期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms21207485
关键词
diabetic neuropathy; central nervous system; motor cortex; corticospinal tract; alpha motoneuron; gamma motoneuron; rehabilitation
资金
- Japan Society for the Promotion of Science (KAKENHI) [18K10726]
- Grants-in-Aid for Scientific Research [18K10726] Funding Source: KAKEN
Although motor deficits in humans with diabetic neuropathy have been extensively researched, its effect on the motor system is thought to be lesser than that on the sensory system. Therefore, motor deficits are considered to be only due to sensory and muscle impairment. However, recent clinical and experimental studies have revealed that the brain and spinal cord, which are involved in the motor control of voluntary movement, are also affected by diabetes. This review focuses on the most important systems for voluntary motor control, mainly the cortico-muscular pathways, such as corticospinal tract and spinal motor neuron abnormalities. Specifically, axonal damage characterized by the proximodistal phenotype occurs in the corticospinal tract and motor neurons with long axons, and the transmission of motor commands from the brain to the muscles is impaired. These findings provide a new perspective to explain motor deficits in humans with diabetes. Finally, pharmacological and non-pharmacological treatment strategies for these disorders are presented.
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