Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

Targeting DNA repair to drive immune responses: it's time to reconsider the strategy for clinical translation

(2020) Nobuyuki Takahashi et al.   CLINICAL CANCER RESEARCH

Phase I/II trial of nano-camptothecin CRLX101 with capecitabine and radiotherapy as neoadjuvant treatment for locally advanced rectal cancer

(2019) Hanna K. Sanoff et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting Topoisomerase I in the Era of Precision Medicine

(2019) Anish Thomas et al.   CLINICAL CANCER RESEARCH

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma

(2019) Keith T. Schmidt et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Efficacy of the nanoparticle–drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I–IIa clinical trial

(2016) S. M. Keefe et al.   ANNALS OF ONCOLOGY

Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

(2016) Anne-Gaëlle Dosne et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

(2016) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of nanoparticle drug loading on the pharmacokinetics of anticancer agents

(2015) Jennifer S Petschauer et al.   Nanomedicine

Translational Impact of Nanoparticle-Drug Conjugate CRLX101 with or without Bevacizumab in Advanced Ovarian Cancer

(2014) E. Pham et al.   CLINICAL CANCER RESEARCH

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Population pharmacokinetics of PEGylated liposomal CPT-11 (IHL-305) in patients with advanced solid tumors

(2013) Huali Wu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

(2013) Glen J. Weiss et al.   INVESTIGATIONAL NEW DRUGS

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle

(2013) S. Eliasof et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin

(2009) Mark E. Davis   ADVANCED DRUG DELIVERY REVIEWS

Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

(2009) Brian J. Anderson et al.   Drug Metabolism and Pharmacokinetics

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements

(2009) T. Schluep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA