Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma

Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors

(2020) Yunlong Ma et al.   Aging-US

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

(2019) Jingmei Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

(2019) Siew-Kim Khoo et al.   JOURNAL OF IMMUNOLOGY

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

(2019) Manuel A.R. Ferreira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanistic interpretation of non-coding variants for discovering transcriptional regulators of drug response

(2019) Xiaoman Xie et al.   BMC BIOLOGY

Asthma severity, nature or nurture

(2019) Benjamin A. Raby   CURRENT OPINION IN PEDIATRICS

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies

(2019) Milton Pividori et al.   Lancet Respiratory Medicine

Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

(2018) Ana Julia de F.C. Lichtenfels et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

(2018) Zhaozhong Zhu et al.   NATURE GENETICS

Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

(2018) Cui-Ping Yang et al.   Nature Communications

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

(2018) Amber Dahlin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

(2018) Nick Shrine et al.   Lancet Respiratory Medicine

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma

(2017) Y. Liu et al.   Scientific Reports

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

(2017) Gina M. Calabrese et al.   Cell Systems

Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population

(2016) Kaung Si Thu et al.   APMIS

Identification of SLC25A37 as a major depressive disorder risk gene

(2016) Yong-Xia Huo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma

(2016) Michael J. McGeachie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis

(2016) Timothy E Sweeney et al.   Lancet Respiratory Medicine

Genome-wide association studies (GWAS) and their importance in asthma

(2015) A. García-Sánchez et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Heritability and confirmation of genetic association studies for childhood asthma in twins

(2015) V. Ullemar et al.   ALLERGY

Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes

(2015) Yaron Tomer et al.   JOURNAL OF AUTOIMMUNITY

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

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An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder

(2015) Nirmala Akula et al.   NEUROPSYCHOPHARMACOLOGY

Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma

(2015) Berran Yucesoy et al.   TOXICOLOGICAL SCIENCES

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

(2015) J. Pinero et al.   Database-The Journal of Biological Databases and Curation

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Asthma

(2013) Fernando D Martinez et al.   LANCET

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

(2013) Klaus Bønnelykke et al.   NATURE GENETICS

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

(2013) Anne Hinks et al.   NATURE GENETICS

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

(2013) Vinod Kumar et al.   PLoS Genetics

Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome-Wide Association Study

(2013) Gisela Orozco et al.   Arthritis & Rheumatology

GLAD4U: deriving and prioritizing gene lists from PubMed literature

(2012) Jérôme Jourquin et al.   BMC GENOMICS

HLA-DQ strikes again: Genome-wide association study further confirmsHLA-DQin the diagnosis of asthma among adults

(2012) J. Lasky-Su et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

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Interpreting noncoding genetic variation in complex traits and human disease

(2012) Lucas D Ward et al.   NATURE BIOTECHNOLOGY

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

StemCellDB: The Human Pluripotent Stem Cell Database at the National Institutes of Health

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Genome-wide association study to identify genetic determinants of severe asthma

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Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case–control study

(2012) Naoya Fujino et al.   BMJ Open

Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline

(2011) Jeong-Hyun Kim et al.   JOURNAL OF HUMAN GENETICS

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Genome-wide association studies for discovery of genes involved in asthma

(2011) LOUBNA AKHABIR et al.   RESPIROLOGY

A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes

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Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

(2010) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

Genetic analysis of radiation-induced changes in human gene expression

(2009) Denis A. Smirnov et al.   NATURE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

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Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

(2008) Emmanuelle Bouzigon et al.   NEW ENGLAND JOURNAL OF MEDICINE