Review
Endocrinology & Metabolism
Caiyi Long, Haoyue Feng, Wen Duan, Xin Chen, Yuemeng Zhao, Ying Lan, Rensong Yue
Summary: The prevalence of PCOS in women with T2DM is approximately 21%. Women of childbearing age with T2DM have a higher prevalence of PCOS compared to adolescents. Women with T2DM should pay attention to screening and prevention of PCOS to protect reproductive health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Samaneh Soleymani, Mohammad Hossein Ayati, Mohammad Javad Mansourzadeh, Nazli Namazi, Arman Zargaran
Summary: This systematic review and meta-analysis examined the effects of silymarin on the components of cardiometabolic syndrome (CMS) in adults. The results showed that silymarin had positive effects on reducing fasting blood glucose levels, hemoglobin A1C, total cholesterol, triglyceride, and low-density lipoprotein-cholesterol, and increasing high-density lipoprotein-cholesterol. However, its effects on BMI were not statistically significant.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Anna Krentowska, Irina Kowalska
Summary: Metabolic characteristics in PCOS patients vary among different phenotypes, with hyperandrogenic and classic phenotype patients showing more adverse profile. Normoandrogenic PCOS patients generally do not differ significantly in metabolic characteristics from controls, although some studies reported a more adverse profile in certain ethnic groups.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Anastasia Vatopoulou, Maria-Eleni Dionelli, Alexis Papanikolaou, Sonia Grover
Summary: Adolescents with PCOS exhibit various cardiometabolic risk factors, suggesting the importance of early identification for preventing cardiovascular diseases in adulthood.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Nur Syakirah Othman, Nur Aishah Che Roos, Amilia Aminuddin, Jaya Kumar Murthy, Adila A. Hamid, Azizah Ugusman
Summary: This review provides comprehensive information on the effects of Piper sarmentosum on hypertension and diabetes mellitus. The studies suggest that Piper sarmentosum has the potential to lower blood pressure and blood glucose levels, making it a natural source of antidiabetic and antihypertensive agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Pawel Dybciak, Dorota Raczkiewicz, Ewa Humeniuk, Tomasz Powrozek, Mariusz Gujski, Teresa Malecka-Massalska, Artur Wdowiak, Iwona Bojar
Summary: This meta-analysis utilized research utilizing the Hospital Anxiety and Depression Scale (HADS) to determine the prevalence, mean level, standardized mean difference, and probability of depression in patients with PCOS. The results indicate an increased risk of depressive symptoms in women with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Christos Chatzakis, Evangelia Tsakmaki, Aggeliki Psomiadou, Nikolaos Charitakis, Makarios Eleftheriades, Konstantinos Dinas, Dimitrios Goulis, Alexandros Sotiriadis
Summary: This systematic review and meta-analysis study aimed to investigate the correlation between different diagnostic criteria of polycystic ovary syndrome (PCOS) and the development of maternal and neonatal complications. The results showed that the prevalence of gestational diabetes mellitus did not differ according to the criteria used, while women diagnosed with PCOS per the National Institutes of Health criteria were at a higher risk of preeclampsia.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Qingzi Yan, Dan Qiu, Xiang Liu, Qichang Xing, Renzhu Liu, Yixiang Hu
Summary: This review study found that gestational diabetes mellitus is common among women with polycystic ovary syndrome. There is significant heterogeneity in the incidence of gestational diabetes mellitus among different studies, and several variables including age, area, quality score, and sample size were suggested as significant sources of this heterogeneity.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Cardiac & Cardiovascular Systems
Li-Da Wu, Nan Zhou, Jin-yu Sun, Hao Yu, Ru-Xing Wang
Summary: Sitagliptin alone or in combination with other antidiabetic agents significantly reduces serum total cholesterol and LDL-C in patients with type 2 diabetes mellitus, while no significant difference was observed in serum triglycerides or HDL-C.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Medical Laboratory Technology
Andrijana Milankov, Maja Milanovic, Natasa Milosevic, Jan Sudji, Sladana Pejakovic, Natasa Milic, Artur Bjelica, Milica Medic Stojanoska
Summary: This study investigated the association between phthalate exposure and the development of metabolic syndrome in women with polycystic ovary syndrome (PCOS). The results showed that phthalate concentrations were correlated with obesity, glucose and lipid impairment, and disrupted testosterone levels.
CLINICA CHIMICA ACTA
(2023)
Review
Obstetrics & Gynecology
Jeffrey Pea, Jahnay Bryan, Cynthia Wan, Alexis L. Oldfield, Kiran Ganga, Faith E. Carter, Lynn M. Johnson, Marla E. Lujan
Summary: This systematic review and diagnostic meta-analysis examined the diagnostic accuracy of ultrasonographic features of ovarian morphology in the diagnosis of PCOS. The results showed that follicle number per ovary (FNPO) was the most accurate diagnostic marker in adult women. Ovarian volume (OV) and follicle number per single cross-section (FNPS) had similar sensitivities to FNPO but lower specificities and accuracies. In adolescents, ovarian volume may be a reliable ultrasonographic marker for PCOS diagnosis, although current evidence is limited.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Biochemistry & Molecular Biology
Licy L. Yanes Cardozo, Damian G. Romero
Summary: PCOS is the most common endocrine disorder in reproductive-age women, with heterogeneous clinical presentations and involvement of multiple abnormal physiological pathways. Women with PCOS also have a high prevalence of cardiometabolic risk factors, but there is limited evidence-based therapeutic agents available to treat these complications. Recent studies suggest opportunities for timely effective medical care for women with PCOS, highlighting the unmet need for effective and safe management of the cardiometabolic complications in these patients.
Review
Endocrinology & Metabolism
Lilah Tsaitlin-Mor, Adva Cahen-Peretz, Yaakov Bentov, Tomer Ben-Shushan, Hagai Levine, Asnat Walfisch
Summary: Early-term delivery poses a modest risk for long-term pediatric type 1 diabetes compared with full-term offspring. Whenever medically possible, elective delivery should be avoided before 39 completed weeks of gestation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Carrie Riestenberg, Anika Jagasia, Daniela Markovic, Richard P. Buyalos, Ricardo Azziz
Summary: The study estimated the excess prevalence and economic burden of pregnancy-related and long-term health morbidities attributable to PCOS, showing an additional total healthcare-related economic burden of $4.3 billion annually in the United States. Together with prior analysis, the economic burden of PCOS is estimated at $8 billion annually in 2020 USD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Chemistry, Medicinal
Reza Tabrizi, Peyman Nowrouzi-Sohrabi, Kamran Hessami, Shahla Rezaei, Mohammad Jalali, Amir Savardashtaki, Saeed Shahabi, Ali-Asghar Kolahi, Amirhossein Sahebkar, Saeid Safiri
Summary: Ginkgo biloba may have a significant effect on HbA1c and HDL-cholesterol levels in patients with T2DM, but more studies are needed to confirm its potential impact on cardiometabolic parameters.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Susanne R. De Rooij, Laura S. Bleker, Rebecca C. Painter, Anita C. Ravelli, Tessa J. Roseboom
Summary: This study found that individuals born around the time of the Dutch famine in 1944-45 suffered lasting consequences of prenatal undernutrition, especially during early gestation. Undernutrition during gestation affects the development of organs and tissues, alters behavior, and increases the risk of chronic diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Sjoerd M. Verwijs, Yigal M. Pinto, Diederik W. D. Kuster, Jolanda van der Velden, Jacqueline Limpens, Juliette C. van Hattum, Saskia N. van der Crabben, Ronald H. Lekanne Deprez, Arthur A. M. Wilde, Harald T. Jorstad
Summary: Studies have shown that genetic variants associated with cardiomyopathies may be related to improved physical performance. This may explain the prevalence of such variants in athletes and the general population.
Review
Dermatology
Sanne E. Uitentuis, Caroline Bambach, Yannick S. Elshot, Jacqueline Limpens, Alexander C. J. van Akkooi, Marcel W. Bekkenk
Summary: Synthesis of available data indicates no significant differences in recurrence and survival rates between different clinical excision margins and MMS in treating MCC.
DERMATOLOGIC SURGERY
(2022)
Article
Pediatrics
Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel Ganzevoort
Summary: This study reflects on the unexpected finding of pulmonary hypertension in infants born within the Dutch STRIDER trial and discusses its definition and possible pathophysiological mechanisms. It was found that infants of mothers allocated to antenatal sildenafil had a higher rate of pulmonary hypertension compared to those in the placebo group.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Cardiac & Cardiovascular Systems
Frank Meijerink, Samme M. de Witte, Jacqueline Limpens, Robbert J. de Winter, Berto J. Bouma, Jan Baan
Summary: This study aimed to determine the prognostic value of pulmonary hypertension (PH), right ventricular (RV) dysfunction, and tricuspid regurgitation (TR) on mortality after transcatheter mitral valve repair (TMVR). The results showed that patients with significant mitral regurgitation (MR) and concomitant PH, RV dysfunction, or TR had worse prognosis after TMVR. Careful assessment of these parameters should be done before making clinical decisions for TMVR.
