Review
Chemistry, Applied
Wenjing Lu, Zhifeng Yang, Juan Chen, Di Wang, Yu Zhang
Summary: This review highlights the antiviral mechanisms of sulfated polysaccharides, suggesting that they may interfere with various steps in the virus life cycle or enhance host immune response. Additionally, the antiviral activity of sulfated polysaccharides is influenced by factors such as degree of substitution, substitution position, molecular weight, and spatial conformation, providing insights for the development of novel therapeutic agents.
CARBOHYDRATE POLYMERS
(2021)
Article
Plant Sciences
Qiaobian He, Xiaobin Li, Xiaoling Wang, Hongxiang Lou, Peihong Fan
Summary: Dactylicapnos torulosa has been traditionally used as a therapeutic remedy. A combined strategy using phytochemical and biological approaches was conducted to identify the effective components of D. torulosa. New alkaloids isolated showed promising antithrombotic effects, which may be attributed to their inhibitory effect on platelet aggregation.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Meijia He, Yajing Yang, Zhuling Shao, Junyan Zhang, Changning Feng, Lei Wang, Wenjun Mao
Summary: Marine macroalgae are efficient producers of sulfated polysaccharides with diverse bioactivities. A heparinoid-active sulfated polysaccharide was isolated from the green alga Cladophora oligoclada, showing potent anticoagulant activity through the inhibition of coagulation factors. These results suggest that the sulfated polysaccharide has the potential to be developed as an anticoagulant agent for thrombotic diseases.
Article
Polymer Science
Dan Lin, Cheng-Jian Xu, Yang Liu, Yu Zhou, Shuang-Li Xiong, Hua-Chang Wu, Jing Deng, Yu-Wen Yi, Ming-Feng Qiao, Hang Xiao, Sook-Wah Chan, Yi Lu
Summary: The structures of two polysaccharides (CTLP-1 and CTLP-2) from Carthamus tinctorius L. were analyzed. Both polysaccharides exhibited high antioxidant activities, indicating their potential as antioxidants.
Article
Food Science & Technology
Mingyue Shen, Xianxiang Chen, Lixin Huang, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The sulfated polysaccharide (SMP) from Mesona chinensis Benth exhibits immunomodulatory effects by inducing various immune responses and improving antioxidant capacity. The SMP can be used as functional foods for its beneficial effects on immune regulation and overall health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Hao Tang, Jinwen Huang, Qingxia Yuan, Kunling Lv, Haiqiong Ma, Tingting Li, Yonghong Liu, Shunli Mi, Longyan Zhao
Summary: In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa and sulfated, showing potential as an anticoagulant. CPP-1 was mainly composed of D-mannopyranose, 3-O-methylated D-mannopyranose, and D-galactopyranose. The sulfated Chlorella mannogalactan (SCM) derived from CPP-1 demonstrated strong anticoagulant activity, making it a possible safer alternative to heparin-like drugs.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Ji Kang, Xing Jia, Nifei Wang, Meng Xiao, Shuang Song, Shufen Wu, Zhenjing Li, Shujun Wang, Steve W. Cui, Qingbin Guo
Summary: This review compares the structural characteristics of marine sulfated polysaccharides and summarizes their functional and biological activities, as well as the influence of sulfate groups on their properties. The aim is to provide a deeper understanding of marine SPs for their industrial applications in various fields.
FOOD HYDROCOLLOIDS
(2022)
Review
Food Science & Technology
Yingying Feng, Teketay Wassie, Renyou Gan, Xin Wu
Summary: Marine algae are an important untapped source of functional food, with sulfated polysaccharides exhibiting various bioactivities, particularly immunomodulation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Tian Zhang, Wenjuan Liu, Chengyang Fu, Yuhe Qiao, Kaimin Xiao, Li Ren, Caixia Feng, Jingmei Wang, Weixia Yang, Xiao-Qiang Li, Wei Cao
Summary: Two homogeneous polysaccharides (APS-4I and APS-4II) were isolated from Angelica sinensis in this study, with APS-4II showing better inhibitory effects on melanoma growth and positive impacts on immune response and cell functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Qing Li, Yunhui Yang, Yijian Li, Yingqi Mi, Xuanxuan Ma, Aili Jiang, Zhanyong Guo
Summary: Natural polysaccharides were chemically modified to obtain derivatives with enhanced biological activity. These derivatives exhibited improved antioxidant, antifungal, and antibacterial properties compared to the raw polysaccharides. The synthesized compounds also showed no cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Zhiwei Li, Yuanhao Wei, Yawen Wang, Ran Zhang, Chuanjie Zhang, Caixing Wang, Xuebing Yan
Summary: Highly substituted sulfated alfalfa polysaccharides (SAP) were successfully synthesized via the chlorosulfonic acid (CSA)-pyridine (Pyr) method. The optimized reaction conditions resulted in a maximum degree of substitution of 0.724. SAP exhibited improved water solubility and biological activity, showing better antioxidant activity, antibacterial ability, and promotion of intestinal epithelial cells' viability compared to non-sulfated alfalfa polysaccharides (AP). Furthermore, SAP showed potential in inhibiting obesity.
Article
Agricultural Engineering
Junchi Li, Yumin Fan, Gangliang Huang, Hualiang Huang
Summary: This article summarizes the extraction methods of Zizylphus vulgaris polysaccharides, reviews their structural characteristics, activities, and structure-activity relationship, and analyzes the existing problems, aiming to provide reference and theoretical basis for improving the utilization of Zizylphus vulgaris polysaccharides.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Abul Hossain, Deepika Dave, Fereidoon Shahidi
Summary: Sea cucumbers contain sulfated polysaccharides (SPs) with diverse pharmacological effects, including anticoagulant, anti-inflammatory, and anticancer activities. The effects of SPs depend on their structural characteristics, such as the degree of sulfation, position, molecular weight, and distribution of branches. However, these effects are also influenced by the species, origin, harvesting season, and extraction methods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yimeng Li, Xuxiang Guo, Ruifang Zhong, Changming Ye, Jian Chen
Summary: Polysaccharides LNP-1 and LNP-2 were extracted and purified from Lepista nuda, and their structural characteristics and biological activities were evaluated. The molecular weights of LNP-1 and LNP-2 were determined, and their monosaccharide compositions were analyzed. Both LNP-1 and LNP-2 exhibited anti-proliferation effects on A375 cells and LNP-2 showed better cellular antioxidant activity. RT-PCR results indicated that LNP-1 and LNP-2 could induce macrophages to secrete immune-modulatory factors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Huifang Wang, Meiyu Yuan, Gaoheng Li, Yuxin Tao, Xuanyu Wang, Sheng Ke, Min Zhuang, Anqi Wang, Zhongkai Zhou
Summary: This research characterized the structure of Cyperus esculentus polysaccharide (CEP) and its acetylated form (ACEP), and investigated the effects of acetylation on various properties. The results showed that both CEP and ACEP were heteropolysaccharides consisting of multiple sugars. Acetylation improved thermal stability and exhibited greater antioxidant activity. Furthermore, CEP and ACEP protected cells against inflammation. This study highlights the potential of C. esculentus for the functional food industry.
Article
Chemistry, Applied
Nayonara Lanara Sousa Dutra, Tarcisio Vieira de Brito, Diva de Aguiar Magalhaes, Stefany Guimaraes Sousa, Jalles Arruda Batista, Cynthia Maria Carvalho Pereira, Jayro dos Santos Ferreira, Lauanda da Rocha Rodrigues, Jose Victor do Nascimento Lima, Ieda Figueira de Albuquerque, Roosevelt Delano S. Bezerra, Carlos Eduardo da Silva Monteiro, Alvaro Xavier Franco, Pedro Marcos Gomes Soares, David Di Lenardo, Daniel Fernando Pereira Vasconcelos, Francisco Clark Nogueira Barros, Ana Lucia Ponte Freitas, Andre Luiz dos Reis Barbosa
Summary: Marine macroalgae contain sulfated polysaccharides (PLS) with antioxidant and anti-inflammatory effects. Extracted PLS from Gracilaria caudata show therapeutic potential for UC, reducing inflammatory processes and oxidative stress in mice models.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Antonia Carla de Jesus Oliveira, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Lais Ramos Monteiro de Lima, Thaisa Cardoso Oliveira, Fatima Garcia-Villen, Cesar Viseras, Regina C. M. de Paula, Pedro Jose Rolim-Neto, Fernando Hallwass, Edson C. Silva-Filho, Durcilene Alves da Silva, Jose Lamartine Soares-Sobrinho, Monica Felts de la Roca Soares
Summary: Chemical modification of polysaccharides using microwave irradiation for the synthesis of phthalated cashew gum was investigated in this study, showing promising properties for improving the treatment of Chagas disease. The modified biopolymers were characterized for their structural and physicochemical properties, and the nanoparticles used for drug delivery systems exhibited specific characteristics such as size, zeta potential, and in vitro release behavior.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Lais Ramos Monteiro Lima, Everton Lucas de Lima Ramos, Maria Francilene Souza Silva, Fabio de Oliveira Silva Ribeiro, Jeanlex S. Sousa, Claudia Pessoa, Durcilene Alves Silva, Judith P. A. Feitosa, Haroldo C. B. Paula, Regina Celia Monteiro de Paula
