Automated characterization of fatty liver disease and cirrhosis using curvelet transform and entropy features extracted from ultrasound images

Fatty liver disease (FLD) is reversible disease and can be treated, if it is identified at an early stage. However, diagnosed at the later stage, it can progress to an advanced liver disease such as cirrhosis which may ultimate' lead to death. Therefore, it is essential to detect it at an early stage before the disease progresses to an irreversible stage. Several non-invasive computer-aided techniques are proposed to assist in the early detection of FLD and cirrhosis using ultrasound images. In this work, we are proposing an algorithm to discriminate automatically the normal, FLD and cirrhosis ultrasound images using curvelet transform (CT) method. Hight order spectra (HOS) bispectrum, HOS phase, fuzzy, Kapoor, max, Renyi, Shannon, Vajda and Yager entropis.. are extracted from CT coefficients. These extracted features are subjected to locality sensitive discriminar analysis (LSDA) feature reduction method. Then these LSDA coefficients ranked based on F-value are fed different classifiers to choose the best performing classifier using minimum number of features. Our propose technique can characterize normal, FLD and cirrhosis using probabilistic neural network (PNN) classifier wit an accuracy of 97.33%, specificity of 100.00% and sensitivity of 96.00% using only six features. In addition these chosen features are used to develop a liver disease index (LDI) to differentiate the normal, FLD an( cirrhosis classes using a single number. This can significantly help the radiologists to discriminate FLD an( cirrhosis in their routine liver screening.