Article
Cardiac & Cardiovascular Systems
Daniel Burkhoff, Veli K. Topkara, Gabriel Sayer, Nir Uriel
Summary: This review provides a comprehensive overview of research into LVAD therapy for heart failure, including the hemodynamic effects of LVAD support and the structural, cellular, and molecular aspects of LVAD-associated reverse remodeling. The review also discusses the synergistic effects of LVAD support with heart failure therapies on clinical outcomes and myocardial biology.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sung-Min Cho, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, Leora T. Yarboro
Summary: Comparing two contemporary centrifugal-flow left ventricular assist devices, HM3 is associated with lower hazard of major NAEs compared to HVAD in both early postimplantation period and constant hazard phase.
Review
Cardiac & Cardiovascular Systems
Sunit-Preet Chaudhry, Adam D. DeVore, Himabindu Vidula, Michael Nassif, Karol Mudy, Edo Y. Birati, Timothy Gong, Pavan Atluri, Duc Pham, Benjamin Sun, Aditya Bansal, Samer S. Najjar
Summary: This review provides an overview of durable LVADs, discussing patient selection and the basic principles of LVAD care. It also covers common complications associated with LVAD therapy. The goal is to help general cardiologists recognize potential LVAD candidates and understand the principles of managing LVAD patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, General & Internal
Gregory S. Troutman, Michael Genuardi
Summary: Survival rates for patients with end-stage heart failure continue to improve after implantation of a left ventricular assist device (LVAD). More patients are opting for long-term treatment with LVADs rather than bridge-to-transplant therapy, therefore it is crucial for healthcare providers to be familiar with the physiology, operation, and common complications of these devices. This review article provides an overview of the history, development, and operation of modern LVADs, as well as a discussion of common complications and suggested approaches to LVAD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Taiyo Kuroda, Chihiro Miyagi, Kiyotaka Fukamachi, Jamshid H. Karimov
Summary: Compared to LVAD therapy for advanced heart failure, the options of BVAD and TAH for mechanical circulatory support (MCS) are still challenging.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Nutrition & Dietetics
Gennaro Martucci, Federico Pappalardo, Harikesh Subramanian, Giulia Ingoglia, Elena Conoscenti, Antonio Arcadipane
Summary: Heart failure remains a major global cause of morbidity, hospitalization, and mortality. Advances in LVAD technology offer hope for HF patients, but research and attention to endocrine function are also crucial.
Article
Cardiac & Cardiovascular Systems
George Gill, Georgina Rowe, Qiudong Chen, Jad Malas, Jason Thomas, Achille Peiris, Robert Cole, Joanna Chikwe, Dominick Megna, Dominic Emerson
Summary: This study included 221 patients with cardiogenic shock who received support treatment with Impella 5.0 or 5.5 devices, and the results showed that these two devices provided safe and effective temporary mechanical support in appropriately selected patients. It was also found that the rate of device exchange was lower in Impella 5.5 patients compared to the most recent Impella 5.0 patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Medicine, General & Internal
Mahmoud Abdelshafy, Kadir Caliskan, Goksel Guven, Ahmed Elkoumy, Hagar Elsherbini, Hesham Elzomor, Erhan Tenekecioglu, Sakir Akin, Osama Soliman
Summary: Acute right-sided heart failure is a complex clinical syndrome with a lack of evidence-based literature. Temporary right-ventricular assist device is a potential treatment option. This study found variations in successful t-RVAD weaning rates and 30-day survival rates. The most commonly reported complications include bleeding, acute kidney injury, stroke, and device malfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Senthil Anand, Timothy Barry, Reza Arsanjani, Lisa LeMond
Summary: This article reviews the utility of both TTE and TEE in managing patients with cardiac assist devices.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Ming-Sing Si, Vikram Sood, Reshma Biniwale, David Peng
Summary: Ventricular assist devices have significantly reduced mortality in children with end-stage heart failure awaiting transplant. Valve abnormalities, such as regurgitation, can impact the efficacy of hemodynamic support provided by these devices, so clinicians should carefully assess and repair any valve abnormalities in order to effectively support this diverse population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Ilana Schlam, Andy Y. Lee, Song Li, Farooq H. Sheikh, Raja Zaghlol, Binaya Basyal, Christopher Gallagher, Ezequiel Molina, Claudius Mahr, Richard K. Cheng, Ana Barac
Summary: The study described cancer treatment approaches, complications, and survival among patients with active cancer on LVAD support. Cancer diagnosis was associated with an increased risk of death. Patients with cancer had fewer gastrointestinal bleeding compared with non-cancer comparators.
