Article
Chemistry, Physical
Raj Kumar, Shivani Uppal, Kumari Mansi, Joydeep Das, Satish Kumar Pandey, Khushwinder Kaur, S. K. Mehta
Summary: This study reports the fabrication of TPGS assisted clove oil in water nanoemulsion for the delivery of polyphenolic nutraceuticals curcumin and resveratrol and analyzes their synergetic healing potential. The nanoemulsion exhibited antimicrobial activity and showed enhanced effectiveness against different bacterial strains when combined with curcumin and resveratrol. The formulated system also demonstrated anti-tumor activity on breast cancer cell lines MDA MB 231 and Hep G2, expanding the biological applications of the system.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Meenakshi Dudi, Raj Kumar, Priyanshi Saini, Aashima Sharma, Satish Kumar Pandey, Harjot Kaur, Ravinder Kumar, S. K. Mehta
Summary: In this study, OST-loaded oil in water nano-emulsion (OST-NEm) was prepared using a low-cost and highly effective ultrasonication emulsification method. The NEm showed good storage stability and stability under different salt concentrations and pH conditions. The cell viability studies confirmed the lack of toxicity of OST-NEm up to a concentration of 160 muM. OST and OST-NEm exhibited higher antioxidant potential compared to the control substance BHT.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Acoustics
Rania A. Hashad, Ritu Singla, Sukhvir Kaur Bhangu, Edwina Jap, Haiyan Zhu, Anton Y. Peleg, Luke Blakeway, Christoph E. Hagemeyer, Francesca Cavalieri, Muthupandian Ashokkumar, Karen Alt
Summary: In this study, a novel nanocarrier system was developed using the natural food preservative peptide Nisin. The system, called nisin-shelled nanoemulsions (NSNE), exhibited stable and uniform nanoemulsion structure with high bactericidal activity and drug loading capacity. Moreover, the nisin shell was used for the specific attachment of a cancer targeting ligand, leading to the successful assembly of targeted NSNE loaded with the chemotherapeutic drug Doxorubicin. The targeted NSNE demonstrated cancer-specific binding and enhanced cytotoxicity to HER2 expressing tumor cells.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Weiming Zhong, Puyu Tang, Ting Liu, Tianyu Zhao, Jiajing Guo, Zhipeng Gao
Summary: This study prepared Linalool nano-emulsion (LN) with different medium chain triglycerides (MCT) concentrations using the ultrasonic method. LN showed good stability and strong antibacterial activity against Aeromonas hydrophila, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.3125% and 0.625% v/v, respectively. The nano-emulsion exhibited a disruptive effect on cell membranes, highlighting its potential in controlling and preventing A. hydrophila in aquaculture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Asmaa O. Manaa, Hoda H. Bagjdadi, Nefertiti A. El-Nikhely, Lamia A. Heikal, Lobna S. El-Hosseiny
Summary: This study successfully developed a stable nanoemulsion of oregano essential oil (ONE) and evaluated its antibacterial and anticancer effects, finding that the nanoemulsion exhibited improved activity. Furthermore, the nanoemulsion significantly inhibited cell proliferation and induced apoptosis, as evidenced by upregulation of apoptotic markers and downregulation of proliferation markers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Steplinpaulselvin Selvinsimpson, P. Gnanamozhi, V Pandiyan, Mani Govindasamy, Mohamed A. Habila, Najla AlMasoud, Yong Chen
Summary: The photocatalytic and antibacterial performance of tin doped zinc oxide nanoparticles synthesized via ultrasonic aided co-precipitation technique were investigated. The increase in dopant concentration led to changes in crystal structure and optical properties. Specifically, 5% Sn doped ZnO nanoparticles showed enhanced dye elimination rate and antibacterial activity compared to 3% Sn doped ZnO.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Applied
Camila A. Palla, Aixa Aguilera-Garrido, Maria Elena Carrin, Francisco Galisteo-Gonzalez, Maria Jose Galvez-Ruiz
Summary: This study successfully loaded curcumin into monoglyceride (MG) oleogels and produced stable gelled-oil nanoemulsions. The effects of ultrasonication processing parameters and formulation on particle size and stability were evaluated, and a surfactant mixture of Pluronic F-68 and Tween 80 with a low oleogel/aqueous phase ratio produced the most stable nanoemulsions. The results also showed that structuring oil particles with MG crystals can enhance the encapsulation efficiency of curcumin and slow down its release.
