期刊
CURRENT OPINION IN CELL BIOLOGY
卷 66, 期 -, 页码 43-50出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.05.001
关键词
Developmental biology; Neural Crest; Epithelial-to-mesenchymal transition; Cell migration; Collective migration
类别
资金
- National Institutes of Health [K99DE029240, R01DE027538, R01DE027568]
Epithelial-to-mesenchymal transition (EMT) is a dynamic process that produces migratory cells from epithelial precursors. However, EMT is not binary; rather it results in migratory cells which adopt diverse strategies including collective and individual cell migration to arrive at target destinations. Of the many embryonic cells that undergo EMT, the vertebrate neural crest is a particularly good example which has provided valuable insight into these processes. Neural crest cells from different species often adopt different migratory strategies with collective migration predominating in anamniotes, whereas individual cell migration is more prevalent in amniotes. Here, we will provide a perspective on recent work toward understanding the process of neural crest EMT focusing on how these cells undergo collective and individual cell migration.
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