Elimination of spiral waves in a one-layer and two-layer network of pancreatic beta cells using a periodic stimuli

Regulating the glucose level in human body is achieved through the Pancreatic beta cells and the glucose release is mainly governed by the bursting activity of the beta cells. The Pernarowski model is one of the well known Pancreatic model and is analogous to some of the well known neuron models. The Pernarowski model exhibits chaotic spiking and periodic bursting. In this paper we investigate the dynamical properties of the model through various tools like stability of equilibrium, Hopf's bifurcation, Lyapunov exponents and bifurcation diagrams. As was discussed in literatures the neuron models exhibit spiral waves and so we are interested in understanding such spiral wave generation in the Pernarowski model. For this we construct One-layer and Two-layer network of beta cells and study the impact of the plane waves on the spiral wave existence. We show that by a selection of the amplitude and frequency of the stimuli, we can eliminate the spiral waves in the both One-layer and Two-layer network of beta cells. (C) 2020 Elsevier Ltd. All rights reserved.