Article
Microbiology
Bo Ao, Fei He, Jing Lv, Junming Tu, Zheng Tan, Honglin Jiang, Xiaoshan Shi, Jingjing Li, Jianjun Hou, Yuanliang Hu, Xian Xia
Summary: In this study, a fungus with high resistance to toxic tellurite [Te(IV)] was isolated. The fungus efficiently reduced Te(IV) to less toxic Te(0), forming rod-shaped biogenic nanoparticles (Bio-TeNPs) intracellularly. The extracted Bio-TeNPs consisted of Te(0), proteins, lipids, aromatic compounds, and carbohydrates, and exhibited excellent antibacterial ability against various bacteria. Moreover, the Bio-TeNPs showed excellent antioxidant capacity and no cytotoxicity. These findings suggest the potential of strain AB1 in bioremediation and the Bio-TeNPs as antibacterial nanomaterials.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Environmental
Artjima Ounkaew, Pornnapa Kasemsiri, Natnaree Srichiangsa, Salim Hiziroglu, Kanvisit Maraphum, Jetsada Posom, Somnuk Theerakulpisut, Manunya Okhawilai, Prinya Chindaprasirt
Summary: This study developed silver nanoparticles synthesized using spent green tea to coat paper for antibacterial and ethylene-reducing properties, potentially delaying the ripening of fruits in novel packaging.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Yingshan Jin, Yuting Lu, Anbazhagan Sathiyaseelan, Xin Zhang, Kumar Vishven Naveen, Myeong-Hyeon Wang
Summary: Peony seed cake extract (PSCE) was used to synthesize silver nanoparticles (Ag NPs) with antibacterial, antioxidant, and cytotoxicity properties. The PSCE-Ag NPs showed a spherical shape, average size of 105.6 ± 3.49 nm, and a zeta potential of -41.8 ± 12.6 mV. They effectively inhibited the growth and biofilm formation of various bacteria and exhibited strong free radical scavenging ability. Furthermore, the PSCE-Ag NPs were non-toxic to erythrocytes, egg-chorioallantoic membrane, and human embryonic kidney cells (HEK293), while significantly suppressing breast cancer cell (BT474) growth.
Article
Materials Science, Multidisciplinary
Ganeswar Sahu, Mamata Das, Chinmayee Sethy, Radhika Wazalwar, Chanakya Nath Kundu, Ashok M. Raichur, Jasaswini Tripathy
Summary: This study presents the fabrication of composite films with enhanced antibacterial activity using ionic liquid, which showed superior antibacterial activity compared to films fabricated without ionic liquid. Additionally, the composite materials exhibited low cytotoxicity on different cell lines, indicating good biocompatibility.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Parisa Maleki, Fahimeh Nemati, Aida Gholoobi, Alireza Hashemzadeh, Zahra Sabouri, Majid Darroudi
Summary: CeO2 nanoparticles and silver-doped Ce1-xAgxO2 nanoparticles were synthesized using a green bioprocess with Salvia seeds extract as a capping agent. The nanoparticles showed uniform spherical morphology with an average size of 62 nm. In vitro cytotoxicity was evaluated on EPG human gastric cancer cell line, and antibacterial activity was tested against Staphylococcus aureus and Pseudomonas aeruginosa.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Plant Sciences
Vo Thi Dieu Trang, Maria Dalgaard Mikkelsen, Marlene Vuillemin, Sebastian Meier, Hang Thi Thuy Cao, Jan Muschiol, Valentina Perna, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Jesper Holck, Tran Thi Thanh Van, Huynh Hoang Nhu Khanh, Anne S. Meyer
Summary: Fucoidanases are enzymes that hydrolyze alpha-glycosidic linkages in fucoidans, sulfated polysaccharides found in brown seaweeds. A novel fucoidanase, Fhf2, was identified in a marine bacterium and found to be more stable in a truncated form. The truncated Fhf2 showed activity on fucoidans from different seaweed species and had optimal activity at 37 degrees C and pH 8. This enzyme could be valuable in producing highly sulfated oligosaccharides for fucoidan bioactivity investigations.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Chemical
Zhichao Zhang, Yucai He
Summary: Microbial contamination is a serious issue that poses risks to people's lives. This paper focuses on the synthesis of a fish scale charcoal nanosilver antibacterial composite using waste fish scale as a carbon substrate. The material exhibited excellent antibacterial activity against various pathogenic bacteria, with an inhibition zone of up to 32 mm and an antibacterial rate exceeding 99.9%. Moreover, the fish scale/silver composite demonstrated sustained antibacterial ability and reusability. Overall, this material shows great potential in addressing microbial pollution.
