期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 86, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2020.106713
关键词
Geraniol; PI3K/Akt/NF-kappa B; MAPK; Chondrocyte; Osteoarthritis; Inflammatory
资金
- Zhejiang Province Science and Technology Department Public Welfare Technology Research Program/Experimental Animal Project [LGD19H060001]
- Zhejiang Province Chinese Medicine Science and Technology Project [2013ZQ024]
- Zhejiang Province Health Department Project [2019RC052]
Osteoarthritis (OA) is a degenerative disease that has received increasing attention among the elderly. Its clinical manifestation is primarily long-term joint pain. Evidence for the pharmacological effects of geraniol in various diseases is accumulating. However, whether geraniol has a therapeutic effect against OA remains to be determined. In this study, we discussed the anti-inflammatory effects of geraniol in IL-1 beta-induced chondrocytes and the anti-cartilage degradation effects in a mouse model of destabilization of the medial meniscus (DMM). In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1 beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. Besides, geraniol inhibited the expression of MMP-9 and ADAMTS-5, and reversed the degradation of aggrecan and type II collagen. Mechanistically, we revealed that geraniol suppressed IL-1 beta-stimulated PI3K/Akt/NF-kappa B and MAPK activation. Importantly, we have found in animal experiments that oral treatment of geraniol was beneficial in protecting articular cartilage from degradation. Overall, these data indicated that geraniol may have the potential to be developed as an effective treatment for OA.
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