期刊
CURRENT OPINION IN ONCOLOGY
卷 32, 期 6, 页码 631-639出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCO.0000000000000679
关键词
3D models; glioblastoma; interaction; invasion; microenvironment
类别
资金
- IDEX Bordeaux (International PhD fellowship)
- INSERM
- University of Bordeaux
- Strauss Aclon foundations
- Canadian Institutes of Health Research Foundation
- Nouvelle Aquitaine Region
Purpose of review This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. Recent findings We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasion. Recent works discovered the role of new molecular players in GBM invasion, and, most importantly, better models are emerging which better recapitulate GBM invasion. Summary Invasive properties of glioblastoma make complete surgical resection impossible and highly invasive cells are responsible for tumor recurrence. In this review, we focus on recent updates describing how invasive cells progress in the surrounding tissue along brain structures. We also provide an overview of the current knowledge on key cells and molecular players within the microenvironment that contribute to the invasive process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据