期刊
IMMUNOLOGIC RESEARCH
卷 68, 期 5, 页码 296-309出版社
SPRINGER
DOI: 10.1007/s12026-020-09149-1
关键词
Th17 cells; Psoriasis; Differentiation; IL-17A; IL-17F; IL-21; IL-22; IL-26
类别
资金
- China Pharmaceutical University Double First-Class University project [CPU2018GY32]
- National Major Scientific and Technological Special Project for Significant New Drugs Development during the Thirteenth Five-year Plan Period [2016ZX09101031]
- China Pharmaceutical University Double First-Class Construction Graduate Education and Teaching Project [JGYB201909]
T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical role in the pathogenesis of these disorders. In this review, we introduced the signaling and transcriptional regulation of Th17 cells. And then, we demonstrate the immunopathology role of Th17 cells and functions of the related cytokines in the psoriasis to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease.
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