期刊
ENVIRONMENTAL RESEARCH
卷 188, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2020.109864
关键词
Bile acids; Celiac disease; Exposome; Lipidomics; PFAS
资金
- Vetenskapsradet [2016-05176]
- Formas [2019-00869]
- JDRF [1-SRA-2016-342-M-R, 1SRA-2019-732-M-B]
- European Union [BMH4-CT98-3314]
- Novo Nordisk Foundation
- Academy of Finland [292538]
- Center of Excellence in Molecular Systems Immunology and Physiology Research [250114]
- Special Research Funds for University Hospitals in Finland
- Swedish Research Council [2016-05176] Funding Source: Swedish Research Council
- Formas [2019-00869] Funding Source: Formas
Celiac disease (CD) is a systemic immune-mediated disorder with increased frequency in the developed countries over the last decades implicating the potential causal role of various environmental triggers in addition to gluten. Herein, we apply determination of perfluorinated alkyl substances (PFAS) and combine the results with the determination of bile acids (BAs) and molecular lipids, with the aim to elucidate the impact of prenatal exposure on risk of progression to CD in a prospective series of children prior the first exposure to gluten (at birth and at 3 months of age). Here we analyzed PFAS, BAs and lipidomic profiles in 66 plasma samples at birth and at 3 months of age in the Type 1 Diabetes Prediction and Prevention (DIPP) study (n = 17 progressors to CD, n = 16 healthy controls, HCs). Plasma PFAS levels showed a significant inverse association with the age of CD diagnosis in infants who later progressed to the disease. Associations between BAs and triacylglycerols (TGs) showed different patterns already at birth in CD pmgressors, indicative of different absorption of lipids in these infants. In conclusion, PFAS exposure may modulate lipid and BA metabolism, and the impact is different in the infants who develop CD later in life, in comparison to HCs. The results indicate more efficient uptake of PFAS in such infants. Higher PFAS exposure during prenatal and early life may accelerate the progression to CD in the genetically predisposed children.
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