Article
Biochemistry & Molecular Biology
Virginia Casas-Arrojo, Juan Decara, Maria de los Angeles Arrojo-Agudo, Claudia Perez-Manriquez, Roberto T. Abdala-Diaz
Summary: Porphyridium cruentum's sulfated polysaccharides exhibit strong immunomodulatory and cytotoxic effects, inducing IL-6 cytokines and TNF-alpha. They show potential as a valuable ingredient in nutraceutical products.
Article
Food Science & Technology
Liangnan Cui, Lei Chen, Guang Yang, Yakun Li, Zhonghui Qiao, Ying Liu, Yue Meng, Yifa Zhou, Lin Sun
Summary: WGFPN is a heterogalactan with a molecular weight of 11.0 kDa, characterized by a less branched (1->4)-α-D-galactan and a significantly branched (1->6)-α-D-galactan. It has potential immunomodulatory effects both in vitro and in vivo.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Yang Yang, Jihong Li, Qing Hong, Xuehong Zhang, Zhenmin Liu, Tiehua Zhang
Summary: Five fractions of polysaccharides from Hericium erinaceus were obtained through column chromatography, with HEP-1 showing significant immunostimulatory effects by promoting the production of various immune-related molecules via multiple signaling pathways.
Article
Chemistry, Applied
Shiqiang Wang, Gang Li, Xinfei Zhang, Yuqian Wang, Yi Qiang, Bulei Wang, Jiabin Zou, Junfeng Niu, Zhezhi Wang
Summary: Polysaccharides obtained from Polygonatum sibiricum (PSP) were purified and characterized in this study. The PSP1 sample had the highest content and best solubility. The main sugar residue linkages were identified as 1)-beta-D-Fruf-(2 -> 1)-beta-D-Fruf-(2 -> 1), 1 -> -beta-D-Fruf-(2 -> 6)alpha-D-Glcp (1 ->,-> 4)-beta-D-Manp-(1 -> 4)-beta-D-Manp-(1 -> and -> 6)-beta-D-Glcp-(1 -> 4)-beta-D-Manp-(1 ->. Branch chain analysis revealed the presence of -> 1,6)-beta-D-Fruf-(2 ->, beta-D-Fruf-(2 ->,-> 1,6)-beta-D-Fruf-(2 ->,-> 6)-beta-D-Fruf(2 -> linkages, with the link site at position C-6. In vitro antioxidant activity tests showed that PSP1 had scavenging effects on DPPH, hydroxyl radical, superoxide anion radical, and exhibited a specific chelating ability for ferrous ions. These findings suggest that P. sibiricum polysaccharides may possess potential antioxidant properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Xue-Lian Jiang, Gai-Fan Ma, Bin-Bin Zhao, Yan Meng, Lin-Lin Chen
Summary: A novel homogeneous polysaccharide (PNPB1) was isolated from Panax notoginseng with the molecular weight of 9.3 x 10(5) Da. PNPB1 significantly enhanced the immune function in mice, including increased body weight, improved thymus and spleen indices, increased white blood cells count, enhanced lymphocyte proliferation, NO and cytokine production, as well as improved phagocytosis and TLR2 expression of macrophages.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Shaza M. Elhusseiny, Taghrid S. El-Mahdy, Nooran S. Elleboudy, Mohamed M. S. Farag, Khaled M. Aboshanab, Mahmoud A. Yassien
Summary: This study investigated the immunomodulatory activity of five common edible mushrooms in rats. The results showed that the mushroom extracts significantly enhanced the immune system with increased white blood cells, lymphocytes, lysozyme activity, NO concentration, and cytokines.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Zongping Zhu, Jiao Chen, Yi Chen, Yuntong Ma, Qingsong Yang, Yunqiu Fan, Chaomei Fu, Boonjai Limsila, Rui Li, Wan Liao
Summary: This study focused on the extraction, structure, and antioxidant activity of turmeric polysaccharides (TPs). Different polysaccharide fractions were purified and analyzed, with TPs-2 exhibiting the strongest antioxidant effects. Overall, the results indicated that TPs have great potential as natural antioxidants in functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhang, Narsimha Reddy, Cheang Soo Khoo, Sundar Rao Koyyalamudi
Summary: “Artemisia annua L. polysaccharides (AAPs) have shown antioxidant and immunostimulatory activities, with AAP-1 exhibiting the highest potential. These polysaccharides can be potential candidates for immunotherapy and cancer treatment.”
