Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qiu-Yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-Fei Xia, Yong Du, Run-Duan Lin, Li-Qiong Yang, Yu-Ting Sun, Da-Jun Yang, Jian Sun, Lin Zhang
Summary: High expression of AKAP8L is associated with poor prognosis of ESCC and can be considered an independent risk factor for ESCC.
CANCER CELL INTERNATIONAL
(2022)
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Lijun Zhao, Lili Yu, Xiangpeng Wang, Jangtao He, Xiaofei Zhu, Rui Zhang, Angang Yang
Summary: Esophageal squamous cell carcinoma (ESCC) is a deadly and common malignancy in China. Exosomes, tiny extracellular vesicles produced by all cells, play a crucial role in intercellular communication and have been studied as potential therapeutic strategies for cancer. Recent global analyses have explored the functions and regulatory mechanisms of exosomes in malignant diseases. Exosomes have been shown to have clinical value as diagnostic and prognostic markers for cancer. However, our understanding of their clinical significance and mechanisms of action in ESCC is limited and requires further review. This article provides an overview of current research on ESCC tumor-derived exosomes and non-ESCC-derived exosomes, focusing on their functions and mechanisms in ESCC progression, as well as the challenges and opportunities in their clinical translation.
Article
Biophysics
Qingfu Zhu, Hao Xu, Liu Huang, Jiaxin Luo, Hengrui Li, Rui Yang, Xiaoling Liu, Fei Liu
Summary: This study investigates the potential of extracellular vesicles (EVs) as biomarkers for esophageal cancer diagnosis. The researchers successfully isolated and identified differentially expressed proteins in EVs from esophageal cancer patients using the EXODUS and ELISA techniques. They found that EV-CD14 could be a potential diagnostic biomarker for esophageal cancer. The application of ELISA for the detection and screening of esophageal cancer based on circulating EV-CD14 showed high accuracy and sensitivity.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Oncology
Waku Hatta, Tomoyuki Koike, Kaname Uno, Naoki Asano, Atsushi Masamune
Summary: This review discusses the additional treatment and recent advances in the field of non-curative endoscopic resection for superficial esophageal squamous cell carcinoma and early gastric cancer. The development of risk stratification for metastatic recurrence, identification of different recurrence patterns, and the establishment of a novel treatment strategy are discussed. Predicting prognosis and quality of life is crucial for optimal therapeutic decision-making in such patients.
Article
Oncology
Sheila Coelho Soares-Lima, Isabela Martins Gonzaga, Diego Camuzi, Pedro Nicolau-Neto, Raissa Vieira da Silva, Simone Guaraldi, Maria Aparecida Ferreira, Hector Hernandez-Vargas, Zdenko Herceg, Luis Felipe Ribeiro Pinto
Summary: The study suggests that overexpression of IL6 may play a key role in the carcinogenesis of ESCC, contributing to ESCC development through a homogeneous antiapoptotic signaling via BCL3 overexpression. The study also supports the potential of using BCL3 mRNA expression as a biomarker for ESCC detection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Liqing Qiu, Jing Yue, Lingyu Ding, Zihao Yin, Ke Zhang, Hongfang Zhang
Summary: In this review, the impact of cancer-associated fibroblasts (CAFs) on esophageal squamous cell carcinoma (ESCC) is highlighted, including the induction of chemoresistance, radioresistance, migration, invasion, and immune escape. The origin of CAFs and the influence of ESCC cells on CAF activation are also discussed. Furthermore, the clinical prospects and future trends of CAFs-targeted therapies in ESCC are emphasized. A better understanding of the molecular biology of CAFs may contribute to the development of novel anti-ESCC strategies.
Article
Surgery
Keisuke Okuno, Masanori Tokunaga, Yusuke Kinugasa, Hideo Baba, Yasuhiro Kodera, Ajay Goel
Summary: The objective of this study was to establish a liquid-biopsy assay to predict response to neoadjuvant therapy (NAT) in esophageal squamous cell carcinoma (ESCC) patients. The researchers translated tissue-based microRNA (miRNA) and messenger RNA (mRNA) expression biomarkers into a liquid biopsy assay and successfully developed a predictive model for NAT resistance in ESCC patients.
Article
Genetics & Heredity
Weihong Xie, Guiying Sun, Jicun Zhu, Huimin Wang, Zhuo Han, Peng Wang
Summary: The study found that anti-POSTN and anti-TIMP1 autoantibodies may serve as potential biomarkers for the diagnosis of esophageal squamous cell carcinoma (ESCC).