Article
Food Science & Technology
Bo Ao, Jing Lv, Hongmei Yang, Fei He, Yuanliang Hu, Bing Hu, Honglin Jiang, Xixiang Huo, Junming Tu, Xian Xia
Summary: In this study, biological selenium nanoparticles (Bio-SeNPs) synthesized by Moringa oleifera extract and selenite were used to inhibit Listeria monocytogenes and Corynebacterium diphtheriae. The results showed that these Bio-SeNPs exhibited significant antibacterial activity and could effectively inhibit the growth of both strains.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agricultural Engineering
Jiansong Chen, Liangliang An, Jin Ho Bae, Ji Won Heo, Song Yi Han, Yong Sik Kim
Summary: In this study, aminated lignin-silver complex was prepared as an effective antibacterial agent using kraft lignin. The complex showed antibacterial activity against various bacteria, making it a potential green alternative to silver nanoparticles.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Physical
Felix J. Geissel, Varvara Platania, Alexander Gogos, Inge K. Herrmann, Georgios N. Belibasakis, Maria Chatzinikolaidou, Georgios A. Sotiriou
Summary: This study demonstrates that the concentration of Ag ions in solution is the major factor driving the antibiofilm effect of nanosilver coatings, independent of Ag size and coating thickness. The antibiofilm effect predominantly stems from the released Ag ions rather than direct bacterial contact inhibition, especially for coatings featuring the smallest Ag particle sizes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Medicinal
Nora Kirsten, Julia Ohmes, Maria Dalgaard Mikkelsen, Thuan Thi Nguyen, Martina Bluemel, Fanlu Wang, Deniz Tasdemir, Andreas Seekamp, Anne S. Meyer, Sabine Fuchs
Summary: Fucoidans, sulfated and fucose-rich polysaccharides from brown seaweed, have multiple promising biological effects, including anti-inflammatory properties. In this study, high molecular weight (HMW) fucoidan extract with higher purity was found to reduce the inflammatory response of endothelial cells in cases of LPS-induced bacterial infection, indicating their potential use as an anti-inflammatory agent.
Article
Chemistry, Inorganic & Nuclear
Ramachandran Vinayagam, Kyung Eun Lee, Ernest David, Muhammad Nurul Matin, Sang Gu Kang
Summary: A novel wedelolactone-loaded poly-lactic-co-glycolic acid nanoparticle was synthesized and showed significant antibacterial and anticancer properties. The nanoparticles exhibited stable spherical shape with a surface charge of -33.0 mV, and effective inhibition of bacterial growth and breast cancer cell proliferation.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Electrochemistry
S. Sivakala, E. Rishad Baig, C. Molji, Aravind Aashish, Asha S. Kumar, Sudha J. Devaki
Summary: This study successfully tuned the shape of silver nanoparticles through a bio-based surfactant capping method and elucidated the mechanism for the formation of different shapes. It was found that silver nanowires exhibited superior catalytic efficiency, which can be utilized for studying other organic reactions.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Medicinal
Huan Li, Shuang Fu, Lijia Liu, Xuan Yuan, Yudan Wang, Chunhong Zhang, Hongxing Dong, Toshifumi Satoh
Summary: The increasingly growing epidemics of multidrug-resistant bacteria pose a severe threat to public health. This study synthesized a series of N-terminal dipeptide mimetics and evaluated their biological activities. The results showed that these mimetics exhibited broad-spectrum antibacterial activity with high selectivity, making them potential candidates for combating antibiotic resistance and cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hassan Al-Karagoly, Atiaf Rhyaf, Hala Naji, Salim Albukhaty, Faizah A. AlMalki, Amal A. Alyamani, Jawaher Albaqami, Salman Aloufi
Summary: This study synthesized iron oxide nanoparticles (IONPs) using Nigella sativa (N. sativa) seed extract as a reducing agent and demonstrated their excellent cytotoxicity and antibacterial properties. The biosynthesized IONPs showed highly stable dispersal with noncytotoxic effects and strong antibacterial activity against E. coli and S. aureus.