Summary: In this study, aminated poly(N-isopropylacrylamide) was successfully grafted onto oxidized galactomannan polysaccharide from Delonix regia via Schiff base reaction. The self-organizing ability of the obtained nanoparticle copolymers was investigated, showing promising potential for drug delivery with good cell viability and transition temperature close to human body temperature. The use of free aldehyde groups in the oxidized polysaccharide for pro-drug formation with substances possessing NH2 groups was also highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Lindauro C. Pereira Junior, Fernando G. Nascimento, Samara R. B. D. Oliveira, Glauber C. Lima, Francisco Diego S. Chagas, Venicios G. Sombra, Judith P. A. Feitosa, Eliane M. Soriano, Marcellus H. L. P. Souza, Guilherme J. Zocolo, Lorena M. A. Silva, Regina C. M. de Paula, Renan O. S. Damasceno, Ana Lucia P. Freitas
Summary: The study isolated and characterized a polysaccharide from the marine alga Acanthophora spicifera, which exhibited protective potential against chemically-induced gastric mucosa injury. The sulfated polysaccharide showed promising gastroprotective effects by preventing lipid peroxidation and enhancing the defense mechanisms of the gastric mucosa.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Antonia Ariana Camelo Passos, Mighay Lovera, Maria do Socorro Rocha Bastos, Jeanny da Silva Maciel, Venicios Goncalves Sombra, Renata Chastinet Braga, Ana Cristina de Oliveira Monteiro Moreira, Renato de Azevedo Moreira
Summary: This study successfully optimized the enzymatic hydrolysis process to produce low-viscosity dietary fiber from galactomannan. The hydrolysis significantly reduced the molecular mass and increased the dietary fiber content. The detailed analysis of physical and chemical characteristics of the hydrolyzed product showed its promising potential for applications in the food industry.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biochemistry & Molecular Biology
Thaisa Cardoso de Oliveira, Antonia Carla de Jesus Oliveira, Yuri Basilio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C. M. de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Monica Felts de La Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: A new hydrophobic polymer based on angico gum (AG) was developed, and new nanoparticles were produced to expand the applications of natural polysaccharides in nanomedicine. By utilizing Plackett-Burman's experimental design, nanoparticles with different characteristics were successfully produced. NVP-loaded PAG nanoparticles showed significant promotion of drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Maria K. S. O. Abreu, Maria A. S. Silva, Dieric S. Abreu, Ana R. Richter, Regina C. M. de Paula, Vera R. L. Constantino, Igor F. Vasconcelos, Francisco G. S. de Oliveira, Acacio S. de Melo, Marcio A. Correa, Izaura C. N. Diogenes
Summary: This study improves the colloidal stability of CoFe2O4 in water media by encapsulating it in CMCG. The results show that after encapsulation, CoFe2O4 forms a polymer-caged MNPs aggregate with a negatively charged layer. Despite the dilution effect of CMCG, the material maintains magnetization.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Fabio de Oliveira Silva Ribeiro, Fatima de Cassia Evangelista de Oliveira, Claudia Pessoa, Jhones do Nascimento Dias, Patricia Albuquerque, Edymilais da Silva Sousa, Sidney Goncalo de Lima, Lais Ramos Monteiro de Lima, Venicios G. Sombra, Regina Celia Monteiro de Paula, Even Herlany Pereira Alves, Daniel Fernando Pereira Vasconcelos, Darllan Damasceno Fontenele, Bruno Iles, Jand Venes Rolim Medeiros, Alyne Rodrigues de Araujo, Durcilene Alves da Silva, Jose Roberto de Souza de Almeida Leite
Summary: Lemon gum (LG) was isolated and characterized from Citrus x latifolia in Brazil. The biocompatibility of LG was evaluated in vitro and in vivo, and it showed antiproliferative activity against human prostate adenocarcinoma cancer cells. The results indicate the potential of LG for biomedical and biotechnological applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Raimundo Fernandes de Araujo Junior, George A. Lira, Timo Schomann, Romulo S. Cavalcante, Natalia Feitosa Vilar, Regina Celia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B. Chan, Luis J. Cruz
Summary: This study investigates the down-regulation of interaction between tumour-associated macrophages (TAMs) and colorectal cancer cells by nanoparticles (NPs) loaded with retinoic acid (RA) and coated with cholesterol (CHO), in combination with an anti-PD-L1 immune checkpoint inhibitor. The IL-10R/IL-10 axis is shown to overstimulate the STAT3 pathway and downregulate the NF-kappa B signalling pathway, leading to immunosuppression and epithelial-mesenchymal-transition of colorectal cancer. The use of RA-loaded NPs coated with CHO and anti-PD-L1 is found to be more effective in blocking this signalling pathway.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Polymer Science
Francisco das C. M. Brito, Wilton C. Lopes, Fabio O. S. Ribeiro, Raiza Raianne Luz Rodrigues, Klinger Antonio da Franca Rodrigues, Fabricio dos Santos Machado, Ana Jersia Araujo, Jose Delano Barreto Marinho Filho, Antonia Carla J. Oliveira, Edson C. S. Filho, Irisvan S. Ribeiro, Regina C. M. de Paula, Fernando Hallwass, Vicente Galber F. Viana, Durcilene A. Silva
Summary: This study modified the cashew gum through an amine reaction, which changed its molecular weight and surface charge. The amine group binding to the gum was confirmed, and cytotoxicity tests showed that the modified gum had increased thermal stability and no cytotoxic potential at concentrations below 50.0 mg/L.
Article
Chemistry, Multidisciplinary
Aline T. dos Santos, Emerson L. da Silva, Raquel C. Montenegro, Jeanlex S. de Sousa, Regina C. M. de Paula, Judith P. A. Feitosa
Summary: Copolymers of N-isopropylacrylamide (NIPAm) grafted with Dextran sulfate (DS) hold great potential for drug release, especially in targeted delivery to inflamed regions. Two different ratios of the copolymers were synthesized and confirmed using spectroscopic techniques. These copolymers demonstrated self-organization behavior in aqueous medium at temperatures above 34°C, with sizes smaller than 300 nm and spherical shapes. DS-g-3PNIPAm showed specificity to leukemic cells without affecting normal cell proliferation. Encapsulating and delivering the poorly water-soluble drug MTX using DS-g-3PNIPAm can overcome its severe side effects and improve bioactivity and stability. Among the thermo-responsive copolymers and targeted MTX nanocarriers, the DS-g-PNIPam exhibited the best performance.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Ana R. Richter, Jose G. Veras-Neto, Jeanlex S. Sousa, Josilayne F. S. Mendes, Raquel O. S. Fontenelle, Stephanie A. N. M. Silva, Jose D. B. Marinho-Filho, Ana J. Araujo, Judith P. A. Feitosa, Haroldo C. B. Paula, Francisco M. Goycoolea, Regina C. M. de Paula
Summary: This study reports the effect of acyl chain length on hydrophobized cashew gum derivatives. By using different anhydrides, the properties of nanoparticles and drug delivery were investigated, resulting in nanoparticles with desirable properties.
COLLOIDS AND INTERFACES
(2022)
Article
Polymer Science
Carlos Pinheiro Chagas de Lima, Andreia Hansen Oster, Fabio Rossi Cavalcanti, Regina Celia Monteiro de Paula, Judith Pessoa Andrade Feitosa
Summary: The study showed that sulfated chicha gum (SCHG) can act as an effective elicitor, enhancing the activity of guaiacol peroxidase and polyphenol oxidases while increasing the lignin content in apple fruits. Plant exudate may serve as an abundant, renewable, and safe source of elicitors.
POLIMEROS-CIENCIA E TECNOLOGIA
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