Article
Biochemistry & Molecular Biology
Xue-Xia Liu, Ling-Biao Gu, Guang-Jie Zhang, Hua-Min Liu, Ya-Ting Zhang, Kun-Peng Zhang
Summary: This study investigated the cellulase-assisted extraction of Chinese yam polysaccharides and determined the optimal conditions. Three polysaccharide fractions were purified and analyzed, with CYP3 showing the strongest antioxidant activity. Methylation and NMR analysis were used to elucidate the detailed structure of CYP3. The results suggest that CYP3 could be utilized as an antioxidant in food processing, pharmaceuticals, and other applications.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Peng Bai, Hui-Ming Zhou, Ke-Rui Zhu, Qin Li
Summary: The present study aimed to investigate the influence of thermal processing on the water-soluble polysaccharides in chickpeas. It was found that thermal processing caused cell wall breakage and increased the extraction rate of polysaccharides. However, it also led to a decrease in branching degree and molecular weights, as well as changes in the structure and thermal stability of polysaccharides. Interestingly, thermal processing enhanced the antioxidant activities of the polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Libo Wang, Lianyu Li, Jingyu Gao, Jing Huang, Yu Yang, Yaqin Xu, Shuang Liu, Wenqing Yu
Summary: The polysaccharide (DRP) extracted from dandelion roots was selenylated to produce sDRP-1 and sDRP-2, which showed enhanced antioxidant activities and immune modulation effects, indicating their potential as novel immunoenhancers. This study provides valuable insights into the application of dandelion polysaccharides and the utilization of dandelion resources.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
UnHak Pak, Hao Cheng, Xianbin Liu, Yuwen Wang, ChungHyok Ho, HyonIl Ri, Jing Xu, Xiaodan Qi, Haitao Yu
Summary: In this study, we isolated and characterized a pectic polysaccharide, WSMP-A2b, from Swertia mileensis. WSMP-A2b is mainly composed of RG-I, RG-II, and HG domains, with a mass ratio of 2.1:1.0:2.2. WSMP-A2b exhibited strong antioxidant activity, potentially attributed to its high galacturonic acid content. Moreover, WSMP-A2b showed protective effects against oxidative stress in INS-1 cells by reducing ROS production and increasing the GSH/GSSG ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Shuhui Wang, Yujie Yang, Qun Wang, Zhiqin Wu, Xiaojuan Liu, Shuxi Chen, Aimei Zhou
Summary: FCP-2-1, a water-soluble polysaccharide rich in galacturonic acid, was extracted from finger citron and purified. Its structure and immunomodulatory activity were investigated. FCP-2-1 mainly consisted of galacturonic acid, galactose, and arabinose, and its main linkage types were determined to be & RARR;5)-& alpha;-L-Araf-(1 & RARR; and & RARR;4)-& alpha;-D-GalpA-(1 & RARR;. FCP-2-1 showed significant immunomodulatory effects on macrophages in vitro, improving cell viability, enhancing phagocytic activity, and increasing secretion of NO and cytokines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jinglei Li, Haishan Wu, Yuting Liu, Jian Nan, Hyun Jin Park, Yanping Chen, Liu Yang
Summary: The chemical structure and immunomodulatory ability of extracellular polysaccharide MEP 2a from Morchella esculenta were investigated, providing a basis for further research and potential applications.
Article
Food Science & Technology
Guoyong Yu, Jing Zhao, Yunlu Wei, Linlin Huang, Fei Li, Yu Zhang, Quanhong Li
Summary: In this study, subcritical water (SCW) was used to modify pumpkin polysaccharides, leading to changes in rheological and emulsifying properties. Different treatment temperatures resulted in variations in molecular weight distribution and enhanced antioxidant activity. The results demonstrate that SCW treatment is an effective method for improving solution properties and antioxidant activity of pumpkin polysaccharides.
Article
Chemistry, Applied
Zhou Dong, Yanyin Lin, Hui Wu, Mengmeng Zhang
Summary: This study successfully enriched selenium in Tenebrio molitor larvae, increasing the total selenium content and discovering the presence of organic selenium. Selenium was unevenly distributed in protein fractions, and the protein hydrolysate of selenium-enriched larvae exhibited strong antioxidant and immunoregulatory activities after hydrolysis.
Article
Biotechnology & Applied Microbiology
Lisha Hao, Mengmeng Zhang, Xiaofeng Li, Xuan Xin, Faling Lei, Xueneng Lai, Guanglei Zhao, Hui Wu
Summary: Esculin, a polyphenol with poor lipophilicity, was successfully acylated using a whole-cell catalytic strategy to improve its properties. Various esculin esters with different fatty chain lengths were synthesized, with some exhibiting cytotoxicity on cells. This study offers insight into the potential applications of esculin esters as food additives or drugs.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Qiping Zhan, Qian Wang, Qi Liu, Yifang Guo, Fan Gong, Lihua Hao, Hui Wu, Zhou Dong
Summary: This study investigated the changes in antioxidant capacities of protein fractions from Sacha inchi seeds during simulated gastrointestinal digestion, showing that the digestion process increased their antioxidant activity, especially the glutelin fraction. This highlights the potential application of glutelin hydrolysates as natural antioxidant supplements to prevent non-communicable diseases.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Mengmeng Zhang, Xuan Xin, Hui Wu, Hong Zhang
Summary: Proteases extracted from soybean seedlings germinated on the sixth day showed the highest activity and were able to effectively reduce the bitterness of soybean protein hydrolysates without compromising their antioxidant activity.
