Article
Dentistry, Oral Surgery & Medicine
Junho Jung, Gyu-Jo Shim, Minah Kim, Youngjae Yoon, Jae-Eun Kim, Seong-Suk Jue, Bilal Al-Nawas, Yong-Dae Kwon
Summary: The study demonstrated that preoperative PTH administration significantly reduced the number of empty lacunae and increased the number of blood vessels, suggesting more viable bone tissue in this group. However, postoperative PTH administration showed no significant differences compared to controls. Therefore, preoperative PTH use may represent a better prophylactic regimen for preventing MRONJ.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Luca Dalle Carbonare, Monica Mottes, Maria Teresa Valenti
Summary: Osteonecrosis of the jaw is a severe clinical condition characterized by exposed bone that does not heal over time. Diagnosis is primarily clinical with imaging feedback playing a confirmatory role. Medication-related osteonecrosis of the jaw, particularly induced by bisphosphonates, has been widely discussed, but the exact mechanism remains debatable.
Article
Dentistry, Oral Surgery & Medicine
Daigo Yoshiga, Izumi Yoshioka, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga
Summary: This study aimed to investigate the benefits of adjuvant daily or weekly teriparatide injections in treating exposed bony MRONJ lesions. The results showed that TPTD treatment helped in the coverage of exposed bone, shortened the healing period, and did not increase the risk of complications.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kang-Min Kim, Sehyang Kim, Hyun Hwang, Hey-Yun Kim, Dohyun Kim, Jung-Hyun Park, HyeRan Choo, Jin-Woo Kim
Summary: This case-control study examined the therapeutic effects of daily or weekly administration of teriparatide in the management of medication-related osteonecrosis of the jaw (MRONJ). The results showed that both daily and weekly injection groups had significantly faster healing compared to the control groups. Complete resolution of MRONJ was more likely in participants who received teriparatide injections.
Article
Pharmacology & Pharmacy
Kirti Chopra, Namrita Malhan
Summary: MRONJ is a painful and intractable disease of the jaw with no established effective treatment, however, teriparatide may play an important role in the treatment with good efficacy.
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Gianluca Colapinto, Funda Goker, Riccardo Nocini, Massimo Albanese, Pier Francesco Nocini, Salvatore Sembronio, Francesca Argenta, Massimo Robiony, Massimo Del Fabbro
Summary: The aim of this randomized study was to evaluate the effect of pentoxifylline and tocopherol in patients that had developed MRONJ after tooth extractions. The study showed that patients who received pharmacological treatment had better mucosal healing after 1 month and clinical and radiographic healing of the bone lesion after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yaron Haviv, Zehava Geller, Sigal Mazor, Yair Sharav, Naama Keshet, Yehuda Zadik
Summary: The study analyzed data from 77 MRONJ patients, with most receiving bisphosphonates for cancer (79%) and osteoporosis (17%). Pain was present in 67.5% of patients, with 36.5% experiencing moderate-to-severe pain. Female gender was significantly associated with pain, and osteonecrosis lesions after dental surgery had a higher risk of pain.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Multidisciplinary
Salvatore D'Amato, Antonio Troiano, Giorgio Lo Giudice, Davide De Cicco, Mario Rusciano, Gianpaolo Tartaro, Giuseppe Colella
Summary: Surgical resection showed higher complete healing cases and statistically significant difference in recurrence rate compared to debridement. Debridement is an unfavorable prognostic factor when compared to surgical resection, with a 4.9 times higher risk of recurrence. Quality of life mean values improved significantly in the surgical resection group and slightly in the debridement group.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhiqiang Feng, Jingang An, Yang He, Yi Zhang
Summary: This study compared the clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis versus malignancy. The results showed differences between the osteoporosis and malignancy groups in terms of incubation periods, cumulative doses of bisphosphonates, and the proportion of patients receiving antiangiogenic agents. However, the two groups had similar surgical treatment outcomes.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Review
Medicine, General & Internal
Hemil Dario Rosales, Henry Garcia Guevara, Stefania Requejo, Maria Dianella Jensen, Julio Acero, Sergio Olate
Summary: This study analyzed medication-related osteonecrosis of the jaw (MRONJ) in children and young patients, and its relation with oral surgery. The study found a low presence of MRONJ in children and young patients treated with antiresorptive drugs. Data collection was weak, and details of therapy were not clear in most of the included articles.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
H. Mahmood, I Siddique, A. McKechnie
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2020)
Article
Dentistry, Oral Surgery & Medicine
Claire L. Wilson, Hanya Mahmood, Alison Loescher
BRITISH DENTAL JOURNAL
(2020)
Article
Oncology
Hanya Mahmood, Muhammad Shaban, Nasir Rajpoot, Syed A. Khurram
Summary: This paper reviews recent literature on the use of Artificial Intelligence/Machine Learning (AI/ML) methods for diagnostic evaluation of head and neck cancers (HNC) through automated image analysis. The studies show that these methods can achieve high accuracy in detection by using various imaging modalities.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Seda Camalan, Hanya Mahmood, Hamidullah Binol, Anna Luiza Damaceno Araujo, Alan Roger Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Syed Ali Khurram, Metin N. Gurcan
Summary: Oral cancer is among the top ten most common cancers globally, with the need for early accurate diagnosis emphasized. This study aims to develop deep learning methods for image classification and highlight decision-making regions using heat maps. Through validation on datasets from different countries, it was shown that better performance could be achieved by using patches instead of whole lesion images and analyzing predictive regions through class activation map analysis.
