Review
Oncology
Manuela Santarosa, Roberta Maestro
Summary: The loss of epithelial integrity and the role of autophagy in cancer progression, particularly in the context of dysregulation of cell adhesion molecules like E-cadherin, are crucial factors. Cell adhesion and EMT play significant roles in the transition process of cancer, while autophagy may have dual effects on tumor progression, acting as both a suppressor and a promoter through mechanisms like EMT and drug resistance.
Article
Multidisciplinary Sciences
Liam P. Dow, Guido Gaietta, Yair Kaufman, Mark F. Swift, Moara Lemos, Kerry Lane, Matthew Hopcroft, Armel Bezault, Cecile Sauvanet, Niels Volkmann, Beth L. Pruitt, Dorit Hanein
Summary: The authors developed a micropatterning workflow that allows control of cell positioning and morphology. By characterizing the nanoscale details of protein micropatterns on electron microscopy grids, they were able to study the structural changes governing cell-cell signaling.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Debanjan Barua, Martina Nagel, Rudolf Winklbauer
Summary: This study comprehensively analyzes cell-cell contacts in multilayered tissues of the Xenopus gastrula model, identifying varying roles of different factors in intercellular contacts, with Syndecan-4 playing a dominant role. By systematically examining the contributions of adhesion factors to intercellular contacts, the study sheds light on the complexity of cell-cell interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Allison P. Kann, Margaret Hung, Robert S. Krauss
Summary: This article discusses the importance of direct contact between muscle stem cells and their neighbors, emphasizing the impact of changes in the niche during quiescence and injury on cell proliferation, self-renewal, and differentiation.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Yin Tong, Priscilla S. W. Cheng, Chung Sze Or, Sarah S. K. Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y. K. Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S. Y. Chan, April S. Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H. N. Yan
Summary: Cell-cell and cell-matrix adhesions play a critical role in gastric cancer progression, especially in gastric cancer with dysregulated RHO signaling.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Qiongyu Li, Yixuan Xie, Rachel Rice, Emanual Maverakis, Carlito B. Lebrilla
Summary: Antigen-antibody proximity labeling (AAPL) is a novel method to map the antigen interaction sites as well as interactors of antibody-targeted proteins. Oxidative proteomic analysis can determine the degree of oxidation, the site of oxidation within the targeted antigen, and the interacting proteins that were in close proximity to the targeted antigen.
Article
Cell Biology
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang
Summary: In this study, the researchers found that TRIM3, an E3 ligase, promotes ER alpha signaling activity and breast cancer progression. Depletion of TRIM3 inhibits breast cancer cell proliferation and migration, and unbiased RNA sequencing data showed that TRIM3 is crucial for estrogen signaling activity on a genome-wide scale. The researchers also demonstrated that TRIM3 associates with ER alpha and promotes its stability by inducing a specific ubiquitin modification. These findings provide a novel posttranslational mechanism in estrogen signaling and suggest that modulation of TRIM3 expression or function could be a promising approach for breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Cell Biology
Andrea Ravasio, Eugenia Morselli, Cristina Bertocchi
Summary: Cells respond to mechanical forces and physical cues from their environment, with autophagy playing a major role in maintaining cellular processes and regulating interactions with the environment. This review summarizes the interaction between autophagy and mechanotransduction machinery associated with cell adhesions, termed as "Mechanoautophagy".
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Alison E. Obr, Joseph J. Bulatowicz, Yun-Juan Chang, Virginia Ciliento, Alexander Lemenze, Krystopher Maingrette, Quan Shang, Emily J. Gallagher, Derek LeRoith, Teresa L. Wood
Summary: The reduction of IGF1R expression is associated with the upregulation of pathways necessary for promoting metastasis in breast cancer. Functional analysis reveals that decreased IGF1R signaling leads to a dysregulation of cadherin expression, resulting in reduced cell adhesion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Claudia Martins-Lima, Vera Miranda-Goncalves, Joao Lobo, Vera Constancio, Pedro Leite-Silva, Catarina Guimaraes-Teixeira, Sara Monteiro-Reis, Jose Pedro Sequeira, Mariana Cantante, Celine S. Goncalves, Bruno M. Costa, Rui Henrique, Carmen Jeronimo
Summary: The switching of E-, P-, and R-cadherin in BlCa is associated with tumor progression, with RCAD potentially playing an oncogenic role in BlCa progression. Promoter methylation is unlikely to be the mechanism underlying cadherin expression deregulation.
Review
Biochemistry & Molecular Biology
Jooske L. Monster, Lars J. S. Kemp, Martijn Gloerich, Rachel S. van der Post
Summary: Gastric cancer is the fourth leading cause of cancer-related deaths worldwide, and patients with diffuse-type gastric cancer have a poor prognosis with limited effectiveness of conventional chemotherapies. However, recent advancements in mouse and organoid models, as well as multi-omic analyses, are shedding light on the mechanisms responsible for DGC initiation and progression, offering potential opportunities for targeted therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Cell Biology
Madeleine Dorsch, Manuela Kowalczyk, Melanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M. Gruener
Summary: Research shows that statins induce a partial epithelial-to-mesenchymal transition phenotype in cancer cells of solid tumors, reducing cellular plasticity by enforcing a mesenchymal-like state that increases metastatic seeding ability while also decreasing the formation of secondary tumors due to heterogeneous treatment responses.
Article
Pharmacology & Pharmacy
Dan Tian, Qing Qin, Mingfei Li, Xiaoyu Li, Qing Xu, Qianzhou Lv
Summary: This study found significantly elevated levels of EphA2, VCAM-1, and Hcy in patients with arteriosclerosis, with EphA2 knockdown leading to impaired cell adhesion and migration. Furthermore, the interaction between PGRN and EphA2 signaling pathway may play a crucial role in Hcy-induced endothelial injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Matylda Barbara Mielcarska, Magdalena Bossowska-Nowicka, Felix Ngosa Toka
Summary: The presence of endosomal Toll-like receptors (TLRs) on the cell surface may contribute to inflammatory signaling pathways in host responses, with possible simultaneous activation from both intracellular and cell membrane sites. Transport of various forms of endosomal TLRs to the cell membrane could be a normal process orchestrated by cysteine proteases-cathepsins, impacting immune response mechanisms. Among endosomal TLRs, TLR3 represents an evolutionarily distinct group, with differently glycosylated forms transported to the cell membrane by UNC93B1, possibly influencing immune response implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Olga Witkowska-Pilaszewicz, Rafal Pingwara, Jaroslaw Szczepaniak, Anna Winnicka
Summary: Clenbuterol is gaining popularity for weight loss and bodybuilding, but is prohibited in anti-doping control. Research suggests that clenbuterol can inhibit the inflammatory process. Beta 2-adrenoceptor stimulation has enhanced anti-inflammatory properties in well-trained horses, but can create a pro-inflammatory environment in inexperienced horses.
Article
Agriculture, Dairy & Animal Science
Malgorzata Masko, Malgorzata Domino, Tomasz Jasinski, Olga Witkowska-Pilaszewicz
Summary: This study compared the physical activity-dependent blood indicators between school, endurance and race horses, finding that school horses showed similarities with endurance horses in some parameters and with race horses in others. Blood testing is crucial for monitoring training and performance in equine athletes, with different types of horses exhibiting distinct profiles in physiological demands and exercise metabolism.