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pathology
Guorui Sun, Yanru Yang, Jin Liu, Zizhao Gao, Tianqi Xu, Jia Chai, Junpeng Xu, Zhenge Fan, Tian Xiao, Qingge Jia, Mingyang Li
Summary: This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Mengjie Yu, Wei Wen, Xin Yi, Wei Zhu, Jiye Aa, Guangji Wang
Summary: This study found impaired oxidative stress function in ESCC patients and identified risk metabolites associated with the development of ESCC. The levels of alpha-tocopherol and cysteine decreased progressively, while the levels of aminomalonic acid increased progressively. A high level of aminomalonic acid was a risk factor for the development of ESD to ESCC and for lymphatic metastasis in ESCC patients. A low level of alpha-tocopherol was an independent risk factor for ESCC. The panel constructed by glycolic acid, oxalic acid, glyceric acid, malate, and alpha-tocopherol performed well in distinguishing ESD/ESCC from healthy controls.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Zheng Zhao, Shuyue Yang, Anni Zhou, Xiao Li, Rui Fang, Shutian Zhang, Guiping Zhao, Peng Li
Summary: Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal and prevalent malignancies in China. Exosomes play a crucial role in the formation and development of ESCC by promoting intercellular communication within the tumor microenvironment. Exosome-encapsulated cargos such as miRNAs have potential utility in the diagnosis, prognosis, and treatment of ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Yuebo Song, Mingxuan Li, Kazuo Sugimoto, Yi Han, Jia Liu, Bin Ma, Hujie Song, Chi Zhang, Ying Gao
Summary: The China Amyotrophic Lateral Sclerosis Registry of Patients with Traditional Chinese Medicine (CARE-TCM) aims to gather and study data on the TCM interventions ALS patients receive, their clinical characteristics, and how these interventions affect clinical measures. By collecting detailed patient data and comparing results, it is expected to improve the efficiency and quality of TCM clinical trial design.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Liubing Hu, Jiyue Liu, Hideaki Shimada, Masaaki Ito, Kazuo Sugimoto, Takaki Hiwasa, Qinghua Zhou, Jianshuang Li, Si Shen, Hao Wang
Summary: Atherosclerosis (AS) and cancers are major global causes of mortality and morbidity. They share common risk factors and researchers have discovered potential serum biomarkers, such as BRAT1-Abs and WDR1-Abs, for AS and GI cancers. BRAT1-Ab shows better predictive potential for GI cancers compared to WDR1-Ab. High levels of BRAT1-Ab are also associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Wenlu Wang, Yang Xiao, Shijie Han, Yang Zhang, Daocheng Gong, Hao Wang, Boguang Wang
Summary: Vehicle-mounted indoor-outdoor dual-smog chamber (JNU-VMDSC) is an effective tool for studying the formation mechanisms of air pollution. It can simulate quasi-realistic atmospheric conditions and meets the requirements of general atmospheric chemistry simulation studies. The preliminary results of photochemical simulations using JNU-VMDSC are consistent with literature reports and it provides a convenient and reliable means to study atmospheric photochemical reactions and control composite air pollution.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Masaaki Ito, Takaki Hiwasa, Satoshi Yajima, Takashi Suzuki, Yoko Oshima, Tatsuki Nanami, Makoto Sumazaki, Fumiaki Shiratori, Shu-Yang Li, Yasuo Iwadate, Kazuo Sugimoto, Masahiro Mori, Satoshi Kuwabara, Hirotaka Takizawa, Hideaki Shimada
Summary: This study analyzed the levels of anti-CFL1 and anti-ACTB antibodies in serum samples of patients with esophageal carcinoma and found significant clinical significance. The combination of low anti-CFL1 and high anti-ACTB antibodies is associated with poor prognosis in esophageal carcinoma.
Article
Environmental Sciences
Chunlin Zhang, Jiangyong Li, Wenlong Zhao, Qian Yao, Hao Wang, Boguang Wang
Summary: This study investigates the contribution of open biomass burning (OBB) to formaldehyde (HCHO) levels in Guangdong Province, southern China. Using satellite and model methods, the researchers estimate the emissions of HCHO and volatile organic compounds (VOCs) from OBB and quantify their impact on ambient HCHO. The results show that OBB significantly influences HCHO levels in the region, especially in areas with frequent fires.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Changda Wu, Haydn Trounce, Erin Dunne, David W. T. Griffith, Scott D. Chambers, Alastair G. Williams, Ruhi S. Humphries, Luke T. Cravigan, Branka Miljevic, Chunlin Zhang, Hao Wang, Boguang Wang, Zoran Ristovski
Summary: This study presents the first comprehensive measurements of aerosol properties in the tropical warm pool of Australian waters, revealing intense non-marine related aerosol emissions in the region. Fossil fuel combustion was found to be the dominant contributor to black carbon concentrations, with biomass burning making significant contributions in certain areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Hao Wang, Ruo-Fei Tian, Xue Liang, Jing Fan, Zi-Chuan Duan, Xin-Yu Fan, Jia-Jia Zhang, Dong-Sheng Yao, Zhi-Nan Chen, Ling Li
Summary: In this study, a prognostic model based on four oxidative stress genes was constructed to predict the prognosis of pancreatic adenocarcinoma patients. The model has important predictive value for clinical individualized therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Issei Tomita, Hiroaki Tsuruta, Mako Yasuda-Yamahara, Kosuke Yamahara, Shogo Kuwagata, Yuki Tanaka-Sasaki, Masami Chin-Kanasaki, Yukihiro Fujita, Eiichiro Nishi, Hideki Katagiri, Hiroshi Maegawa, Shinji Kume
Summary: Accumulating evidence suggests that ketone bodies have health benefits, especially for longevity. However, the role of endogenous ketogenesis in mammalian life span and the safety and efficacy of long-term exogenous ketone body supplementation remain unclear. This study shows that a deficiency in endogenous ketogenesis shortens life span in mice, and this can be prevented by daily ketone body supplementation. It is also found that the timing of ketone body supplementation has different effects on mortality rates in normal and aged mice. In conclusion, endogenous ketogenesis affects mammalian survival, and the administration method and health status are important factors in the effects of ketone body supplementation.