JACC: CARDIOONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Deepak Acharya, Toshinobu Kazui, Dina Al Rameni, Tushar Acharya, Edward Betterton, Elizabeth Juneman, Renzo Loyaga-Rendon, Kapildeo Lotun, Ranjith Shetty, Arka Chatterjee
Summary: Aortic valve disorders, including pre-existing and de novo aortic insufficiency, can lead to worsened LVAD effectiveness and heart failure symptoms. Severe AI is associated with poor outcomes in LVAD patients. Diagnosis of AI requires echocardiographic, device assessment, and/or catheterization studies, as standard echocardiographic criteria are insufficient. Management includes repair or replacement of the aortic valve at the time of LVAD implantation for pre-existing AI, while de novo AI on LVAD support poses challenges and may require repeat surgical intervention or percutaneous techniques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Douglas D. Franz, Wael F. Hussein, Graham Abra, Charles D. Diskin, Vishal Duggal, Jeffrey J. Teuteberg, Tara Chang, Brigitte Schiller
Summary: This case series study found that approximately half of the patients who underwent outpatient hemodialysis after receiving LVAD either recovered kidney function or underwent combined heart and kidney transplantation. Additionally, the study suggests that outpatient hemodialysis centers, in partnership with LVAD treatment teams, can successfully provide hemodialysis to patients on LVAD support.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
James Farag, Kei Woldendorp, Nicholas McNamara, Paul G. Bannon, Silvana F. Marasco, Antonio Loforte, Evgenij Potapov
Summary: This study reviewed 12 publications and found that the median 30-day survival rate for CF-BiVAD recipients was 90%, while the 12-month survival rate was 58.5%. The median pump thrombosis rate was 31% and pump exchange rate was 9%. The study highlights the need for an on-label CF-BiVAD.
ANNALS OF CARDIOTHORACIC SURGERY
(2021)
Article
Surgery
James J. Whitbread, Katherine A. Giuliano, Eric W. Etchill, Alejandro Suarez-Pierre, Jennifer S. Lawton, Steven Hsu, Kavita Sharma, Chun W. Choi, Robert S. D. Higgins, Ahmet Kilic
Summary: Analysis of heart transplant candidates revealed that while patients with VADs experienced longer inactive periods and an overall increased risk of inactivity, their risk of inactivity due to deteriorating condition was not significantly different from patients without VADs. Furthermore, VAD patients had a smaller proportion of inactive periods attributed to deteriorating conditions, indicating that VADs may provide protective benefits for waitlist patients.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Julie K. K. Vishram-Nielsen, Farid Foroutan, Saima Rizwan, Serena S. Peck, Julia Bodack, Ani Orchanian-Cheff, Finn Gustafsson, Heather J. Ross, Eddy Fan, Vivek Rao, Filio Billia, Ana Carolina Alba
Summary: This study evaluated the short-term mortality and predictive factors in patients with FM supported by VA-ECMO. The results showed a pooled short-term mortality rate of 35%, with younger populations having lower mortality. Factors such as female sex, receiving a biopsy, cardiac arrest, left ventricular unloading, and earlier recruitment time frame did not explain heterogeneity. Various indicators were identified as independent predictors of mortality.
HEART FAILURE REVIEWS
(2023)
Article
Medicine, General & Internal
D. S. Lee, S. E. Straus, M. E. Farkouh, P. C. Austin, M. Taljaard, A. Chong, C. Fahim, S. Poon, P. Cram, S. Smith, R. S. McKelvie, L. Porepa, M. Hartleib, P. Mitoff, R. M. Iwanochko, A. MacDougall, S. Shadowitz, H. Abrams, E. Elbarasi, J. Fang, M. J. Schull, S. Mak, H. J. Ross, J. A. Udell
Summary: The use of a hospital-based strategy to support clinical decision making and rapid follow-up for patients with acute heart failure led to a lower risk of death and hospitalization for cardiovascular causes within 30 days compared to usual care.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Alessandro de Bortoli, David H. Birnie
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Physiology
Elizabeth Karvasarski, Robert F. Bentley, Tayler A. Buchan, Felipe H. Valle, Stephen P. Wright, Isaac S. Chang, John T. Granton, Susanna Mak
Summary: Exercise leads to increased pulmonary vascular afterload, but in healthy individuals, this afterload stabilizes during steady-state exercise. This study aimed to examine how exercise-associated stresses are altered in pre- and post-capillary pulmonary hypertension (PH). The results showed that in pre-capillary PH, the diastolic pressure gradients continued to increase during exercise, while in post-capillary PH, the increase in diastolic pressure gradient was limited. These exercise-specific patterns highlight the differences in pulmonary vascular afterload responses among different PH conditions.
PHYSIOLOGICAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Ana C. Alba, Tayler A. Buchan, Sudipta Saha, Steve Fan, Catherine Demers, Stephanie Poon, Susanna Mak, Abdul Al-Hesayen, Mustafa Toma, Shelley Zieroth, Kim Anderson, Liane Porepa, Sharon Chih, Nadia Giannetti, Valeria Rac, Wayne C. Levy, Heather J. Ross, Gordon H. Guyatt
Summary: Physicians often make errors in estimating patient prognosis in heart failure. A study compared physician predictions to model predictions and found that predictive models had higher accuracy in predicting 1-year mortality.
