Article
Chemistry, Multidisciplinary
Ruifang Gao, Linzhu Su, Tianrong Yu, Jian Liu, Henny C. van der Mei, Yijin Ren, Gaojian Chen, Linqi Shi, Brandon W. Peterson, Henk J. Busscher
Summary: To prevent collateral tissue damage, photothermal nanoparticles were encapsulated in specific shell polymeric micelles, allowing for successful accumulation and eradication in infectious biofilms without observed cytotoxicity. Encapsulated nanoparticles demonstrated faster infection eradication and reduced staphylococcal counts in surrounding tissue in mice, promoting faster wound healing.
Article
Nanoscience & Nanotechnology
Xiaodie Yuan, Xia Zhao, Rui Xia, Zhigang Xie, Yuan Lin, Zhaohui Su
Summary: This study successfully developed a magnetic field-driven and near-infrared-responsive NO delivery system for biofilm treatment. The system achieved a spatial and temporal-controlled release of NO in biofilms, demonstrating a synergistic antibacterial effect and accelerated wound healing process.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Chen-Guang Liu, Chao-Ping Fu, Yu-Hong Shi, Jun Zhong, Han-Xiao Tang, Jian-Ting Zhang, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: The study focuses on utilizing near-infrared light-induced self-propelled nanoparticles for deep tumor penetration and cancer therapy. With a rocket-like structure and pH-responsive degradation, it achieved NIR and pH dual-responsive photothermal-enhanced therapy.
MATERIALS & DESIGN
(2022)
Article
Nanoscience & Nanotechnology
Kaili Yang, Heng Dong, Weijun Xiu, Lihui Yuwen, Yongbin Mou, Zhaowei Yin, Bin Liang, Lianhui Wang
Summary: Multifunctional smart hollow Cu2MoS4 nanospheres (H-CMS NSs) were developed as a self-adaptive approach to eliminate biofilms and regulate macrophage inflammation in implant infections. These nanospheres exhibit enzyme-like activities and can generate reactive oxidative species (ROS) to kill bacteria and modulate macrophage polarization. Under ultrasound (US) irradiation, the antibacterial property and POD-like activity of H-CMS NSs can be further enhanced. After biofilm elimination, the H-CMS NSs exhibit catalase (CAT)-like activity to eliminate excessive ROS and promote tissue healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Meihui Yin, Min Yang, Daoping Yan, Lijiao Yang, Xiaohui Wan, Jipeng Xiao, Yongchao Yao, Jianbin Luo
Summary: In this study, a novel gold-nanorod-based chemo-photothermal-integrated antimicrobial platform was developed, which exhibited surface-charge-switchable and near-infrared-induced size-transformable activities. This platform showed enhanced killing efficiency against multidrug-resistant bacteria and their biofilms, particularly methicillin-resistant Staphylococcus aureus (MRSA) infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Orthopedics
Jemi Ong, Rose Godfrey, Alexa Nazarian, Joshua Tam, Lynn Drake, Brad Isaacson, Paul Pasquina, Dustin Williams
Summary: Biofilm contamination at the skin-implant interface of osseointegrated implants can lead to infection, irritation, and discomfort. Traditional washing methods are inadequate, and this study investigated the potential of antimicrobial blue light (aBL) as a biofilm management option. The results showed that aBL reduced bacterial counts at the interface, indicating its effectiveness in reducing biofilm burden.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hongbo Yu, Xiaomu Xu, Zheng Xie, Xiuhong Huang, Licheng Lin, Yanpeng Jiao, Hong Li
Summary: This study constructed an efficient antibacterial system mediated by near-infrared light using ZnO/Ti3C2Tx nanomaterial. The ZnO/Ti3C2Tx showed excellent photothermal ability and antibacterial performance, as well as good biological safety.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Hongbo Yu, Xiaomu Xu, Zheng Xie, Xiuhong Huang, Licheng Lin, Yanpeng Jiao, Hong Li
Summary: This study constructed an efficient antibacterial system mediated by near-infrared light for synergistic antibacterial and biofilm dissipation. The prepared nanomaterial showed strong photothermal ability and improved antibacterial performance. In vitro cell culture and animal experiments demonstrated its good biological safety. This new type of nanomaterial has the potential to replace traditional antibacterial agents.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Dongchao Qiu, Chuchu Zheng, Youyun Zeng, Lixia Wu, Chen Huang, Ying Ran, Yiqin Ding, Jiayi Shi, Xiaojun Cai, Yihuai Pan
Summary: A synergistic antimicrobial nanoplatform (Pec@PLL-MoS2) based on programmed enzymolysis and photothermal therapy was developed, which effectively eradicated biofilm infections and promoted wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Xiangjun Chen, Rong Guo, Changrong Wang, Keke Li, Xinyu Jiang, Huayu He, Wei Hong
Summary: This study developed a novel pH-sensitive micelle system that can release azithromycin-loaded cationic micelles in acidic biofilm microenvironment, enhancing drug penetration and retention within biofilms. The system showed potential as an anti-biofilm agent by improving drug-bacterium interactions and in vivo therapeutic performance.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Manlin Qi, Xuan Ren, Wen Li, Yue Sun, Xiaolin Sun, Chunyan Li, Siyao Yu, Lin Xu, Yanmin Zhou, Shuyan Song, Biao Dong, Lin Wang
Summary: This study successfully developed a near-infrared light triggered nanoplatform with dual functions of antibacterial and anti-inflammatory effects. It can effectively treat periodontal disease by killing bacteria and dispersing biofilms, as well as inhibiting inflammation through the release of gas molecules. The nanoplatform shows promising therapeutic potential for periodontal diseases and other refractory infections in deep tissues.