Article
Engineering, Environmental
Yu Wang, Tao Liu, Daocheng Gong, Hao Wang, Hai Guo, Minping Liao, Shuo Deng, Huang Cai, Boguang Wang
Summary: This study found that PAN was photochemically formed in the Nanling mountains of South China, with methylglyoxal, acetaldehyde, radicals, and other OVOCs as the main precursors. When polluted air masses invaded the area, anthropogenic aromatics intensified PAN formation. The net PAN formation reduced hydroxyl radical level, impaired local radical cycling, and suppressed local O3 production. These findings deepen our understanding of PAN photochemistry and the impact of anthropogenic intrusions on mountainous regions' background atmosphere.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Shintaro Ide, Yoshiro Maezawa, Koutaro Yokote
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Yoshiro Maezawa, Yusuke Endo, Satomi Kono, Tomohiro Ohno, Yuumi Nakamura, Naoya Teramoto, Ayano Yamaguchi, Kazuto Aono, Takuya Minamizuka, Hisaya Kato, Takahiro Ishikawa, Masaya Koshizaka, Minoru Takemoto, Toshinori Nakayama, Koutaro Yokote
Summary: Psoriasis, a chronic inflammatory skin disease, is associated with obesity and myocardial infarction. Obesity-induced changes in lipid metabolism promote the differentiation of T helper 17 (Th17) cells, leading to chronic inflammation. This study found that weight loss through diet and exercise decreased Th17 cells and improved psoriasis in an obese patient with type 2 diabetes. This supports the hypothesis that obesity increases Th17 cells and chronic inflammation, contributing to psoriasis and atherosclerosis.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Clinical Neurology
Miao Lin, Liubing Hu, Si Shen, Jiyue Liu, Yanyan Liu, Yixian Xu, Honglin Chen, Kazuo Sugimoto, Jianshuang Li, Ikuo Kamitsukasa, Takaki Hiwasa, Hao Wang, Anding Xu
Summary: In this study, PABPC1 was identified as a potential biomarker for the prediction and diagnosis of atherosclerosis and pan-cancer through SEREX screening and bioinformatics analysis.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shu-Yang Li, Yoichi Yoshida, Masaaki Kubota, Bo-Shi Zhang, Tomoo Matsutani, Masaaki Ito, Satoshi Yajima, Kimihiko Yoshida, Seiichiro Mine, Toshio Machida, Aiko Hayashi, Minoru Takemoto, Koutaro Yokote, Mikiko Ohno, Eiichiro Nishi, Kenichiro Kitamura, Ikuo Kamitsukasa, Hirotaka Takizawa, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Katsuro Iwase, Hideaki Shimada, Yasuo Iwadate, Takaki Hiwasa
Summary: Autoantibodies against inflammatory cytokines can be used to prevent atherosclerosis. This study measured serum anti-CSF2 antibody levels in patients with atherosclerosis or solid cancer. The results showed that the levels of anti-CSF2 antibody were significantly higher in patients with acute ischemic stroke, acute myocardial infarction, diabetes mellitus, and chronic kidney disease compared to healthy donors. The study suggests the potential utility of anti-CSF2 antibody as a risk factor for atherosclerosis-related stroke.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Dermatology
Akihiko Yamaguchi, Toshifumi Takahashi, Takeshi Kato, Toshihiro Tanaka, Eiichiro Nishi, Noriki Fujimoto
Summary: It has been reported that nardilysin (NRDC) is associated with malignancies in a conflicting manner, but its role in cutaneous malignancies has not been investigated. Immunohistochemical staining revealed that NRDC expression is observed in all extramammary Paget's disease (EMPD) cases, while other cutaneous malignancies did not show increased NRDC expression. It was found that NRDC staining was weaker in the marginal parts of EMPD lesions than in the central parts, and tumor cells tended to be distributed beyond the macroscopic skin lesions in these cases, suggesting that decreased NRDC expression in the marginal zones may be associated with the ability of tumor cells to produce the cutaneous manifestation of EMPD.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Hing Cho Cheung, Chengyu Nie, Mintao Huang, Tingting Yang, Hao Wang, Celine Siu Lan Lee, Chenglei Pei, Jun Zhao, Baoling Liang
Summary: A measurement campaign was conducted in Guangzhou, China to study particle pollution. The results showed severe particle pollution in both urban and suburban areas, influenced by monsoon and land-sea breeze systems. The study also found that local emissions, mainly from vehicles, significantly contributed to the pollution, while reduced human activities during the Chinese New Year period led to lower emissions. Additionally, the study highlighted the impact of new particle formation on particle pollution.
AEROSOL AND AIR QUALITY RESEARCH
(2022)