GREEN PROCESSING AND SYNTHESIS
(2022)
Article
Biochemistry & Molecular Biology
Yulia V. Vereshchagina, Anastasiya A. Mironova, Dmitry V. Bulgakov, Victor P. Bulgakov
Summary: The rolB gene transferred from Agrobacterium rhizogenes to plants can be stably inherited in the plant offspring. Proteomic analysis of rolB-expressing Arabidopsis thaliana plants revealed both upregulated and downregulated proteins, some of which are associated with plant defense systems and interaction with pathogens. These findings contribute to our understanding of the impact of the rolB gene on plants and further research on plant defense systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Anna Egorova, Andrey Shelenkov, Konstantin Kuleshov, Nina Kulikova, Aleksey Chernyshkov, Igor Manzeniuk, Yulia Mikhaylova, Vasiliy Akimkin
Summary: This study analyzed 11 multidrug-resistant samples of Salmonella enterica obtained from 8 regions in Russia in 2021 using whole-genome sequencing. The samples exhibited different profiles of antimicrobial resistance and virulence genes. It was found that four representative samples carried large self-transmissible plasmids harboring genes related to antibiotic resistance and virulence. These findings contribute to our understanding of the epidemiology of this important foodborne pathogen.
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Olga O. Grigoryeva, Maxim L. Lovat, Anna E. Egorova, Andrei V. Grinchenko, Vadim V. Kumeiko, Maria V. Marey, Vasily N. Manskikh, Olga A. Dontsova, Mikhail Yu. Vysokikh, Petr V. Sergiev
Summary: Small peptides are important components of mitochondrial proteome, and the mitochondrial peptide Mtln plays a crucial role in respiratory complex I functioning and other processes in mitochondria. Knockout of Mtln in mice leads to obesity, triglyceride accumulation, and depletion of tricarboxylic acids cycle intermediates, indicating its important physiological functions. In addition, Mtln deficiency also impairs muscle strength, disrupts mitochondrial cardiolipin balance, and affects respiratory chain performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Ekaterina A. Guseva, Olga O. Grigoryeva, Maxim L. Lovat, Anna E. Egorova, Andrei V. Grinchenko, Vadim V. Kumeiko, Maria V. Marey, Vasily N. Manskikh, Olga A. Dontsova, Mikhail Y. Vyssokikh, Petr V. Sergiev
Summary: A small protein, Mitoregulin (Mtln), localized in mitochondria, plays a role in oxidative phosphorylation and fatty acid metabolism. Mtln knockout mice develop obesity and show damage to cardiolipin and creatine kinase oligomerization in muscle tissue. In this study, we investigate kidney-related phenotypes in aged Mtln knockout mice and found decreased respiratory complex I activity and excessive cardiolipin damage in kidney mitochondria similar to muscle mitochondria of Mtln knockout mice. Aged male mice with Mtln knockout exhibited increased renal proximal tubules' degeneration while aged female mice without Mtln showed a higher frequency of decreased glomerular filtration rate. Additionally, the amount of Mtln partner protein, Cyb5r3, decreased significantly in the kidneys of Mtln knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Polymer Science
Vladimir E. Silant'ev, Mikhail E. Shmelev, Andrei S. Belousov, Aleksandra A. Patlay, Roman A. Shatilov, Vladislav M. Farniev, Vadim V. Kumeiko
Summary: Brain tumors are difficult to treat due to their various forms and limited effective chemotherapeutic agents. This is further complicated by the poor transport of drugs across the blood-brain barrier. Carbohydrate-based nanoparticles offer a promising solution for targeted drug delivery, providing biocompatibility, biodegradability, and reduced side effects.
Article
Biology
Tatiana Y. Gorpenchenko, Galina N. Veremeichik, Yurii N. Shkryl, Yulia A. Yugay, Valeria P. Grigorchuk, Dmitry V. Bulgakov, Tatiana V. Rusapetova, Yulia V. Vereshchagina, Anastasiya A. Mironova, Evgeniyy P. Subbotin, Yuriy N. Kulchin, Victor P. Bulgakov
Summary: HOS1 gene is an important regulator of plant cold tolerance and developmental processes. Silencing HOS1 gene increases cold tolerance and moderately increases ROS levels under low and high light conditions. HOS1 is required for maintaining ROS homeostasis under cold conditions and prevents overinduction of defense mechanisms.
Article
Chemistry, Medicinal
Roza V. Usoltseva, Anastasiya O. Zueva, Olesya S. Malyarenko, Stanislav D. Anastyuk, Olga P. Moiseenko, Vladimir V. Isakov, Mikhail I. Kusaykin, Airong Jia, Svetlana P. Ermakova
Summary: This study reports the structure of fucoidan from Sargassum miticum and its enhanced inhibitory effect on the colony formation of cancer cells when used in combination with a glycolysis inhibitor.