Article
Chemistry, Multidisciplinary
Qian Zhou, Tengjiao Wang, Kunpeng Li, Shanyu Zhang, Kun Wang, Weilin Hong, Rongjun Liu, Peng Li
Summary: Biofilm-associated infections (BAI) are a serious threat to public health, and novel therapy based on carbon monoxide (CO) is gaining recognition. However, the low bioavailability of CO has hindered CO therapy, such as inhaled gas treatment. Additionally, the use of CO releasing molecules (CORM) has shown low therapeutic efficacy in BAI. Therefore, improving the efficiency of CO therapy is crucial. In this study, we proposed polymeric CO releasing micelles (pCORM) composed of amphiphilic copolymers that self-assemble and release CO passively in the biofilm microenvironment. Combined with the antibiotic amikacin, pCORM significantly enhanced its bactericidal efficiency against biofilm-encapsulated multidrug-resistant bacteria, offering a promising approach to combat BAI.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Lin-Zhu Su, Yong Liu, Yuan-Feng Li, Ying-Li An, Lin-Qi Shi
Summary: With the rise of multidrug-resistant pathogens, bacterial infections pose an increasing threat to public health. Polymer-based materials have been developed to combat this issue, but challenges remain in translating these systems into clinical use.
CHINESE JOURNAL OF POLYMER SCIENCE
(2021)
Article
Engineering, Biomedical
Huifang Ma, Yizhang Tang, Fan Rong, Kun Wang, Tengjiao Wang, Peng Li
Summary: Due to the protection of extracellular polymeric substances, conventional antimicrobial agents often face challenges in penetrating and accumulating in biofilm. To tackle this issue, researchers developed a surface charge adaptable nitric oxide (NO) nanogenerator for biofilm permeation, retention, and eradication. This nanogenerator consisted of a core-shell structure, with thermo-sensitive NO donor conjugated AuNPs on cationic poly(dopamine-co-glucosamine) nanoparticle (PDG@Au-NO) as the core, and anionic phenylboronic acid-acryloylmorpholine (PBAM) copolymer as the shell. The nanogenerator showed long circulation and good biocompatibility. Upon reaching the acidic biofilm, the nanogenerator's surface charge would switch to positive, allowing for infiltration and accumulation in the deep layers of the biofilm. In addition, the nanogenerator could generate sustained NO to disrupt the biofilm's integrity at physiological temperature, and upon near-infrared (NIR) irradiation, it could generate hyperthermia and explosive NO release to effectively eradicate drug-resistant bacteria biofilm. This rational design provides a promising approach for developing nanosystems against biofilm-associated infections.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yale Yue, Hejia Li, Xinwei Wang, Baohua Zhang, Yao Li, Yiting Liu, Xiaotu Ma, Guangna Liu, Xiao Zhao, Jinjin Shi
Summary: This study proposes an intelligent responsive nanoparticle triggered by near-infrared light, which can have a prolonged blood circulation half-life and improved tumor enrichment, and easily penetrate deep tumor tissues. The results show that this intelligent nanoparticle successfully integrates photothermal therapy and chemotherapy, effectively inhibiting tumor cell growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Jialin Cai, Jianye Yang, Xin Xie, Jie Ding, Leyan Liu, Wanyu Tian, Yushan Liu, Zhiyong Tang, Baozhong Liu, Siyu Lu
Summary: This study reports a cross-linked porous carbon-doped MoO2 (C-MoO2)-based catalyst for electrochemical hydrogen evolution reaction (HER). The presence of carbon atoms in C-MoO2 adjusts its electronic structure, and the loaded small Ru nanoparticles provide fast water dissociation rate and moderate H adsorption strength. The Ru/C-MoO2 catalyst exhibits low overpotential and excellent stability in a pH-universal environment.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ling Bai, Shijie Jia, Yidan Gao, Chuan Li, Xin Chen, Shuang Zhou, Junwen Han, Fengchun Yang, Xin Zhang, Siyu Lu
