Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin

(2020) Sreyoshi Mitra et al.   Nature Communications

From evolution to function: Two sides of the same CENP-B coin?

(2020) Riccardo Gamba et al.   EXPERIMENTAL CELL RESEARCH

Spt6 is a maintenance factor for centromeric CENP-A

(2020) Georg O. M. Bobkov et al.   Nature Communications

SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization

(2019) Hang Fu et al.   CELL RESEARCH

Structure of the Human Core Centromeric Nucleosome Complex

(2019) Praveen Kumar Allu et al.   CURRENT BIOLOGY

DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

(2019) Yael Nechemia-Arbely et al.   NATURE CELL BIOLOGY

Plk1 protects kinetochore–centromere architecture against microtubule pulling forces

(2019) Robert F Lera et al.   EMBO REPORTS

CENP ‐C unwraps the human CENP ‐A nucleosome through the H2A C‐terminal tail

(2019) Ahmad Ali‐Ahmad et al.   EMBO REPORTS

Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication

(2019) Thelma M. Escobar et al.   CELL

Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential

(2019) S. Zachary Swartz et al.   DEVELOPMENTAL CELL

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization

(2019) Reito Watanabe et al.   JOURNAL OF CELL BIOLOGY

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

(2019) Kaige Yan et al.   NATURE

Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome

(2019) Yoshimasa Takizawa et al.   STRUCTURE

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

(2019) Frauke Liebelt et al.   Nature Communications

The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

(2019) Kristina Wagner et al.   Cell Reports

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation

(2019) Raymond T. Suhandynata et al.   PLoS Genetics

Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1

(2018) Riki Terui et al.   GENES & DEVELOPMENT

Unexpected conformational variations of the human centromeric chromatin complex

(2018) Jitendra Thakur et al.   GENES & DEVELOPMENT

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

(2018) Georg O.M. Bobkov et al.   JOURNAL OF CELL BIOLOGY

Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell

(2018) Shengya Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Transcribing Centromeres: Noncoding RNAs and Kinetochore Assembly

(2018) Paul B. Talbert et al.   TRENDS IN GENETICS

N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin

(2018) Kentaro Ohkuni et al.   G3-Genes Genomes Genetics

Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

(2018) Nazaret Reverón-Gómez et al.   MOLECULAR CELL

HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX

(2018) Jonathan Nye et al.   PLoS One

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

(2018) Chuanhe Yu et al.   SCIENCE

MCM2 promotes symmetric inheritance of modified histones during DNA replication

(2018) Nataliya Petryk et al.   SCIENCE

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation

(2018) Jinpu Yang et al.   PLoS Genetics

Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle

(2018) Manu Shukla et al.   CURRENT BIOLOGY

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

(2018) Ewelina Zasadzińska et al.   DEVELOPMENTAL CELL

Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points

(2017) Yael Nechemia-Arbely et al.   JOURNAL OF CELL BIOLOGY

SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication

(2017) Nitika Taneja et al.   MOLECULAR CELL

Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N

(2017) Sagar Chittori et al.   SCIENCE

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition

(2017) Lucie Y. Guo et al.   Nature Communications

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

(2017) Roshan L. Shrestha et al.   Oncotarget

Decoding the centromeric nucleosome through CENP-N

(2017) Satyakrishna Pentakota et al.   eLife

Long-Term Retention of CENP-A Nucleosomes in Mammalian Oocytes Underpins Transgenerational Inheritance of Centromere Identity

(2016) Evan M. Smoak et al.   CURRENT BIOLOGY

Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy

(2016) Hong-Yeoul Ryu et al.   GENES & DEVELOPMENT

CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers

(2016) Jitendra Thakur et al.   GENOME RESEARCH

Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers

(2016) Xia Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements

(2016) Claudio Ponte de Albuquerque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO-targeted ubiquitin ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin

(2016) Kentaro Ohkuni et al.   MOLECULAR BIOLOGY OF THE CELL

Insights from biochemical reconstitution into the architecture of human kinetochores

(2016) John R. Weir et al.   NATURE

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

(2016) Robert F Lera et al.   Nature Chemical Biology

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

(2016) Samantha J Falk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

(2016) Samantha J Falk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects

(2016) Erica M. Hildebrand et al.   PLoS Genetics

Enhancer regions show high histone H3.3 turnover that changes during differentiation

(2016) Aimee M Deaton et al.   eLife

Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription

(2015) Chin-Chi Chen et al.   DEVELOPMENTAL CELL

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

Two distinct modes for propagation of histone PTMs across the cell cycle

(2015) Constance Alabert et al.   GENES & DEVELOPMENT

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

(2015) Harsh Nagpal et al.   MOLECULAR BIOLOGY OF THE CELL

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks

(2015) Hongda Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stable complex formation of CENP-B with the CENP-A nucleosome

(2015) Risa Fujita et al.   NUCLEIC ACIDS RESEARCH

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

Oocyte development, meiosis and aneuploidy

(2015) Marie MacLennan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks

(2015) Hongda Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

(2015) Sandra Catania et al.   PLoS Genetics

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX

(2014) Nicolas Lacoste et al.   MOLECULAR CELL

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

(2014) Yasuhiro Arimura et al.   Scientific Reports

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Control of Nuclear Activities by Substrate-Selective and Protein-Group SUMOylation

(2013) Stefan Jentsch et al.   Annual Review of Genetics

Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition

(2013) Ewelina Zasadzińska et al.   EMBO JOURNAL

How mammals pack their sperm: a variant matter

(2013) A. Boskovic et al.   GENES & DEVELOPMENT

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes

(2013) Dani L. Bodor et al.   MOLECULAR BIOLOGY OF THE CELL

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

The octamer is the major form of CENP-A nucleosomes at human centromeres

(2013) Dan Hasson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo

(2012) Minh Bui et al.   CELL

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly

(2012) Emily A. Bassett et al.   DEVELOPMENTAL CELL

High Mitotic Activity of Polo-like Kinase 1 Is Required for Chromosome Segregation and Genomic Integrity in Human Epithelial Cells

(2012) Robert F. Lera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

(2012) Reto Gassmann et al.   NATURE

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm

(2012) Nitika Raychaudhuri et al.   PLOS BIOLOGY

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The F Box Protein Partner of Paired Regulates Stability of Drosophila Centromeric Histone H3, CenH3CID

(2011) Olga Moreno-Moreno et al.   CURRENT BIOLOGY

Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP

(2011) H. Hu et al.   GENES & DEVELOPMENT

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres

(2011) Eun Shik Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

(2011) Meghan C. Barnhart et al.   JOURNAL OF CELL BIOLOGY

Dynamics of CENP-N kinetochore binding during the cell cycle

(2011) D. Hellwig et al.   JOURNAL OF CELL SCIENCE

Maintenance of Silent Chromatin through Replication Requires SWI/SNF-like Chromatin Remodeler SMARCAD1

(2011) Samuel P. Rowbotham et al.   MOLECULAR CELL

In vitro centromere and kinetochore assembly on defined chromatin templates

(2011) Annika Guse et al.   NATURE

Crystal structure of the human centromeric nucleosome containing CENP-A

(2011) Hiroaki Tachiwana et al.   NATURE

Drosophila CENH3 Is Sufficient for Centromere Formation

(2011) M. J. Mendiburo et al.   SCIENCE

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

The SUMO protease SENP6 is essential for inner kinetochore assembly

(2010) Debaditya Mukhopadhyay et al.   JOURNAL OF CELL BIOLOGY

Dual recognition of CENP-A nucleosomes is required for centromere assembly

(2010) Christopher W. Carroll et al.   JOURNAL OF CELL BIOLOGY

Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4

(2010) Geetha Hewawasam et al.   MOLECULAR CELL

An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain

(2010) Prerana Ranjitkar et al.   MOLECULAR CELL

The structure of (CENP-A–H4)2 reveals physical features that mark centromeres

(2010) Nikolina Sekulic et al.   NATURE

A GTPase switch maintains CENP-A at centromeric chromatin

(2010) Lisa Prendergast et al.   NATURE CELL BIOLOGY

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A

(2010) Anaïck Lagana et al.   NATURE CELL BIOLOGY

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tetrameric organization of vertebrate centromeric nucleosomes

(2010) E. K. Dimitriadis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partitioning of Histone H3-H4 Tetramers During DNA Replication-Dependent Chromatin Assembly

(2010) M. Xu et al.   SCIENCE

Global turnover of histone post-translational modifications and variants in human cells

(2010) Barry M Zee et al.   Epigenetics & Chromatin

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Active establishment of centromeric CENP-A chromatin by RSF complex

(2009) Marinela Perpelescu et al.   JOURNAL OF CELL BIOLOGY

Condensin Regulates the Stiffness of Vertebrate Centromeres

(2009) Susana A. Ribeiro et al.   MOLECULAR BIOLOGY OF THE CELL

CENP-H–containing Complex Facilitates Centromere Deposition of CENP-A in Cooperation with FACT and CHD1

(2009) Masahiro Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N

(2009) Christopher W. Carroll et al.   NATURE CELL BIOLOGY

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

(2009) Federica Ferri et al.   NUCLEIC ACIDS RESEARCH

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

(2009) Alexander Samoshkin et al.   PLoS One

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Dynamics of inner kinetochore assembly and maintenance in living cells

(2008) Peter Hemmerich et al.   JOURNAL OF CELL BIOLOGY

Structural and Functional Dissection of Mif2p, a Conserved DNA-binding Kinetochore Protein

(2008) R. L. Cohen et al.   MOLECULAR BIOLOGY OF THE CELL