Article
Chemistry, Applied
Qi Liu, Qian Wang, Ping He, Yi Zhang, Leiman Pan, Yong Chen, Hui Wu, Mengmeng Zhang
Summary: The study showed that selenium enrichment improved the gel properties and digestive products of egg white, with selenium-enriched egg white exhibiting higher gel strength and antioxidant activity compared to ordinary egg white.
Article
Biochemistry & Molecular Biology
Wenbo Chen, Xiaolu Zhu, Lei Wang, Xuan Xin, Mengmeng Zhang
Summary: In this study, the effects of two polysaccharides (MC-1 and MC-2) found in maca roots on intestinal immunity and inflammation were investigated. The results showed that these polysaccharides activated intestinal immunity and alleviated intestinal inflammation in vitro. Additionally, they promoted the secretion of certain cytokines while inhibiting the secretion of inflammatory factors.
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Xuan Xin, Guanglei Zhao, Yucong Zou, Xiao-Feng Li
Summary: By synthesizing ester derivatives, the lipophilicity and lipid-lowering activity of baicalin were improved. These esters showed better absorption and lipid-lowering effects in cell models, but were easily hydrolyzed and unstable under neutral conditions.
BIOORGANIC CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Ping He, Leiman Pan, Hui Wu, Lina Zhang, Yi Zhang, Yizhe Zhang, Jinxi Yang, Zhengli Lin, Mengmeng Zhang
Summary: This study demonstrates that the hydrolysate of Maca protein enhances the immunomodulatory activity in macrophages and identifies the peptide RNPFLP as the most potent immunomodulatory peptide in the hydrolysate. Experimental evidence shows that RNPFLP activates macrophages through the NF-Kappa B and MAPK signaling pathways mediated by TLR2 and TLR4 receptors. Furthermore, the study reveals the important role of the N9-H60 active site in arginine in the immunomodulatory activity of RNPFLP.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Yangwei Shan, Chongzhen Sun, Jishan Li, Xin Shao, Junfeng Wu, Mengmeng Zhang, Hong Yao, Xiyang Wu
Summary: Mulberry leaf protein has antioxidant and anti-inflammatory properties, and can alleviate immunosuppression by modulating gut microbiota and immune response, making it a promising dietary supplement for maintaining gut health.
Article
Food Science & Technology
Zhengli Lin, Junwen Lai, Ping He, Leiman Pan, Yizhe Zhang, Mengmeng Zhang, Hui Wu
Summary: In this study, six novel ACE inhibitor peptides were identified in maca protein hydrolysates, and RSRGVFF exhibited prominent ACE inhibitory activity. The analysis of the structure-activity relationship revealed that arginine at the N-terminal and two phenylalanines at the C-terminal contributed to the inhibitory activity. These findings suggest that maca protein may play a role in the antihypertensive activity.
Article
Food Science & Technology
Ping He, Mengmeng Zhang, Yizhe Zhang, Hui Wu, Xiaoyuan Zhang
Summary: In this research, the effect of selenium enrichment on dough fermentation characteristics of yeast was studied. It was found that selenium enrichment increased the CO2 production and sugar consumption rate of Saccharomyces cerevisiae in dough fermentation, leading to improved final volume and rheological index of dough. Moreover, using selenium-enriched yeast as a starter resulted in selenium-enriched bread with higher overall acceptability, better texture properties, and increased cell density in stomatal morphology.
Article
Food Science & Technology
Yizhe Zhang, Ping He, Leiman Pan, Zhengli Lin, Jinxi Yang, Hui Wu, Mengmeng Zhang
Summary: This study revealed the immunological impact of earthworm protein autolysate on immunosuppressed mice model and identified and evaluated its active peptides, providing a potential resource for immunomodulatory peptides.
Article
Biochemistry & Molecular Biology
Ping He, Yizhe Zhang, Ruyang Chen, Zhaoli Tong, Mengmeng Zhang, Hui Wu
Summary: This study found that Maca protein can alleviate inflammatory bowel disease (IBD) by modulating the gut microbiota and inflammatory response. It improves disease symptoms and tissue damage, and promotes the production of short-chain fatty acids. It regulates the immune balance through the SCFAs-GPR41/43/HDAC1 signaling pathway.
Article
Biochemistry & Molecular Biology
Ping He, Qian Wang, Qiping Zhan, Leiman Pan, Xuan Xin, Hui Wu, Mengmeng Zhang
Summary: Duck egg white (DEW) is explored as a source of immunomodulatory peptides, with papain hydrolysate (PH) showing high hydrolysis degree and strong activity. Among the nine identified peptides, five exhibit strong activity, with TQIDKVVHFDKLPGF peptide showing the highest immunomodulatory activity. Molecular docking results suggest good affinity between these peptides and toll-like receptor 2 and 4, with three selected peptides forming stable bonds contributing to their immune activity.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