Summary: Under visible light illumination, the p-n WO3/SnSe2 heterojunction significantly activates the oxygen evolution reaction (OER) catalysis of CoFe-layered double hydroxide (CF)/carbon nanotubes (CNTs), achieving a low overpotential of 224 mV at 10 mA cm(-2) and a small Tafel slope of 47 mV dec(-1), surpassing RuO2 and most previously reported transition metal-based OER catalysts. The p-n WS heterojunction exhibits strong light absorption and produces photogenerated carriers, with the photogenerated holes trapped by CF to suppress charge recombination and facilitate charge transfer, accelerating OER kinetics and enhancing the OER activity. This study highlights the possibility of using heterojunctions to activate OER catalysis and advances the design of energy-efficient catalysts for water oxidation systems using solar energy.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yongqiang Zhang, Manyu Li, Siyu Lu
Summary: A universal method has been developed to prepare long-lived multicolored phosphorescent carbon dot-based composites without the need for heavy metal doping. The CDs are encapsulated in silica, which undergoes a high-temperature calcination process, resulting in blue, green, yellow, and red phosphorescence. The CD-based composites show promising applications in 3D multichannel information storage and encryption.
Article
Materials Science, Multidisciplinary
Nan Wang, Rui Sun, Wen Xu, Xue Bai, Junhua Hu, Siyu Lu, Donglei Zhou, Hongwei Song
Summary: Doping with Sb3+ greatly improves the PLQY of Mn2+ emission in CsPbCl3 NCs. LEDs based on CsPbCl3:Mn2+, Sb3+ NCs achieve improved EQE and luminance.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Multidisciplinary
Lu Zi, Wen Xu, Zhijiang Song, Rui Sun, Sen Liu, Tianyu Xie, Jinyang Zhu, Siyu Lu, Hongwei Song
Summary: We developed a facile solvothermal method to incorporate various metal ions into double perovskite microcrystals, significantly boosting the photoluminescence quantum yield. The doped crystals exhibited high stability, brightness, and excellent color performance, making them suitable for solid-state lighting applications.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Yuanqing Sun, Jiaqing Luo, Manxue Zhang, Jun Li, Jingkun Yu, Siyu Lu, Weiyu Song, Yuechang Wei, Zhenxing Li, Jian Liu
Summary: In this study, an inducing electron delocalization method with Fe single atoms as inducers was used to regulate the electron structure of Au nanoclusters, leading to satisfactory intrinsic HER activity. The hybrid catalyst Au-Fe1NC/NF exhibited outstanding alkaline HER and OER activities due to the strong synergistic effect between Au nanoclusters and Fe single atoms.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Wenhui Wang, Yongteng Zhang, Zeshu Wang, Xueping Liu, Siyu Lu, Xianglong Hu
Summary: A drug-free macromolecular therapeutic was designed to target both endoplasmic reticulum (ER) and mitochondria, inducing ER stress and mitochondrial dysfunction to promote cancer cell death. In vitro experiments showed that the designed nanoparticles effectively entered ER and mitochondria, increasing expression of ER stress-related proteins and inducing oxidative stress in mitochondria. This strategy provides a potential approach for cancer theranostics in precision nanomedicine.
Article
Chemistry, Multidisciplinary
Zhixiong Wang, Albert Jin, Zhen Yang, Wei Huang
Summary: Nitric oxide (NO) is a gaseous transmitter that regulates various important functions in the human body. Delivering NO for therapeutic purposes is challenging, but recent advancements in biotechnology and nanomedicine have shown promising results in improving its efficacy and reducing side effects. This review highlights the potential of NO nanomedicines in treating infectious diseases and provides insights into their design strategies and applications.
