Article
Nutrition & Dietetics
Seonghwan Moon, Minju Kim, Yeonhee Kim, Seungmin Lee
Summary: This study investigated the effects of dietary iron deficiency and non-heme iron on the development of colitis-associated colorectal cancer (CAC). It was found that both iron deficiency and iron overload diets suppressed the growth of colonic tumors in a mouse model. Long-term iron deficiency or overload may negate the progression of CAC.
Review
Food Science & Technology
Yaxing Man, Tiantian Xu, Benu Adhikari, Cunshan Zhou, Yuchuan Wang, Bo Wang
Summary: About one-third of the world population suffers from iron deficiency, and diet delivery of iron is an effective but potentially side-effect causing approach. Developing new iron-rich products with high bioavailability and stability is crucial. Common foods such as cereals and bakery products are still the best vehicles for iron fortification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Ana M. Puga, Maria de Lourdes Samaniego-Vaesken, Ana Montero-Bravo, Mar Ruperto, Teresa Partearroyo, Gregorio Varela-Moreiras
Summary: Gut microbiota plays a crucial role in human health, and both diet and iron supplementation have an impact on it. Iron supplementation can potentially harm the gut microbiota, therefore it should be used with caution and recommended only to individuals with confirmed iron deficiency or iron-deficiency anemia. Further population studies are needed to confirm these findings.
Review
Microbiology
Arista Nienaber, Mary A. Uyoga, Robin C. Dolman-Macleod, Linda Malan
Summary: Tuberculosis (TB) is characterized by chronic non-resolving inflammation, which leads to anaemia of infection and iron deficiency anaemia (IDA) in TB patients. Although anaemia in TB patients is associated with poor clinical outcomes, managing anaemia is complicated due to the bacteria's reliance on iron. Anaemia of infection is likely to resolve with correct TB drug treatment, while IDA may require iron supplementation. This review provides insights into iron metabolism in TB, its contribution to iron deficiency and anaemia, and the association between iron status and clinical outcomes, as well as the available trials on iron supplementation in TB.
Article
Environmental Sciences
Ke Gu, Aimin Wu, Bing Yu, Tingting Zhang, Xin Lai, Junzhou Chen, Hui Yan, Ping Zheng, Yuheng Luo, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen
Summary: Iron plays a pivotal role in intestinal inflammation, ferroptosis, and the modulation of the gut microbiome. This study found that iron overload exacerbated colitis in mice by modulating ferroptosis and perturbing the gut microbiota. Specific microbial taxa and their associated metabolites were closely intertwined with both colitis and ferroptosis markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, Research & Experimental
Li Liang, Qingqing Xiong, Jingxia Kong, Chenying Tian, Linfeng Miao, Xiaofeng Zhang, Huahua Du
Summary: The study demonstrated that intraperitoneal iron supplementation could alleviate colonic and systemic inflammation, restore intestinal barrier function, regulate intestinal immune homeostasis, and increase mucous secretion of goblet cells in the colon.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Nutrition & Dietetics
Chih-Wei Tsao, Yuan-Ru Liao, Ting-Chia Chang, Yih-Fong Liew, Chin-Yu Liu
Summary: This study aimed to investigate the effects of iron supplementation on spermatogenesis and testicular functions in iron-deficient rats. The results showed that iron deficiency resulted in poorer spermatogenesis and testis dysfunction, while iron supplementation reversed the impairment and improved antioxidant levels.
Review
Endocrinology & Metabolism
Sama Anvari, Yasith Samarasinghe, Nouf Alotaiby, Maria Tiboni, Mark Crowther, Aristithes G. Doumouras
Summary: Iron deficiency and iron deficiency anemia are common complications following bariatric surgery, with variable strategies for iron supplementation. Oral iron was effective in about half of the studies, while both oral and intravenous iron were used for treatment, with intravenous iron showing higher effectiveness. Further high-quality prospective trials are needed to determine the optimal dosage, route, and duration of iron supplementation after bariatric surgery.
Article
Pediatrics
Mingyan Li, Ying Lv, Jionghuan Ying, Lin Xu, Weijun Chen, Quan Zheng, Chai Ji, Jie Shao
Summary: The study found that a daily dose of 2 mg/kg iron supplement is effective in maintaining iron homeostasis in preterm infants, and factors such as Hb levels at birth and at 3 months, gender, and feeding patterns can affect the prevalence of iron deficiency and iron deficiency anemia.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Alexander Hoffmann, David Haschka, Lara Valente de Souza, Piotr Tymoszuk, Markus Seifert, Laura von Raffay, Richard Hilbe, Verena Petzer, Patrizia L. Moser, Manfred Nairz, Guenter Weiss
Summary: Iron supplementation worsens the clinical course of bacterial infection in anaemic mice by increasing iron delivery to bacteria and impairing the immune response. This has important implications for iron supplementation strategies in areas with high endemic burden of infections.
Article
Nutrition & Dietetics
Guillermo Bastida, Claudia Herrera-de Guise, Alicia Algaba, Yolanda Ber Nieto, Jose Manuel Soares, Virginia Robles, Fernando Bermejo, Esteban Saez-Gonzalez, Fernando Gomollon, Pilar Nos
Summary: This study showed that sucrosomial iron (SI) treatment is effective and well-tolerated for patients with iron deficiency anemia (IDA) and inflammatory bowel disease (IBD) who are intolerant to oral iron salts. It significantly increased hemoglobin levels and improved quality of life for patients.
Article
Nutrition & Dietetics
Isabella Stelle, Lorraine K. McDonagh, Ilias Hossain, Anastasia Z. Kalea, Dora I. A. Pereira
Summary: Despite challenges such as rural location and cultural context, the staff conducting the iron deficiency anaemia trial in the Upper River Region of the Gambia believed that the overall impact was beneficial. They perceived that the facilitators and benefits outweighed the barriers, including impacts on education and healthcare, locally recruited staff, and local partnerships. This study serves as a useful example of community involvement and partnership for further health improvement programs.
Article
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi
Summary: This article discusses the blood-related issues caused by chronic diseases and treatment strategies for anemia. Emphasis is placed on the need for not only iron supplementation, but also providing all precursor molecules necessary for heme synthesis. Research shows that in elderly anemic patients, implementing personalized treatment strategies including supplementation of essential amino acids and vitamins can lead to a faster increase in hemoglobin levels.
Article
Geriatrics & Gerontology
Lea Valeska Blum, Philipp Zierentz, Lotta Hof, Jan Andreas Kloka, Leila Messroghli, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Summary: This study found that intravenous iron supplementation can increase hemoglobin levels in elderly surgical patients with anemia, reducing the need for blood transfusions. Severely anemic patients who received iron supplementation 6-10 days and > 10 days before surgery showed an increase in hemoglobin levels of 0.6 and 1.2 g/dl respectively. Overall, 58% of anemic iron-deficient patients experienced an increase in hemoglobin of > 0.5 g/dl.
Article
Food Science & Technology
Lu Yang, Jin Wang, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang
Summary: AFT contamination is a serious global issue, and researchers are developing HMONs materials to enhance adsorption capacity for AFT, enabling identification, determination, and regulation. HMONs have larger surface area and typical hollow cavities, with stronger adsorption capacity, showing potential in identifying and controlling mycotoxins in food matrices.
Article
Food Science & Technology
Jin Wang, Jia-Qiang Hu, Yu-Jie Song, Jia Yin, Yuan-Yi-Fei Wang, Bo Peng, Bo-Wei Zhang, Jing-Min Liu, Lu Dong, Shuo Wang
Summary: The study found that 2'-FL has protective effects on the intestines and brain of aging mice, reducing oxidative stress damage and inflammation. In addition, it improves gut barrier function, increases short-chain fatty acid content in the intestine, and increases the abundance of probiotics. In the brain, 2'-FL significantly inhibits apoptosis and increases the expression of SIRT1.
Review
Agriculture, Multidisciplinary
Jin Wang, Meng-Shan Chen, Rui-Shan Wang, Jia-Qiang Hu, Shuang Liu, Yuan-Yi-Fei Wang, Xiao-Long Xing, Bo-Wei Zhang, Jing-Min Liu, Shuo Wang
Summary: HMOs, the third most important nutrient in breast milk, play a crucial role in regulating neonatal intestinal immunity, fighting infections, reducing inflammation, and promoting brain development. However, a comprehensive review on the structure-activity relationships and dose-dependent effects of HMOs is lacking. This review provides an overview of the structures and synthetic pathways of HMOs, and summarizes the identified structure-function relationships. It also highlights recent advances in understanding the interactions between health benefits and dosage effects based on cellular tests and animal experiments.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chi-Xuan Yao, Lu Dong, Lu Yang, Jin Wang, Shi-Jie Li, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang
Summary: In this study, a dual-emission metal-organic framework-based ratiometric fluorescence probe was developed for rapid and simple detection of Cu2+ and Pb2+. The novel CQDs/QDs@ZIF-67 composite exhibited significantly aligned ratiometric fluorescence signal with the concentration of metal ions, achieving an extremely low detection limit. It showed potential for rapid and cost-effective detection of these two metal ions.
Article
Nutrition & Dietetics
Lu Dong, Cai-yi Qiu, Rui-can Wang, Yan Zhang, Jin Wang, Jing-min Liu, Hua-ning Yu, Shuo Wang
Summary: This study focused on the formation of Maillard hazards in air fried fries and found that the extent of browning, hardness, and the contents of Maillard hazards all increased with air frying temperature and time. Air frying fries also resulted in higher levels of slowly digestible starch and lower levels of resistant starch compared to deep frying.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ang Li, Jin Wang, Ruixin Kou, Mengshan Chen, Bowei Zhang, Yan Zhang, Jingmin Liu, Xiaolong Xing, Bo Peng, Shuo Wang
Summary: This study found that Oolong tea intervention can significantly reduce weight gain, adipose tissue mass, and blood lipid levels caused by a high-fat diet in mice, as well as improve fat accumulation, liver damage, glucose intolerance, and inflammation. In addition, Oolong tea can restore gut microbiota dysbiosis in obese mice. The results suggest that Oolong tea may be a potential measure for preventing obesity and regulating gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Engineering, Environmental
Chun -Yang Li, Shi-Wen Lv, Lu Yang, Jin Wang, Jing-Min Liu, Shuo Wang
Summary: This research presents a simple synthesis method for flower-shaped COF (nanoflower) with a strong hydrophobic surface. The nanoflower COF is used for affinity adsorption and selective enrichment of various hydrophobic biotoxins. The COF@MIP achieved selective identification of specific biotoxin with high specificity and sensitivity. The materials showed good reusability and were successfully applied to the analysis of common cereals.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Chi-Xuan Yao, Lu Yang, Jin Wang, Huan Lv, Xue-Meng Ji, Shi-Jie Li, Jing-Min Liu, Shuo Wang
Summary: A straightforward smartphone-based analytical strategy for on-site detection of hexavalent chromium and lysine has been demonstrated using dual-emission carbon quantum dots (DECQDs). The DECQDs show dual-emission peaks and can be used as dual-mode detection probes. The strategy, combined with smartphone technology, allows for visual smart sensors that can be used for in-situ detection of targets. The strategy has shown good performance in the quantification of hexavalent chromium and lysine in complex samples and offers new perspectives for food safety and rapid inspection.
