Article
Clinical Neurology
Chaofan Sui, Hongwei Wen, Shengpei Wang, Mengmeng Feng, Haotian Xin, Yian Gao, Jing Li, Lingfei Guo, Changhu Liang
Summary: CSVD patients with cerebral microbleeds (CMBs) have extensive white matter microstructural deterioration. Using DTI-derived diffusivity and anisotropy metrics, we found that CSVD patients with CMBs showed significant FA decrease and AD, RD, and MD increases in cognitive and sensorimotor-related white matter tracts.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan E. Poirier, Neville G. Suskin, Alexander V. Khaw, Jonathan D. Thiessen, Joel K. Shoemaker, Udunna C. Anazodo
Summary: The study aimed to assess the effects of cardiac rehabilitation on the WM microstructure of ischemic heart disease patients. It was found that cardiac rehabilitation can improve the WM microstructure in patients, reducing changes in fractional anisotropy (FA) and mean diffusivity (MD).
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Geriatrics & Gerontology
Yongjia Shao, Zijian Wang, Bin Ji, Hang Qi, Shangci Hao, Gang Li, Yue Zhang, Qian Xi
Summary: The olfactory ability of patients with mild cognitive impairment was found to be lower overall and positively correlated with cognitive assessment results. Fractional anisotropy changes significantly in regions such as the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe among MCI patients. Fibrous connections in certain brain regions, like the entorhinal cortex, were stronger in MCI patients, indicating a potential compensatory mechanism in the olfactory pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Harri Merisaari, Linnea Karlsson, Noora M. Scheinin, Satu J. Shulist, John D. Lewis, Hasse Karlsson, Jetro J. Tuulari
Summary: This study analyzed DTI images of 133 neonates, finding significant bias in ROI values when only 6 directions were used, while the difference to scalar values calculated from 54 direction DTI was negligible when using 24 directions and above. Therefore, DTI measurements from data with at least 24 directions may be used in comparisons with DTI measurements from data with higher numbers of directions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Hikaru Sugimoto, Mihoko Otake-Matsuura
Summary: Diffusion tensor imaging (DTI) is used to investigate white matter properties in the brain. This study aims to examine the effects of a cognitive intervention program (PICMOR) on older adults' cognitive function and white matter fiber health. Results showed improved verbal fluency task scores in the intervention group compared to the control group. Tract-based spatial statistics analyses revealed higher FA values and lower MD, AD, or RD values in the intervention group across various fiber tracts. The findings suggest left frontal white matter structures may be responsible for the enhancement of verbal fluency.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Guanglu Li, Jiajia Zhu, Xingqi Wu, Tingting Liu, Panpan Hu, Yanghua Tian, Kai Wang
Summary: This longitudinal study found that higher levels of free water in the whole brain and the visual processing system were associated with an increased risk of future psychosis in Parkinson's disease. Furthermore, adding the visual processing system's free water as a marker improved the accuracy of predicting psychosis in Parkinson's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Shirui Cheng, Xiaohui Dong, Jun Zhou, Chenjian Tang, Wenhua He, Yang Chen, Xinyue Zhang, Peihong Ma, Tao Yin, Yimei Hu, Fang Zeng, Zhengjie Li, Fanrong Liang
Summary: Patients with knee osteoarthritis (KOA) exhibit structural and functional alterations in white matter, as revealed by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Extensive white matter changes are observed in sensorimotor and pain-related regions in KOA patients. Additionally, a negative correlation is found between disease severity and white matter abnormalities in KOA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lin Mei, Xiaodan Li, Guifei Zhou, Tingting Ji, Jun Chen, Zhifei Xu, Yun Peng, Yue Liu, Hongbin Li, Jie Zhang, Shengcai Wang, Yamei Zhang, Wentong Ge, Yongli Guo, Yue Qiu, Xinbei Jia, Jinghong Tian, Li Zheng, Jiangang Liu, Jun Tai, Xin Ni
Summary: The study found that male children with severe OSA demonstrated more severe issues in neurocognition, attention, sleep quality, and brain white matter integrity compared to those with mild OSA, while no significant differences were observed in female children.
Review
Geriatrics & Gerontology
Xia Wei, Chunyan Luo, Qian Li, Na Hu, Yuan Xiao, Nian Liu, Su Lui, Qiyong Gong
Summary: This study utilized meta-analysis to identify the most prominent and replicable white matter abnormalities in Parkinson's disease patients. Results showed FA reduction in the body of the corpus callosum and the left inferior fronto-occipital fasciculus. Additionally, a positive correlation between the percentage of male PD patients and FA values in the corpus callosum body was found.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yao-Ching Fang, Ling-Fei Wei, Chaur-Jong Hu, Yong-Kwang Tu
Summary: Abnormal circulating angiogenetic factors observed in MMD patients may play a critical role in the formation of Moyamoya vessels, promoting intimal hyperplasia in vessels and excessive collateral formation. These factors drive the development of Moyamoya disease through endothelial hyperplasia, smooth muscle migration, and atypical neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neuroimaging
Qin Shen, Yawu Liu, Jie Guo, Hongchun Zhang, Yijuan Xiang, Haiyan Liao, Sainan Cai, Bing Zhou, Min Wang, Siyu Liu, Jinyao Yi, Zishu Zhang, Changlian Tan
Summary: This study found that impaired white matter integrity in specific regions, mainly in the left hemisphere, is associated with severe depressive symptoms in patients with Parkinson's disease. The study provides insight into the pathophysiology of depression in PD patients.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Kareem El Naamani, Ching-Jen Chen, Roland Jabre, Hassan Saad, Jonathan A. Grossberg, Adam A. Dmytriw, Aman B. Patel, Mirhojjat Khorasanizadeh, Christopher S. Ogilvy, Ajith Thomas, Andre Monteiro, Adnan Siddiqui, Gustavo M. Cortez, Ricardo A. Hanel, Guilherme Porto, Alejandro M. Spiotta, Anthony J. Piscopo, David M. Hasan, Mohammad Ghorbani, Joshua Weinberg, Shahid M. Nimjee, Kimon Bekelis, Mohamed M. Salem, Jan-Karl Burkhardt, Akli Zetchi, Charles Matouk, Brian M. Howard, Rosalind Lai, Rose Du, Rawad Abbas, Georgios S. Sioutas, Abdelaziz Amllay, Alfredo Munoz, Elias Atallah, Nabeel A. Herial, Stavropoula Tjoumakaris, Michael Reid Gooch, Robert H. Rosenwasser, Pascal Jabbour
Summary: This study compares the rates of symptomatic strokes between direct and indirect revascularization surgeries for moyamoya and finds that both modalities have comparable rates of overall strokes. Therefore, the choice of revascularization modality can be made based on the patient's risk assessment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Yumeng Gu, Ping Zhao, Wenjun Feng, Xiaoshuang Xia, Xiaolin Tian, Yu Yan, Xiaowen Wang, Decheng Gao, Yanfen Du, Xin Li
Summary: This study aims to investigate the relationship between diffusion tensor imaging (DTI) indicators and cerebral small vessel disease (CSVD) with depressive states, and explore the underlying mechanisms of white matter damage in CSVD with depression. The results showed significant correlations between FA, MD values, and structural network indicators in DTI parameters and depressive symptoms in CSVD patients.
Article
Neurosciences
Yingteng Zhang, Feibiao Zhan
Summary: This study found that the corona radiata, corpus callosum and superior longitudinal fasciculus were the white matter fiber tracts mainly affected in AD patients. Additionally, the integration of FA, MD, and RD into multi-metric could effectively distinguish AD patients from healthy controls.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Sung Ho Jang, Eun Bi Choi
Summary: This study found differences in the thalamocortical tract between vegetative state (VS) and minimally conscious state (MCS) patients with hypoxic-ischemic brain injury (HI-BI), particularly in the prefrontal cortex and posterior parietal cortex.
Article
Neurosciences
Shihao He, Ziqi Liu, Zongsheng Xu, Ran Duan, Li Yuan, Chu Xiao, Zhe Yi, Rong Wang
Article
Clinical Neurology
Guangchao Shi, Cunxin Tan, Ran Duan, Shu Li, Ying He, Dong Zhang, Rong Wang
Summary: Direct bypass surgery improves blood flow and flow direction in patients with moyamoya disease, significantly increasing blood flow in the M4 segment. Postoperatively, blood flow direction typically changes to a bi-directional pattern, with a significant difference in flow volume between the distal and proximal sides of the M4 segment. Additionally, patients with a change in flow direction in the distal M4 segment are associated with lower risks of postoperative infarctions.
NEUROSURGICAL REVIEW
(2021)
Article
Neurosciences
Shihao He, Ziqi Liu, Yanchang Wei, Ran Duan, Zongsheng Xu, Cai Zhang, Li Yuan, Tian Li, Ning Ma, Xin Lou, Xiaoyuan Liu, Rong Wang
Summary: Patients with asymptomatic Moyamoya disease showed declines in computational ability and short-term memory compared to healthy controls. Additionally, they exhibited decreased cerebral blood flow in specific brain regions and reduced network connectivity, which were significantly associated with cognitive decline.
Article
Clinical Neurology
Shihao He, Ran Duan, Ziqi Liu, Cai Zhang, Tian Li, Yanchang Wei, Ning Ma, Rong Wang
Summary: This study revealed significant declines in short-term memory and lower brain network connectivity in asymptomatic carotid artery stenosis (aCAS) patients compared to controls, with the decreased connectivity significantly correlated with memory impairment. The findings suggest that alterations in network connectivity may be an essential mechanism underlying cognitive decline in aCAS patients.