Article
Chemistry, Applied
O. A. Ghazy, M. T. Fouad, H. H. Saleh, A. E. Kholif, T. A. Morsy
Summary: This study aimed to characterize the nanoemulsion of anise seed extract and compared its efficacy against pathogenic bacteria with bulk extract. Results showed that the nanoemulsion had higher antimicrobial activity and major components included anethole, naringenin, and taxifolin. The average droplet size of the nanoemulsion was around 400 nm, and it performed better than bulk extract against some foodborne pathogenic bacteria.
Article
Food Science & Technology
Samar Sayed Ibrahim, Urvashi Sahu, Pothiyappan Karthik, Subramanian Ezhil Vendan
Summary: Nanoemulsion is a promising delivery system for delivering bioactive molecules against insect pests. This study aimed to prepare eugenol based nanoemulsions (EL-NE) and investigate their fumigant toxicity against Sitophilus oryzae adults, as well as the residual characteristics of eugenol on treated grains and beetles. The optimized EL-NEs showed enhanced fumigant toxicities and increased persistence of eugenol, indicating their potential as eco-friendly nano-biofumigants for integrated pest management.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Food Science & Technology
Diqiong Wang, Mingming Zhong, Yufan Sun, Lin Fang, Yuanda Sun, Baokun Qi, Yang Li
Summary: This study investigated the stability, rheological properties, and encapsulation efficiency of LP nanoemulsions under different pH conditions. Results indicated superior performance in neutral and alkaline environments, providing valuable theoretical reference for further applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zinab Moradi Alvand, Masoud Rahimi, Hasan Rafati
Summary: This study improved the antibacterial activity of Satureja Khuzestanica essential oil nanoemulsions by employing chitosan, resulting in enhanced interaction of nanodroplets with the bacterial membrane. The chitosan-coated nanoemulsion showed a significant rupturing effect on the E. coli cell membrane and rapid release of cellular contents. Applying microfluidic chips intensified the antibacterial activity, disrupting bacterial integrity in a shorter time compared to the conventional method.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Thiloka M. Dassanayake, Arosha C. Dassanayake, Nalin Abeydeera, Bishnu D. Pant, Mietek Jaroniec, Min-Ho Kim, Songping D. Huang
Summary: Polyethylene glycol-coated gamma-alumina nanoparticles show strong antibacterial activity, especially against drug-resistant bacteria, without causing resistance development.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Applied
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Nabil A. Alhakamy, Shadab Md
Summary: Phytochemicals, particularly resveratrol, formulated into nanoemulsions through ultrasonication show promising potential for the treatment of neurodegenerative disorders. The nanoemulsion formulation demonstrated superior in vitro release and permeation properties, as well as high brain targeting efficacy in rat intranasal administration. Incorporation of resveratrol into nanoemulsions could be a promising alternative for managing Alzheimer's disease.
Article
Agriculture, Multidisciplinary
Sadaf Mansouri, Mohammadreza Pajohi-Alamoti, Narjes Aghajani, Behnaz Bazargani-Gilani, Alireza Nourian
Summary: The study developed a nanoemulsion of Thymus daenensis L. essential oil as a natural preservative for use in mayonnaise, demonstrating high stability and antibacterial effects. The nanoemulsion showed inhibition of three bacterial strains but pure essential oil had stronger antibacterial effects. In mayonnaise, the optimal nanoemulsion received higher sensory scores compared to sodium benzoate.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Nor Azrini Nadiha Azmi, Amal A. M. Elgharbawy, Hamzah Mohd Salleh, Muhammad Moniruzzaman
Summary: Fish by-product oil and lemon oil have potential applications in various industries, but their poor stability has hindered their usage. This study successfully formed an oil-in-water nanoemulsion of lemon and fish by-product oils (NE-FLO) using ultrasonication. NE-FLO showed outstanding biological properties including antioxidant, antibacterial, cell cytotoxicity, and anti-inflammatory activities.