Article
Cardiac & Cardiovascular Systems
Jordana B. Cohen, Gary F. Mitchell, Dipender Gill, Stephen Burgess, Mahboob Rahman, Thomas Hanff, Vasan S. Ramachandran, Karen Mutalik, Raymond R. Townsend, Julio A. Chirinos
Summary: In this study, we used prospective cohort data and Mendelian randomization analyses to show that greater large artery stiffness (LAS) is associated with an increased risk of developing type 2 diabetes. LAS may play an important role in glucose homeostasis and could serve as a useful marker for future diabetes risk.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Peripheral Vascular Disease
Michal Schafer, Lorna P. Browne, Uyen Truong, Petter Bjornstad, Shoshana Tell, Janet Snell-Bergeon, Amy Baumgartner, Kendall S. Hunter, Jane E. B. Reusch, Alex J. Barker, Kristen J. Nadeau, Irene E. Schauer
Summary: In this study, researchers tested whether BCQR could improve vascular health in youth with T1D. The results showed that compared to placebo, BCQR could lower blood pressure and improve aortic stiffness and pressure hemodynamics. Therefore, BCQR may help improve arterial stiffness in youth with T1D and longer-term studies are needed to confirm these findings.
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Caifeng Shi, Aiqin He, Xiaomei Wu, Lulu Wang, Xueting Zhu, Lei Jiang, Junwei Yang, Yang Zhou
Summary: The urinary levels of IL-18 appear to be associated with greater pulse wave velocity (PWV) in patients with T2D, indicating a link between urinary IL-18 and arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Madonna Salib, Arnaud Simon, Nicolas Girerd, Anna Kearney-Schwartz, Patrick Rossignol, Athanase Benetos, Luc Frimat, Sophie Girerd
Summary: The deterioration of arterial stiffness in the late post-transplantation period is associated with an increased risk of cardiovascular events, while early changes in pulse-wave velocity (PWV) are not significantly associated with cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Marieta P. Theodorakopoulou, Artemios G. Karagiannidis, Maria-Eleni Alexandrou, Fotini Iatridi, Michalis Christodoulou, Theodoros Dimitroulas, Aikaterini Papagianni, Pantelis A. Sarafidis
Summary: This study examined the ambulatory central blood pressure and arterial stiffness parameters in patients with and without intradialytic hypertension (IDH). The results showed that IDH patients had higher levels of central blood pressure and arterial stiffness parameters compared to non-IDH patients. Additionally, the two groups displayed different trajectories over the 48-hour period, with IDH patients showing consistently high values. These findings suggest that increased arterial stiffness may be a significant factor associated with the high burden of cardiovascular disease in this population.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Hematology
Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecca Li, Sophie L. Boerboom, Yin-Ching Chen, Shih-Jen Hwang, Chen Yao, Fumito Ichinose, Donald B. Bloch, Mark E. Lindsay, Gregory D. Lewis, Jayashri R. Aragam, Udo Hoffmann, Gary F. Mitchell, Naomi M. Hamburg, Ramchandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Warren M. Zapol, Susan Cheng, Jason D. Roh, Christopher J. O'Donnell, Christopher Nguyen, Daniel Levy, Jennifer E. Ho
Summary: This study finds an association between ucMGP levels and arterial stiffness, as well as future HFpEF. Experimental studies using mice also support the link between Mgp heterozygosity and arterial stiffness. These findings suggest a potential role of therapeutic targeting MGP in HFpEF.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juraj Jug, Didi Delalic, Valerija Bralic Lang, Tomislav Bulum, Ingrid Prkacin
Summary: This study aimed to compare the pulse wave velocity (PWV) values in subjects with prediabetes, non-dipper profile, and arterial hypertension with their values in healthy subjects. The results showed that subjects with prediabetes and non-dipping profiles had significantly higher PWV values. Age, blood pressure, nocturnal indices, and fasting plasma glucose were identified as independent predictors of PWV values. These findings highlight the importance of prediabetes and non-dipping hypertension as factors contributing to increased PWV.
