Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry

(2015) Christian Rückert et al.   JOURNAL OF BIOTECHNOLOGY

A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine BacteriumStreptomycessp. CNQ-509

(2014) Philipp Zeyhle et al.   CHEMBIOCHEM

A roadmap for natural product discovery based on large-scale genomics and metabolomics

(2014) James R Doroghazi et al.   Nature Chemical Biology

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

(2014) N. Ziemert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

(2014) Marnix H. Medema et al.   PLoS Computational Biology

Phylogenetic and Chemical Diversity of a Hybrid-Isoprenoid-Producing Streptomycete Lineage

(2013) Kelley A. Gallagher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Napyradiomycin Derivatives, Produced by a Marine-Derived Actinomycete, Illustrate Cytotoxicity by Induction of Apoptosis

(2013) Lauge Farnaes et al.   JOURNAL OF NATURAL PRODUCTS

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

(2013) Marnix H. Medema et al.   MOLECULAR BIOLOGY AND EVOLUTION

Novel Marine Phenazines as Potential Cancer Chemopreventive and Anti-Inflammatory Agents

(2012) Tamara P. Kondratyuk et al.   Marine Drugs

ProtTest 3: fast selection of best-fit models of protein evolution

(2011) Diego Darriba et al.   BIOINFORMATICS

Convergent strategies in biosynthesis

(2011) Tohru Dairi et al.   NATURAL PRODUCT REPORTS

Evolutionary Relationships of Microbial Aromatic Prenyltransferases

(2011) Tobias Bonitz et al.   PLoS One

Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes

(2010) Kelley A Gallagher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Widespread homologous recombination within and between Streptomyces species

(2010) James R Doroghazi et al.   ISME Journal

Nitropyrrolins A−E, Cytotoxic Farnesyl-α-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete FamilyStreptomycetaceae

(2010) Hak Cheol Kwon et al.   JOURNAL OF NATURAL PRODUCTS

Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides⊥

(2010) Andrew W. Schultz et al.   JOURNAL OF NATURAL PRODUCTS

Sponge-DerivedStreptomycesProducing Isoprenoids via the Mevalonate Pathway

(2010) Miho Izumikawa et al.   JOURNAL OF NATURAL PRODUCTS

Origins and Early Evolution of the Mevalonate Pathway of Isoprenoid Biosynthesis in the Three Domains of Life

(2010) J. Lombard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

(2010) Anne Osbourn   TRENDS IN GENETICS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Prenyl transfer to aromatic substrates: genetics and enzymology

(2009) Lutz Heide   CURRENT OPINION IN CHEMICAL BIOLOGY

Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria

(2009) Shams Tabrez Khan et al.   FEMS MICROBIOLOGY LETTERS

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria

(2009) Kevin Penn et al.   ISME Journal

Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, meroterpenoids and phenazines: The ABBA prenyltransferase family

(2009) Orwah Saleh et al.   PHYTOCHEMISTRY

The ABBA family of aromatic prenyltransferases: broadening natural product diversity

(2008) M. Tello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The evolution of gene collectives: How natural selection drives chemical innovation

(2008) M. A. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA