Article
Obstetrics & Gynecology
Vera Ruth Mitter, Pascale Fasel, Claudia Berlin, Sofia Amylidi-Mohr, Beatrice Mosimann, Marcel Zwahlen, Michael von Wolff, Alexandra Sabrina Kohl Schwartz
Summary: This study compared the perinatal outcomes of stimulated and unstimulated IVF babies with all children born in Switzerland, and found that stimulated IVF babies had higher risks of low birthweight and being small for gestational age, while unstimulated IVF babies had no significant increased risks compared to all Swiss children.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Christopher Allen, David McLernon, Sohinee Bhattacharya, Abha Maheshwari
Summary: Pregnancies conceived with donor sperm have a lower odds of early pregnancy loss and ectopic pregnancy compared to pregnancies conceived with partner sperm.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Summary: Technology and evolving regulatory framework have led to changes in medical terminology, particularly in describing the relationships between gamete and embryo donors and recipients. The use of social media and DNA testing has made it necessary to move away from terms like "known" and "anonymous" and adopt more accurate terms like "directed" and "nonidentified".
FERTILITY AND STERILITY
(2022)
Review
Medicine, General & Internal
Martina Balli, Anna Cecchele, Valerio Pisaturo, Sofia Makieva, Giorgia Carullo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano'
Summary: This article reviews the advantages and limitations of conventional IVF and discusses fundamental questions related to the technique. It provides insights into the opportunities and best practices in human c-IVF in the field of reproductive medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Irene Hervas, Rocio Rivera-Egea, Alberto Pacheco, Maria Gil Julia, Ana Navarro-Gomezlechon, Laura Mossetti, Nicolas Garrido
Summary: This multicenter retrospective cohort study found that high paternal DNA fragmentation does not contribute to adverse maternal events during pregnancy or worse neonatal outcomes. However, it may be associated with a higher ratio of male livebirths.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Danilo Cimadomo, Gemma Fabozzi, Lisa Dovere, Roberta Maggiulli, Laura Albricci, Federica Innocenti, Daria Soscia, Adriano Giancani, Alberto Vaiarelli, Maurizio Guido, Filippo Maria Ubaldi, Laura Rienzi
Summary: The study aimed to evaluate the impact of cryo-storage duration on clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer. It concluded that cryo-storage duration does not affect these outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Di Chen, Xiaoyan Mao, Jie Zhang, Ling Wu
Summary: This study suggests that the maternal ABO blood type may influence the obstetric and perinatal outcomes following frozen embryo transfer (FET). The study found that different ABO blood types were associated with different risks of gestational diabetes mellitus, large for gestational age babies, hypertensive diseases of pregnancy, and low birthweight in both singleton and twin pregnancies. These findings highlight the importance of patient characteristics in affecting the outcomes of IVF.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Yi-Chen He, Kai-Zhen Su, Jie Cai, Qing-Xia Meng, Yan-Ting Wu, He-Feng Huang
Summary: This study explored the association between anti-Mullerian hormone (AMH) levels and perinatal outcomes in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The study found that abnormal AMH levels increased the risk of intrahepatic cholestasis of pregnancy (ICP) regardless of the number of live births, while high AMH levels increased the risks of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) in multiple deliveries. However, there was no association between AMH levels and adverse neonatal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Willem Ombelet, Jonathan Van Blerkom, Geeta Nargund, Mia Janssen, Petra Jacobs, Ingrid Van der Auwera, Nathalie Dhont, Eugene Bosmans, Viktor-Jan Vertessen, Rudi Campo
Summary: This study compared the perinatal outcomes of babies conceived through different assisted reproductive technologies and found no significant difference in the perinatal outcomes of babies conceived through a simplified IVF culture system and intracytoplasmic sperm injection.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Paraskevi Vogiatzi, Abraham Pouliakis, Maria Sakellariou, Aikaterini Athanasiou, Adamantios Athanasiou, Alexandros Colaghis, Renata Finelli, Dimitrios Loutradis, Ralf Henkel, Ashok Agarwal
Summary: This retrospective cohort study found that advanced paternal age and reduced sperm motility negatively impact the outcomes of oocyte donation-intracytoplasmic sperm injection (OD-ICSI), affecting fertilization rates, embryo quality, pregnancy success, and live birth rates. Asthenozoospermia in male partners was associated with lower success rates in biochemical pregnancy, clinical pregnancy, and live birth in OD-ICSI cycles. Personalized management strategies incorporating male fertility evaluations based on these findings are crucial for improving treatment outcomes in assisted reproduction.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Caitlin R. Sacha, Daksha Gopal, Chia-Ling Liu, Howard R. Cabral, Judy E. Stern, Daniela A. Carusi, Catherine Racowsky, Charles L. Bormann
