Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD

Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66 Shc

(2018) Sarah Costantino et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy

(2018) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

(2015) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart

(2015) Weitao Cong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure

(2015) Alessandra Dei Cas et al.   JACC-Heart Failure

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

(2014) Sebastian C. Hasenfuss et al.   Cell Metabolism

Lack of Salt-Inducible Kinase 2 (SIK2) Prevents the Development of Cardiac Hypertrophy in Response to Chronic High-Salt Intake

(2014) Sergej Popov et al.   PLoS One

Epigenetic signatures and vascular risk in type 2 diabetes: A clinical perspective

(2013) Francesco Paneni et al.   ATHEROSCLEROSIS

Deletion of the Activated Protein-1 Transcription Factor JunD Induces Oxidative Stress and Accelerates Age-Related Endothelial Dysfunction

(2013) Francesco Paneni et al.   CIRCULATION

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

(2013) P. Mathiyalagan et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function

(2012) Yingmei Zhang et al.   BMC Medicine

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

(2012) Jing Huang et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Jun and JunD-dependent functions in cell proliferation and stress response

(2010) A Meixner et al.   CELL DEATH AND DIFFERENTIATION

Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells

(2010) Kenichiro Koda et al.   CIRCULATION

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Cardiovascular Epigenetics

(2010) Andrea Baccarelli et al.   Circulation-Cardiovascular Genetics

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Regulation of Cardiac Gene Expression by KLF15, a Repressor of Myocardin Activity

(2010) Joost J. Leenders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

(2009) M. Sulaiman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Abnormal Glucose Metabolism in Acute Myocardial Infarction

(2009) Dan E. Høfsten et al.   JACC-Cardiovascular Imaging

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin Signaling

(2008) Gaëlle Laurent et al.   Cell Metabolism

JunD Protects the Liver from Ischemia/Reperfusion Injury by Dampening AP-1 Transcriptional Activation

(2008) Jennifer J. Marden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple facets of junD gene expression are atypical among AP-1 family members

(2008) J M Hernandez et al.   ONCOGENE

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE