Review
Medicine, General & Internal
Hamdan Alamri
Summary: Oral health is crucial for children with special healthcare needs, but there are significant inequalities in oral health outcomes for these children. Coordinated efforts between dental professionals and healthcare facilitators are necessary to prioritize the oral health needs of these vulnerable children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Lydie A. Lebrun-Harris, Maria Teresa Canto, Pamella Vodicka, Marie Y. Mann, Sara B. Kinsman
Summary: Children and youth with special health care needs (CYSHCN) have higher rates of preventive oral health (POH) service use but worse oral health status than those without special health care needs. Factors associated with decreased prevalence of POH services among CYSHCN include age, household education, language, health insurance, medical home, and teeth condition. Ensuring appropriate use of POH services among CYSHCN is crucial for reducing oral health problems.
Article
Pediatrics
Ayako Ide-Okochi, Hiromi Funayama, Yoshinobu Asada
Summary: This study investigated pediatric dentists' perceptions of children with potential chronic difficulties. Four themes emerged: children exhibiting possible DDs, severe rampant caries possibly due to maltreatment, dental phobia possibly due to mental health problems, and a complicated home environment with mothers exhibiting poor oral health literacy. Participants' concept of children of concern included risks of poor oral health and mental health problems, suggesting the importance of multidisciplinary professionals being aware of children's oral and mental health status as well as potential DDs and child maltreatment during health checkups.
Article
Public, Environmental & Occupational Health
Raghad Obeidat, Amal Noureldin, Anneta Bitouni, Hoda Abdellatif, Shirley Lewis-Miranda, Shuling Liu, Victor Badner, Peggy Timothe
Summary: This study found significant differences in oral health needs, unmet dental needs, and utilization of dental services between children with developmental disorders/disabilities (DD) and children without DD. Poverty, lack of insurance, a high level of disability, and living in the western United States were identified as factors contributing to the higher odds of oral health needs among children with DD.
Article
Medicine, General & Internal
Maria Pilar Pecci-Lloret, Julia Guerrero-Girones, Belen Lopez-Gonzalez, Francisco Javier Rodriguez-Lozano, Daniel Onate-Cabrerizo, Ricardo E. Onate-Sanchez, Miguel R. Pecci-Lloret
Summary: The study aimed to analyze the medical characteristics, postoperative complications, and treatment outcomes of children with special health care needs recommended for dental treatment under general anesthesia in the Spanish Dental Care Program. The research found that GA is a safe procedure for dental treatment of CSHCN, with minimal postoperative complications and good treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Rawan Rasheed Alwattban, Lama Saleh Alkhudhayr, Sanaa Najeh Al-Haj Ali, Ra'fat Ibrahim Farah
Summary: This study found that the severity of dental caries in children, caregivers' education level and occupation, and age group of the child have a significant impact on oral health-related quality of life. Mothers were found to be better proxies for their children's oral health-related quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jagan Kumar Baskaradoss, Aishah AlSumait, Eman Behbehani, Muawia A. Qudeimat
Summary: This study found an association between caregiver oral health literacy levels and plaque scores in their children.
Article
Health Care Sciences & Services
Szu-Yu Hsiao, Ping-Ho Chen, Shan-Shan Huang, Cheng-Wei Yen, Shun-Te Huang, Shu-Yuan Yin, Hsiu-Yueh Liu
Summary: The study assessed dental treatment needs and risk factors for children with disabilities in Taiwan, finding that a majority required restorative dental treatment due to dental caries. Most children had multiple teeth and surfaces requiring treatment, with significant risk factors including parents with lower socioeconomic status and poor oral health habits. Addressing these factors through dental treatment, hygiene education, and dietary modifications is essential for reducing dental caries in children with disabilities.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Benzian, E. Beltran-Aguilar, M. R. Mathur, R. Niederman
Summary: Oral health care must be an integral part of essential health care, covering urgent and basic oral care, with the need for standards and consensus to define which dental interventions fall under essential oral health care. Collaboration among stakeholders is essential.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Arwa Z. Gazzaz, Richard M. Carpiano, Denise M. Laronde, Jolanta Aleksejuniene
Summary: This study examined the association between child SHCN and dental care, and found that parental psychosocial factors play a crucial role in child dental care, especially instrumental social support. Parental social support is an important determinant of child dental care outcomes and can help reduce unmet dental needs in children with SHCN.
Article
Dentistry, Oral Surgery & Medicine
Courtney Lang, Darragh Kerr, Donald L. Chi
Summary: The study found that children with special health care needs enrolled in Medicaid are just as likely as children without special health care needs to use preventive oral health care, but barriers to oral health care access persist for CSHCN.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2021)
Article
Pediatrics
Matthew A. Jay, Ruth Gilbert
Summary: The study found that a high proportion of children in care or in need during school years had received SEN provision, and a significant proportion of children who were neither in care nor in need had also received SEN provision. Healthcare, SEN provision, and social care services focus on the same population of children and better integration of these services could lead to synergies and cost-efficiencies.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Review
Health Care Sciences & Services
Peivand Bastani, Mohammadtaghi Mohammadpour, Arash Ghanbarzadegan, Giampiero Rossi-Fedele, Marco A. Peres
Summary: The study identified key determinants affecting the provision of dentistry services for children with special health care needs (CSHCN), including needs assessment, policy advice, oral health interventions, providers' perception, and access barriers. Assessing the needs of CSHCN can lead to evidence-informed policymaking and appropriate policy advice, which can ultimately improve the accessibility and quality of oral and dental health services for this vulnerable group.
BMC HEALTH SERVICES RESEARCH
(2021)
Review
Pediatrics
Diyana Shereen Anwar, Mohd Yusmiaidil Putera Mohd Yusof, Mas Suryalis Ahmad, Budi Aslinie Md Sabri
Summary: Oral health is a likely source of health inequalities in children with special health care needs. This systematic review explores the evidence of family influence on these children's dental caries status. The study finds that family influences, such as tooth brushing behavior, parents' education level, and diet pattern, have a significant relationship with the dental caries status of the children.
Review
Nutrition & Dietetics
Jessica R. L. Lieffers, Amanda Goncalves Troyack Vanzan, Janine Rover de Mello, Allison Cammer
Summary: This scoping review aimed to identify and map the real-world nutrition care practices of oral health professionals and dietitians for optimizing oral health. Most articles provided self-reported data on OHP practices but lacked specific information on the care provided, while few studies examined the practices of dietitians. Barriers to nutrition care by OHPs were common, with limited information available on collaboration between dietitians and OHPs.
Editorial Material
Clinical Neurology
Orrin Devinsky
Article
Multidisciplinary Sciences
Timothee Proix, Jaime Delgado Saa, Andy Christen, Stephanie Martin, Brian N. Pasley, Robert T. Knight, Xing Tian, David Poeppel, Werner K. Doyle, Orrin Devinsky, Luc H. Arnal, Pierre Megevand, Anne-Lise Giraud
Summary: Researchers extracted consistent and specific neural features from patients performing speech production tasks and found that low-frequency power and cross-frequency dynamics play a key role in decoding imagined speech.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Muge Ozker, Werner Doyle, Orrin Devinsky, Adeen Flinker
Summary: Hearing one's own voice is crucial for fluent speech production and can help detect and correct vocalization errors in real time. Research has found that both the auditory cortex and the dorsal precentral gyrus play important roles in processing auditory error signals during speech production.
Article
Psychology, Biological
Sam Norman-Haignere, Laura K. Long, Orrin Devinsky, Werner Doyle, Ifeoma Irobunda, Edward M. Merricks, Neil A. Feldstein, Guy M. McKhann, Catherine A. Schevon, Adeen Flinker, Nima Mesgarani
Summary: The human brain integrates information across multiple timescales to derive meaning from sound. Our study reveals that the auditory cortex hierarchically integrates across diverse timescales ranging from 50 to 400 ms, and different neural populations with short and long integration windows exhibit distinct functional properties.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Clinical Neurology
Smriti Patodia, Alyma Somani, Joan Liu, Alice Cattaneo, Beatrice Paradiso, Maria Garcia, Muhammad Othman, Beate Diehl, Orrin Devinsky, James D. Mills, Jackie Foong, Maria Thom
Summary: Multiple lines of evidence suggest a link between deficient serotonin function and SUDEP, with chronic treatment using serotonin reuptake inhibitors shown to reduce the risk factors associated with SUDEP. Decreased medullary serotonergic neurons, which regulate respiration in response to hypercapnia, have been found in post-mortem SUDEP cases. Additionally, the high innervation of serotonergic neurons in the amygdala and hippocampus, regions involved in seizure-related respiratory dysregulation, further supports the potential involvement of altered serotonergic networks in SUDEP.
Review
Clinical Neurology
Johanna W. Bunschoten, Nafisa Husein, Orrin Devinsky, Jacqueline A. French, Josemir W. Sander, Roland D. Thijs, Mark R. Keezer
Summary: There is insufficient evidence to support or refute the association between lamotrigine and sudden death or ECG abnormalities. The high risk of bias in most studies and inconsistency in reported results contribute to the uncertainty of this association.
Article
Multidisciplinary Sciences
Dominique F. Leitner, Evgeny Kanshin, Manor Askenazi, Yik Siu, Daniel Friedman, Sasha Devore, Drew Jones, Beatrix Ueberheide, Thomas Wisniewski, Orrin Devinsky
Summary: This pilot study found that short-term everolimus before epilepsy surgery in TSC and FCD resulted in no adverse events and trending lower mTOR signaling (phospho-S6). Future studies should evaluate implications of our findings, including coagulation system activation and everolimus efficacy in FCD, in larger studies with long-term treatment to better understand molecular and clinical effects.
Article
Clinical Neurology
Orrin Devinsky, Angelica Marmanillo, Theresa Hamlin, Philip Wilken, Daniel Ryan, Conor Anderson, Daniel Friedman, George Todd
Summary: This study examined the safety and efficacy of medical cannabis formulations containing CBD and THC for the treatment of epilepsy. The results showed that there was no significant difference in seizure frequency, duration, postictal duration, or use of rescue medication compared to baseline. There was also no improvement in behavioral disorders or sleep duration. The study found that the medication was generally well tolerated, with few adverse events. However, the doses of CBD used in the study were lower than in previous studies. Larger randomized trials are needed to further investigate the efficacy of CBD:THC products for epilepsy, sleep, and behavior.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Jerzy P. P. Szaflarski, Orrin Devinsky, Merrick Lopez, Yong D. D. Park, Pilar Pichon Zentil, Anup D. D. Patel, Elizabeth A. A. Thiele, Robert T. T. Wechsler, Daniel Checketts, Farhad Sahebkar
Summary: The CBD expanded access program initiated in 2014 provided additional CBD treatment for patients with treatment-resistant epilepsies. The study showed that CBD treatment was effective in reducing seizure frequency and had an acceptable safety profile for long-term use in patients with treatment-resistant epilepsies.
Article
Clinical Neurology
Robert J. Flamini, Anne M. Comi, E. Martina Bebin, Michael G. Chez, Gary Clark, Orrin Devinsky, Shaun A. Hussain, Paul D. Lyons, Anup D. Patel, Jillian L. Rosengard, Farhad Sahebkar, Eric Segal, Laurie Seltzer, Jerzy P. Szaflarski, Arie Weinstock
Summary: The CBD Expanded Access Program provided CBD treatment to patients with treatment-resistant epilepsy and showed a significant reduction in seizure frequency. CBD was well tolerated and effective in treating both convulsive and nonconvulsive seizure types. Controlled trials are needed to further confirm these findings.
Editorial Material
Clinical Neurology
Pavel Klein, Gregory L. Krauss, Bernhard J. Steinhoff, Orrin Devinsky, Michael R. Sperling
Summary: Despite the approval of numerous antiseizure medications (ASMs), a significant number of epilepsy patients still experience seizures. Two new ASMs, cenobamate and fenfluramine, have shown improved efficacy in reducing seizures with sustained results. However, these medications are underutilized, likely due to limited knowledge, access restrictions, and insufficient post-launch information about their efficacy and safety. Addressing these issues can improve seizure control and ultimately reduce morbidity and mortality in epilepsy patients.
Article
Clinical Neurology
Joseph Sullivan, Lieven Lagae, J. Helen Cross, Orrin Devinsky, Renzo G. Guerrini, Kelly Knupp, Linda Laux, Marina Nikanorova, Tilman Polster, Dinesh Talwar, Berten Ceulemans, Rima M. Nabbout, Gail S. Farfel, Bradley R. Galer, Arnold Gammaitoni, Michael Lock, Anupam E. Agarwal, Ingrid Scheffer, FAiRE DS Study Grp
Summary: This study examined the safety and effectiveness of fenfluramine in treating convulsive seizures in patients with Dravet syndrome. The results showed that patients treated with fenfluramine had lower seizure frequency and longer interval between seizures compared to the placebo group. Common side effects of fenfluramine were observed, but no evidence of severe cardiac or vascular issues was found.
Review
Clinical Neurology
Laura Gould, Victoria Delavale, Caitlin Plovnick, Thomas Wisniewski, Orrin Devinsky
Summary: Febrile seizures are associated with an increased risk of epilepsy and rare cases of sudden unexplained death. Mortality rates varied in different studies, with some reporting no deaths and others identifying a significant percentage of deaths associated with febrile seizures. Minor hippocampal histopathological anomalies were common in sudden deaths with or without a history of febrile seizures. Most electroencephalography (EEG) studies were normal, and neuroimaging studies suggested increased right hippocampal volumes. Longer-term prospective studies are needed to fully understand the outcomes of simple or brief complex febrile seizures.
Article
Multidisciplinary Sciences
Rodrigo Ordonez Sierra, Lizeth Katherine Pedraza, Livia Barcsai, Andrea Pejin, Qun Li, Gabor Kozak, Yuichi Takeuchi, Anett J. Nagy, Magor L. Lorincz, Orrin Devinsky, Gyoergy Buzsaki, Antal Berenyi
Summary: Dysregulated fear reactions can be caused by maladaptive processing of trauma-related memories. By manipulating hippocampal SWRs and cortical oscillations, fear extinction can be enhanced in male rats. The modified fear memories become resistant to recall and do not spontaneously reemerge. This effect is mediated by D2 receptor signaling-induced synaptic remodeling in the basolateral amygdala. These findings demonstrate the potential of neuromodulation in augmenting extinction learning and provide a new avenue for anxiety disorder treatments.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Heather E. Olson, Sam Amin, Nadia Bahi-Buisson, Orrin Devinsky, Eric D. Marsh, Elia Pestana-Knight, Rajsekar R. Rajaraman, Alex A. Aimetti, Eva Rybak, Fanhui Kong, Ian Miller, Joseph Hulihan, Scott Demarest
Summary: This study reports the 2-year safety and clinical outcomes of ganaxolone treatment in patients with CDD. The results show that ganaxolone significantly reduces major motor seizure frequency and maintains its efficacy and safety over the long term.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
