Article
Multidisciplinary Sciences
John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, Andrei Tarasov, Frances M. Ashcroft, Philip J. S. Stork, Richard H. Goodman
Summary: Cellular metabolism is regulated to ensure efficient energy production and consumption. Fluorescent biosensors enable real-time detection of metabolite abundance with single-cell resolution. Researchers have developed a new biosensor called HYlight, which can reliably report the dynamics of glycolysis in living cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yuyi Liu, Zhengfu Feng, Pingmei Zhang, Honghao Chen, Song Zhu, Xin Wang
Summary: Aerobic glycolysis, with its abnormal activity in tumor cells, is likely involved in regulating chemoresistance and radiation therapy resistance in malignant tumors. However, research on its functions and mechanisms in the molecular mechanisms of resistance to radiotherapy in malignant tumors is still at an early stage. This review collects recent studies on the effects of aerobic glycolysis and radiation therapy resistance in malignant tumors, aiming to further understand the progress in this area.
Article
Cell Biology
Yunfei Liao, Zaili Luo, Yifeng Lin, Huiyao Chen, Tong Chen, Lingli Xu, Sean Orgurek, Kalen Berry, Monika Dzieciatkowska, Julie A. Reisz, Angelo D'Alessandro, Wenhao Zhou, Q. Richard Lu
Summary: PRMT3 is highly enriched in both GBM and low-grade gliomas, and its over-expression predicts poorer overall survival rate. Knockdown of PRMT3 inhibits the proliferation and migration of GBM cell lines and patient-derived glioblastoma stem cells (GSC), while its over-expression promotes GSC growth by promoting cell cycle progression. PRMT3 promotes GSC growth by increasing glycolysis and the transcriptional regulator HIF1 alpha. Inhibition of PRMT3 impairs the growth of GBM cells.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Chuncha Bao, Siyi Zhu, Kangping Song, Chengqi He
Summary: This review explores the role and mechanism of glucose metabolism, specifically focusing on the involvement of hexokinase 2 (HK2), in the pathogenesis of osteoarthritis (OA). Studies have shown that aerobic glycolysis plays a crucial role in OA, and HK2 is considered a key regulator of glucose metabolism. The elevated expression of HK2 in OA synovial tissue suggests its potential therapeutic effect in managing OA.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Adriana Fernanda K. Vizuete, Fernanda Froes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, Andre Quincozes-Santos, Carlos Alberto Goncalves
Summary: Neuroinflammation, characterized by glial cell activation, plays a crucial role in the pathogenesis of neurological disorders and neurodegenerative diseases. This study investigates the effects of lipopolysaccharide-induced neuroinflammation on neurometabolic reprogramming and the glycolytic pathway. The findings suggest that interfering with neurometabolism may be a promising strategy for downregulating neuroinflammation and reducing negative neurological outcomes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Yannan Zhang, Fangfang Zheng, Fan Wang, Xingqian Liu, Cong Xiang, Shiyu Fu, Kun Shen, Geng Liu
Summary: Altered glycolytic pathways have contrasting effects on the development of pancreatic ductal tumors depending on the tumor stage. Overexpression of PFKFB3-HK2-GLUT1 accelerates tumor progression, while overexpression of LDHA-PDK1 slows down tumor progression.
Article
Endocrinology & Metabolism
Jiaping Zheng, Yunzhen Xie, Lingjia Ren, Liqin Qi, Li Wu, Xiaodong Pan, Jianxing Zhou, Zhou Chen, Libin Liu
Summary: The study demonstrated that GLP-1 can improve cognition in Alzheimer's disease by enhancing aerobic glycolysis, reducing oxidative phosphorylation levels, and oxidative stress. GLP-1 also alleviated glycolysis declines in astrocytes and promoted neuronal support through activation of the PI3K/Akt pathway.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kathrin Koedderitzsch, Ekaterina Zezina, Lingzi Li, Matthias Herrmann, Nadine Biesemann
Summary: The study revealed a direct role of TNF in the glycolytic reprogramming of FLS, confirming the potency of immunometabolism in RA. TNF stimulation was shown to enhance glycolysis, reduce GLUT1 and GAPDH levels, which may be linked to treatment response in patients.
SCIENTIFIC REPORTS
(2021)
Article
Neuroimaging
Akifumi Hagiwara, Jingwen Yao, Catalina Raymond, Nicholas S. Cho, Richard Everson, Kunal Patel, Danielle H. Morrow, Brandon R. Desousa, Sergey Mareninov, Saewon Chun, David A. Nathanson, William H. Yong, Gafita Andrei, Ajit S. Divakaruni, Noriko Salamon, Whitney B. Pope, Phioanh L. Nghiemphu, Linda M. Liau, Timothy F. Cloughesy, Benjamin M. Ellingson
Summary: The study quantified abnormal metabolism of diffuse gliomas using aerobic glycolytic imaging, finding significantly lower aerobic glycolytic index (AGI) in IDH mutant gliomas than wild-type, and strong correlations between AGI and glucose metabolism and key glycolytic protein expression.
NEUROIMAGE-CLINICAL
(2021)
Article
Gastroenterology & Hepatology
Qianhui Dou, Aaron K. Grant, Cody Callahan, Patricia Coutinho de Souza, David Mwin, Adam L. Booth, Imad Nasser, Marwan Moussa, Muneeb Ahmed, Leo L. Tsai
Summary: This study investigated the glycolytic regulation factors in hepatocellular carcinoma (HCC) and explored their potential therapeutic targets. The results showed that inhibiting PFKFB3 can prevent glycolytic-mediated HCC proliferation, which can be monitored by in vivo h13C MRI.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Food Science & Technology
Aihong Liang, Lan'e Huang, Huiqing Liu, Weiguo He, Xiaocan Lei, Meixiang Li, Suyun Li, Hongxing Liang, Gang Chen, Jinru Tang, Fengyu Chen, Xiting Cao, Yiyao Wang, Xiaobu Shen, Xi Chen
Summary: This study discovered that resveratrol can protect the ovaries of PCOS rats by restoring glycolytic activity, providing potential therapeutic targets for the treatment of PCOS.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Yi Chen, Lei Yang, Ning Liu, Qiancheng Shi, Xiaoqin Yin, Xiaodong Han, Weidong Gan, Dongmei Li
Summary: The study revealed that HIF1A is a target gene of NONO-TFE3 fusion, promoting aerobic glycolysis and angiogenesis in NONO-TFE3 tRCC under hypoxia. Inhibition of HIF-1 alpha using PX-478 suppressed the progression of NONO-TFE3 tRCC under hypoxia, suggesting HIF-1 alpha as a potential therapeutic target for this type of cancer.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Gastroenterology & Hepatology
Chang Li, Yuning Zhou, Ruozheng Wei, Dana L. Napier, Tomoko Sengoku, Michael C. Alstott, Jinpeng Liu, Chi Wang, Yekaterina Y. Zaytseva, Heidi L. Weiss, Qingding Wang, B. Mark Evers
Summary: Our findings indicate that glycolytic activity is essential for maintaining the self-renewal of intestinal stem cells (ISCs), and inhibiting glycolysis contributes to the differentiation of secretory lineages from ISCs. The dysregulation of glycolysis in ISCs disrupts the balance between self-renewal and differentiation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Lei Zhao, Qiong Wu, Xiaoli Wang, Shiqi Wang, Xiaoguang Shi, Zhongyan Shan, Weiping Teng
Summary: Hashimoto's thyroiditis patients have increased metabolism activity in CD4+ T cells, activating the mTOR/HIF-1α/HK2/glycolysis pathway. Treatment with 2DG and metformin can reduce this pathway activation, restoring the balance of CD4+ T cell differentiation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Patricia Mingo-Casas, Ana-Belen Blazquez, Marta Gomez de Cedron, Ana San-Felix, Susana Molina, Estela Escribano-Romero, Eva Calvo-Pinilla, Nereida Jimenez de Oya, Ana Ramirez de Molina, Juan-Carlos Saiz, Maria-Jesus Perez-Perez, Miguel A. Martin-Acebes
Summary: This study reveals that West Nile virus (WNV) infection leads to a misbalance of glucose homeostasis in the central nervous system, resulting in the upregulation of aerobic glycolysis and a reduction of mitochondrial oxidative phosphorylation. Transcriptomics analyses in infected mice indicate the upregulation of hexokinases 2 and 3 (Hk2 and Hk3), as well as pyruvate dehydrogenase kinase 4 (Pdk4), suggesting the importance of glycolysis in WNV infection. Inhibitors targeting glycolysis alleviate WNV-induced neuroinflammation, demonstrating the potential druggability of the glycolytic pathway for developing therapies against WNV pathology.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell Biology
