Article
Endocrinology & Metabolism
Luca D'Onofrio, Silvia Pieralice, Ernesto Maddaloni, Carmen Mignogna, Sara Sterpetti, Lucia Coraggio, Cecilia Luordi, Gloria Guarisco, Gaetano Leto, Frida Leonetti, Silvia Manfrini, Raffaella Buzzetti
Summary: The study found that the COVID-19 lockdown did not significantly affect glycemic control in T2D patients, but those with poor psychological well-being may experience worsening glycemic control due to lockdown restrictions. These findings could help healthcare providers in managing diabetes after the end of the second wave of COVID-19.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Monia Garofolo, Michele Aragona, Cosimo Rodia, Pierpaolo Falcetta, Alessandra Bertolotto, Fabrizio Campi, Stefano Del Prato, Giuseppe Penno
Summary: The study assessed the impact of COVID-19 lockdown on glucose control in adults with type 1 diabetes, showing that most patients maintained good glucose control during the lockdown period.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Fortunato Lombardo, Giuseppina Salzano, Bruno Bombaci, Pietro Basile, Giovanni Lucania, Angela Alibrandi, Stefano Passanisi
Summary: During the lockdown period, pediatric patients with T1D showed significant improvements in glycemic control, but only a subset of patients were able to maintain satisfactory diabetes outcomes in the months following the lockdown.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Michael Lockhart, Deirdre Green, Diarmuid Smith
Summary: Lockdown was found to improve glycemic control in young adult diabetic patients, but it was also associated with weight gain. Lifestyle changes during lockdown may explain this finding.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Benjamin Udoka Nwosu, Layana Al-Halbouni, Sadichchha Parajuli, Gabrielle Jasmin, Emily Zitek-Morrison, Bruce A. Barton
Summary: The study found that there was no significant change in glycemic control in children and adolescents with type 1 diabetes during the 2020 pandemic lockdown in the US.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Elina Hakonen, Tero Varimo, Anna-Kaisa Tuomaala, Paivi J. Miettinen, Mari-Anne Pulkkinen
Summary: The glycemic control in children with type 1 diabetes did not worsen during the lockdown period in Finland, and those using insulin pumps even showed improvement in their control. This suggests that social distancing measures may have positively impacted insulin pump usage.
Review
Endocrinology & Metabolism
Yanping Han, Yuqing Chen, Chenyu Sun, Zhen Zhou
Summary: Compared with the pre-lockdown period, there was a significant improvement in the glycemic control of pediatric patients with type 1 diabetes (T1D) during and after the COVID lockdown. However, there was no significant change in HbA1c.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Linda A. DiMeglio
Summary: The global outbreak of SARS-CoV-2 has had unprecedented consequences, especially for individuals with chronic diseases like type 1 diabetes. Emerging evidence has shown that individuals with type 1 diabetes have been severely affected by COVID-19, experiencing limited access to healthcare during lockdowns and increased morbidity and mortality compared to non-diabetic peers.
Article
Endocrinology & Metabolism
A. R. Dover, S. A. Ritchie, J. A. McKnight, M. W. J. Strachan, N. N. Zammitt, D. J. Wake, S. Forbes, R. H. Stimson, F. W. Gibb
Summary: During the stringent lockdown measures in the UK, people with type 1 diabetes using flash glucose monitoring did not experience a significant deterioration in glycemic control. However, socio-economic deprivation appeared to increase the risk of decline in glycemic control, highlighting the importance of targeted support during challenging times.
Article
Endocrinology & Metabolism
Abrar M. Al-Mutairi, Mohammad A. Alshabeeb, Salah Abohelaika, Fadhel A. Alomar, Keshore R. Bidasee
Summary: This study investigated the impact of telemedicine on glycemic control in patients with type 2 diabetes during the COVID-19 lockdown in Saudi Arabia. The results showed that 63.1% of patients maintained good glycemic control and some patients showed improvement through telemedicine. Male patients had better glycemic control compared to female patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hooi Peng Cheng, Jeanne Sze Lyn Wong, Nalini M. Selveindran, Janet Yeow Hua Hong
Summary: During the lockdown, deterioration in glycaemic control and lifestyle changes were more pronounced in patients with T2DM and pubertal adolescent boys. Significant increases in HbA1c values were observed in patients with T2DM, while there was no significant change in patients with T1DM. Pre-pubertal children with T1DM showed improved glycaemic control possibly due to parental supervision, but weight and BMI SDS increased in this group. Both groups experienced reduced meal frequency, lower physical activity levels, increased screen time, and longer sleep duration during the lockdown.
Article
Public, Environmental & Occupational Health
Claudia Vetrani, Ilaria Calabrese, Silvia Di Rienzo, Mariasofia Pagliuca, Annamaria Rivieccio, Raffaele De Angelis, Gabriele Riccardi, Angela Albarosa Rivellese, Giovanni Annuzzi, Lutgarda Bozzetto
Summary: During the COVID-19 lockdown, individuals with T1D using HAP decreased animal protein intake and increased carbohydrate intake, primarily in whole grains and low-glycemic-index products. These changes did not impact blood glucose control but resulted in more regular meal timing and reduced physical activity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Marianna Rachmiel, Yael Lebenthal, Kineret Mazor-Aronovitch, Avivit Brener, Noa Levek, Neria Levran, Efrat Chorna, Michal Dekel, Galia Barash, Zohar Landau, Orit Pinhas-Hamiel
Summary: The study showed that telehealth visits benefited pediatric and young adult patients with T1D during COVID-19, but this modality is not suitable for a significant proportion of patients.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Anca Balintescu, Marcus Lind, Mikael Andersson Franko, Anders Oldner, Maria Cronhjort, Bjorn Eliasson, Christer Svensen, Johan Martensson
Summary: This study found an association between glycated haemoglobin (HbA1c) and sepsis in adults with type 1 diabetes, and explored the relationship between HbA1c and mortality among individuals who developed sepsis. It revealed a J-shaped relationship between HbA1c and sepsis risk, with the lowest risk observed at HbA1c levels about 53 mmol/mol (7.0%). HbA1c was not associated with mortality in individuals affected by sepsis.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Claudia Eberle, Stefanie Stichling
Summary: During the COVID-19 lockdown, glycemic control significantly improved in patients with type 1 diabetes, potentially due to positive changes in self-care and digital management. However, patients with type 2 diabetes experienced a short-term worsening in glycemic parameters. Further research is needed to understand the causes and effective management of type 2 diabetes during lockdown.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Gastroenterology & Hepatology
Ilaria Barchetta, Carla Lubrano, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Arianna Dellanno, Alberto Di Biasio, Frida Leonetti, Gianfranco Silecchia, Andrea Lenzi, Maria Gisella Cavallo
Summary: This study found a close relationship between NAFLD-related liver fibrosis, lower bone mineral density, and degraded microarchitecture in obese individuals. This suggests potential common pathways underlying liver and bone involvement in obesity and insulin resistance-associated disorders.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
D. Bruttomesso, C. Irace, P. Pozzilli
Summary: This study reported on glycemic control in Italian participants with type 1 diabetes and found that younger patients had better glycemic control compared to older patients. Factors such as body mass index and adherence to diet were associated with glycemic control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini
Summary: This study compared the effectiveness of dapagliflozin to DPP-4 inhibitors in achieving individualized HbA1c targets and extra-glycaemic endpoints in elderly patients with type 2 diabetes. The results showed that patients initiating dapagliflozin had a lower likelihood of reaching individualized HbA1c targets compared to those initiating DPP-4 inhibitors. However, they experienced greater improvements in body weight and blood pressure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ernesto Maddaloni, Lucia Coraggio, Rocco G. Amendolara, Marco G. Baroni, Maria Cavallo, Massimiliano Copetti, Efisio Cossu, Paola D'Angelo, Luca D'Onofrio, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Kyoungmin R. Park, Rury Holman, Vincenzo Trischitta, Raffaella Buzzetti, UMMER Study Diabet Grp