Summary: This study compares the obstetric and perinatal outcomes of single-step and sequential culture media systems for embryo conception. The results indicate that single-step culture is associated with increased odds of LGA, while there were no significant differences in other outcomes.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Willem Ombelet, Jonathan Van Blerkom, Liesbeth Bruckers, Nathalie Dhont, Geeta Nargund, Rudi Campo
Summary: To make IVF more affordable, researchers have developed a simplified culture system (SCS) that has proven to be effective. Compared to conventional IVF, singletons born after using SCS have significantly lower rates of preterm birth and low birthweight. These findings offer a promising perspective for implementing low-cost IVF in low and middle income countries (LMIC).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marta Ciaffaglione, Marco Reschini, Martina Balli, Cristina Guarneri, Maria Carla Palermo, Monica Pinna, Valerio Pisaturo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano
Summary: This study demonstrates that different post-thaw embryo culture timings do not negatively affect pregnancy outcomes. These findings are important in organizing the workflow in embryological laboratories.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lin Wang, Jing Wang, Nan Lu, Jiayin Liu, Feiyang Diao
Summary: This study found that for women with previous cesarean sections, the pregnancy outcomes were similar to those with previous vaginal delivery in single embryo transfer cycles, and the presence of cesarean scar defect (CSD) was associated with a significant reduction in live birth rate, especially in patients with large CSD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Weronika A. Szlachetka, Tiberiu A. Pana, Mamas A. Mamas, Joao H. Bettencourt-Silva, Anthony K. Metcalf, John F. Potter, David J. McLernon, Phyo K. Myint
Summary: This study aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score, utilizing factors such as age, sex, disease classification, etc. Internal validation showed an optimism-adjusted c-statistic of 0.76 and calibration slope of 0.98. This model is the first 10-year mortality score in stroke with potential clinical application value.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Obstetrics & Gynecology
David J. McLernon, Edwin-Amalraj Raja, James P. Toner, Valerie L. Baker, Kevin J. Doody, David B. Seifer, Amy E. Sparks, Ethan Wantman, Paul C. Lin, Siladitya Bhattacharya, Bradley J. Van Voorhis
Summary: This study aims to develop in vitro fertilization (IVF) prediction models to estimate individualized chances of cumulative live birth, providing guidance for IVF treatment at different time points.
FERTILITY AND STERILITY
(2022)
Review
Oncology
Melanie Turner, Peter Murchie, Sarah Derby, Ariel Yuhan Ong, Lauren Walji, David McLernon, Mary-Joan Macleod, Rosalind Adam
Summary: Existing research suggests that people living with and beyond cancer are at a higher risk of stroke, with the risk varying between different types of cancer and stroke. Certain cancers have been associated with significantly increased stroke incidence after diagnosis.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Obstetrics & Gynecology
Edwin-Amalraj Raja, Siladitya Bhattacharya, Abha Maheshwari, David J. McLernon
Summary: This population-based retrospective cohort study compares the perinatal outcomes between frozen and fresh embryo transfer (ET) in singletons, sets of twins, and siblings. The study found that frozen ET is associated with a lower risk of preterm birth, low birthweight, and congenital anomalies in singletons and twins. However, there is a higher risk of high birthweight and being large for gestational age. Singletons conceived following frozen ET have a lower risk of low birthweight and being small for gestational age compared to a singleton sibling born after fresh ET. Overall, frozen ET appears to have both advantages and disadvantages in perinatal outcomes.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Mariam B. Ratna, Siladitya Bhattacharya, N. van Geloven, David J. McLernon
Summary: This study aimed to develop an IVF prediction model to estimate individualized chances of a live birth over multiple complete cycles of IVF in couples embarking on their second complete cycle of treatment. The model showed moderate discriminative ability and evidence of overprediction, but after recalibration, the fit was much improved. Key predictors of live birth were identified, such as female age, number of eggs retrieved in the first complete cycle, and the outcome of the first complete cycle.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Rui Wang, David J. McLernon, Shimona Lai, Marian G. Showell, Zi-Jiang Chen, Daimin Wei, Richard S. Legro, Ze Wang, Yun Sun, Keliang Wu, Lan N. Vuong, Pollyanna Hardy, Anja Pinborg, Sacha Stormlund, Xavier Santamaria, Carlos Simon, Christophe Blockeel, Femke Mol, Anna P. Ferraretti, Bruce S. Shapiro, Forest C. Garner, Rong Li, Christos A. Venetis, Ben W. Mol, Siladitya Bhattacharya, Abha Maheshwari
Summary: This study aims to systematically review and meta-analyze randomized controlled trials comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy in order to determine which strategy is more appropriate for different couples and identify the corresponding protocols.
