期刊
CLINICAL NEUROPHYSIOLOGY
卷 131, 期 12, 页码 2851-2860出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2020.09.023
关键词
Intracranial electrodes; Epilepsy surgery; Cortical localization; High-gamma activation; Machine learning
资金
- Procter Foundation
- Cincinnati Children's Research Foundation
- Division of Neurology at Cincinnati Children's Hospital Medical Center
Objective: A novel analytic approach for task-related high-gamma modulation (HGM) in stereoelectroencephalography (SEEG) was developed and evaluated for language mapping. Methods: SEEG signals, acquired from drug-resistant epilepsy patients during a visual naming task, were analyzed to find clusters of 50-150 Hz power modulations in time-frequency domain. Classifier models to identify electrode contacts within the reference neuroanatomy and electrical stimulation mapping (ESM) speech/language sites were developed and validated. Results: In 21 patients (9 females), aged 4.8-21.2 years, SEEG HGM model predicted electrode locations within Neurosynth language parcels with high diagnostic odds ratio (DOR 10.9, p < 0.0001), high specificity (0.85), and fair sensitivity (0.66). Another SEEG HGM model classified ESM speech/language sites with significant DOR (5.0, p < 0.0001), high specificity (0.74), but insufficient sensitivity. Time to largest power change reliably localized electrodes within Neurosynth language parcels, while, time to center-of mass power change identified ESM sites. Conclusions: SEEG HGM mapping can accurately localize neuroanatomic and ESM language sites. Significance: Predictive modelling incorporating time, frequency, and magnitude of power change is a useful methodology for task-related HGM, which offers insights into discrepancies between HGM language maps and neuroanatomy or ESM. (c) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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