Article
Pathology
Hanya Mahmood, Mike Bradburn, Nasir Rajpoot, Nadim Mohammed Islam, Omar Kujan, Syed Ali Khurram
Summary: This study explores the correlation between individual histological features of Oral Epithelial Dysplasia (OED) and prognosis. Two prognostic scoring systems were proposed, which have the potential to simplify OED grading and aid patient management.
Article
Oncology
Hanya Mahmood, Adam Shephard, Paul Hankinson, Mike Bradburn, Anna Luiza Damaceno Araujo, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Kris D. Mccombe, Stephanie G. Craig, Jacqueline James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Nasir Rajpoot, Syed Ali Khurram
Summary: This study conducted a digital quantitative analysis of OED and developed a novel prognostic model that outperforms existing grading systems. The model had superior predictive potential for malignant transformation and OED recurrence. External validation supported the strength of this model for prognosis.
BRITISH JOURNAL OF CANCER
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Neda Azarmehr, Adam Shephard, Hanya Mahmood, Nasir Rajpoot, Syed Ali Khurram
Summary: This paper explores an optimized method for segmentation of epithelium and nuclei in oral pathology images. The experimental results demonstrate excellent segmentation accuracy and the ability to predict lesion risk.
MEDICAL IMAGE UNDERSTANDING AND ANALYSIS, MIUA 2022
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Adam J. Shephard, Simon Graham, R. M. Saad Bashir, Mostafa Jahanifar, Hanya Mahmood, Syed Ali Khurram, Nasir M. Rajpoot
Summary: Oral epithelial dysplasia (OED) is a precancerous diagnosis in the oral cavity, and accurately predicting its grade and transition to malignancy is crucial for early treatment. A deep learning framework HoVer-Net+ is proposed for simultaneous segmentation of nuclei and epithelial layers in OED cases, showing state-of-the-art performance with no additional costs. This method has the potential for future studies in malignancy prediction and other computational pathology tasks.
2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021)
(2021)
Proceedings Paper
Engineering, Biomedical
R. M. Saad Bashir, Hanya Mahmood, Muhammad Shaban, Shan E. Ahmed Raza, M. Moazam Fraz, Syed Ali Khurram, Nasir M. Rajpoot
Summary: Oral dysplasia is a pre-malignant stage of oral epithelial carcinomas, where accurate grading is crucial for treatment decisions and prognosis. Pathologists have significant variability in assessment, highlighting the need for automated grading systems to improve accuracy and reliability.
MEDICAL IMAGING 2020: DIGITAL PATHOLOGY
(2021)
Review
Oncology
H. Mahmood, M. Shaban, B. I. Indave, A. R. Santos-Silva, N. Rajpoot, S. A. Khurram
Meeting Abstract
Pathology
H. Mahmood, A. Smith, S. A. Khurram
Meeting Abstract
Pathology
H. Mahmood, S. A. Khurram
Meeting Abstract
Pathology
H. Mahmood, M. Shaban, I. Indave, A. Santos-Silva, N. Rajpoot, S. A. Khurram
Review
Medicine, General & Internal
Mohammed Anabtawi, James Wege, Hanya Mahmood, Bahaa Alsaeed Dareen Amro, Alan Patterson
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)