Summary: This study evaluated the possible associations of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease (CVD) and diabetic retinopathy (DR) in type 2 diabetes patients. The findings showed that osteocalcin was associated with CVD, while osteoprotegerin and osteopontin were associated with DR.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Federica Sentinelli, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Diego Bailetti, Efisio Cossu, Arcangelo Barbonetti, Maria Totaro, Olle Melander, Maria Gisella Cavallo, Marco Giorgio Baroni
Summary: Neurotensin (NT) is a small protein that regulates energy balance and functions as both a neurotransmitter in the brain and a gastrointestinal peptide. This study aimed to investigate the genetic regulation of plasma pro-NT levels. Seven sequence variations in the NT gene (NTS) were identified, including a polymorphism (rs2234762) that was more frequent in individuals with lower pro-NT levels. Carriers of the rs2234762 variant had lower pro-NT levels and reduced insulin resistance, independent of metabolic confounders. This suggests that the NTS rs2234762 gene variant may contribute to a more favorable metabolic profile in overweight and obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavia Agata Cimini, Antonella Tramutola, Ilaria Barchetta, Valentina Ceccarelli, Elena Gangitano, Simona Lanzillotta, Chiara Lanzillotta, Maria Gisella Cavallo, Eugenio Barone
Summary: BVRA protein levels can change dynamically in response to insulin and are greater in individuals with lower insulin sensitivity, indicating a correlation with insulin resistance and secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandro Csermely, Alessandro Mantovani, Mario Luca Morieri, Luisa Palmisano, Maria Masulli, Efisio Cossu, Marco Giorgio Baroni, Katia Bonomo, Flavia Agata Cimini, Gisella Cavallo, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Riccardo Maria Pollis, Raffaella Aldigeri, Alessandra Dei Cas, Saula Vigili de Kreutzenberg, Giovanni Targher
Summary: A study of 1,417 adult T1DM patients found that the prevalence of MAFLD with significant fibrosis was lower in those using CSII therapy compared to MDI therapy, primarily due to age differences.
DIABETES & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Ernesto Maddaloni, Angela Carlone, Dario Pitocco, Giulia Leanza, Concetta Suraci, Maria G. Altomare, Maria Cavallo, Ilaria Barchetta, Susanna Morano, Chiara Moretti, Lucia Coraggio, Natalia Visalli, Flavia Tramontana, Riccardo Schiaffini, Antonino Crino, Raffaella Buzzetti, Paolo Pozzilli, MDIAB study grp
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D'Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
Summary: This study aimed to validate the association of a 14-metabolite score with all-cause mortality in type 2 diabetes and explore whether it could improve existing mortality prediction models. The results showed a significant association between the 14-metabolite score and mortality in type 2 diabetes, although the effect size was lower compared to the general population. However, a simplified version of the score without two specific metabolites improved patient analysis and classification of mortality risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Valentina Maria Cambuli, Marco Giorgio Baroni
Summary: This article provides a synthetic overview of research in the treatment of type 1 diabetes, focusing on the development of intelligent insulins and the use of artificial intelligence in automated insulin therapy. It outlines the latest developments in the search for intelligent insulins and the promising advances in the use of artificial intelligence for glucose control. The future of insulin treatment in type 1 diabetes appears promising with the potential for a closed-loop artificial pancreas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
A. Concistre, L. Petramala, C. L. Pugliano, M. Celi, F. Vinci, E. Assanto, I. Barchetta, E. P. Perrone, S. Rella, F. Iannazzo, A. Angheloni, L. Coraggio, F. Di Rienzo, D. Maggi, F. Circosta, G. Galardo, M. Muscaritoli, C. Letizia
Summary: COVID-19 clinical presentation varies greatly, and identifying high-risk patients is crucial for early treatment and intensive follow-up. This study investigated negative prognostic factors in hospitalized COVID-19 patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)