Article
Medicine, Research & Experimental
Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie, Melissa Smallfield, Le Kang, Alpha Berry Fowler, Amy Ladd, Kenneth Ellenbogen, Benjamin Van Tassell, W. Gregory Hundley, Antonio Abbate
Summary: Cardiac sarcoidosis is a rare disease that can lead to life-threatening complications, and this trial aims to investigate the effectiveness of IL-1 blockade with anakinra in combating systemic and cardiac inflammation in patients with this condition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chloe Duvall, Noelle Pavlovic, Natalie s. Rosen, Alison l. Wand, Jan m. Griffin, David R. Okada, Harikrishna Tandri, Edward k. Kasper, Michelle Sharp, Edward S. Chen, Jonathan Chrispin, Nisha A. Gilotra
Summary: This study found that females and Black individuals with cardiac sarcoidosis (CS) were more likely to have symptomatic heart failure. Treatment differences included higher corticosteroid usage in females and more frequent steroid-sparing agent use in Black participants. The results suggest that sex and race may contribute to distinct clinical phenotypes of CS.
JOURNAL OF CARDIAC FAILURE
(2023)
Review
Physiology
Huihui Li, Chen Chen, Dao Wen Wang
Summary: Despite the growing evidence of the importance of inflammation in the pathophysiological mechanisms of heart failure, most clinical trials targeting inflammatory responses in HF have yielded neutral or worsening outcomes. Further research is needed to better understand the role of inflammation in HF pathogenesis and to identify new therapeutic targets.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Ausra Mongirdiene, Julius Liobikas
Summary: Chronic heart failure (CHF) is a long-term condition where the heart has difficulty pumping blood enriched in oxygen and required nutrients to the body's tissues. Inflammation is a key factor in promoting CHF, and monocytes, a group of cells in the blood and tissues, play a role in both pro- and anti-inflammatory processes. This review aims to summarize current studies on the function of different monocyte subsets in CHF, particularly in patients with preserved or reduced left ventricle ejection fractions, and their relationship to inflammatory markers.
Review
Medicine, Research & Experimental
Xiaobo Jiang, Peng Ning, Fang Yan, Jianfeng Wang, Wei Cai, Fan Yang
Summary: Cardiovascular disease is a major global burden, leading to disability and deaths worldwide. Understanding the mechanisms of cardiac remodeling in response to cardiovascular diseases is crucial for improving clinical outcomes. This review focuses on the role of Myeloid Differentiation Protein 1 (MD1) in regulating cardiac pathophysiology and its potential clinical value.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Yen-Nien Lin, Ahmed Ibrahim, Eduardo Marban, Eugenio Cingolani
Summary: Arrhythmogenic cardiomyopathy (AC) is a genetic disease characterized by progressive heart muscle breakdown and inflammation. Myocardial inflammation is a key feature in the early stages of the disease, and targeting inflammation has shown promise in preclinical models for slowing disease progression.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kaemmerer
Summary: The study found that overexpression of PDE2 can reduce the likelihood of ventricular arrhythmia, mainly by preventing the increase of cellular triggers mediated by Epac and CaMKII, indicating that activating myocardial PDE2 may be a novel intracellular antiarrhythmic therapeutic strategy in heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Alessandro De Bortoli, David H. Birnie
Summary: Approximately 5% of sarcoidosis patients develop cardiac manifestations, presenting with conduction abnormalities, ventricular arrhythmias, and heart failure. Diagnosis is challenging and requires clinical suspicion and expertise in advanced cardiac imaging. Malignant arrhythmias and heart failure are common adverse events, highlighting the importance of timely diagnosis and appropriate treatment.