Article
Neurosciences
Ziqi Liu, Shihao He, Yanchang Wei, Ran Duan, Cai Zhang, Tian Li, Ning Ma, Xin Lou, Rong Wang, Xiaoyuan Liu
Summary: Extensive cognitive impairment was found in Moyamoya disease patients with stroke. There was a widespread and asymmetrical decrease in cortical complexity in both hemispheres, with more significant changes in the left hemisphere with right-sided infarction.
Article
Cell Biology
Shihao He, Xun Ye, Ran Duan, Yahui Zhao, Yanchang Wei, Yanru Wang, Ziqi Liu, Xiaokuan Hao, Xiaolin Chen, Qiang Hao, Hao Wang, Yuanli Zhao, Rong Wang
Summary: This study demonstrates that the low expression of genes associated with epigenetic regulation, such as SOX6 and RBM33, may be related to vascular occlusion in MMD, while the overexpression of KCNMA1 and GALNT2 may be related to vascular hyperplasia. These results suggest that DNA methylation is involved in the pathogenesis of MMD, and new pathogenic genes are proposed as biological markers.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Orthopedics
Tao Li, Yaobin Yin, Zhe Yi, Zhe Guo, Zhenlin Guo, Shanlin Chen
Summary: This study developed and evaluated a convolutional neural network for identifying scaphoid fractures on radiographs, and compared its diagnostic performance with the decision of hand surgeons. The results showed that the performance of the convolutional neural network was similar to the surgeons' decision, indicating its potential for reliable identification of scaphoid fractures.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Article
Orthopedics
Yaobin Yin, Ke Xu, Nan Zhang, Zhe Yi, Bo Liu, Shanlin Chen
Summary: This study reveals the clinical and epidemiological features of scaphoid fracture nonunion in Chinese patients, showing that nonunion is mainly caused by delayed treatment and misdiagnosis. The findings suggest that timely treatment and improved diagnosis can lower the prevalence of nonunion.
ORTHOPAEDIC SURGERY
(2022)
Article
Endocrinology & Metabolism
Shihao He, Jianfeng Liang, Guifeng Xue, Yanru Wang, Yahui Zhao, Ziqi Liu, Xiaokuan Hao, Yanchang Wei, Xiaolin Chen, Hao Wang, Shuai Kang, Rong Wang, Yuanli Zhao, Xun Ye
Summary: This study investigates the association between exosomal RNA profiling and the pathogenesis of moyamoya disease (MMD) and intracranial atherosclerotic disease (ICAD). The differential expression of exosomal RNAs, including IPO11 and PRMT1 circRNAs, may be related to angiogenesis in MMD, while downregulation of CACNA1F circRNA may be related to vascular occlusion. The findings suggest the potential utility of exosomal RNAs as biological markers in MMD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Orthopedics
Zhe Yi, Weiya Qi, Shanlin Chen, Yuhao Zhang, Bo Liu
Summary: This study describes a novel mini-invasive surgical technique of arthroscopic-assisted reduction and robot-assisted fixation for the treatment of perilunate fracture dislocations. The technique allows for precise reduction and accurate placement of the K-wires/screws into the carpal bones through optimal biomechanical paths. The results showed satisfactory functional recovery and clinical outcomes.
ORTHOPAEDIC SURGERY
(2023)
Article
Orthopedics
Yaobin Yin, Zhixin Wang, Zhe Yi, Rebecca Qian Ru Lim, Shanlin Chen, Bo Liu
Summary: The study compared robotic-assisted and traditional freehand percutaneous scaphoid fixation in terms of number of guidewire attempts, fluoroscopy time, radiation dose, and screw centrality. Robotic-assisted surgery showed superior outcomes with accurate screw placement, lower radiation exposure, and fewer guide wire attempts compared to the traditional method.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Multidisciplinary Sciences
Shihao He, Xiaokuan Hao, Ziqi Liu, Yanru Wang, Junze Zhang, Xilong Wang, Fei Di, Rong Wang, Yuanli Zhao
Summary: This study investigated the DIAPH1 gene mutation in an Asian population and compared the angiographic features of MMD patients with and without the mutation. DIAPH1 gene mutation was detected in 18% of the MMD patients, and there was a significantly higher rate of posterior cerebral artery involvement in the mutation positive group. DIAPH1 gene mutation is not a major genetic risk gene for Asian patients with moyamoya disease but may play an important role in the involvement of posterior cerebral artery.
SCIENTIFIC REPORTS
(2023)
Letter
Oncology
Shihao He, Yanru Wang, Ziqi Liu, Junze Zhang, Xiaokuan Hao, Xilong Wang, Zhenyu Zhou, Rong Wang, Yuanli Zhao
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)