Article
Medicine, General & Internal
David J. McLernon, Daniele Giardiello, Ben Van Calster, Laure Wynants, Nan van Geloven, Maarten van Smeden, Terry Therneau, Ewout W. Steyerberg, STRATOS Initiative
Summary: Risk prediction models need validation to assess their performance. This article focuses on evaluating predictions and improving clinical decision making using survival models based on Cox proportional hazards regression. The authors present a case study on breast cancer patients, where a Cox regression model is developed and validated for prediction of recurrence or death.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
David J. McLernon, Siladitya Bhattacharya
Summary: The improvement in IVF cryopreservation techniques has led to an increase in elective single embryo transfer, reducing multiple pregnancy rates. Clinical prediction models are useful in estimating couples' chances of success and guiding future treatment. This review discusses different models for predicting cumulative live birth and recommends when and which models should be used.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Christopher Allen, David McLernon, Sohinee Bhattacharya, Abha Maheshwari
Summary: Pregnancies conceived with donor sperm have a lower odds of early pregnancy loss and ectopic pregnancy compared to pregnancies conceived with partner sperm.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Rafael Venson, Abha Maheshwari, Scott M. M. Nelson, Kathleen A. A. Boyd
Summary: The aim of this study was to calculate the average cost of IVF and ICSI cycles for NHS-funded treatment in Scotland. The study found that there is no standardised NHS tariff for these treatments in Scotland, and there is variation amongst different centres providing NHS services. The average cost of fresh IVF and ICSI cycles was found to be 3247 pounds and 3473 pounds, respectively, while frozen cycles averaged 938 pounds.
Article
Obstetrics & Gynecology
D. Cimadomo, M. J. de los Santos, G. Griesinger, G. Lainas, N. Le Clef, D. J. McLernon, D. Montjean, B. Toth, N. Vermeulen, N. Macklon
Summary: This article provides the first ESHRE good practice recommendations for defining and managing recurrent implantation failure (RIF) in patients undergoing ART. RIF is a challenge in the ART clinic, with numerous investigations and interventions offered and applied without clear biological rationale or evidence of benefit. The recommendations include investigating causes and contributing factors of RIF, as well as improving the chances of a successful pregnancy.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Edwin-Amalraj Raja, Siladitya Bhattacharya, Abha Maheshwari, David J. McLernon
Summary: This study compared perinatal outcomes of fresh blastocyst transfer and fresh cleavage stage embryo transfer in singletons, twins, and singleton siblings. The results showed that singleton babies born following fresh blastocyst transfer had a lower risk of being small for gestational age (SGA) or having a congenital anomaly compared to those born following fresh cleavage stage transfer. However, singleton babies born following fresh blastocyst transfer were at a higher risk of being large for gestational age (LGA). Twins resulting from fresh blastocyst transfer were also at a slightly higher risk of preterm birth. These findings highlight the potential benefits and risks associated with blastocyst stage transfer.
HUMAN REPRODUCTION OPEN
(2023)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)