CIRCULATION JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Jason R. B. Dyck, Samuel Sossalla, Nazha Hamdani, Ruben Coronel, Nina C. Weber, Peter E. Light, Coert J. Zuurbier
Summary: SGLT2 inhibitors have promising effects in treating heart failure patients. This review summarizes the cardiac effects of SGLT2i, including their impact on inflammation, oxidative stress, ion transport, and metabolism. These mechanisms play a crucial role in the development of heart failure.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jukka Lehtonen, Valtteri Uusitalo, Pauli Poyhonen, Mikko Mayranpaa, Markku Kupari
Summary: Cardiac sarcoidosis (CS) is characterized by granulomas infiltrating the myocardium, leading to conduction disturbances, ventricular tachyarrhythmias, and heart failure. However, imaging studies have shown that cardiac involvement occurs much more frequently than clinically detectable cases. Definitive diagnosis of CS requires myocardial biopsy and histopathology, but a combination of extracardiac histology, clinical manifestations, and cardiac imaging findings can provide a high likelihood of diagnosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Marios Rossides, Susanna Kullberg, Johan Grunewald, Anders Eklund, Daniela Di Giuseppe, Johan Askling, Elizabeth Arkema
Summary: This study found that the risk of heart failure in patients with sarcoidosis is significantly increased, especially in the first two years after diagnosis. Diabetes, atrial fibrillation, and other arrhythmias were identified as the strongest independent clinical predictors of heart failure in sarcoidosis.
Article
Cardiac & Cardiovascular Systems
Mingxin Liu, Jianhua Zhao, Yonghua Lu, Zhi Chen, Xiaojian Feng, Gang Pan
Summary: This study found that Gab1 plays an important role in pressure overload-induced ventricular arrhythmias, exerting a cardioprotective effect by inhibiting the TLR4/MyD88/NF-κ B signaling pathway.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure and their relationship with mortality. The results showed that VT/VF events were uncommon but strongly associated with mortality in heart failure patients. These events seem to be markers of disease severity rather than risk of sudden death.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Jeremy P. Moore, Ariane Marelli, Luke J. Burchill, Henry Chubb, S. Lucy Roche, Ari M. Cedars, Paul Khairy, Ali N. Zaidi, Jan Janousek, David S. Crossland, Robert H. Pass, Jeffrey P. Jacobs, Jonathan N. Menachem, David S. Frankel, Sabine Ernst, Jim T. Vehmeijer, Mitchell Cohen
Summary: Heart failure and arrhythmia are the most important cardiovascular diseases among adults with congenital heart disease, and they often overlap and interact with each other. It is crucial for clinical management to recognize these interactions and have access to the available pharmacologic and interventional resources.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu-Long Li
Summary: Heart failure is a significant global public health issue, with coronary heart disease-induced HF being the most common type, accounting for over 50%. Cardiac sympathetic overactivation is a major cause of mortality in HF patients and involves complex regulatory mechanisms at multiple levels of the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jan M. Griffin, Mathew S. Maurer
Summary: Cardiac amyloidosis is a rare disease with limited therapeutic options, but advancements in diagnostic modalities and emerging therapies are challenging the traditional beliefs about its prognosis. Early recognition and prompt initiation of novel agents are crucial in improving the outcomes for patients with ATTR-CA.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Surgery
Kevin J. Clerkin, Jan M. Griffin, Justin A. Fried, Jayant Raikhelkar, Rashmi Jain, Veli K. Topkara, Marlena Habal, Farhana Latif, Susan Restaino, Paolo C. Colombo, Koji Takeda, Yoshifumi Naka, Maryjane A. Farr, Gabriel Sayer, Nir Uriel
Summary: Conditional survival (CS) is a dynamic method of survival analysis that estimates an individual's future survival probability changes post-transplant based on different prognostic variables. This study on heart transplant recipients found that women have higher long-term CS probabilities than men, and patients experiencing rejection and infection requiring hospitalization during the first year post-transplant had persistently decreased CS probabilities. These findings provide valuable information for patients and clinicians on future outcomes.
CLINICAL TRANSPLANTATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Jan Griffin, Richard Cheng
Article
Cardiac & Cardiovascular Systems
Jan M. Griffin, Jessica Chasler, Alison L. Wand, David R. Okada, J. Nikolhaus Smith, Elie Saad, Hari Tandri, Jonathan Chrispin, Michelle Sharp, Edward K. Kasper, Edward S. Chen, Nisha A. Gilotra
Summary: This study compared the efficacy of prednisone monotherapy and prednisone in combination with mycophenolate mofetil in 77 patients with cardiac sarcoidosis. The combination therapy group showed lower prednisone exposure and reduced cardiac inflammation, with most patients experiencing improvement or complete resolution in cardiac uptake. Mycophenolate mofetil was well tolerated, suggesting that this combination therapy may be a promising treatment option for cardiac sarcoidosis.
