Article
Plant Sciences
Omar A. A. Al-Elwany, Khaulood A. Hemida, Mohamed A. Abdel-Razek, Taia A. Abd El-Mageed, Mohamed T. El-Saadony, Synan F. AbuQamar, Khaled A. El-Tarabily, Ragab S. Taha
Summary: Salinity poses a major threat to agricultural production systems, but the use of exogenous folic acid has shown promise in reducing the negative effects of salt stress on Plectranthus amboinicus. Experimental results demonstrate that foliar spraying with folic acid enhances the plant's salt tolerance, leading to improved growth and essential oil production.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Bonsignore Maria, Messina Concetta Maria, Bellante Antonio, Manuguerra Simona, Arena Rosaria, Santulli Andrea, Maricchiolo Giulia, Del Core Marianna, Sprovieri Mario
Summary: Specimens of Sparus aurata were exposed to sub-lethal concentrations of Hg and Cd for 25 days. Bioaccumulation of Hg was highest in gills, while Cd bioaccumulation was highest in the liver. Gills and skin were reliable targets for biomonitoring after short-term exposure. Exposure to both metals caused significant increases in metal concentrations in the kidney and liver. Biochemical analysis showed a reduction in lipid levels and decrease in polyunsaturated fatty acids (PUFA) in the liver, indicating oxidative stress. Molecular markers related to oxidative stress and lipid metabolism were also affected by exposure. The study suggests the possibility of using these biomarkers to explore fish metabolic responses to environmental pollution.
Article
Agriculture, Dairy & Animal Science
Concetta Maria Messina, Manfredi Madia, Simona Manuguerra, Cristobal Espinosa-Ruiz, Maria Angeles Esteban, Andrea Santulli
Summary: It is known that intensive farming exposes fish to multiple sources of stress, increasing their susceptibility to pathogens and disease outbreaks, which can lead to economic losses. In recent years, research has focused on using bioactive compounds from microalgae, plants, and microorganisms as dietary supplements to improve fish growth performance, health, and immune system. The use of natural immunostimulants is considered a promising alternative to promote fish health, productivity, and sustainability. This study evaluated the effects of adding Halobacterium salinarum, a potential probiotic strain, in the diet of farmed gilthead seabream on growth and immune responses.
Article
Agronomy
Danut Ioan Strui, Daniel Mierlita, Andrea Bunea
Summary: The aim of this research was to investigate the effects of partial soybean meal replacement with L. albus seeds and enzyme addition in the laying quail diets on productive performance, digestion, blood biochemical indices, and egg quality. The results showed that using enzymes could increase the proportion of lupine in the diet without affecting egg production, egg weight, feed conversion rate, and physical-chemical quality parameters of the eggs. Furthermore, the use of lupine improved the carotenoid content and quality of the egg yolk fats, in favor of omega-3 fatty acids.
Article
Veterinary Sciences
Yujie Zhang, Ningbo Zhang, Lin Liu, Yan Wang, Jinyi Xing, Xiuling Li
Summary: This study examined the effects of folic acid on gene expression in the liver of broilers using RNA-seq technology. Different doses of folic acid were found to regulate gene expression levels, providing valuable insights into the molecular mechanisms of folic acid in liver lipid metabolism regulation.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Plant Sciences
Yanping Wang, Jinzhu Li, Li Yang, Zhulong Chan
Summary: This study reveals that melatonin can promote primary root growth in plants by regulating auxin transport and modulating cytokinin signaling pathway.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Biochemistry & Molecular Biology
Eman A. El-Khateeb, Mohamed S. Youssef, Mohammed M. Mira, Abir U. Igamberdiev, Robert D. Hill, Claudio Stasolla
Summary: Oxygen deprivation caused by waterlogging reduces crop productivity, including the oil-producing crop Brassica napus L. This study investigated the early responses of B. napus plants to waterlogging by over-expressing or down-regulating class 1 (BnPgb1) and class 2 (BnPgb2) phytoglobins (Pgbs). Suppression of BnPgb1 exacerbated the decrease in gas exchange parameters and plant biomass, while suppression of BnPgb2 had no effect. Over-expression of BnPgb1 attenuated waterlogging symptoms and activated the antioxidant system and transcriptional induction of folic acid (FA), which could contribute to plant tolerance to waterlogging stress.
Article
Environmental Sciences
Chris Major Ncho, Chaemi Jeong, Vaishali Gupta, Akshat Goel
Summary: This study conducted a meta-analysis to investigate the response of chickens to GABA supplementation under various stressful conditions. The results showed that GABA supplementation via drinking water was more effective in reducing feed conversion ratio in heat-stressed birds, higher doses of GABA led to increased body weight gain, and longer duration of supplementation resulted in higher feed intake. Additionally, GABA had an impact on immune responses and blood parameters with a longer supplementation period.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin, Jihui Tang, Xi Cao
Summary: Breast cancer is a common and dangerous disease, and multi-drug chemotherapy can effectively treat it. In this study, lipid nanoemulsions were developed to deliver PTX and DHA for the treatment of breast cancer. The results showed that the nanoemulsions had a sustained drug release and exhibited high cytotoxicity, effectively inhibiting tumor growth and prolonging survival time.
Article
Spectroscopy
Bingying Wang, Lijun Guo, Xiangtong Yan, Faju Hou, Linlin Zhong, Hui Xu
Summary: Nitrogen-doped carbon dots (N-CDs) were synthesized from pine needles through one-step hydrothermal synthesis without the use of any chemical reagents. The fluorescence quenching and absorbance enhancement of N-CDs were observed upon the addition of Fe3+ and folic acid (FA). A dual-mode detection sensor utilizing fluorescence and UV-Vis spectrophotometry was established for the determination of Fe3+ and FA. The sensor exhibited a linear range of 0.1-540 μM for Fe3+ and 0.1-165 μM for FA under optimized conditions. Additionally, NOR and OR logic gates were successfully constructed based on the dual-mode sensor signals. The proposed dual-mode detection sensor is simple, efficient, and stable, demonstrating successful application in the determination of Fe3+ and FA in practical samples with satisfactory results.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Joaquin Guerra, Jesus Devesa
Summary: In addition to genetic mutations, abnormal epigenetic changes play a crucial role in the development of head and neck cancer. Researchers are currently developing drugs, known as epidrugs, to correct these epigenetic alterations. Some compounds with antioxidant effects have been found to be effective in preventing malignant lesions and reducing complications from cytotoxic treatment. Studies have also shown promising results for certain compounds in the treatment of head and neck squamous cell carcinoma.
Article
Chemistry, Physical
Mustafa M. Muhsen, Selma M. H. Al-Jawad, Ali A. Taha
Summary: In this research, novel copper sulfide (CuS) nanoprisms with high surface area were prepared using a two-phase colloidal method. Modified with folic acid, the CuS nanoprisms were utilized as a photothermal agent for targeting cancer treatment with NIR laser. Characterization results showed that the prepared CuS nanoprisms had an absorption spectrum with two peaks in the UV-visible and near infrared region. The conjugation of folic acid significantly reduced the peak in the UV-visible range and decreased the optical energy gap. Photothermal treatment results indicated that the FA-CuS nanoprisms exhibited high efficiency in photothermal therapy.
Article
Environmental Sciences
Nasim Ghasemzadeh, Alireza Iranbakhsh, Zahra Oraghi-Ardebili, Sara Saadatmand, Sodabeh Jahanbakhsh-Godehkahriz
Summary: Cold plasma application can mitigate the damage of heavy metals on plants, improve yield and stress resistance of wheat, and affect the fatty acid profile. The use of 120 seconds of cold plasma treatment can effectively alleviate cadmium stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Veterinary Sciences
Sahar Farahnak Roudsari, Houman Rajabi Islami, Seyed Abdolmajid Mousavi, Mehdi Shamsaie Mehrgan
Summary: The study showed that dietary FA-coated nanochitosan significantly improved the growth performance, feed utilization, antioxidant status, and immune responses of rainbow trout. The antioxidant responses were highest in fish fed with 0.50 mg/kg FA-coated nanochitosan, and immune responses showed a linear increase with increasing dietary FA-coated nanochitosan levels.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Physical
Mohammad Yahyavi, Farideh Badalkhani-Khamseh, Nasser L. Hadipour
Summary: This study investigates the performance of folic acid-functionalized carbon nanotubes (CNT) as a pH-responsive carrier for fluorouracil (5-FU) drug through molecular dynamics simulations. The results demonstrate that folic acid does not affect the loading capacity of CNT at neutral pH, but it decreases at lower pH. The simulations suggest that folic acid plays an important role in the controlled release of 5-FU from CNT, making it suitable for targeted drug delivery applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Environmental Sciences
Tahar Gharred, Rabeb Mannai, Mariem Belgacem, Jamel Jebali
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Environmental Sciences
Chayma Gharred, Maroua Jenzri, Zied Bouraoui, Hamadi Guerbej, Jamel Jebali, Tahar Gharred
Summary: This study evaluated the impact of seawater pollution from various Tunisian coastal areas on sea urchin fertilization and embryo development. The contaminated seawater showed higher levels of trace metals and was correlated with reduced fertility and larval frequency. Monitoring sea urchin bioassays could be useful for detecting exposure of marine ecosystems to mixed pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Zied Bouraoui, Afef Amri, Jamel Jebali, Tahar Gharred, Hamadi Guerbej
Summary: This study investigated the effects of dietary lipid reduction in seabream and found that reducing lipid levels can improve fish quality without impairing fish welfare.
JOURNAL OF APPLIED AQUACULTURE
(2022)
Article
Fisheries
Afef Amri, Zied Bouraoui, Sara Balbuena-Pecino, Encarnacion Capilla, Tahar Gharred, Zohra Haouas, Hamadi Guerbej, Karim Hosni, Isabel Navarro, Jamel Jebali
Summary: This study assesses the effects of different concentrations of Aloe vera powder in gilthead sea bream feed. The results show that 0.5% Aloe vera can effectively stimulate growth, but higher concentrations may disrupt lipid metabolism and cause liver steatosis.
Article
Fisheries
Maroua Jenzri, Chayma Gharred, Zied Bouraoui, Hamadi Guerbej, Jamel Jebali, Tahar Gharred
Summary: In this study, the potential benefits of Holothuria (Roweothuria) poli in the bioremediation of aquaculture farm effluents in the Mediterranean Sea were investigated. It was found that the addition of H. poli reduced the levels of pollutants in the wastewater. Additionally, the study examined the response of H. poli to various stress conditions, including mechanical, chemical, and hypoxic stimuli.
AQUACULTURE RESEARCH
(2022)