates can accept new functional groups across C2-C3 bonds or independently at C2. A new method using aqueous photoredox catalysis has been developed to selectively introduce C3 substituents into tryptophan mimetics, using water as a transient protecting group.
Article
Pharmacology & Pharmacy
Sara Bettonte, Mattia Berton, Felix Stader, Manuel Battegay, Catia Marzolini
Summary: Physiologically based pharmacokinetics (PBPK) modelling was used to simulate the switch from efavirenz to intramuscular cabotegravir/rilpivirine (IM CAB/RPV). The simulations showed that IM CAB concentrations slightly decreased during the switch, but remained above the minimal efficacy threshold; IM RPV concentrations also had a modest reduction, but did not put at risk of having suboptimal drug levels.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Antonio Cascajosa-Lira, Concepcion Medrano-Padial, Silvia Pichardo, Jose Manuel de la Torre, Alberto Banos, Angeles Jos, Ana M. Camean
Summary: This study focused on analyzing the toxicokinetic profile of propyl-propane-thiosulfonate (PTSO) in the agricultural food sector. In silico and in vitro techniques were used to perform a pilot-study, and ecotoxicity studies were conducted to evaluate the environmental impact of the compound. The results showed the formation of detoxified metabolites and highlighted the need for further in vivo assays to confirm the findings.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yenju Chu, Abigail Wong, Haojie Chen, Liuhang Ji, Chaolong Qin, Wanshan Feng, Michael J. Stocks, Pavel Gershkovich
Summary: A military helicopter crash in Vietnam resulted in 13 deaths and 3 injuries. The cause of the accident is under investigation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)