JOURNAL OF CARDIAC FAILURE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Richard Cheng, Jan Griffin
Review
Cardiac & Cardiovascular Systems
Alison L. Wand, Jonathan Chrispin, Elie Saad, Monica Mukherjee, Allison G. Hays, Nisha A. Gilotra
Summary: Cardiac sarcoidosis is a recognized cause of heart failure and arrhythmia. Diagnosing this condition has been historically challenging, but advancements in cardiac imaging have improved diagnostic capabilities. Echocardiography, cardiac magnetic resonance imaging, and F-18-fluorodeoxyglucose positron emission tomography are important tools for diagnosing and managing cardiac sarcoidosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Wajahat Khatri, Michael Polydefkis, Joban Vaishnav, Elie Saad, Lilja B. Solnes, Steven P. Rowe
Summary: Transthyretin cardiac amyloidosis is an overlooked cause of heart failure caused by misfolded protein deposition. A case study of a 70-year-old woman with a pleural effusion highlights the importance of using SPECT/CT to address inaccuracies in uptake ratios.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jonathan A. Aun, Edward Hulten, Elie Saad
Summary: This case report presents a woman in her 30s with chronic residual chest pain and dyspnoea on exertion, ultimately diagnosed with mild three-vessel microvascular disease through N-13 Ammonia PET myocardial perfusion imaging. Coronary microvascular disease plays a crucial role in determining myocardial ischaemia and assessing coronary flow reserve is essential for diagnosis and prognostic value. PET myocardial perfusion imaging serves as a non-invasive and highly accurate tool for diagnosis, complementing coronary angiography.
Review
Cardiac & Cardiovascular Systems
Eric Xie, Eric Sung, Elie Saad, Natalia Trayanova, Katherine C. C. Wu, Jonathan Chrispin
Summary: Sudden cardiac death is a major cause of mortality, and conventional risk stratification methods based on ejection fraction may not be accurate for certain patients. Advanced cardiac imaging techniques such as CMR, SPECT, PET, and CT offer promising and non-invasive means of assessing the underlying myocardial substrate and predicting the risk of sudden death. Machine learning algorithms can enhance predictive performance in combination with established imaging techniques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tushar Garg, Rudolf A. Werner, Hyun Woo Chung, Wajahat Khatri, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Elie Saad, Steven P. Rowe
Summary: The use of prostate-specific membrane antigen targeted PET imaging for the evaluation of prostate cancer has significantly increased in recent decades. PSMA-RADS-3A lesions, which are indeterminate for the presence of disease, are commonly seen. PSA levels can indicate true positivity in patients with PSMA-RADS-3A lesions.
Meeting Abstract
Cardiac & Cardiovascular Systems
Hannah Rosenblum, Jan Griffin, Masatoshi Minamisawa, Narayana Prasad, John Vest, Matthew White, Scott Solomon, Daniel Burkhoff, Mathew Maurer
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Gabriel Sayer, Sharon Slomovich, MaryJane Farr, Jayant Raikhelkar, Kevin Clerkin, Jan Griffin, Veli Topkara, Kelly Axsom, Justin Fried, Melana Yuzefpolskaya, Paolo Colombo, Mathew Maurer, Nir Uriel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Dylan P. Marshall, Ronald Laracuente, Matthew Carey, Kevin Clerkin, Amirali Masoumi, Jayant Raikhelkar, Jan Griffin, Jay S. Leb, Yuji Kaku, Sneha Jain, Joseph E. Sanchez, Hiroo Takayama, Melana Yuzefpolskaya, Paolo Colombo, Koji Takeda, Gabriel Sayer, Yoshifumi Naka, Nir Uriel, Veli Topkara, Justin Fried
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)