A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

(2020) Mitchell E. Allen et al.   Communications Biology

Functional exercise capacity, strength, balance and motion reaction time in Barth syndrome

(2019) Brittany Hornby et al.   Orphanet Journal of Rare Diseases

A Bayesian Analysis to Determine the Prevalence of Barth Syndrome in the Pediatric Population

(2019) Paighton C. Miller et al.   JOURNAL OF PEDIATRICS

New targets for monitoring and therapy in Barth syndrome

(2016) W. Reid Thompson et al.   GENETICS IN MEDICINE

Clinical Characteristics and Outcomes of Cardiomyopathy in Barth Syndrome: The UK Experience

(2015) Sok-Leng Kang et al.   PEDIATRIC CARDIOLOGY

Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

(2014) Sumit Parikh et al.   GENETICS IN MEDICINE

Bendavia, a Mitochondria-targeting Peptide, Improves Postinfarction Cardiac Function, Prevents Adverse Left Ventricular Remodeling, and Restores Mitochondria-related Gene Expression in Rats

(2014) Wangde Dai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Barth syndrome

(2013) Sarah LN Clarke et al.   Orphanet Journal of Rare Diseases

The stability and activity of respiratory Complex II is cardiolipin-dependent

(2012) Christine T. Schwall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function

(2009) Steven M. Claypool   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES