Article
Cardiac & Cardiovascular Systems
Yuni Choi, Nicole Larson, Lyn M. Steffen, Pamela J. Schreiner, Daniel D. Gallaher, Daniel A. Duprez, James M. Shikany, Jamal S. Rana, David R. Jacobs
Summary: The study found that consuming a plant-centered, high-quality diet starting in young adulthood is associated with a lower risk of cardiovascular disease by middle age. Both long-term consumption and a shift towards this type of diet were linked to a reduced risk of CVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Yuni Choi, Lyn M. Steffen, Haitao Chu, Daniel A. Duprez, Daniel D. Gallaher, James M. Shikany, Pamela J. Schreiner, Gautam R. Shroff, David R. Jacobs
Summary: A plant-centered high-quality diet is associated with a reduced risk of kidney function deterioration in individuals with mild CKD, suggesting the importance of diet in kidney health.
JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Xiuling Wang, Jiali Song, Yan Gao, Chaoqun Wu, Xingyi Zhang, Teng Li, Jianlan Cui, Lijuan Song, Wei Xu, Yang Yang, Haibo Zhang, Jiapeng Lu, Xi Li, Jiamin Liu, Xin Zheng
Summary: The study found a dose-response association between weight gain from young to middle adulthood and the odds of metabolic syndrome. The association varied across different BMI categories at young adulthood. Weight maintenance was found to be effective in mitigating the burden of metabolic syndrome, especially among individuals with low or normal weight.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Nagisa Morikawa, Michael P. Bancks, Yuichiro Yano, Masanari Kuwabara, Angelo L. Gaffo, Daniel A. Duprez, Myron D. Gross, David R. Jacobs
Summary: The study revealed that a high-increasing serum urate trajectory during young adulthood is associated with an increased risk of cardiovascular disease by middle age. This association may be explained by the blood pressure levels during the exposure period.
Article
Cardiac & Cardiovascular Systems
So-Yun Yi, Lyn M. Steffen, Xia Zhou, James M. Shikany, David R. Jacobs
Summary: This study examined the long-term associations of walnut, other nut, and no nut consumption with diet quality and cardiovascular disease risk factors. The findings suggest that walnut consumption is associated with better diet quality and cardiovascular disease risk factors.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Zhenyu Xiong, Jiaying Li, Yifen Lin, Xiaomin Ye, Peihan Xie, Shaozhao Zhang, Menghui Liu, Yiquan Huang, Xinxue Liao, Xiaodong Zhuang
Summary: The intensity of hypertensive exposure in young adults is associated with subclinical atherosclerosis in middle age, providing better prognostic value for early cardiovascular risk than baseline blood pressure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Meagan E. Gray, Sejong Bae, Rekha Ramachandran, Nicholas Baldwin, Lisa B. VanWagner, David R. Jacobs, James G. Terry, James M. Shikany
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly rising. This study investigated the associations of diet quality and dietary patterns with NAFLD and found that higher diet quality and a meat-based dietary pattern were significantly associated with NAFLD prevalence.
Article
Endocrinology & Metabolism
Venkatesh L. Murthy, Matthew Nayor, Mercedes Carnethon, Jared P. Reis, Donald Lloyd-Jones, Norrina B. Allen, Robert Kitchen, Paolo Piaggi, Lyn M. Steffen, Ramachandran S. Vasan, Jane E. Freedman, Clary B. Clish, Ravi Shah
Summary: This study identified metabolic abnormalities in young adulthood that are associated with heightened risk of diabetes, independent of traditional risk factors, and these signatures replicate across the life course.
Article
Peripheral Vascular Disease
Takashi Hisamatsu, Donald M. Lloyd-Jones, Laura A. Colangelo, Kiang Liu
Summary: The study revealed that individuals with high sodium and low potassium intake experienced significant increases in blood pressure levels and were at higher risk of developing hypertension during the follow-up period. The findings emphasize the importance of reducing sodium intake and increasing potassium intake for hypertension prevention among young adults.
JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Donald M. Lloyd-Jones, Cora E. Lewis, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Jared P. Reis
Summary: The CARDIA study began in 1985-1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of cardiovascular health and disease, as well as associations between neighborhood environment, lifestyle behaviors, and biological risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Oncology
Sofia Christakoudi, Panagiota Pagoni, Pietro Ferrari, Amanda J. Cross, Ioanna Tzoulaki, David C. Muller, Elisabete Weiderpass, Heinz Freisling, Neil Murphy, Laure Dossus, Renee Turzanski Fortner, Antonio Agudo, Kim Overvad, Aurora Perez-Cornago, Timothy J. Key, Paul Brennan, Mattias Johansson, Anne Tjonneland, Jytte Halkjaer, Marie-Christine Boutron-Ruault, Fanny Artaud, Gianluca Severi, Rudolf Kaaks, Matthias B. Schulze, Manuela M. Bergmann, Giovanna Masala, Sara Grioni, Vittorio Simeon, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Charlotta Rylander, Kristin Benjaminsen Borch, J. Ramon Quiros, Miguel Rodriguez-Barranco, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Isabel Drake, Tanja Stocks, Christel Haggstrom, Sophia Harlid, Merete Ellingjord-Dale, Elio Riboli, Konstantinos K. Tsilidis
Summary: The study found that weight gain in middle adulthood was positively associated with multiple cancers, supporting avoiding weight gain and encouraging weight loss.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Yinan Zheng, Brian Joyce, Shih-Jen Hwang, Jiantao Ma, Lei Liu, Norrina Allen, Amy Krefman, Jun Wang, Tao Gao, Drew Nannini, Haixiang Zhang, David R. Jacobs, Myron Gross, Myriam Fornage, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, Dongquan Chen, Philip Greenland, Daniel Levy, Lifang Hou, Donald Lloyd-Jones
Summary: This study found that cardiovascular health from young adulthood is associated with midlife epigenetic programming. The findings demonstrate the role of epigenetic markers in response to cardiovascular health changes and highlight the potential of epigenomic markers for precision cardiovascular disease prevention and earlier detection of subclinical cardiovascular disease.
Article
Medicine, General & Internal
Sneha Thatipelli, Kiarri N. Kershaw, Laura A. Colangelo, Penny Gordon-Larsen, David R. Jacobs, Mark T. Dransfield, Daniel Meza, Sharon R. Rosenberg, George R. Washko, Trisha M. Parekh, Mercedes R. Carnethon, Ravi Kalhan
Summary: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood is associated with greater decline in lung function and higher risk of future emphysema.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Geriatrics & Gerontology
Masoud Isanejad, Lyn M. Steffen, James G. Terry, James M. Shikany, Xia Zhou, David R. Jacobs Jr, John Jeffrey Carr, Brian T. Steffen
Summary: Improving diet quality may contribute to better body composition. This study found that healthier food choices may influence body composition.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel S. Gidding, Laura A. Colangelo, Chike C. Nwabuo, Cora E. Lewis, David R. Jacobs, Pamela J. Schreiner, Joao A. C. Lima, Norrina B. Allen
Summary: The PDAY risk score based on post-mortem measurements was found to be highly predictive of future ASCVD events in young adults. The presence of coronary artery calcium improved risk prediction only if the score was 0. Cumulative risk exposure and PDAY score at age 18-30 were also significant factors for predicting ASCVD.
EUROPEAN HEART JOURNAL
(2022)
Article
Behavioral Sciences
Vivienne M. Hazzard, Katie A. Loth, Ross D. Crosby, Stephen A. Wonderlich, Scott G. Engel, Nicole Larson, Dianne Neumark-Sztainer
Summary: This study examined the relationship between food availability and binge eating among individuals experiencing food insecurity (FI). The findings showed that higher levels of momentary food security predicted greater subsequent binge-eating symptoms relative to one's average level. This association was significant only among individuals using food assistance programs, engaging in resource trade-off coping strategies, or having low food security-related self-efficacy.
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Cardiac & Cardiovascular Systems
Ravi Shah, Lyn M. Steffen, Matthew Nayor, Jared P. Reis, David R. Jacobs Jr, Norrina B. Allen, Donald Lloyd-Jones, Katie Meyer, Joanne Cole, Paolo Piaggi, Ramachandran S. Vasan, Clary B. Clish, Venkatesh L. Murthy
Summary: Metabolite signatures of diet are associated with long-term CM-CVD independent of lifestyle and traditional risk factors. Metabolomics improves precision to identify adverse consequences and pathways of diet-related CM-CVD.
EUROPEAN HEART JOURNAL
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Drew R. R. Nannini, Yinan Zheng, Brian T. Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R. R. Jacobs, Pamela J. J. Schreiner, Kristine Yaffe, Philip Greenland, Donald M. M. Lloyd-Jones, Lifang Hou
Summary: The study reveals the association between marijuana use and DNA methylation levels, with a stronger correlation in recent and cumulative users. The research also identifies pathways and diseases related to cellular proliferation, hormone signaling, infections, schizophrenia, bipolar disorder, and substance-related disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Kelley Pettee Gabriel, Byron C. Jaeger, Cora E. Lewis, Stephen Sidney, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, JamesM. Shikany, Kara M. Whitaker, Alexander Arynchyn, Barbara Sternfeld
Summary: This study found that higher early-adulthood cardiorespiratory fitness and greater retention of early-adulthood cardiorespiratory fitness throughout midlife were associated with a lower risk of premature death and CVD events.
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Nutrition & Dietetics
Karla N. Kendrick, Hyunju Kim, Casey M. Rebholz, Elizabeth Selvin, Lyn M. Steffen, Stephen P. Juraschek
Summary: The type of plant-based diet may affect the risk of hospitalization with respiratory infections or any infection. A healthy plant-based diet and a higher plant-based diet index were associated with a lower risk of hospitalization for respiratory infections and any infections, while an unhealthy plant-based diet showed no significant associations with hospitalization risk.
Article
Genetics & Heredity
Lisa de las Fuentes, Karen L. M. Schwander, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler, Yun Ju Sung, Patricia B. Munroe, Clint L. Miller, Hugo Aschard, Stella Aslibekyan, Traci M. Bartz, Lawrence F. Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F. Feitosa, Xiuqing Guo, Fernando P. Hartwig, Andrea Horimoto, Ivana Kolcic, Elise Lim, Yongmei Liu, Alisa K. Manning, Jonathan Marten, Solomon K. Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A. Richard, Paul M. Ridker, Albert V. Smith, Dina Vojinovic, Alan B. Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I. Freedman, Chuan Gao, Franco Giulianini, Sarah E. Harris, Meian He, Fang-Chi Hsu, Brigitte Kuehnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikainen, Ilja M. Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Niek Verweij, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Yiqiang Zhan, Najaf Amin, Dan E. Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A. Brody, Ulrich Broeckel, Archie Campbell, Mickael Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf de Faire, Renee de Mutsert, H. Janaka de Silva, Paul S. de Vries, Ahn Do, Jessica D. Faul, Virginia Fisher, James S. Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C. Charles Gu, Goeran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M. Arfan Ikram, David R. Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O. Kilpelainen, Woon-Puay Koh, Pirjo Komulainen, Carl D. Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Magi, Ani W. Manichaikul, Colin A. McKenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P. Nelson, Jeffrey R. O'Connell, Nicholette D. Palmer, Alexandre C. Pereira, Thomas Perls, Annette Peters, Ozren Polasek, Olli T. Raitakari, Kenneth Rice, Treva K. Rice, Stephen S. Rich, Charumathi Sabanayagam, Pamela J. Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A. Smith, John M. Starr, Konstantin Strauch, E. Shyong Tai, Kent D. Taylor, Michael Y. Tsai, Andre G. Uitterlinden, Diana van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M. Becker, Amelie Bonnefond, Donald W. Bowden, Richard S. Cooper, Ian J. Deary, Jasmin Divers, Tonu Esko, Paul W. Franks, Philippe Froguel, Christian Gieger, Jost B. Jonas, Norihiro Kato, Timo A. Lakka, Karin Leander, Terho Lehtimaki, Patrik K. E. Magnusson, Kari E. North, Ioanna Ntalla, Brenda Penninx, Nilesh J. Samani, Harold Snieder, Beatrice Spedicati, Pim van der Harst, Henry Voelzke, Lynne E. Wagenknecht, David R. Weir, Mary K. Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel Chasman, Michele Evans, Ervin R. Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L. Horta, Sharon L. R. Kardia, Jose Eduardo Krieger, Dennis O. Mook-Kanamori, Patricia A. Peyser, Michael M. Province, Bruce M. Psaty, Igor Rudan, Xueling Sim, Blair H. Smith, Rob M. van Dam, Cornelia M. van Duijn, Tien Yin Wong, Donna K. Arnett, Dabeeru C. Rao, James Gauderman, Ching-Ti Liu, Alanna C. Morrison, Jerome I. Rotter, Myriam Fornage
Summary: This study conducted a genome-wide meta-analysis to investigate the interaction between educational attainment and lipid levels. They identified novel lipid loci that were not previously detected by analyses limited to main genetic effects. The study also highlighted the potential importance of brain-adipose-liver communication in lipid metabolism and identified gene targets that interact with drugs approved by the FDA.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Daniel J. Mcdonough, Mahesh Mathew, Zachary C. Pope, Pamela J. Schreiner, David R. Jacobs Jr, Lisa B. Vanwagner, John Jeffrey Carr, James G. Terry, Kelley Pettee Gabriel, Jared P. Reis, Mark A. Pereira
Summary: This study examined the association between lifestyle factors and NAFLD and found that regular moderate-vigorous aerobic and muscle-strengthening activities, along with reduced television viewing time, significantly reduce the risk of NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Anna S. Clarke, Chris Faulk, Gerald C. Shurson, Daniel D. Gallaher, Lee J. Johnston
Summary: This study aimed to evaluate the effectiveness of feeding beta-hydroxy-beta-methylbutyrate (HMB) to pregnant mice in improving birth weight uniformity and growth performance of offspring. The results showed that dietary HMB supplementation in pregnant mice did not affect birth weight, variations in birth weight, or growth performance of offspring.
Article
Geriatrics & Gerontology
Masoud Isanejad, Lyn M. Steffen, James G. Terry, James M. Shikany, Xia Zhou, David R. Jacobs Jr, John Jeffrey Carr, Brian T. Steffen
Summary: Improving diet quality may contribute to better body composition. This study found that healthier food choices may influence body composition.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)