Article
Multidisciplinary Sciences
Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, Jing Han
Summary: This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. Multiple logistic regression and smooth curve fitting analysis were performed using the non-institutionalized US population from NHANES 2011-2018. The results showed an inverse association between serum albumin levels and CHD risk, with lower levels of serum albumin associated with a higher risk of CHD. Subgroup analysis indicated that this correlation was statistically significant in female patients over 60 years with hypertension but without diabetes.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Maryam Mahjoubin-Tehran, Yong Teng, Amin Jalili, Seyed Hamid Aghaee-Bakhtiari, Alexander M. Markin, Amirhossein Sahebkar
Summary: Atherosclerosis, a common type of cardiovascular disease, is caused by inflammatory chronic lesions in the arterial wall and can lead to heart disease and stroke. Despite efforts to improve therapeutic approaches, challenges remain, necessitating the search for more effective treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Elias Bjornson, Dimitrios Samaras, Martin Adiels, Joel Kullberg, Fredrik Backhed, Goeran Bergstrom, Anders Gummesson
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with increased risk of coronary heart disease (CHD). ApoB-containing lipoproteins, including LDLs and TRLs, mediate a portion of the increased risk of atherosclerosis in people with NAFLD. Mediation analysis in a cohort of middle aged individuals showed that apoB, plasma triglycerides, and TRL-cholesterol mediate a significant proportion of the association between liver fat and coronary artery calcium score (CACS), with a higher degree of mediation observed for TRLs compared to LDLs. These results highlight the potential role of TRL-lowering in reducing NAFLD-associated coronary artery disease risk.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Carmen Valentina Cristescu, Sophie Alain, Simona Maria Ruta
Summary: The number of deaths related to cardiovascular disease is increasing every year, despite all available therapies and the aggressive campaigns for lifestyle modification and prevention of risk factors. This review focuses on the current scientific evidence for the role of CMV infection in the development of acute atherosis and atherosclerosis from placentation throughout life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Pedro Covas, Eison De Guzman, Ian Barrows, Andrew J. Bradley, Brian G. Choi, Joseph M. Krepp, Jannet F. Lewis, Richard Katz, Cynthia M. Tracy, Robert K. Zeman, James P. Earls, Andrew D. Choi
Summary: This article discusses high-yield articles in cardiovascular imaging, focusing on the application of coronary CT angiography methods and atherosclerosis quantification in general cardiologists. It also examines the evolving use of artificial intelligence in medicine.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Computer Science, Artificial Intelligence
Hongliang Yang, Zinan Li, Zhongyu Wang
Summary: In the current medical era, the major cause of the global rise in death rate is atherosclerosis disease, a complex diagnosis with early signs often overlooked. To improve the prediction accuracy of cardiovascular diseases, a support system for biosensor-assisted deep learning concepts has been proposed to detect atherosclerosis disease. Through clinical data, a mathematical model based on deep learning-assisted k-means geometric distribution artificial neuron model can accurately predict heart disease during atherosclerotic plaque formation.
NEURAL COMPUTING & APPLICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Jiao Luo, Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: This study investigated the associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. The results showed that high neutrophil counts were associated with an increased risk of all cardiovascular outcomes. Genetic studies also supported this finding. No robust associations were found for other types of leukocytes in the two-sample MR analysis.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Nunzio Montelione, Francesco Loreni, Antonio Nenna, Vincenzo Catanese, Lucia Scurto, Chiara Ferrisi, Mohamad Jawabra, Teresa Gabellini, Francesco Alberto Codispoti, Francesco Spinelli, Massimo Chello, Francesco Stilo
Summary: Atherosclerosis-related coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Statins have proved to be the most effective treatment, but there are limitations related to administration and side effects. Polymers and nanoparticles can enhance the effect of statins by increasing bioavailability and target specificity. Poly-lactic-co-glycolic acid (PLGA) is the most promising drug delivery system.
