Article
Biochemistry & Molecular Biology
Cihan Gur, Fatih Mehmet Kandemir, Cuneyt Caglayan, Emine Satici
Summary: This study found that hesperidin has a protective effect against paclitaxel-induced hepatorenal toxicity by reducing oxidative stress, inflammation, apoptosis, and autophagy, and improving liver and kidney functions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Halil Sezgin Semis, Fatih Mehmet Kandemir, Ozgur Kaynar, Tuba Dogan, Sefik Murat Arikan
Summary: The study showed that hesperidin has potential protective effects against paclitaxel-induced sciatic nerve damage by reducing apoptosis, alleviating endoplasmic reticulum stress, and relieving neuropathic pain associated with paclitaxel-induced peripheral neuropathy.
Article
Biochemistry & Molecular Biology
Nurhan Akaras, Cihan Gur, Sefa Kucukler, Fatih Mehmet Kandemir
Summary: The potential protective effect of zingerone against sodium arsenite-induced nephrotoxicity was investigated. The study found that zingerone significantly reduced oxidative stress, inflammation, apoptosis, and autophagy in kidney tissue, thus mitigating kidney damage caused by sodium arsenite.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Behcet Varisli, Ekrem Darendelioglu, Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Aydin Genc, Ozge Kandemir
Summary: This study found that hesperidin (HSP) can alleviate the injury of rat heart tissue induced by sodium fluoride (NaF). HSP can increase the activities of SOD, CAT, and GPx, and levels of GSH, while suppressing lipid peroxidation. Additionally, HSP can reverse the changes in apoptotic, autophagic, and inflammatory parameters induced by NaF, as well as modulate the gene expression levels of the PI3K/Akt/mTOR signaling pathway and cardiac markers.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Neurosciences
Mustafa Onur Yildiz, Hamit Celik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gur, Ibrahim Bayav, Aydin Genc, Ozge Kandemir
Summary: Hesperidin has protective effects against NaF-induced neurotoxicity by reducing lipid peroxidation, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.
Article
Fisheries
Hao Chen, Xin Chen, Jun Ma
Summary: This study investigates the protective effects of hesperidin (HDN), a flavonoid found in citrus fruits, on cell damage caused by deoxynivalenol (DON) toxicity. The results show that HDN can reduce inflammation, autophagy, and apoptosis induced by DON exposure in grass carp liver cells. This research provides insights into the biological threats faced by fish under DON exposure and highlights the potential application of HDN in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Sefa Kuecuekler, Cuneyt Caglayan, Selcuk Oezdemir, Selim Comakli, Fatih Mehmet Kandemir
Summary: Through animal experiments, it has been shown that hesperidin (HSP) can alleviate the neurotoxicity induced by chlorpyrifos (CPF), an organophosphate pesticide, by improving the antioxidant status of brain tissue and reducing inflammation and cell apoptosis.
METABOLIC BRAIN DISEASE
(2023)
Article
Environmental Sciences
Shuting Li, Chenglan Jiang, Jingwen Tan, Qian Zhou, Jinyao Yin, Yuefeng He
Summary: In this study, it was found that sodium arsenite upregulates circDHX34 expression in a dose-dependent manner in MDA-MB-231 cells, and knockdown of circDHX34 promotes cell proliferation and inhibits apoptosis. Further investigations revealed that knockdown of circDHX34 upregulates the expression levels of antiapoptotic genes BCL2 and BCL2L1 and downregulates the expression levels of proapoptotic genes CASP8 and CASP9.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Iman Fatemi, Hamidreza Khalili, Saeed Mehrzadi, Zahra Basir, Alireza Malayeri, Mehdi Goudarzi
Summary: This study evaluated the effect of chrysin on sodium arsenite-induced hepatotoxicity, showing that chrysin significantly mitigated liver toxicity and had a hepatoprotective effect. Chrysin was most effective at a dose of 100 mg/kg/day.
