Article
Pharmacology & Pharmacy
Bianca Hazt, Gabriela Pereira Parchen, Lilian Fernanda Martin do Amaral, Patricia Rondon Gallina, Sandra Martin, Odinei Hess Goncalves, Rilton Alves de Freitas
Summary: Pickering emulsions, stabilized by solid particles instead of molecular or classical surfactants, provide long-term stability against emulsion coalescence. They are environmentally and skin-friendly, offering new sensorial experiences. Besides conventional oil-in-water emulsions, unconventional multiple, oil-in-oil, and water-in-water emulsions have great potential for various applications in pharmaceutical and cosmetic products, such as oil-free systems, permeation enhancers, and topical drug delivery agents. However, despite their potential, commercial products of these Pickering emulsions are not yet available. This review discusses important aspects such as phase behavior, particle properties, rheology, sensorial perception, and current development trends of these emulsions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Rabia Zia, Albert T. Poortinga, Akmal Nazir, Mutamed Ayyash, Cornelus F. Van Nostrum
Summary: This study produced acid-responsive antibubbles for gastric drug delivery by replacing hydrophobized fumed silica particles with calcium carbonate particles. The results showed that the antibubbles were stable under acidic conditions and released the encapsulated drug.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Jia-qi Zhang, Hai-chao Li, Jie Wang, Sha-sha Liu, Jun Li, De-qiang Li
Summary: This study utilized dopamine-functionalized pectin-based Pickering emulsions for anti-inflammatory medication. The dopamine functionalization induced significant differences in wettability, zeta potential, particle size, and PDI value compared with the oxidized pectin. The resultant Pickering emulsions showed excellent stability, stored well for 30 days, and had nano-scale spherical particles when dried.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Applied
Wenjing Li, Dongjie Huang, Weixuan Song, Fangxin Ouyang, Wenxuan Li, Ye Song, Feng Li, Yang Jiang, Qingrong Huang, Dapeng Li
Summary: This study constructed zein-proanthocyanidins-pectin ternary composites (ZPAAPs) as stabilizer to establish Pickering emulsions with potential delivery capacity. The emulsion appeared pink and remained stable during long-term storage in the range of 0.1 to 0.7 oil phase. CLSM showed that the oil droplets were coated with a covering layer formed by ZPAAPs, effectively preventing droplet congregation. The rheological results indicated that ZPAAPEs had an elastic gel-like structure. Additionally, ZPAAPEs still contained 54.4% curcumin after storage for 15 days, and the bioavailability of curcumin was increased to 39.7% +/- 0.3. These studies may contribute to the controllable fabrication of Pickering emulsions for nutrient delivery in the food and pharmaceutical fields.
Article
Engineering, Biomedical
Yiqun Du, Tiantian Song, Jie Wu, Xiao-Dong Gao, Guanghui Ma, Yuchen Liu, Yufei Xia
Summary: This study developed mannosylated Pickering emulsions for targeted delivery of multiple effective components in cancer vaccines. The emulsion increased cellular targeting, cellular uptake, and activation, resulting in enhanced immune activation and potent anti-tumor effects. The strategic loading of components in the emulsion could serve as a targeted delivery platform for enhanced cancer vaccines.
Article
Chemistry, Physical
Asma Sharkawy, Ana Margarida Silva, Francisca Rodrigues, Filomena Barreiro, Alirio Rodrigues
Summary: The study evaluated chitosan/collagen peptides nanoparticles-stabilized Pickering emulsions as an effective carrier for the topical delivery of cannabidiol. Among them, olive oil-prepared emulsion showed good stability and long-term storage ability, which is beneficial for the topical delivery of CBD.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Asma Sharkawy, Filomena Barreiro, Alirio Rodrigues
Summary: This study investigated the effect of the degree of deacetylation of chitosan on the properties of chitosan/gum Arabic particles and Pickering emulsions. The formulation with higher degree of deacetylation showed higher stability and smaller emulsion droplet size. There was no significant difference in the absorption of cannabidiol between the two formulations.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Bi Wu, Yang Li, Yuanyuan Li, Heng Li, Lele Li, Qiang Xia
Summary: In this study, alginate/pectin hydrogel beads were prepared to encapsulate resveratrol-loaded Pickering emulsions. The suitable ratio of pectin and alginate enhanced the encapsulation efficiency and loading capacity of the hydrogel beads. The beads had a spherical shape with even distribution of the emulsion within the polymer network. The beads were physically cross-linked and resveratrol existed in an amorphous or dissolved form. The hydrogel beads provided protection to resveratrol and maintained its antioxidant capacity. Furthermore, the hydrogels significantly reduced the release of fatty acids and resveratrol during in vitro digestion, especially with the appropriate ratio of sodium alginate and pectin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu
Summary: Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs. Drug NCs have been used as solid emulsifiers to prepare nanocrystal self-stabilized Pickering emulsions (NCSSPEs), which can increase drug loading and reduce side effects. These emulsions impede the dissolution of drug NCs and can further enhance their oral bioavailability, especially for BCS IV drugs. In this study, CUR-NCs stabilized Pickering emulsions were prepared using either indigestible or digestible oils. The emulsions significantly increased the oral bioavailability of CUR-NCs, with the digestibility of the oil phase affecting the intactness of the NCs.
Article
Agriculture, Multidisciplinary
Nanlong Hong
Summary: This study successfully prepared an alkyl chain-bridged lignin polymer and used an ultrafiltration method to classify it into three fractions with narrow molecular weight distribution. Novel Pickering emulsions without additives and organic solvents were prepared using these three fractions. The emulsion formulated with the highest molecular weight fraction showed the best performance, consisting of droplets. The study also investigated the effects of oil-water ratios and fraction-3 dosages on the emulsions. UV spectroscopy revealed strong absorption properties of the prepared emulsions, making them suitable for applications in cosmetics, particularly sunscreen creams. Furthermore, the Pickering emulsion was effective in delivering ibuprofen, achieving a high embedding rate of 10%. This suggests that lignin-based polymer-stabilized Pickering emulsions have potential for drug delivery.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jianzhong Jiang, Shijie Yu, Wanqing Zhang, Haojie Zhang, Zhenggang Cui, Wenshui Xia, Bernard P. Binks
Summary: The novel charge-reversible surfactant can stabilize smart n-octane-in-water emulsions responsive to pH by transforming from anionic carboxylate to cationic form at different pH values. This allows for intelligent and precise control of stability, viscosity, and droplet size of the emulsions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Food Science & Technology
Iveta Klojdova, Constantinos Stathopoulos
Summary: Pickering emulsions, stabilized by adsorbed particles, have high potential for application in the food industry. They provide more benefits compared to emulsions stabilized with surfactants, such as lower susceptibility to coalescence and possible encapsulation and controlled release of functional compounds. Additionally, they can be used for fat reduction and encapsulation of sensitive compounds.
Article
Pharmacology & Pharmacy
Johanna Michael, Diana Bessa de Sousa, Justin Conway, Erick Gonzalez-Labrada, Rodolphe Obeid, Julia Tevini, Thomas Felder, Birgit Hutter-Paier, Horst Zerbe, Nadine Paiement, Ludwig Aigner
Summary: The study reformulated the leukotriene receptor antagonist Montelukast (MTK) into a mucoadhesive film, which demonstrated significantly improved bioavailability in clinical studies. The oral film may reduce the non-responder rate in asthma patients and offer potential repurposing of MTK in other diseases. Additionally, the film showed promising penetration of the blood-brain barrier, suggesting potential therapeutic use in neurodegenerative diseases like dementias and stroke.
Article
Food Science & Technology
Yu Guo, Chao Wu, Ming Du, Songyi Lin, Xianbing Xu, Pei Yu
Summary: The present study found that 3% casein modulated by solution pH could be an outstanding stabilizer for oil-in-water Pickering HIPEs, with control over rheological properties and enhanced stability and viscoelasticity. The casein particles at different pH levels exhibited varied zeta-potential and three-phase contact angles, indicating their irreversible anchoring at the oil-water interface. The stability of the HIPEs against heating and sensitivity to frozen-thawing treatment were also observed, highlighting the potential of casein particles for providing electrostatic repulsion and steric hindrance to prevent coalescence or flocculation of oil drops in Pickering HIPEs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dafei Li, Yingni Wu, Haoran Yin, Wei Feng, Xiaoshuang Ma, Huining Xiao, Wenfeng Xin, Chengcheng Li
Summary: In this study, a polysaccharide from Panax Notoginseng (SPNP) was utilized as a Pickering stabilizer to create stable Pickering emulsions. The SPNP possessed a porous network structure with nanoparticles surrounding a rough surface. Through rheological measurements, it was determined that the Pickering emulsions formed gel-like structures. The emulsions displayed excellent stability in terms of storage, pH, ionic strength, temperature, and freeze-thaw cycles, making them applicable in various industries such as food, biomedical, and cosmetics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Yuzhen Tian, Qianqian Lv, Zhongjian Chen, Dongdong Wang, Xia Mao, E. Sun, Cunwu Zuo, Baihong Chen
Summary: This study investigated the gene expression profiles of 'Zaosu' pear trees infected with Valsa canker using RNA sequencing. The study identified differentially expressed genes associated with immune responses and the reasons for Valsa canker invasion in 'Zaosu' pears.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Pharmacology & Pharmacy
Lingyu Hang, Chengying Shen, Yuye Xue, Wei Wu, Baode Shen, Hailong Yuan
Summary: Nanotechnology is a primary strategy to enhance the oral bioavailability of poorly water soluble drugs. This study tracks the translocation of oral herpetrione amorphous nanoparticles and finds that most nanoparticles are degraded or absorbed in the gastrointestinal tract, with fluorescent signals observed in the gastrointestinal tract and liver. Only a small amount of the nanoparticles penetrate cell monolayers.
JOURNAL OF DRUG TARGETING
(2023)
Review
Pharmacology & Pharmacy
Yuehong Ren, Wei Wu, Xingwang Zhang
Summary: Targeted drug delivery is being constantly improved based on a better understanding of diseases. Oral delivery of particulates is challenging due to biochemical aggressivity and immune exclusion in the gut. The feasibility of oral targeting to remote sites beyond the gastrointestinal tract is still not clear. The limited evidence and lack of quantification of systemically exposed particles do not support the success of oral targeting, but the lymphatic pathway may provide an alternative portal for peroral particles to reach remote target sites.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Kaiheng Liu, Wenjuan Liu, Zirong Dong, Luyu Zhang, Qiuyu Li, Renjie Zhang, Haisheng He, Yi Lu, Wei Wu, Jianping Qi
Summary: This study utilized enteric mesoporous silica nanoparticles to load ionic liquids, improving oral drug delivery. The in vitro experiments showed enhanced oral absorption of the drugs, suggesting the potential of this platform for delivering poorly water-soluble drugs and biologics orally.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Hulin Fan, Wei Wu, Zhongjian Chen, Quangang Zhu, Xun Sun
Summary: Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive disease. Real-time monitoring of surgical resection would be beneficial for the surgical treatment of TNBC. In this study, a novel NIR-II fluorescent probe, FD-1050@NPs-cRGD, was designed and synthesized to target TNBC, showing great potential for tumor imaging.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Pharmacology & Pharmacy
Yuze Sheng, Zhongjian Chen, Wei Wu, Yi Lu
Summary: Biofilms are colonies of microorganisms embedded in extracellular polymeric substances (EPS) that cause antibiotic resistance and persistent bacterial infections. Nanoparticles (NPs) can enhance the inhibition and eradication of biofilms by delivering antibiotics with improved EPS penetration and localized drug concentration. Novel strategies such as size optimization, surface modification, stimuli-triggered release, and combined approaches are being developed to further enhance the antibiofilm capacity of NPs. Therefore, NPs offer an effective and promising approach to combat biofilms.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Multidisciplinary
Ni Dong, Zhenyun Liu, Haisheng He, Yi Lu, Jianping Qi, Wei Wu
Summary: In this study, different shapes of red blood cell membrane-coated mesoporous silica nanoparticles were synthesized to verify the concept of multivalent interactions. The experiments demonstrated strengthened binding and internalization of disk-shaped particles with cells, further confirming the significance of multivalent interactions in enhancing active targeting efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Fulong Man, Yinqian Yang, Haisheng He, Jianping Qi, Wei Wu, Yi Lu
Summary: We attempted to establish an in vitro dissolution protocol that is similar to in vivo dissolution by physically embedding aggregation-caused quenching (ACQ) fluorophores inside the lattice of aripiprazole (APZ) crystals. The fluorescence of the fluorophore illuminated the APZ crystals but was quenched upon dissolution of APZ-HCs, allowing for real-time monitoring of intact APZ-HCs. The good correlation between fluorescent quenching and dissolution justified reliable quantification of intact APZ crystals. By comparing the residual percentage of fluorescence intensity in rats treated with APZ-HCs over time, which was converted to in vivo dissolution, the in vitro dissolution profile of APZ was established with a similarity factor larger than 50 compared to in vivo dissolution.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu
Summary: Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs. Drug NCs have been used as solid emulsifiers to prepare nanocrystal self-stabilized Pickering emulsions (NCSSPEs), which can increase drug loading and reduce side effects. These emulsions impede the dissolution of drug NCs and can further enhance their oral bioavailability, especially for BCS IV drugs. In this study, CUR-NCs stabilized Pickering emulsions were prepared using either indigestible or digestible oils. The emulsions significantly increased the oral bioavailability of CUR-NCs, with the digestibility of the oil phase affecting the intactness of the NCs.
Review
Pharmacology & Pharmacy
Lisha Li, Zongguang Tai, Xiying Wu, Junchao Wu, Tingrui Zhang, Zhongjian Chen, Quangang Zhu
Summary: Transdermal drug delivery is a promising strategy for biomacromolecules with advantages like stable blood concentrations, minimal side effects, convenience, and patient compliance. However, the large size, complex structure, and poor stability of biomacromolecules can hinder their penetration through skin barriers.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Xin Wu, Xinmei Chen, Xinyu Wang, Haisheng He, Jianming Chen, Wei Wu
Summary: Paclitaxel-loaded liposomes hold potential for the treatment of breast carcinoma and other cancers. By conjugating paclitaxel with lipids of different chain lengths, the drug release and enzymatic conversion rates can be controlled, affecting the pharmacokinetics, tumor accumulation, and anti-tumor efficacy of liposomal paclitaxel.
CHINESE CHEMICAL LETTERS
(2024)
Article
Endocrinology & Metabolism
Wei Wu, Chunxiu Gong, Yuchuan Li, Yuhua Hu, Haihong Gong, Junfen Fu, Ke Huang, Pin Li, Xiaoping Luo
Summary: This study assessed the long-term efficacy and safety of growth hormone (GH) treatment in Chinese children born small for gestational age (SGA). The results showed that long-term GH treatment was effective at improving height in these children, with normal glucose metabolism and thyroid function throughout the treatment.
HORMONE AND METABOLIC RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