HEART LUNG AND CIRCULATION
(2022)
Review
Urology & Nephrology
Eva V. Vodegel, Arnoud W. Kastelein, Charlotte H. J. R. Jansen, Jacqueline Limpens, Sandra E. Zwolsman, Jan-Paul W. R. Roovers, Carlijn R. Hooijmans, Zeliha Guler
Summary: The study showed that estrogen therapy has a positive effect on vaginal wound healing, improving neovascularisation, wound closure, collagen synthesis, tissue strength, granulation, and inflammatory response. Future research should determine the potential of estrogen therapy to improve surgical outcomes.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Cell Biology
Stijn Mintjens, Mireille N. M. van Poppel, Henk Groen, Annemieke Hoek, Ben Willem Mol, Rebecca C. Painter, Reinoud J. B. J. Gemke, Tessa J. Roseboom
Summary: A study found that a preconception lifestyle intervention in obese infertile women did not have an effect on the cardiometabolic health of their offspring. Low follow-up rates and selection bias may have hindered the detection of potential effects. Future studies need to account for these factors to confirm whether a preconception lifestyle intervention can improve the cardiometabolic health of children of obese mothers.
Review
Obstetrics & Gynecology
Kelly Nijsten, Larissa A. W. Jansen, Jacqueline Limpens, Martijn J. J. Finken, Marjette H. Koot, Iris J. Grooten, Tessa J. Roseboom, Rebecca C. Painter
Summary: This systematic review evaluated the effects of maternal hyperemesis gravidarum on offspring health. The results suggest that hyperemesis gravidarum is associated with increased risk of anxiety disorder, sleep problems, attention deficit (hyperactivity) disorder, and autism spectrum disorder in offspring.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Charlotte E. van Dijk, Sofie H. Breuking, Sophie Jansen, Jacqueline C. E. J. M. Limpens, Brenda M. Kazemier, Eva Pajkrt
Summary: The objective of this study was to compare indications for cervical cerclage and their associated complications in singleton pregnancies. The study found that ultrasound-indicated and history-indicated cerclage had fewer complications compared to physical examination-indicated cerclage. There is a need for standardized reporting of complications in studies on cervical cerclage.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Dermatology
Y. S. Elshot, D. C. K. S. Tio, A. S. E. van Haersma-de With, W. Ouwerkerk, B. Zupan-Kajcovski, M. B. Crijns, C. E. J. M. Limpens, W. M. C. Klop, M. W. Bekkenk, A. J. M. Balm, M. A. de Rie
Summary: This study aimed to evaluate the effect of different surgical techniques and reflectance confocal microscopy (RCM) on local recurrence and survival outcomes of lentigo maligna (melanoma) (LM/LMM). The results showed that microscopically controlled surgical techniques were more effective in reducing the rate of local recurrence compared to wide local excision.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Behavioral Sciences
A. Boots, A. M. Wiegersma, Y. Vali, M. van den Hof, M. W. Langendam, J. Limpens, E. V. Backhouse, S. D. Shenkin, J. M. Wardlaw, T. J. Roseboom, S. R. de Rooij
Summary: Environmental exposures during pregnancy can negatively impact brain development and increase the risk of Alzheimer's disease. This systematic review examines the evidence linking prenatal exposures to brain biomarkers associated with AD. The review identified 79 studies reporting on prenatal exposures such as alcohol, smoking, illicit drugs, and nutritional deficiencies, which were associated with smaller brain volumes. The findings highlight the importance of the prenatal environment in shaping the risk of neurodegenerative diseases in later life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Renee J. Burger, Tessa J. Roseboom, Wessel Ganzevoort, Sanne J. Gordijn, Eva Pajkrt, Ameen Abu-Hanna, Martine Eskes, Aleid G. Leemhuis, Ben W. Mol, Christianne J. M. de Groot, Anita C. J. Ravelli
Summary: This study investigates the association between gestational age, sociodemographic characteristics, and school performance at the age of 12. Results show that longer gestational age is associated with better school performance, regardless of socio-demographic factors. Factors such as maternal education, maternal age, and ethnicity also influence school performance. Preterm children and those from socially or economically disadvantaged backgrounds are more vulnerable to the negative impact of preterm birth on school performance. Caution is needed in interpreting the results due to differential loss to follow-up.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Review
Psychiatry
Aline Marileen Wiegersma, Amber Boots, Miranda w W. Langendam, Jacqueline Limpens, Susan D. D. Shenkin, Aniko Korosi, Tessa J. J. Roseboom, Susanne R. de Rooij
Summary: This systematic review examined the association between prenatal factors and later risk for dementia, finding that prenatal factors related to a suboptimal prenatal environment are associated with an increased risk of dementia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Kayleigh D. Gultig, Susanne R. de Rooij, Charlotte E. Hilberdink, Miranda Olff, Tessa J. Roseboom, Mirjam van Zuiden
Summary: This study investigated whether genetic variations in the glucocorticoid receptor (GR) modulate the effects of prenatal famine exposure on PTSD symptom severity in late adulthood. The results showed that individuals exposed to famine during early gestation without the GR Bcll haplotype had a stronger association between adulthood trauma and PTSD symptom severity, indicating increased susceptibility to PTSD. These findings highlight the importance of considering genetics and environmental contexts throughout life, including the prenatal environment.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)