Article
Engineering, Environmental
Shi-Wen Lv, Qiuyu Zheng, Lingjie Ye, Chun-Yang Li, Jing-Min Liu, Yanqing Cong, Shuo Wang
Summary: In this study, a Fe-g-C3N4/alpha-Fe2O3 composite with an active N-Fe-O bridge was successfully prepared, which broadened the light absorption range and inhibited the recombination of photoinduced electron-hole pairs. Moreover, the elaborate construction of N-Fe-O bridges based on coordination interaction reduced electrochemical impedance and facilitated electron transfer. The Fe-g-C3N4/alpha-Fe2O3 composite exhibited excellent photocatalytic performance in simultaneous removal of tetracycline (TC) and Cr(VI), and the electron transfer from TC to Cr(VI) played a crucial role in TC oxidation and Cr(VI) reduction under visible light. The findings of this work not only provided a highly-efficient photocatalyst with N-Fe-O bridges, but also offered new insights into the simultaneous removal of organic pollutants and heavy metals.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Agriculture, Multidisciplinary
Qisijing Liu, Jing Wang, Chixuan Yao, Lu Yang, Lei Zhao, Liqiong Guo, Jing-Min Liu, Shuo Wang
Summary: Nanotechnology, biotechniques, and chemical engineering have emerged as new trends in agriculture and food science, particularly in the areas of hazard elimination using micro-/nanomaterials. While these advanced analytical techniques with high sensitivity and specificity offer great potential for the industry, there are concerns surrounding the potential risks to human health posed by the rapid development of micro-/nanostructures.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Chemical
Chun -Yang Li, Lu Yang, Jing Wang, Shi-Wen Lv, Jin Wang, Jing-Min Liu, Shuo Wang
Summary: This study presents the first example of using Fe/Co co-doped layered double hydroxides as photocatalysts for the degradation of heterocyclic amines (HCAs) through sulfate radical advanced oxidation processes (SR-AOPs). The FeCo-LDH/PS system efficiently degraded 12 different kinds of HCAs and showed good reusability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Applied
Lu Yang, Lin-Qing Nie, Jing Wang, Chun -Yang Li, Jin Wang, Jing-Min Liu, Shuo Wang
Summary: Integration of functional micro-/nano-frameworks with various analytical techniques is favored to produce advanced and practical methods for identification, inspection, and regulation of hazards in agro-food products. Herein, two novel synthetic strategies were developed for the preparation of core-shell structured ZIF-8@COF and hollow-structured covalent organic frameworks (HCOFs). The HCOFs adsorbent exhibited high stability, universality, and adsorption affinity for advanced glycation end products (AGEs) and aflatoxins (AFTs) compared to pristine COF. The applicability of this method was verified by analyzing infant formula samples using HPLC and HPLC-MS/MS, with satisfying recoveries of 87.3%-98.9%. Furthermore, HCOF showed potential ability to adsorb and remove AGEs from plasma without causing other risks.
Article
Engineering, Environmental
Lu Yang, Jing Wang, Chun-Yang Li, Qisijing Liu, Jin Wang, Jing Wu, Huan Lv, Xue-Meng Ji, Jing-Min Liu, Shuo Wang
Summary: Biotoxins with high toxicity can be transformed into biochemical weapons, posing a significant threat to international public security. A molecular imprinting platform (HMON@MIP) was developed using hollow-structured microporous organic networks (HMONs) as imprinting carriers, enhancing the adsorption performance in terms of specificity, imprinting cavity density, and adsorption capacity. The platform shows promising generalizability by producing various MIP adsorbents through changing the biotoxin template, such as aflatoxin and sterigmatocystin. The developed imprinting platforms have great potential for precise food safety inspection.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jing Wu, Yong Liu, Lijun Peng, Qisijing Liu, Dawei Wang, Xu Jing, Yaozhong Hu, Jing Lin, Hanyue Fu, Xuemeng Ji, Jingmin Liu, Huan Lv, Bo Peng, Bowei Zhang, Liqiong Guo, Shuo Wang
Summary: This paper introduces a portable, origami-type paper device with a plasmonic fluor-labeled microneedle sensing module for the multiplexed quantification of anemia biomarkers in whole blood. The device can rapidly accomplish sequential steps, including serum separation, target enrichment, and multiplexed readout. It enables efficient sampling of trace targets and improves signal detection compared to traditional assays. The device has the potential for rapid and accurate diagnosis of anemia in real practice, with features such as small sample volume, short assay time, low cost, stability, and user-friendliness.
Article
Nutrition & Dietetics
Jin Wang, Ang Li, Jiaqiang Hu, Bowei Zhang, Jingmin Liu, Yan Zhang, Shuo Wang
Summary: This study investigates the effects of the frying process on the nutritional properties, physicochemical quality, and in vitro digestibility of instant noodle products. The frying process leads to a decrease in carbohydrate, protein, fiber, total starch, and digestible starch, but an increase in fat and resistant starch. It also improves the texture, surface color, and sensory properties of instant noodle products, as well as the cooking quality. The fried instant noodles have a unique structure and protein transformation. The frying process also decreases the in vitro digestibility of starch and protein. Overall, the findings highlight the importance of the frying process in instant noodles and other starch-based prepared food products.
FRONTIERS IN NUTRITION
(2022)