Article
Biochemistry & Molecular Biology
Marat V. Ezhov, Narek A. Tmoyan, Olga I. Afanasieva, Marina I. Afanasieva, Sergei N. Pokrovsky
Summary: Despite high-intensity lipid-lowering therapy, there is still a residual risk of cardiovascular events that may be associated with lipoprotein(a) (Lp(a)). Elevated Lp(a) levels have been shown to be associated with cardiovascular outcomes in patients with coronary heart disease. Data on the role of Lp(a) in cardiovascular events after peripheral revascularization are limited.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Larisa Litvinova, Paolo Poggio, Donato Moschetta, Vasily Nikolaevich Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is a complex cardiovascular disease caused by multiple molecular mechanisms, such as endothelial dysfunction, inflammation, mitochondrial dysfunction, oxidative stress, and lipid metabolism disorders. Metformin, a medication commonly used for diabetes, holds promise as a therapeutic option for atherosclerosis due to shared mechanisms with diabetes. This review summarizes the mechanisms of action of metformin and presents available data from clinical trials on its efficacy in reducing cardiovascular risks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Vasily N. Sukhorukov, Alexander Zhuravlev, Nikolay A. Orekhov, Vladislav Kalmykov, Alexander N. Orekhov
Summary: Atherosclerosis has been a leading cause of death in developed countries for over a decade. The treatment and prevention of this disease are crucial, but there are still gaps in our understanding of its pathogenesis. The mTOR signaling pathway, although well-studied, continues to reveal new details. Therapeutic strategies associated with rapamycin have shown promise in other diseases, suggesting potential effectiveness in atherosclerosis as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sophie Nock, Eima Karim, Amanda J. Unsworth
Summary: Pim kinases are constitutively active serine/threonine kinases that play important roles in cell survival, proliferation, and migration. They have been primarily studied in cancer progression, but recent research indicates their involvement in cardiovascular diseases as well. Pim kinases are widely expressed in cardiovascular tissues and upregulated in various co-morbidities/risk factors for cardiovascular disease. Therefore, targeting Pim kinases may be beneficial for the prevention and treatment of cardiovascular events in high-risk individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stanislaw Surma, Maciej Banach
Summary: Atherosclerotic cardiovascular diseases (ASCVD) are a major cause of premature death worldwide. Biomarkers that can detect and assess the prognosis of ASCVD are highly sought after. Fibrinogen, a protein that increases in concentration in ASCVD patients, may serve as a biomarker for the disease and contribute to its development through genetic polymorphisms and post-translational modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Brandilyn A. Peters, Adam Whalen, Xiaonan Xue, Elizabeth F. Topper, Kathleen M. Weber, Phyllis C. Tien, Seble G. Kassaye, Howard Minkoff, Ervin Fox, Margaret A. Fischl, Lauren F. Collins, Michelle Floris-Moore, Howard N. Hodis, Qibin Qi, David B. Hanna, Anjali Sharma, Kathryn Anastos, Robert C. Kaplan
Summary: This study suggests that menopause may accelerate subclinical atherosclerosis as measured by CIMT in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Clinical Neurology
Friso de Vries, Daniel J. Lobatto, Amir H. Zamanipoor Najafabadi, Maarten C. Kleijwegt, Marco J. T. Verstegen, Pieter J. Schutte, Nienke R. Biermasz, Wouter R. van Furth
Summary: This case report describes a 75-year-old patient with hypopituitarism, bitemporal visual field deficits, and a parasellar mass on pituitary MRI. Surgery revealed the presence of a non-functioning pituitary adenoma and an abutting diaphragm sellae meningioma, which was confirmed by pathological examination. The initial MRI suggested the presence of two separate tumors based on differing densities, but this distinction was not observed on the last preoperative MRI.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Gastroenterology & Hepatology
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Bauge, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloise Woitrain, Niels J. Kloosterhuis, Eleonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberle, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean-Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikael Croyal, Bart van de Sluis, Sven Francque, Francois Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas
Summary: Non-alcoholic fatty liver disease (NAFLD) affects nearly 25% of the global population and is associated with cardiovascular disease (CVD). A study found that apolipoprotein F (APOF) expression was negatively correlated with hepatic steatosis and plasma triglyceride (TG) levels in NAFLD patients. Further experiments showed that overexpression of APOF increased very low density lipoprotein (VLDL)-TG secretion and hepatic lipoprotein remnant clearance, leading to a reduction in plasma TG levels. These findings highlight the important role of APOF in plasma and hepatic lipoprotein metabolism.
Article
Hematology
Dyonne Y. Vos, Melinde Wijers, Marieke Smit, Nicolette Huijkman, Niels J. Kloosterhuis, Justina C. Wolters, Joel J. Tissink, Amanda C. M. Pronk, Sander Kooijman, Patrick C. N. Rensen, Jan Albert Kuivenhoven, Bart van de Sluis
Summary: This study reveals the roles of VPS35L and VPS26C in the transport of LDLR and LRP1 in hepatocytes. VPS35L deficiency reduces surface expression of LDLR and LRP1, leading to increased plasma cholesterol levels. On the other hand, VPS26C deficiency delays clearance of postprandial triglycerides, resulting in elevated plasma triglyceride levels.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Milena Schonke, Zhixiong Ying, Artemiy Kovynev, Wietse In Het Panhuis, Anne Binnendijk, Sabine van Der Poel, Amanda C. M. Pronk, Trea C. M. Streefland, Menno Hoekstra, Sander Kooijman, Patrick C. N. Rensen
Summary: The timing of exercise training plays a critical role in reducing fat mass and early-stage atherosclerotic lesions, as well as affecting the composition of gut microbiota.
Article
Biochemistry & Molecular Biology
Wietse In het Panhuis, Milena Schoenke, Ricky Siebeler, Dorien Banen, Amanda C. M. Pronk, Trea C. M. Streefland, Salwa Afkir, Hetty C. M. Sips, Jan Kroon, Patrick C. N. Rensen, Sander Kooijman
Summary: Circadian disruption affects glucose and lipid metabolism with sex-specific effects. This study demonstrates that circadian disruption has sex-dependent effects on glucose metabolism, aggravated by male sex hormones and partially rescued by female sex hormones.
Article
Neurosciences
Rosanna Caputo, Vincent-Joseph Poirel, Isabel Paiva, Anne-Laurence Boutillier, Etienne Challet, Johanna H. Meijer, Sylvie Raison
Summary: In this study, the researchers investigated the effect of circadian rhythm on NA synthesis in nocturnal rat and diurnal rodent Arvicanthis. The results showed that the tyrosine hydroxylase gene th displayed a 24-hour rhythmic expression in both species. Furthermore, the expression of clock genes showed a phase opposition between the rat and Arvicanthis. These findings suggest that the circadian rhythm of NA may be related to the rhythmic expression of the th gene and differs between nocturnal and diurnal rodents.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Zhixiong Ying, Robin van Eenige, Rosa Beerepoot, Mariette R. Boon, Niels J. Kloosterhuis, Bart van de Sluis, Alexander Bartelt, Patrick C. N. Rensen, Sander Kooijman
Summary: Activation of brown adipose tissue (BAT) with the β3 receptor agonist mirabegron can promote fat oxidation and reduce fat accumulation, but it exacerbates atherosclerosis. However, in the APOE*3-Leiden.CETP mouse model, mirabegron treatment can reduce dyslipidemia and atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Robin van Eenige, Zhixiong Ying, Naomi Tramper, Vera Wiebing, Zohor Siraj, Jan Freark de Boer, Joost M. Lambooij, Bruno Guigas, Hongchang Qu, Tamer Coskun, Mariette R. Boon, Patrick C. N. Rensen, Sander Kooijman
Summary: The combined agonism of GIPR and GLP1R attenuates atherosclerosis severity by reducing inflammation and improving lipid metabolism. This study suggests that combined GIPR/GLP1R agonism may be a promising strategy for reducing cardiometabolic risk in humans.
Article
Cell Biology
Kaiming Yue, Patrick C. N. Rensen, Sander Kooijman
Summary: White and brown adipose tissues are dynamic organs that can anticipate and respond to changes in the environment. Circadian disturbances, common in modern society, increase the risk for metabolic diseases. This mini-review discusses mechanisms and strategies to mitigate disease risk associated with circadian disturbances, as well as the potential applications and therapeutic targets based on our knowledge of circadian rhythms in adipose tissues.