Article
Biochemistry & Molecular Biology
Ian Branford, Shevaun Johnson, Aspinas Chapwanya, Samantha Zayas, Filip Boyen, Matylda Barbara Mielcarska, Lidia Szulc-Dabrowska, Patrick Butaye, Felix Ngosa Toka
Summary: The study delves into the genomics of Dermatophilus congolensis using whole-genome sequencing and bioinformatic analysis, revealing an open pan-genome with potential virulence factors and secondary metabolites. Despite originating from the same geographical location, there is genomic diversity among isolates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Malgorzata Masko, Olga Witkowska-Pilaszewicz, Tomasz Jasinski, Malgorzata Domino
Summary: This study compared the temperatures of pregnant and non-pregnant mares over 11 months, finding no significant differences in ambient and surface temperatures between the two groups during the increasing period. However, during the decreasing period, there were significant differences in slopes for some temperature measurements. The study also found no parallel changes between hair coat features and measured temperatures.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Biochemistry & Molecular Biology
Michal Trela, Olga Witkowska-Pilaszewicz, Dominika Domanska, Monika M. Kaczmarek, Bartosz Pawlinski, Zdzislaw Gajewski, Malgorzata Domino
Summary: This study evaluated the effectiveness of vaginal progesterone inserts therapy in cows with anestrus type II. The expression of progesterone and estrogen receptors in the endometrium was assessed, and blood levels of estradiol and progesterone were evaluated. The results showed a decrease in mRNA expression of certain receptors in both treated and untreated animals. However, treated animals showed an increase in the expression of specific receptors compared to untreated animals. In addition, the recurrence of ovarian cyclicity and pregnancy rates were higher in the treated group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Matylda Barbara Mielcarska, Katarzyna Skowronska, Zbigniew Wyzewski, Felix Ngosa Toka
Summary: Current data strongly indicate that herpes simplex virus type 1 (HSV-1) infection is a contributing factor to Alzheimer's disease (AD). HSV-1 infection causes damage to neurons and glial cells, as well as modifications in their environment, leading to impaired signal transmission and homeostatic and immune functions. This review discusses the pathological alterations in central nervous system (CNS) cells following HSV-1 infection, including inflammatory responses, oxidative damage, and cellular dysfunctions associated with AD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Sintayehu M. Arega, Darryn L. Knobel, Felix N. Toka, Anne Conan
Summary: Recent studies have revealed the additional effects of vaccines known as non-specific effects (NSEs) or heterologous effects of vaccines. This review examines the findings of published studies on NSEs of vaccines developed or repurposed for use in animals, indicating that most vaccines have beneficial NSEs against multiple pathogens and disease conditions. However, there are also a few studies reporting detrimental NSEs from both non-live and live vaccines.
Article
Agronomy
Aleksandra Figarska, Olga Witkowska-Pilaszewicz
Summary: The immunology of pregnancy focuses on the immune responses of a mother and her fetus to each other. Recent research has shed light on the complex immunological processes that allow the developing fetus to survive without being rejected by the mother's immune system. Horses are a valuable animal model for pregnancy immunology research due to their unique anatomy and physiology.
Review
Agronomy
Michal Trela, Dominika Domanska, Olga Witkowska-Pilaszewicz
Summary: Checking the health status of individual animals and herds in a farm is vital for diary production. The acute phase response (APR), a non-specific systemic reaction to tissue injury, is characterized by changes in acute-phase proteins (APPs). Serum amyloid A (SAA), a major APP in cows, is a reliable indicator of various pathologies and treatment effectiveness.
Article
Veterinary Sciences
Darryn L. Knobel, Anne Conan, Felix N. Toka, Sintayehu M. Arega, Charles Byaruhanga, Eric Ogola, Erick M. O. Muok, Jan E. Crafford, Andrew L. Leisewitz, Melvyn Quan, Mary Anna Thrall
Summary: The study investigates the effects of different types of rabies vaccines on mortality rates in a population of free-roaming dogs. The researchers suspect that alum-adjuvanted rabies vaccine may have a detrimental effect on female survival due to its impact on the immune response to infectious and/or parasitic diseases. The study aims to provide evidence for the rational mitigation of non-specific effects of non-live vaccines in high-mortality populations.
BMC VETERINARY RESEARCH
(2022)
Review
Microbiology
Malgorzata Gierynska, Lidia Szulc-Dabrowska, Justyna Struzik, Karolina Paulina Gregorczyk-Zboroch, Matylda Barbara Mielcarska, Felix Ngosa Toka, Ada Schollenberger, Zuzanna Biernacka
Summary: The eradication of smallpox through a global vaccination program led by the World Health Organization was a tremendous achievement. However, the discontinuation of the program resulted in a decline in herd immunity against smallpox, leading to a global health emergency. The smallpox vaccines provided long-lasting protection against not only smallpox but also other zoonotic orthopoxviruses that are now a significant threat to public health.
Meeting Abstract
Immunology
Matylda Barbara Mielcarska, Justyna Struzik, Felix Ngosa Toka
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Felix N. Toka, Zuzanna Biernacka, Justyna Struzik, Malgorzata Gierynska, Lidia Szulc-Dabrowska
JOURNAL OF IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Ian Branford, Filip Boyen, Shevaun Johnson, Samantha Zayas, Aspinas Chapwanya, Patrick Butaye, Felix N. Toka
Summary: This study evaluated the antimicrobial susceptibility of Dermatophilus congolensis isolates and found acquired tetracycline resistance in the island of St. Kitts. Further research is needed to confirm the implications of this observation on the efficacy of treating the disease.
VETERINARY SCIENCES
(2021)