Article
Medicine, General & Internal
Junli Zuo, Huijuan Chao, Biwen Tang, Alberto P. Avolio, Markus P. Schlaich, Janis Marc Nolde, Audrey Adji, Revathy Carnagarin
Summary: Females show a higher susceptibility to weight-related arterial stiffening and rise in blood pressure in obesity compared to males. The linear association between arterial stiffness and BMI remains significant in females but not in males, indicating gender differences in the impact of obesity on cardiovascular health. Our results suggest that female gender is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Roman Jurik, Aleksandra Zebrowska, Petr Stastny
Summary: The systematic review examined the impact of resistance training on arterial stiffness, finding that low and moderate intensity resistance training is beneficial in reducing high arterial stiffness to prevent cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Adjani A. Peralta, Diane R. Gold, Mahdieh Danesh Yazdi, Yaguang Wei, Joel Schwartz
Summary: Our study found an association between short-term PM2.5 exposure and markers of arterial stiffness and central hemodynamics.
ENVIRONMENTAL RESEARCH
(2023)
Article
Physiology
Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Hasan Obeid, Nadege Cote, Karine Duval, Remi Goupil, Mohsen Agharazii
Summary: The acute administration of nitroglycerin leads to a significant reduction in pulse wave velocity of muscular arteries without affecting aortic pulse wave velocity. This results in an unfavorable change in the AB-PWV and AF-PWV ratios, potentially increasing pulse pressure transmission into the microcirculation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Review
Peripheral Vascular Disease
Jonathan P. Law, Luke Pickup, Davor Pavlovic, Jonathan N. Townend, Charles J. Ferro
Summary: Chronic kidney disease (CKD) is a complex condition that affects 10-15% of the global population. There is an inverse relationship between kidney function and cardiovascular events and mortality, independent of age, sex, and other risk factors. The development of CKD-associated cardiomyopathy, characterized by left ventricular changes and fibrosis, is significantly influenced by hypertension. Even in mild to moderate renal impairment, structural and functional changes consistent with CKD-associated cardiomyopathy can be observed.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Transplantation
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty among haemodialysis patients is associated with hospitalization and mortality, but further discrimination of risk is needed due to the high prevalence of frailty. This study found that incorporating self-reported health with frailty measurement can help identify the most at-risk frail individuals.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Depression and frailty are common in haemodialysis recipients and are associated with negative outcomes. When taking frailty into account, depression is associated with lower hospitalization rates but poorer quality of life. Frailty is associated with higher admission rates, mortality, and poorer quality of life. The relationship between frailty and depression and their influence on outcomes is complex and requires further study.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Charles J. Ferro, Alberto Ortiz, Maria Jose Soler, Jean-Michel Halimi, Andrzej Januszewicz, Alexandre Persu, Reinhold Kreutz, Pantelis Sarafidis
Summary: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has become a global pandemic since December 2019. The public restrictive measures implemented in different countries have greatly affected people's daily activities. It is important to understand the impact of these measures on hypertension incidence and blood pressure control.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Alexander D. Lalayiannis, Nicola J. Crabtree, Charles J. Ferro, David C. Wheeler, Neill D. Duncan, Colette Smith, Joyce Popoola, Askiti Varvara, Andromachi Mitsioni, Amrit Kaur, Manish D. Sinha, Lorenzo Biassoni, Simon P. McGuirk, Kristian H. Mortensen, David V. Milford, Jin Long, Mary D. Leonard, Mary Fewtrell, Rukshana Shroff
Summary: This multicenter longitudinal study found that while older adults with chronic kidney disease (CKD) may experience increases in bone mineral density (BMD), they can still develop vascular calcification. In contrast, the growing skeleton of children and young adults with CKD may offer protection against extraosseous calcification. These findings suggest that the growing skeleton may have a buffering capacity against non-skeletal calcification.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Review
Endocrinology & Metabolism
Anna K. Forbes, Rebecca J. Suckling, William Hinton, Michael D. Feher, Debasish Banerjee, Nicholas I. Cole, Simon de Lusignan, Pauline A. Swift
Summary: This systematic review of observational studies indicates that SGLT2 inhibitors have significant kidney benefits for a diverse population of adults with type 2 diabetes. The meta-analysis shows that SGLT2 inhibitors are associated with a 46% lower risk of kidney failure events compared to other glucose-lowering drugs, regardless of baseline eGFR or albuminuria status.
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Emma O'Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig, Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaue, Andrea K. Viecelli, Angela Y. Wang, David C. Wheele, David White, Wolfgang C. Winkelmayer, Charles A. Herzog
Summary: Cardiovascular disease is the leading cause of death in hemodialysis patients. However, there is currently no standardized definition of myocardial infarction (MI) for this population. The international working group recommends specific approaches for interpreting ischemic symptoms and performing baseline electrocardiograms to improve the accuracy of MI diagnosis in hemodialysis patients. While baseline cardiac troponin values are not recommended, serial cardiac biomarkers should be obtained when ischemia is suspected.