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2023)
Review
Immunology
Maaike Schilperoort, David Ngai, Santosh R. Sukka, Kleopatra Avrampou, Hongxue Shi, Ira Tabas
Summary: The process of macrophages engulfing dying cells, known as efferocytosis, is tightly regulated and involves sensing, binding, engulfment, and digestion of apoptotic cells. Efferocytosis not only prevents tissue necrosis and inflammation caused by secondary necrosis of dying cells, but also promotes pro-resolving signaling in macrophages, which is essential for tissue resolution and repair following injury or inflammation. The cargo released from apoptotic cells after their engulfment and digestion by macrophages, containing amino acids, nucleotides, fatty acids, and cholesterol, plays a crucial role in this pro-resolving reprogramming.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Clinical Neurology
Yumeng Wang, Marije Melgers, Johanna H. Meijer, Tom Deboer
Summary: In this study, the effects of a 6-hour sleep deprivation and acute ketamine treatment on vigilance states, locomotor activity, and electroencephalogram (EEG) power density spectra were evaluated in rats. Both treatments increased non-rapid eye movement (NREM) sleep and NREM sleep slow-wave activity (SWA), while decreasing rapid eye movement (REM) sleep. These findings suggest that selective suppression of REM sleep combined with enhanced SWA during NREM sleep may be effective in treating depression.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Rosalie G. J. Rietjens, Gangqi Wang, Anouk I. M. van der Velden, Angela Koudijs, M. Cristina Avramut, Sander Kooijman, Patrick C. N. Rensen, Johan van der Vlag, Ton J. Rabelink, Bram Heijs, Bernard M. van den Berg
Summary: Diabetes is a major risk factor for kidney disease, with diabetic nephropathy occurring in almost half of all diabetic patients. Metabolism has been found to play a crucial role in determining cell fate and repair. Mass spectrometry imaging was used to identify specific metabolic dysregulation in different tissues in order to understand the early metabolic changes in renal cell types caused by diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Zhuang Li, Enchen Zhou, Cong Liu, Hope Wicks, Sena Yildiz, Farhana Razack, Zhixiong Ying, Sander Kooijman, Debby P. Y. Koonen, Marieke Heijink, Sarantos Kostidis, Martin Giera, Ingrid M. J. G. Sanders, Ed J. Kuijper, Wiep Klaas Smits, Ko Willems van Dijk, Patrick C. N. Rensen, Yanan Wang
Summary: This study found that short-chain fatty acids, including butyrate, do not have multiple metabolic benefits in individuals with metabolic syndrome. However, the underlying mechanisms are still unclear. The researchers used antibiotic-induced microbiota depletion and fecal microbiota transplantation (FMT) to investigate the role of gut microbiota in the metabolic benefits of dietary butyrate. They found that dietary butyrate reduced appetite and ameliorated high-fat diet-induced weight gain, and these effects were dependent on the presence of gut microbiota.
Article
Endocrinology & Metabolism
Maaike Schilperoort, David Ngai, Marina Katerelos, David A. Power, Ira Tabas
Summary: The study reveals that transient increase in glycolysis and lactate production are essential for continual efferocytosis, contrasting with prolonged glycolysis in pro-inflammatory macrophages. This unique metabolic process depends on the activation of PFKFB2 enzyme and promotes continual efferocytosis through lactate-mediated upregulation of MerTK and LRP1. Inhibiting this process may provide a potential therapeutic pathway in chronic inflammatory diseases.
Article
Health Care Sciences & Services
Fabian Wolters, Henriet van Middendorp, Omer Van den Bergh, Nienke R. Biermasz, Onno C. Meijer, Andrea W. M. Evers
Summary: This study aims to investigate the effects of scent conditioning during sleep on cortisol and the diurnal rhythm by utilizing the cortisol awakening response (CAR) as an unconditioned response. The results of this study can provide new insights into the effects of learning on cortisol and the diurnal rhythm, with potential clinical implications in the treatment of sleep and stress disorders.
JMIR RESEARCH PROTOCOLS
(2023)