Article
Chemistry, Multidisciplinary
Yimin Zhou, Cong Chang, Zuhao Liu, Qiuling Zhao, Qingni Xu, Chaohua Li, Yuqi Chen, Yueli Zhang, Bo Lu
Summary: The study successfully developed ID@HMSNs-B-HA nanoparticles for targeted drug delivery, showing sustained drug release under acidic conditions with effective inhibition of murine mammary carcinoma (4T1) cells through combined chemotherapy and photodynamic therapy. The results indicated that ID@HMSNs-B-HA could be a promising nano-DDS for cancer treatment.
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Nanxin Zhao, Rongfeng Cai, Yuting Zhang, Xiaoli Wang, Nandi Zhou
Summary: Drug-resistant bacteria, especially those in microbial biofilm, pose a significant threat to human health. Traditional antibiotic treatment is not effective in sterilizing biofilm-associated pathogens, thus new approaches are urgently needed. In this study, researchers developed a pH-gated photosensitizer delivery system using amino-modified hollow mesoporous silica nanoparticles. The system efficiently targeted and released the photosensitizer curcumin into the biofilm, and subsequent photodynamic treatment significantly reduced the number of viable bacteria. This new approach shows promise in combating biofilm-associated infections without the risk of antibiotic resistance.
Article
Biochemistry & Molecular Biology
Yue-Mei Gao, Shih-Han Chiu, Prabhakar Busa, Chen-Lun Liu, Ranjith Kumar Kankala, Chia-Hung Lee
Summary: This study reports the fabrication of core-shell nanostructures for delivering methylene blue and copper-doxorubicin as model drugs for synergistic photodynamic therapy, chemotherapy, and chemodynamic therapy. The designed architectures demonstrate potent anti-cancer efficacy against skin melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Zhi-Yuan Wu, Guan-wei Chen, Cheng-Chang Lee, Zui-Harng Lee, Wei Ting Yuan, Showe-Mei Lin, Hsiu-Mei Lin
Summary: Combination therapy of chemotherapy and photodynamic therapy can improve cancer treatment. In this study, nanoparticles capable of phototherapeutic effects were synthesized, and the combination therapy demonstrated superior anticancer efficacy compared to PDT or chemotherapy alone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Qianru Li, Qianqian Liu, Heli Li, Liyun Dong, Yajie Zhou, Jintao Zhu, Liu Yang, Juan Tao
Summary: Nanomedicine has shown great potential in cancer immunotherapy, but there are still limitations in nanoparticle-based immunotherapy. In this study, researchers discovered that encapsulating a photosensitizer in nanoparticles can achieve synergy between photodynamic therapy and immunotherapy. Through experiments, they demonstrated the significant effectiveness of this nanotherapeutic system in inducing antitumor immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aftab Ullah, Marina Khan, Yibang Zhang, Faisal Raza, Muhammad Hasnat, Jin Cao, Xueyong Qi, Abid Hussain, Daojun Liu
Summary: This study developed hollow mesoporous organosilica nanoparticles (HMONs) with a thioether-hybrid structure for starvation and apoptosis therapy of HCC. The HMONs were surface modified to yield CCM-coated HMONs (TSBRs) with enhanced cell uptake and cytotoxicity. The TSBRs exhibited excellent catalytic activity and effectively reduced tumor size and weight in both in vitro and in vivo settings. The NPs showed long-term safety in vivo. This study demonstrates the anti-cancer potential of TSBRs for HCC treatment.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Yanjun Yang, Fangman Chen, Ning Xu, Qichao Yao, Ran Wang, Xiaochun Xie, Fan Zhang, Yan He, Dan Shao, Wen-fei Dong, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: This study presents a red light-responsive self-destructive carrier for chemo-photodynamic therapy. The carrier achieves dual drug release and degradation of the organosilica matrix upon low-dose red light irradiation, resulting in a synergistic chemo-photodynamic effect. Furthermore, this therapy boosts immunogenic cell death and robust anti-tumor immunity responses.
