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Postlicensure Evaluation of COVID-19 Vaccines

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 324, 期 19, 页码 1939-1940

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AMER MEDICAL ASSOC
DOI: 10.1001/jama.2020.19328

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This Viewpoint explains the test-negative modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.

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