Article
Environmental Sciences
Yue Liu, Wenxue Ma, Qiaohan Liu, Pinnan Liu, Senqiu Qiao, Lihua Xu, Yue Sun, Xiaoxue Gai, Ziwei Zhang
Summary: The study found that decreased Txnrd3 expression promoted nickel-induced mitochondrial apoptosis and inflammation through oxidative stress, aggravating heart damage in mice. Decreased Txnrd3 expression significantly reduced the protective effect of melatonin on nickel exposure.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Cuneyt Caglayan, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Sefa Kucukler, Adnan Ayna
Summary: The study evaluated the protective effects of hesperidin against sodium fluoride-induced hepatotoxicity and nephrotoxicity in rats. Hesperidin administration significantly ameliorated the deviations in kidney function parameters, levels of liver enzymes, antioxidant enzyme activities, and inflammatory markers induced by sodium fluoride. This suggests that hesperidin could be a beneficial supplement for protecting the liver and kidneys against fluoride-induced damage.
Article
Environmental Sciences
Sefa Kucukler, Selim comakli, Selcuk ozdemir, Cuneyt caglayan, Fatih Mehmet Kandemir
Summary: The study showed that hesperidin can reduce the hepato-renal toxicity caused by chlorpyrifos by regulating oxidative stress, inflammation, apoptosis, autophagy, and PARP/VEGF genes in rats. This compound had a significant impact on renal and liver functions in rats, highlighting its potential therapeutic benefits in toxicological conditions.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Yazdan Naderi, Sara Khosraviani, Saba Nasiri, Fahimeh Hajiaghaei, Ehsan Aali, Tannaz Jamialahmadi, Maciej Banach, Amirhossein Sahebkar
Summary: The study evaluated the cardioprotective effects of minocycline against doxorubicin-induced cardiotoxicity in adult male rats. Results showed that minocycline significantly decreased the activity of lactate dehydrogenase and creatine kinase MB, while increasing the activity of catalase and superoxide dismutase in cardiac tissue. Minocycline also reduced the levels of malondialdehyde, TNF-alpha, and IL-18 in cardiac tissue, and alleviated the tissue damage caused by doxorubicin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ting Wang, Lina Zheng, Weiwei Zhang
Summary: Hesperidin can protect SH-SY5Y cells against BV-induced neurotoxicity through inhibition of apoptosis, oxidative stress, and inflammation response.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Adel Alghamdi, Nemat Ali, Muath A. Almeaikl, Hassan M. Hakami, Meshal K. Alyousef, Mohammed AlSwayyed, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Nasser Alsaleh
Summary: This study investigated the toxic effect of Venetoclax (VTX) on the heart and found that VTX treatment resulted in cardiac damages, with major changes in histopathology, elevated cardiac enzymes and hypertrophic gene markers. Additionally, increased oxidative stress, inflammatory markers, and apoptosis were observed, along with a decline in the levels of Bcl-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Ahmet Gokhan Aggul, Naim Uzun, Muslum Kuzu, Parham Taslimi, Ilhami Gulcin
Summary: This study investigated the inhibitory effects of multiple natural compounds from olive leaves on carbonic anhydrase isozymes. The results showed that these compounds have the potential to effectively inhibit the activity of carbonic anhydrase isozymes and can be used for drug development.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Multidisciplinary
Adem Kara, Seda Yakut, Cuneyt Caglayan, Tugce Atcali, Aykut Ulucan, Fatih Mehmet Kandemir
Summary: This study evaluated the potential toxicological effects of favipiravir administration on the liver and kidney tissues of rats. The results showed that favipiravir caused damages to the liver and kidney, including elevated liver and kidney enzymes, oxidative damage, histopathologic changes, apoptotic cell death, and inflammation.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Mustafa Onur Yildiz, Hamit Celik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gur, Ibrahim Bayav, Aydin Genc, Ozge Kandemir
Summary: Hesperidin has protective effects against NaF-induced neurotoxicity by reducing lipid peroxidation, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.
Article
Environmental Sciences
Cihan Gur, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of rutin against liver and kidney toxicity caused by malathion. The results showed that rutin exhibited antioxidant properties and protected liver and kidney tissues from oxidative damage. Furthermore, rutin alleviated endoplasmic reticulum stress and suppressed inflammation, apoptosis, and autophagy markers. It was observed that rutin treatment could alleviate the toxic effects of malathion on liver and kidney tissues.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Behcet Varisli, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gur, Adnan Ayna, Aydin Genc, Seyithan Taysi
Summary: This study reveals the therapeutic effects of chrysin on diclofenac-induced hepatotoxicity by regulating oxidative stress, apoptosis, autophagy, and endoplasmic reticulum stress. In a rat model experiment, chrysin significantly ameliorated liver damage caused by diclofenac.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Chemistry, Medicinal
Seyithan Taysi, Firas Shawqi Algburi, Muhammed Enes Taysi, Cuneyt Caglayan
Summary: Caffeic acid phenethyl ester (CAPE), a main component of propolis, has various pharmacological potentials such as anti-cancer, anti-inflammatory, antioxidant, antibacterial, and antifungal effects. It can bind with replication enzyme and be modified to increase its efficacy in preventing cancer cell proliferation. Additionally, CAPE has inhibitory effects on the main protease enzyme and may be effective against COVID-19.
PHYTOTHERAPY RESEARCH
(2023)
Article
Environmental Sciences
Cihan Gur, Serkan Ali Akarsu, Nurhan Akaras, Sibel Cigdem Tuncer, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of carvacrol against testicular toxicity induced by sodium arsenite. The results showed that carvacrol improved sperm motility and reduced abnormal and dead sperm. It also reduced oxidative stress, inflammation, autophagy, and apoptosis induced by sodium arsenite.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Physical
Kemal Yararli, Ebru Bilen Ozer, Sinan Bayindir, Cuneyt Caglayan, Cuneyt Turkes, Sukru Beydemir
Summary: The synthesis of rhodanine core by greener approaches is important, as it is widely used in the production of drugs. This study aims to develop a new method for synthesizing asymmetric 3,5-diarylRhs using a green approach, which was successfully achieved by reacting aromatic aldehydes with 5-Ar-Rhs 2a and 2b under reflux temperatures of ethanol. The synthesized compounds showed inhibitory activities against cytosolic human carbonic anhydrase I and II and also exhibited drug-like properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Hamit Emre Kizil, Cuneyt Caglayan, Ekrem Darendelioglu, Adnan Ayna, Cihan Gur, Fatih Mehmet Kandemir, Sefa Kucukler
Summary: This study reveals that morin can protect liver tissue from oxidative damage and apoptosis caused by methotrexate. Morin treatment reduces oxidative stress, apoptosis, and regulates liver function indicators and gene expressions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Esra Aktas Senocak, Necati Utlu, Seyda Kurt, Sefa Kucukler, Fatih Mehmet Kandemir
Summary: The research aims to investigate the protective effects of boron against APAP-induced toxicity in rats. Oral administration of boron reduced the harmful effects of APAP on the liver and kidneys, and exerted anti-inflammatory, antioxidant, and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Health Care Sciences & Services
Okan Imre, Cuneyt Caglayan, Mehmet Mustu
Summary: This study examined the relationship between cognitive impairment and inflammatory markers and carotid intima-media thickness (CIMT) in schizophrenia. The results showed that patients with schizophrenia had lower MoCA scores, higher levels of inflammatory markers, and increased CIMT compared to healthy controls. There was a significant negative correlation between MoCA and CIMT.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Okan Imre, Mustafa Karaagac, Cuneyt Caglayan
Summary: This study compared vitamin D levels and related metabolites in patients with bipolar manic episodes, patients in remission after treatment, and a healthy control group. The results showed lower vitamin D levels during manic episodes. Further research is needed to investigate other mood episodes.
BEHAVIORAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mehmet Comez, Mustafa Cellat, Muesluem Kuzu, Ahmet Uyar, Erdinc Turk, Yusuf Selim Kaya, Muhammed Etyemez, Ishak Gokcek, Mehmet Guvenc
Summary: This study investigated the protective effect of tyrosol pretreatment against diclofenac-induced renal damage. The results showed that tyrosol improved diclofenac-induced nephrotoxicity by its anti-inflammatory and antioxidant properties, and had a therapeutic effect on kidney damages.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)