Carboxymethylation of polysaccharides: Synthesis and bioactivities

Polysaccharides are a structurally diverse class of biomolecules with a wide variety of bioactivities. Natural polysaccharides isolated from plants and fungi are used as raw materials in food and pharmaceutical industries due to their therapeutic properties, non-toxicity, and negligible side effects, but many natural polysaccharides possess low bioactivities when compared to synthetic medicines due to their structure and physicochemical properties. Literature studies revealed that carboxymethylation of polysaccharides enhances the bioactivities and water solubility of native polysaccharides significantly, and provide structural diversity and even the addition of new bioactivities. This review article mainly focuses on the recent research on carboxymethylation of polysaccharides including preparation, characterization, and bioactivities. This article also throws light on future directions and scope to develop new carboxymethylated polysaccharide derivatives for many industries such as food processing, cosmetics, nutraceuticals, and pharmaceutical industry. (C) 2020 Elsevier B.V. All rights reserved.