Article
Chemistry, Multidisciplinary
Lin Ai, Yifei Pei, Ziqi Song, Xue Yong, Haoqiang Song, Gongjie Liu, Mingjun Nie, Geoffrey I. N. Waterhouse, Xiaobing Yan, Siyu Lu
Summary: Flexible carbon dot ribbons with excellent optical, electrical and semiconducting properties have been synthesized through efficient packing of individual carbon dots. These ribbons show outstanding stability and fast optoelectronic responses, making them ideal active layer materials for transparent flexible memristors with rapid Chinese character learning capability. This work lays the foundation for wearable artificial intelligence.
Article
Immunology
Nicholas J. MacDonald, Kavita Singh, Karine Reiter, Nguyen Vu, Richard Shimp, Apostolos G. Gittis, Beth Chen, Martin Burkhardt, Baoshan Zhang, Zhixiong Wang, Raul Herrera, Mackenzie Moler, Duck-Yeon Lee, Sachy Orr-Gonzalez, Jessica Herrod, Lynn E. Lambert, Kelly M. Rausch, Olga Muratova, David S. Jones, Yimin Wu, Albert J. Jin, David N. Garboczi, Patrick E. Duffy, David L. Narum
Summary: The development of a malaria vaccine that can block transmission of the parasite from mosquitoes to humans is crucial for malaria elimination efforts. The use of Pfs25, a protein on the surface of the parasite, is being investigated as a transmission-blocking vaccine. Two recombinant forms of Pfs25, Pfs25H and Pfs25M, have been studied for their structural and immunological differences.
Review
Chemistry, Physical
Huimin Wang, Jingjing Huang, Jinmeng Cai, Yingying Wei, Ang Cao, Baozhong Liu, Siyu Lu
Summary: With the development of industrial and agricultural activities, the excessive production of nitrate has become a serious environmental and public health concern. Among various nitrate treatment techniques, electrochemical nitrate reduction reaction (eNRR) has gained significant attention due to its mild conditions and pollution-free nature. However, understanding the eNRR mechanism requires the use of in situ and operando techniques to study the reaction process at a time-resolved and atomic level.
Article
Materials Science, Multidisciplinary
Tengfei Liu, Guangchao Yin, Ziqi Song, Jingkun Yu, Xue Yong, Baowei Zhang, Lin Ai, Siyu Lu
Summary: In this study, four chlorosalicylaldehyde-functionalized carbon dots (CDs) with solid-state fluorescence were prepared via molecular self-assembly. The CDs emitted light at wavelengths ranging from 456 to 584 nm, covering the blue to yellow range. The position of the chlorine atom on the aromatic core of chlorosalicylaldehyde affected the conjugation and molecular orbital energy levels of the CDs, resulting in the observed emission. The self-assembly process exhibited isomeric effects and the multicolor luminescence of the CDs makes them potentially useful in light-emitting diodes and fingerprint detection.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yuanjun Ma, Lilan Wu, Xueyan Ren, Yongqiang Zhang, Siyu Lu
Summary: Large-scale production of full-color carbon dots (CDs) is achieved at room temperature and atmospheric pressure, using o-phenylenediamine as a carbon source and hydrogen peroxide as an oxidant. The obtained kilogram-scale CDs exhibit blue, green, and red fluorescence with high quantum yields. A reasonable formation mechanism is proposed based on chemical structural characterizations. High-quality multi-color and white light-emitting diodes are successfully fabricated, demonstrating potential commercial applications in display and illumination.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Haolin Wang, Lin Ai, Ziqi Song, Mingjun Nie, Jiping Xiao, Guoping Li, Siyu Lu
Summary: This paper reviews the surface modification strategies of carbon dots (CDs) to improve their photophysical and photochemical properties by overcoming the uniformity of surface functional groups and lack of diversity in active sites. Functionalizing CDs using covalent or non-covalent modification can give them unique properties and broaden their applicability.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Shuwen Zhou, Huijuan Cai, Xinjuan He, Zhiyong Tang, Siyu Lu
Summary: This review summarizes the design, classification, and biological applications of antioxidant nanomaterials, including the design strategies for regulating antioxidant activity, different types of antioxidant nanomaterials based on enzymatic properties and scavenged ROS, and the representative biological applications in therapeutics, protection, and other ROS-related applications.
COORDINATION CHEMISTRY REVIEWS
(2024)