Article
Pharmacology & Pharmacy
Yihan Wu, Jingjing Li, Xuemei Zhong, Jinfeng Shi, Yanfen Cheng, Chenglin He, Jiaxin Li, Liang Zou, Chaomei Fu, Meiwan Chen, Jinming Zhang, Huile Gao
Summary: In this study, a pH-sensitive supramolecular nanosystem was designed for co-delivery of Ce6 and TPL, exhibiting ideal drug release characteristics and enhanced cellular uptake capacity. TPL+Ce6/NPs showed significant synergistic chemo-photodynamic therapeutic effects in vitro and in vivo, with lower systemic toxicity in tumor-bearing mice.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chuanyong Fan, Xiyu Wang, Yuwen Wang, Ziyue Xi, Yuxin Wang, Shuang Zhu, Miao Wang, Lu Xu
Summary: In this study, hollow mesoporous silica nanoparticles (HMSNs) coated with polydopamine (PDA) and a D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)-modified hybrid lipid membrane (HMSNs-PDA@liposome-TPGS) were synthesized for drug delivery. The nanocarrier showed enhanced therapeutic anticancer effect through pH/NIR-laser-triggered drug release and had improved blood circulation time and hemocompatibility.
Article
Materials Science, Multidisciplinary
Liuying Zhu, Weiwei Zhang, Ping Song, Wanzhen Li, Xiaolu Chen, Fei Ge, Lin Gui, Kai Yang, Yugui Tao, Du Guocheng
Summary: In this study, a multifunctional nanocarrier based on glutathione-responsive mesoporous silica nanoparticles was designed, which effectively delivered chemotherapy drugs and resisted cancer cells through photodynamic therapy. The synthesized nanocarrier showed excellent efficacy in tumor treatment.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Biochemistry & Molecular Biology
Guangyue Shi, Zhongtao Li, Zhichen Zhang, Qiangqiang Yin, Na Li, Shengchao Wang, Guiqiang Qi, Liguo Hao
Summary: In order to improve the efficacy of breast cancer treatment, Paclitaxel was encapsulated in hyaluronic acid modified hollow mesoporous silica. The resulting formulation exhibited enzyme-responsive drug release and showed enhanced accumulation within cancer cells. It also demonstrated significantly greater cytotoxicity and holds promise as a potent candidate for breast cancer therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Zhiming Zhang, Chenlu Huang, Li Zhang, Qing Guo, Yu Qin, Fan Fan, Boxuan Li, Bao Xiao, Dunwan Zhu, Linhua Zhang
Summary: The study developed a novel drug delivery system using multifunctional nanoparticles loaded with chemotherapeutic agent and photosensitizer for tumor combination therapy. The nanoparticles showed high targeting efficacy, pH-dependent drug release, and significant photothermal and photodynamic effects, providing a promising system for combination therapy.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Misun Kang, Jong-tak Lee, Jae Young Bae
Summary: Formaldehyde emitted from household products is harmful to human health. This study compares the formaldehyde adsorption characteristics of mesoporous and mesoporous hollow silicas synthesized with or without a calcination process. The mesoporous hollow silica synthesized without a calcination process has the best adsorption performance, followed by the mesoporous hollow silica synthesized with a calcination process and mesoporous silica. This research demonstrates the potential of mesoporous hollow silica as an effective support for harmful gas adsorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Berrin Kucukturkmen, Wali Inam, Fadak Howaili, Mariam Gouda, Neeraj Prabhakar, Hongbo Zhang, Jessica M. Rosenholm
Summary: Microfluidics has been used to coat mesoporous silica nanoparticles (MSNs) with polymeric layers for achieving high protein loading and retention. This study demonstrates the potential of microfluidic technologies in the design of protein delivery systems, allowing for multicomponent systems and preservation of protein stability.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)