Article
Multidisciplinary Sciences
Jing-Hui Tian, Nita Patel, Robert Haupt, Haixia Zhou, Stuart Weston, Holly Hammond, James Logue, Alyse D. Portnoff, James Norton, Mimi Guebre-Xabier, Bin Zhou, Kelsey Jacobson, Sonia Maciejewski, Rafia Khatoon, Malgorzata Wisniewska, Will Moffitt, Stefanie Kluepfel-Stahl, Betty Ekechukwu, James Papin, Sarathi Boddapati, C. Jason Wong, Pedro A. Piedra, Matthew B. Frieman, Michael J. Massare, Louis Fries, Karin Lovgren Bengtsson, Linda Stertman, Larry Ellingsworth, Gregory Glenn, Gale Smith
Summary: The study reports the development of a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, showing immunogenicity in mice and protection in baboons with Matrix-M adjuvanted vaccine, supporting ongoing phase 1/2 clinical evaluation of NVX-CoV2373 with Matrix-M (NCT04368988).
NATURE COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Pia Egerup, Line Fich Olsen, Ann-Marie Hellerung Christiansen, David Westergaard, Elin Rosenbek Severinsen, Kathrine Vauvert Rommelmayer Hviid, Astrid Marie Kolte, Amalie Dyhrberg Boje, Marie-Louise Mathilde Friis Bertelsen, Lisbeth Praetorius, Anne Zedeler, Josefine Reinhardt Nielsen, Didi Bang, Sine Berntsen, Jeppe Ethelberg-Findsen, Ditte Marie Storm, Judith Bello-Rodriguez, Andreas Ingham, Joaquim Olle-Lopez, Eva R. Hoffmann, Charlotte Wilken-Jensen, Lone Krebs, Finn Stener Jorgensen, Henrik Westh, Henrik Lovendahl Jorgensen, Nina la Cour Freiesleben, Henriette Svarre Nielsen
Summary: This study investigated the frequency of SARS-CoV-2 antibodies in parturient women, their partners, and newborns, and the association with obstetric and neonatal outcomes. No association was found between SARS-CoV-2 infection and obstetric or neonatal complications, but some newborns born to mothers with antibodies had SARS-CoV-2 IgG antibodies at birth. The study was limited by a lack of statistical power to detect small but potentially meaningful differences between those with and without evidence of infection.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Virology
Catherine Jacob-Dolan, Jared Feldman, Katherine McMahan, Jingyou Yu, Roland Zahn, Frank Wegmann, Hanneke Schuitemaker, Aaron G. Schmidt, Dan H. Barouch
Summary: This study defines the serum profiles in rhesus macaques after SARS-CoV-2 vaccination, showing robust reactivity to SARS-CoV-2 spike protein but reduced cross reactivity to other coronaviruses. Neutralizing antibody responses were predominantly SARS-CoV-2 specific, highlighting the similarities between infection and vaccine-induced immunity for SARS-CoV-2.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Matthew K. Hensley, William G. Bain, Jana Jacobs, Sham Nambulli, Urvi Parikh, Anthony Cillo, Brittany Staines, Amy Heaps, Michele D. Sobolewski, Linda J. Rennick, Bernard J. C. Macatangay, Cynthia Klamar-Blain, Georgios D. Kitsios, Barbara Methe, Ashwin Somasundaram, Tullia C. Bruno, Carly Cardello, Feng Shan, Creg Workman, Prabir Ray, Anuradha Ray, Janet Lee, Rahil Sethi, William E. Schwarzmann, Mark S. Ladinsky, Pamela J. Bjorkman, Dario A. Vignali, W. Paul Duprex, Mounzer E. Agha, John W. Mellors, Kevin D. McCormick, Alison Morris, Ghady Haidar
Summary: This study reports a case of a recipient of chimeric antigen receptor-modified T-cell therapy who developed severe COVID-19 with prolonged viral replication and evolution, along with minimal immune response, suggesting the possibility of prolonged transmission from immunosuppressed patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Pinja Jalkanen, Arja Pasternack, Sari Maljanen, Krister Melen, Pekka Kolehmainen, Moona Huttunen, Rickard Lundberg, Lav Tripathi, Hira Khan, Mikael A. Ritvos, Rauno Naves, Anu Haveri, Pamela Osterlund, Suvi Kuivanen, Anne J. Jaaskelainen, Satu Kurkela, Maija Lappalainen, Kaisa Rantasarkka, Tytti Vuorinen, Jukka Hytonen, Matti Waris, Sisko Tauriainen, Olli Ritvos, Laura Kakkola, Ilkka Julkunen
Summary: Utilizing SARS-CoV-2 nucleoprotein (N) and receptor binding domain (RBD) as antigens in enzyme immunoassays (EIA) among COVID-19 patients showed sensitivity of 77% in the acute phase and 100% in the convalescent phase. Furthermore, SARS-CoV-2 infection significantly increased humoral immune responses against other human coronaviruses.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Virology
Charles W. Stratton, Yi-Wei Tang, Hongzhou Lu
Summary: COVID-19 is considered a global public health emergency and therapy should be based on the pathogenic mechanisms, including testing and treatment, correcting hypoxia, reducing viral load, addressing hyperinflammation, and hypercoagulability, among six major therapeutic goals identified.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Denise J. McCulloch, Michael L. Jackson, James P. Hughes, Sandra Lester, Lisa Mills, Brandi Freeman, Mohammad Ata Ur Rasheed, Natalie J. Thornburg, Helen Y. Chu
Summary: No SARS-CoV-2 antibody-positive samples were found among healthcare users in the greater Seattle area from October 2019 to mid-March 2020, but the prevalence rose to 1.2% by late March and early April 2020.