KIDNEY INTERNATIONAL
(2023)
Review
Transplantation
Patrick B. Mark, Pantelis Sarafidis, Robert Ekart, Charles J. Ferro, Olga Balafa, Beatriz Fernandez-Fernandez, William G. Herrington, Patrick Rossignol, Lucia Del Vecchio, Jose M. Valdivielso, Francesca Mallamaci, Alberto Ortiz, Ionut Nistor, Mario Cozzolino
Summary: Chronic kidney disease (CKD) affects an estimated 850 million people worldwide and the leading causes are diabetes and hypertension. CKD can progress to end-stage kidney disease, requiring kidney replacement therapy. In addition, CKD is a risk factor for cardiovascular disease. Previously, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were the mainstay of treatment, but they did not reduce cardiovascular events and mortality in CKD. However, sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown cardiovascular and renal benefits in clinical trials, revolutionizing cardiorenal protection for patients with diabetes. Recent trials have demonstrated the benefits of SGLT2i in reducing heart failure and progression to kidney failure in patients with CKD and/or heart failure. Specialty societies' guidelines are adapting to support wider use of SGLT2i. The consensus paper from EURECA-m and ERBP summarizes the latest evidence and guidelines for using SGLT2i for cardiorenal protection in CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Sharlene A. Greenwood, Benjamin A. Oliveira, Elham Asgari, Salma Ayis, Luke A. Baker, Nicholas Beckley-Hoelscher, Aicha Goubar, Debasish Banerjee, Sunil Bhandari, Joseph Chilcot, James O. Burton, Philip A. Kalra, Courtney J. Lightfoot, Iain C. Macdougall, Kieran McCafferty, Thomas H. Mercer, Darlington O. Okonko, Chante Reid, Fiona Reid, Alice C. Smith, Pauline A. Swift, Anastasios Mangelis, Emma Watson, David C. Wheeler, Thomas J. Wilkinson, Kate Bramham
Summary: This trial evaluated the effects of iron supplementation on exercise capacity of nonanemic patients with CKD. The results showed that IV iron therapy did not improve exercise capacity at 4 weeks. A larger study is needed to confirm the benefits of IV iron in iron-deficient non-dialysis CKD patients.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study aimed to explore the relationship between frailty scores and cognition, and their associations with hospitalization and mortality. The results showed that increasing frailty by all definitions was associated with poorer cognition. However, cognitive impairment was not directly associated with mortality or hospitalization, but rather correlated with increasing frailty scores.
Article
Cardiac & Cardiovascular Systems
Daniel Murphy, Sami Firoozi, Charles A. Herzog, Debasish Banerjee
Summary: In this study, the relationship between cardiac troponin levels, estimated glomerular filtration rate (eGFR), postinfarction heart failure (HF), and mortality in patients with kidney impairment was investigated. The results showed that peak cardiac troponin T level and eGFR were independent predictors of acute HF severity and death.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Patrick B. Mark, Pantelis Sarafidis, Rajiv Agarwal, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Francesca Mallamaci, Andrzej Wiecek
Summary: Patients with CKD are at high risk of CVD, so it's important to identify and monitor cardiovascular complications and hypertension. Biomarkers like troponins and ECG have limited use in diagnosing cardiac ischemia in these patients. However, techniques like stress echocardiography, myocardial perfusion scintigraphy, and stress testing can help detect coronary disease in patients with CKD.
NATURE REVIEWS NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Jennifer S. Lees, Patrick B. Mark
Summary: Kidney failure is a serious consequence of chronic kidney disease, and a meta-analysis has confirmed the validity and reliability of glomerular filtration rate (GFR) slope as a surrogate marker for kidney failure, despite the varied treatments and disease groups.
NATURE REVIEWS NEPHROLOGY
(2023)
Review
Transplantation
Lucia Del Vecchio, Olga Balafa, Evangelia Dounousi, Robert Ekart, Beatriz Fernandez Fernandez, Patrick B. Mark, Pantelis Sarafidis, Jose M. Valdivielso, Charles J. Ferro, Francesca Mallamaci
Summary: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) complications due to infection with SARS-CoV-2. These complications, including acute inflammatory manifestations, CV events, thrombotic episodes, and arrythmias, can occur during the acute phase of the infection and months after recovery, potentially due to direct viral damage to the myocardium, endothelial damage, and hypercoagulability.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)