Xiao Yang, Yanshuang Zhang, Keyi Geng, Ke Yang, Jiaxiang Shao, Weiliang Xia
Summary: Sirt3 plays a protective role in ischemic stroke by regulating VEGF expression, protecting neuronal cells and the blood-brain barrier, and combating inflammatory responses.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shaowei Xie, Wenshe Sun, Chunfu Zhang, Baijun Dong, Jingxing Yang, Mengfei Hou, Liqin Xiong, Biao Cai, Xuesong Liu, Wei Xue
Summary: The flexible manipulation of cancer cell fate through exogenous stimulation-induced metabolic reprogramming can effectively handle therapy resistance and sensitize tumors to ferroptosis. The proposed heat-triggered tumor-specific ferroptosis strategy utilizing nanoformulation showed promising antitumor effects by inducing oxidative damage and targeting key pro-ferroptotic factors. This work provides insights and strategies for heat-triggered ferroptosis in situ, offering a potential alternative to direct ferroptosis inducers with reduced side effects.
Article
Nanoscience & Nanotechnology
Biao Cai, Mengfei Hou, Shijun Zhang, Zhixiang Xin, Jiwei Huang, Jingxing Yang, Yueming Wang, Xingyun Cai, Shaowei Xie, Chunfu Zhang, Yiran Huang
Summary: The study utilized a phase change material to encapsulate iron oxide nanoparticles and a UPR modulator for enhanced cancer therapy. The theranostic platform showed excellent tumor-targeting properties and effective photothermal-enhanced tumor inhibition both in vitro and in vivo. By inducing ER stress and apoptosis in cancer cells through redox imbalance, the strategy offers novel directions for treating therapy-resistant cancers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yi-Cheng Zhu, Biao Cai, Quan Jiang, Yuan Zhang, Jianjun Sha, Shaowei Xie
Summary: The study developed an interdigitated spiral-based MXene-assisted organic electrochemical transistor biosensor for highly sensitive determination of fPSA/tPSA, demonstrating potential applications in clinical settings.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Immunology
Yuting Wang, Xiaomin Niu, Yirui Cheng, Yanshuang Zhang, Liliang Xia, Weiliang Xia, Shun Lu
Summary: This study found that exosomal PD-L1 is associated with the clinical response to immunotherapy in NSCLC patients and can be used as a biomarker to predict the efficacy of ICIs. NSCLC patients with lower expression level of exosomal PD-L1 at pre-treatment or higher max fold increasing change at 3-6 weeks had higher disease control rate and longer progression-free survival.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha
Summary: This study identifies a mechanism that regulates the expression of a specific protein and gene variant, which is associated with the progression of castration-resistant prostate cancer. This finding may provide a new therapeutic target for treating this disease.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Yanshuang Zhang, Tingyu Wu, Fan Li, Yirui Cheng, Qing Han, Xin Lu, Shun Lu, Weiliang Xia
Summary: This study reveals the oncogenic role of FGF19 in LUSC and uncovers a novel mechanism of coamplification of neighboring genes in promoting cancer growth. FGF19 and CCND1 act together to promote cell proliferation in LUSC through activating signaling pathways and regulating the cell cycle progression. Combined inhibition against FGF19 and CCND1 is more effective than single agent treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Deli Zhuge, Mengchun Chen, Xuewei Yang, Xufei Zhang, Lulu Yao, Li Li, Haonan Wang, Hao Chen, Qingqing Yin, Dongyan Tian, Cuiye Weng, Shuangshuang Liu, Pengpeng Xue, Yijing Lin, Yiruo Sun, Zhuoying Huang, Cen Jie-Nuo Ye, Lan Shen, Jooyoung Huh, Weiliang Xia, Yingzheng Zhao, Yijie Chen
Summary: This study developed a smart targeted nanoformulation that can specifically deliver phototherapeutic agents to MRSA infection sites and effectively kill bacteria through near-infrared irradiation. Additionally, the nanoformulation can promote multiantigenic immunity to prevent secondary MRSA infections.
Article
Cell Biology
Min Lu, Kaixuan Wang, Wenxiang Ji, Yongfeng Yu, Ziming Li, Weiliang Xia, Shun Lu
Summary: FGFR1 activation is positively correlated with PD-L1 transcription in lung squamous cell carcinoma. FGFR1 upregulates PD-L1 expression through YAP, while FGFR1 knockdown decreases tumor growth, reduces immune escape, and induces reactivation of CD8+ T cells. The combination of FGFR1 knockdown and PD-1 blockade synergistically exerts antitumor effects.
CELLULAR IMMUNOLOGY
(2022)
Article
Cell Biology
Yirui Cheng, Xin Lu, Fan Li, Zhuo Chen, Yanshuang Zhang, Qing Han, Qingyu Zeng, Tingyu Wu, Ziming Li, Shun Lu, Cecilia Williams, Weiliang Xia
Summary: NDFIP1 has been identified as a tumor suppressor in multiple solid tumors, but its role in NSCLC and the mechanism involved are still unclear. This study found that NDFIP1 is downregulated in NSCLC samples and cell lines, which is associated with poor overall survival. Moreover, NDFIP1 interacts with TAZ and is required for the loading of TAZ into exosomes. Knockout of NDFIP1 leads to TAZ accumulation and altered cellular TAZ levels through exosome secretion. NDFIP1 also suppresses proliferation in NSCLC, and silencing TAZ reverses the increase in proliferation caused by NDFIP1 knockout. These findings highlight the tumor-suppressive role of NDFIP1 and the exosome-mediated regulation of TAZ in NSCLC.
Article
Oncology
Yanshuang Zhang, Tingyu Wu, Yuting Wang, Zhuo Chen, Jiachen Chen, Shun Lu, Weiliang Xia
Summary: In this study, the researchers discovered a signaling interaction between FGF19 and GLI2 that plays a crucial role in the invasion and metastasis of metastatic lung squamous cell carcinoma (LUSC). They found that FGF19 and GLI2 form a positive feedback loop to promote LUSC cell invasion and metastasis, and intervening with this loop may be a strategy for treating FGF19-driven LUSC metastasis.
Meeting Abstract
Oncology
Qing Han, Qian Reuben Xie, Fan Li, Yirui Cheng, Tingyu Wu, Jianjun Sha, Weiliang Xia
Article
Medicine, Research & Experimental
Qing Han, Qian Rueben Xie, Fan Li, Yirui Cheng, Tingyu Wu, Yanshuang Zhang, Xin Lu, Alice S. T. Wong, Jianjun Sha, Weiliang Xia
Summary: SIRT6 expression is positively correlated with prostate cancer progression, and its loss significantly suppresses proliferation and metastasis of prostate cancer cells. Delivery of siRNA through engineered exosomes can effectively inhibit SIRT6 and consequently inhibit tumor growth and metastasis.