Article
Infectious Diseases
Jong Hoon Hyun, Moo Hyun Kim, Yujin Sohn, Yunsuk Cho, Yae Jee Baek, Jung Ho Kim, Jin Young Ahn, Jun Yong Choi, Joon Sup Yeom, Mi Young Ahn, Eun Jin Kim, Ji-Hyeon Baek, Young Keun Kim, Heun Choi, Su Jin Jeong
Summary: The study found that early use of corticosteroids in patients with severe COVID-19 showed favorable clinical outcomes related to a reduction in the length of hospital stay.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Luther A. Bartelt, Alena J. Markmann, Bridget Nelson, Jessica Keys, Heather Root, Heather Henderson, JoAnn Kuruc, Caroline Baker, D. Ryan Bhowmik, Yixuan J. Hou, Lakshmanane Premkumar, Caleb Cornaby, John L. Schmitz, Susan Weiss, Yara Park, Ralph Baric, Aravinda M. de Silva, Anne Lachiewicz, Sonia Napravnik, David van Duin, David M. Margolis
Summary: In this study, it was found that among high-risk patients admitted for COVID-19, those who received CCP with nAb titers of >1:640 had earlier hospital discharge compared to those who received CCP with lower nAb titers, with no CCP-related adverse events. The significance of this research lies in identifying a dose response of CCP and clinical outcomes based on nAb titers. Although limited by a small study size, these findings support further investigation of high-nAb-titer CCP (>1:640) in the treatment of COVID-19.
Article
Chemistry, Multidisciplinary
Samia A. Elseginy, Manal M. Anwar
Summary: The molecular dynamics simulations of SARS-CoV-2 PLpro inhibitors revealed the stability of both compounds and their interactions with key residues.
Review
Biochemistry & Molecular Biology
Ridhima Kaul, Pradipta Paul, Sanjay Kumar, Dietrich Buesselberg, Vivek Dhar Dwivedi, Ali Chaari
Summary: This review summarizes the activities and structure-activity relationships of flavonoids in combating SARS-CoV-2 from in vitro studies to clinical research. The study found that flavonoids such as quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid show promising activities against SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Critical Care Medicine
Elinor Tan, Jialu Song, Adam M. Deane, Mark P. Plummer
Summary: The systematic review and meta-analysis included 45 studies from 17 countries across four continents, involving 16,561 patients with severe COVID-19 admitted to ICUs. The study revealed that critically ill COVID-19 patients require substantial organ support, with a high mortality rate of 28.1% during hospitalization.
Article
Environmental Sciences
Giuseppina La Rosa, Pamela Mancini, Giusy Bonanno Ferraro, Carolina Veneri, Marcello Iaconelli, Lucia Bonadonna, Luca Lucentini, Elisabetta Suffredini
Summary: Italy had SARS-CoV-2 circulating as early as the end of 2019, with the virus spreading in different geographic regions simultaneously. The study emphasizes the importance of environmental surveillance as an early warning system to monitor virus levels and identify outbreaks before they are officially reported to the healthcare system.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Puya Dehgani-Mobaraki, Asiya Kamber Zaidi, Nidhi Yadav, Alessandro Floridi, Emanuela Floridi
Summary: This study examined the long-term antibody responses in recovered COVID-19 patients, finding that anti-S-RBD IgG can persist for 14 months. It highlighted the correlation between individual symptoms and antibody titers, as well as the higher false-negative rate of antibody tests based on NCP protein.
CLINICAL IMMUNOLOGY
(2021)