Article
Plant Sciences
Galina N. Veremeichik, Tatiana Y. Gorpenchenko, Tatiana V. Rusapetova, Evgenia V. Brodovskaya, Galina K. Tchernoded, Dmitry V. Bulgakov, Yurii N. Shkryl, Victor P. Bulgakov
Summary: This study investigated the stable pRiA4-transformed callus culture of Rubia cordifolia L. and found that the transformed tissue can achieve long-term cultivation without the need for plant growth regulators (PGRs). Moreover, the transformed tissue exhibited higher productivity of anthraquinone (AQ) compared to untransformed tissue. These findings have important implications in selecting optimal PGR combinations for the cultivation of rare, medicinal, and woody plants, and highlight the potential application of genetic modification in plant biotechnology.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Polymer Science
Aleksandra A. A. Patlay, Andrei S. S. Belousov, Vladimir E. E. Silant'ev, Roman A. A. Shatilov, Mikhail E. E. Shmelev, Valeri V. V. Kovalev, Irina V. V. Perminova, Ivan N. N. Baklanov, Vadim V. V. Kumeiko
Summary: We developed films and nanoparticles based on low-esterified pectin hydrogel for drug delivery systems in adjuvant anticancer therapy. These nanostructured biomaterials showed tunable properties and good biocompatibility, and exhibited potential antitumor activity against human glioblastoma cells.
Review
Agronomy
David Adedayo Animasaun, Peter Adeolu Adedibu, Yury Shkryl, Faith Olatayo Emmanuel, Liudmila Tekutyeva, Larissa Balabanova
Summary: Food insecurity is a pressing global issue exacerbated by climate change, conflicts, pandemics, and economic recessions. Genetic engineering of crops offers potential solutions through the development of pest and disease-resistant varieties, increased yield, and edible vaccines. However, government policies in many countries hinder the acceptance and distribution of this technology.
Article
Plant Sciences
Yulia Yugay, Zhargalma Tsydeneshieva, Tatiana Rusapetova, Olga Grischenko, Anastasia Mironova, Dmitry Bulgakov, Vladimir Silant'ev, Galina Tchernoded, Victor Bulgakov, Yury Shkryl
Summary: EVs have been isolated and characterized from callus culture of Arabidopsis thaliana, showing similarities with intact plants in terms of protein and microRNA composition.
Article
Engineering, Biomedical
Yulia A. Yugay, Maria R. Sorokina, Valeria P. Grigorchuk, Tatiana V. Rusapetova, Vladimir E. Silant'ev, Anna E. Egorova, Peter A. Adedibu, Olesya D. Kudinova, Elena A. Vasyutkina, Vladimir V. Ivanov, Alexander A. Karabtsov, Dmitriy V. Mashtalyar, Anton I. Degtyarenko, Olga V. Grishchenko, Vadim V. Kumeiko, Victor P. Bulgakov, Yury N. Shkryl
Summary: This study explores a novel method for synthesizing extracellular silver nanoparticles using Aristolochia manshuriensis cultured cells. The nanoparticles exhibited spherical morphology and were able to inhibit the growth of certain cells and pathogenic microorganisms.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Medicinal
V. V. Surits, R. A. Shkrabov, R. V. Usoltseva, H. H. N. Khanh, S. P. Ermakova
Summary: The composition of water-soluble polysaccharides (fucoidans and laminarans) from two Vietnamese brown algae, Sargassum microcystum and S. serratum, was analyzed. S. microcystum produced fucoidan and laminaran, while S. serratum only produced fucoidan. The structure of the fucoidans was sulfated galactofucans and a sulfated and acetylated heteropolysaccharide, while the laminaran had a main chain of 1,3-bound beta-D-glucose residues with single branches on C6. The obtained sulfated laminaran derivative had sulfate groups at the 2-, 4-, and 6-positions. The polysaccharides showed low cytotoxicity and limited activity against RPMI-7951 human melanoma cells, but demonstrated more significant and selective activity against HuTu-80 human duodenum adenocarcinoma cells.
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Andrei Belousov, Aleksandra Patlay, Vladimir Silant'ev, Valeri V. Kovalev, Vadim Kumeiko
Summary: By tuning the concentration of the polymer and the degree of esterification (DE), we developed 10 variants of pectin-based hydrogels with different viscoelastic properties. The selected variants showed potential for CNS remodeling. Structural characterization indicated differences that may be important for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