CIRCULATION-HEART FAILURE
(2023)
Review
Medicine, General & Internal
Marianne Saragosa, Hardeep Singh, Carolyn Steele Gray, Terence Tang, Ani Orchanian-Cheff, Michelle L. A. Nelson
Summary: This scoping review aims to synthesize the empirical literature on the application of eco-mapping in health services research, including characteristics, populations, methodological approaches, and other features. The study will search relevant databases, screen references, and extract and organize data to answer the research questions. The findings will be disseminated through publications, conference presentations, and stakeholder meetings.
Article
Cardiac & Cardiovascular Systems
Eduard Rodenas-Alesina, Fernando Luis Scolari, Vicki N. Wang, Darshan H. Brahmbhatt, Vesna Mihajlovic, Nicole L. Fung, Madison Otsuki, Filio Billia, Christopher B. Overgaard, Adriana Luk
Summary: A study comparing the outcomes of milrinone and dobutamine in patients with acute decompensated heart failure (ADHF-CS) found that milrinone is associated with lower 30 day mortality and improved haemodynamics. These findings suggest that milrinone may be a more effective treatment for ADHF-CS patients.
Review
Cardiac & Cardiovascular Systems
Eman A. Hamad, Mirnela Byku, Sharon B. Larson, Filio Billia
Summary: The management of chronic heart failure has made significant progress in the past decade, particularly in medical optimization and the use of left ventricular assist devices (LVAD) for potential recovery. Myocardial recovery at different levels is crucial for successful LVAD explantation and sustained recovery. Guideline-directed medical therapy and unloading have been shown to aid in the recovery process. This review provides a summary of medical optimization, assessment for recovery, explantation methodologies, and outcomes post-recovery with durable LVAD explantation.
CLINICAL CARDIOLOGY
(2023)
Review
Critical Care Medicine
Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine Poss, Hannah Schaubroeck, Filio Billia, John C. Marshall, Patrick R. Lawler
Summary: Circulatory shock is a syndrome characterized by hypotension and tissue hypoperfusion. Recent evidence suggests the existence of distinct host-response patterns and heterogeneous pathways in circulatory shock. This review discusses the potential implications of these findings for personalized treatment in clinical trials.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Medicine, Research & Experimental
Veera Ganesh Yerra, Sri Nagarjun Batchu, Harmandeep Kaur, Golam Kabir, Youan Liu, Suzanne L. Advani, Duc Tin Tran, Shadi Sadeghian, Phelopater Sedrak, Filio Billia, Uros Kuzmanov, Anthony O. Gramolini, Deema O. Qasrawi, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kim A. Connelly, Andrew Advani
Summary: Inflammation induces an IFN response in cardiomyocytes, leading to upregulation of ISG15 and its posttranslational modification, ISGylation. ISG15 deficiency improves cardiac function and prevents protein accumulation and promotes autophagy in cardiomyocytes. This study highlights the role of ISG15 and ISGylation in adverse ventricular remodeling and suggests their potential contribution to heart failure development.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Respiratory System
Peter Rassam, Eli M. Pazzianotto-Forti, Umi Matsumura, Ani Orchanian-Cheff, Saina Aliabadi, Manjiri Kulkarni, Rachel L. Fat Fur, Antenor Rodrigues, Daniel Langer, Dmitry Rozenberg, W. Darlene Reid
Summary: Cognitive function in COPD is related to balance, hand dexterity, and dual task function, rather than exercise capacity. Cognitive interventions show variable improvements in cognition and exercise capacity in COPD patients.
CHRONIC RESPIRATORY DISEASE
(2023)
Review
Respiratory System
Ronald Chow, Olivia W. So, James H. B. Im, Kenneth R. Chapman, Ani Orchanian-Cheff, Andrea S. Gershon, Robert Wu
Summary: This review examined significant predictors and prediction scores for readmission among patients with chronic obstructive pulmonary disease (COPD). The study identified several factors, including patient characteristics, hospitalization details, investigation results, and discharge characteristics, that were significantly associated with readmission risk.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Lauren K. Truby, Dimitri Maamari, Amit Saha, Maryjane Farr, Jawan Abdulrahim, Filio Billia, Matthias Peltz, Kiran K. Khush, Thomas J. Wang
Summary: This article provides a contemporary review of the current and future opportunities to use omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, in the field of heart transplantation.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
David Dorian, Fernando L. Scolari, Manhal Habib, Darshan H. Brahmbhatt, Cindy Chow, Beata Bruchal-Garbicz, Sara Hoss, Filio Billia, Raymond Chan, Harry Rakowski, Arnon Adler
Summary: There is no association between exercise intensity or duration and phenotypic expression in genotype-positive HCM patients, which is important for physician-patient discussions and supports the recent trend towards more permissive exercise restrictions in HCM.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)